thalidomide has been researched along with Cleft Palate in 25 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cranial nerve palsy/paresis was only seen in HFM and thalidomide-induced malformations." | 1.30 | Teratological studies on craniofacial malformations. ( Jacobsson, C, 1997) |
| "A new case of Tetraphocomelia--cleft palatee syndrome is described." | 1.25 | The tetraphocomelia -- cleft palate syndrome: description of a new case. ( Grosse, FR; Pandel, C; Wiedemann, HR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (88.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hawgood, BJ | 1 |
| Fraser, FC | 1 |
| KAJII, T | 2 |
| GOTO, M | 1 |
| JOERGENSEN, G | 1 |
| PARTSCH, CJ | 1 |
| SALLER, K | 1 |
| INGALLS, TH | 1 |
| KLINGBERG, MA | 1 |
| FOGH-ANDERSEN, P | 2 |
| Immeyer, F | 1 |
| Szabo, KT | 1 |
| Steelman, RL | 1 |
| Jacobsson, C | 1 |
| Grosse, FR | 1 |
| Pandel, C | 1 |
| Wiedemann, HR | 1 |
| McCredie, J | 1 |
| Jörgensen, G | 1 |
| Lenz, W | 1 |
| Poswillo, DE | 1 |
| Keplinger, ML | 1 |
| Wright, PL | 1 |
| Plank, JB | 1 |
| Calandra, JC | 1 |
| Watanabe, G | 1 |
| Gagliardi, V | 1 |
| Stahl, A | 1 |
| Heaston, TG | 1 |
| Myers, EN | 1 |
| Stoll, S | 1 |
| Weltschew, A | 1 |
| Arbab-Zadeh, A | 1 |
4 reviews available for thalidomide and Cleft Palate
| Article | Year |
|---|---|
[PHARMACOGENETICS].
Topics: Abnormalities, Drug-Induced; Atropine; Cleft Palate; Cortisone; Genetics; Glucosephosphate Dehydroge | 1964 |
CONGENITAL MALFORMATIONS. CLINICAL AND COMMUNITY CONSIDERATIONS.
Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Achondroplasia; Anencephaly; Cleft Pala | 1965 |
Phenocopies.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anemia, Aplastic; Anorexia Nervosa; Arm; Cleft | 1973 |
[Experimental epidemiology].
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Cleft Palate; Congenital Abnormalities; Diabe | 1971 |
21 other studies available for thalidomide and Cleft Palate
| Article | Year |
|---|---|
Professor David Poswillo CBE (1927-2003): Skilled oral and maxillofacial surgeon, influential scientist, teacher and adviser.
Topics: Animals; Cleft Palate; England; Faculty, Dental; Female; History, 20th Century; History, 21st Centur | 2014 |
Of mice and children: Reminiscences of a teratogeneticist.
Topics: Animals; Canada; Cleft Palate; Cortisone; Genetic Counseling; Genetics, Medical; History, 20th Centu | 2008 |
Cleft lip and palate after thalidomide.
Topics: Cleft Lip; Cleft Palate; Humans; Thalidomide | 1963 |
[EAR DEFORMITIES IN THALIDOMIDE EMBRYOPATHY].
Topics: Abnormalities, Drug-Induced; Cleft Palate; Congenital Abnormalities; Cryptorchidism; Ear Deformities | 1964 |
[ON THE FREQUENCY OF MALFORMATIONS IN BAVARIA. 2].
Topics: Abnormalities, Drug-Induced; Anencephaly; Cleft Lip; Cleft Palate; Clubfoot; Congenital Abnormalitie | 1964 |
[THALIDOMIDE AND CLEFT LIP, JAW AND PALATE].
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Female; Humans; Infant; Infant, Newborn; Pregn | 1965 |
[Cleft lip and palate in thalidomide-induced embryopathies].
Topics: Abnormalities, Drug-Induced; Adult; Arm; Child; Child, Preschool; Cleft Lip; Cleft Palate; Ear Defor | 1967 |
Effects of thalidomide treatment of inbred female mice on pregnancy, fetal development, and mortality of offspring.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Death; Fetus; Mice; Pregnancy; Pre | 1967 |
Teratological studies on craniofacial malformations.
Topics: Alkaline Phosphatase; Aminopropionitrile; Amniotic Fluid; Animals; Branchial Region; Cartilage; Clef | 1997 |
The tetraphocomelia -- cleft palate syndrome: description of a new case.
Topics: Abnormalities, Multiple; Arm; Child, Preschool; Cleft Palate; Diagnosis, Differential; Ectromelia; F | 1975 |
Embryonic neuropathy. A hypothesis of neural chest injury as the pathogenesis of congenital malformations.
Topics: Abnormalities, Drug-Induced; Animals; Cell Movement; Central Nervous System; Child; Cleft Palate; Co | 1974 |
[Abnormalities in the field of otorhinolaryngology. Genetic report].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acrocephalosyndactylia; Chromosome Aberrations | 1972 |
Orofacial malformations.
Topics: Animals; Antimetabolites; Cell Differentiation; Cleft Lip; Cleft Palate; Dermoid Cyst; Eye Neoplasms | 1974 |
Teratologic studies with FD and C red no. 2 in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Autopsy; Body Weight; Cleft Palate; Coloring Agents; Female; F | 1974 |
[Teratogenic effects induced by N-phthaloylglutamic acid imide in the maxillofacial region].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Animals, Newborn; Cleft Lip; Cleft Pa | 1971 |
Clinical, orthodontic and radiological findings in the jaws and face of children with dysmelia associated with thalidomide-embryopathy.
Topics: Abnormalities, Drug-Induced; Ankylosis; Cephalometry; Child, Preschool; Cleft Lip; Cleft Palate; Fem | 1968 |
"The induction of cleft palate in experimental animals with thalidomide".
Topics: Abnormalities, Drug-Induced; Cleft Palate; Dentistry; Thalidomide | 1969 |
Congenital anomaly of the middle and inner ear.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Ear, Inner; Ear, Middle; Humans; Infant; Male; | 1968 |
[Animal experiments with thalidomide and a thalidomide-serum mixture].
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Ear Deformities, Acquired; Guinea Pigs; Immune S | 1965 |
Thalidomide experience in Japan.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Ectromelia; Female; Humans; Infant, Newborn; J | 1965 |
Thalidomide and congenital cleft deformities.
Topics: Child, Preschool; Cleft Lip; Cleft Palate; Denmark; Ear Deformities, Acquired; Female; Humans; Male; | 1966 |