thalidomide has been researched along with Cirrhoses, Experimental Liver in 8 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide + CCl(4) treated rats showed minor histological alterations and thinner bands of collagen." | 1.32 | Thalidomide ameliorates carbon tetrachloride induced cirrhosis in the rat. ( Fernández-Martínez, E; García, J; Lara-Ochoa, F; Muriel, P; Pérez-Alvarez, V; Ponce, S; Shibayama, M; Tsutsumi, V, 2003) |
| "Thalidomide-treated group was given thalidomide (10mg/kg/day) intraperitoneally for 10 consecutive days." | 1.32 | Thalidomide salvages lethal hepatic necroinflammation and accelerates recovery from cirrhosis in rats. ( Chen, MF; Ho, YP; Huang, SF; Jan, YY; Yeh, JN; Yeh, TS, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, P | 3 |
| Meng, Q | 1 |
| Liu, J | 1 |
| Wang, C | 1 |
| Muriel, P | 1 |
| Fernández-Martínez, E | 1 |
| Pérez-Alvarez, V | 1 |
| Lara-Ochoa, F | 1 |
| Ponce, S | 1 |
| García, J | 1 |
| Shibayama, M | 1 |
| Tsutsumi, V | 1 |
| Enomoto, N | 1 |
| Takei, Y | 1 |
| Hirose, M | 1 |
| Kitamura, T | 1 |
| Ikejima, K | 1 |
| Sato, N | 1 |
| Yeh, TS | 1 |
| Ho, YP | 1 |
| Huang, SF | 1 |
| Yeh, JN | 1 |
| Jan, YY | 1 |
| Chen, MF | 1 |
| Chong, LW | 1 |
| Hsu, YC | 1 |
| Chiu, YT | 1 |
| Yang, KC | 1 |
| Huang, YT | 1 |
| Lü, P | 1 |
| Luo, HS | 3 |
| Shelley, CP | 1 |
| Xiao, YJ | 3 |
| Liu, SQ | 3 |
| Paul, SC | 1 |
| An, P | 1 |
| Zhou, XP | 1 |
| Chireyath Paul, S | 1 |
| Si, XM | 1 |
8 other studies available for thalidomide and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Thalidomide Accelerates the Degradation of Extracellular Matrix in Rat Hepatic Cirrhosis via Down-Regulation of Transforming Growth Factor-β1.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen Type III; Down-Regulation; Extracellular Matrix; Imm | 2015 |
Thalidomide ameliorates carbon tetrachloride induced cirrhosis in the rat.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Drug Evaluation, Preclini | 2003 |
Protective effect of thalidomide on endotoxin-induced liver injury.
Topics: Animals; Calcium; Disease Progression; Escherichia coli; Immunosuppressive Agents; Kupffer Cells; Li | 2003 |
Thalidomide salvages lethal hepatic necroinflammation and accelerates recovery from cirrhosis in rats.
Topics: Animals; Collagenases; Hepatitis; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; Male; Matrix | 2004 |
Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats.
Topics: Actins; Animals; Collagen; Dimethylnitrosamine; Fibrosis; I-kappa B Proteins; Immunosuppressive Agen | 2006 |
[Effects of thalidomide on the expression of adhesion molecules in experimental hepatic fibrotic rats].
Topics: Animals; Cell Adhesion Molecules; Liver Cirrhosis, Experimental; Male; Rats; Rats, Wistar; Thalidomi | 2006 |
Thalidomide in rat liver cirrhosis: blockade of tumor necrosis factor-alpha via inhibition of degradation of an inhibitor of nuclear factor-kappaB.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Down-Regul | 2006 |
Thalidomide prevents rat liver cirrhosis via inhibition of oxidative stress.
Topics: Actins; Animals; Blotting, Western; Carbon Tetrachloride; Desmin; Glutathione Peroxidase; Immunohist | 2006 |