thalidomide has been researched along with Chronic Lung Injury in 6 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, the potential effects of thalidomide (Thal) on bleomycin (BLM)-induced pulmonary fibrosis were investigated." | 7.85 | Antiinflammation and Antioxidant Effects of Thalidomide on Pulmonary Fibrosis in Mice and Human Lung Fibroblasts. ( Chen, M; Dong, X; Fan, Q; Li, M; Li, X; Wei, W, 2017) |
| "In this study, the potential effects of thalidomide (Thal) on bleomycin (BLM)-induced pulmonary fibrosis were investigated." | 3.85 | Antiinflammation and Antioxidant Effects of Thalidomide on Pulmonary Fibrosis in Mice and Human Lung Fibroblasts. ( Chen, M; Dong, X; Fan, Q; Li, M; Li, X; Wei, W, 2017) |
| "Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity." | 1.39 | Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice. ( Amirshahrokhi, K, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, F | 1 |
| Zhu, J | 1 |
| Zhang, W | 1 |
| Fu, Y | 1 |
| Lin, Z | 1 |
| Dong, X | 2 |
| Li, X | 1 |
| Li, M | 1 |
| Chen, M | 1 |
| Fan, Q | 1 |
| Wei, W | 2 |
| Amirshahrokhi, K | 1 |
| Zhu, H | 1 |
| Shi, X | 1 |
| Ju, D | 1 |
| Huang, H | 1 |
| Singer, NG | 1 |
| McCune, WJ | 1 |
| Lindsay, L | 1 |
| Oliver, SJ | 1 |
| Freeman, SL | 1 |
| Josien, R | 1 |
| Krauss, A | 1 |
| Kaplan, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy and Safety of Thalidomide in the Adjuvant Treatment of Moderate New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273529] | Phase 2 | 100 participants (Anticipated) | Interventional | 2020-02-20 | Not yet recruiting | ||
| The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273581] | Phase 2 | 40 participants (Anticipated) | Interventional | 2020-02-18 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thalidomide and Chronic Lung Injury
| Article | Year |
|---|---|
Update on immunosuppressive therapy.
Topics: Adult; Arthritis, Juvenile; Azathioprine; Behcet Syndrome; Child; Cladribine; Cyclophosphamide; Cycl | 1998 |
5 other studies available for thalidomide and Chronic Lung Injury
| Article | Year |
|---|---|
Thal protects against paraquat-induced lung injury through a microRNA-141/HDAC6/IκBα-NF-κB axis in rat and cell models.
Topics: Animals; Apoptosis; Cell Line; Disease Models, Animal; Female; Histone Deacetylase 6; Inflammation M | 2021 |
Antiinflammation and Antioxidant Effects of Thalidomide on Pulmonary Fibrosis in Mice and Human Lung Fibroblasts.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cells, Cultured; Fibroblasts; Humans; Inflammation; | 2017 |
Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Hydroxyproline; Immunohistochemistry; I | 2013 |
Anti-inflammatory effect of thalidomide on H1N1 influenza virus-induced pulmonary injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Inflammation Mediators; Influenza A Virus, H1N1 Subtype; Lung Inj | 2014 |
Anti-inflammatory effect of thalidomide on H1N1 influenza virus-induced pulmonary injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Inflammation Mediators; Influenza A Virus, H1N1 Subtype; Lung Inj | 2014 |
Anti-inflammatory effect of thalidomide on H1N1 influenza virus-induced pulmonary injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Inflammation Mediators; Influenza A Virus, H1N1 Subtype; Lung Inj | 2014 |
Anti-inflammatory effect of thalidomide on H1N1 influenza virus-induced pulmonary injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Inflammation Mediators; Influenza A Virus, H1N1 Subtype; Lung Inj | 2014 |
Modulation of hyperoxia-induced TNF-alpha expression in the newborn rat lung by thalidomide and dexamethasone.
Topics: Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Fema | 2000 |