thalidomide has been researched along with Cancer, Embryonal in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lenalidomide was well tolerated but did not show efficacy in heavily pretreated patients with cisplatin-refractory and multiply relapsed germ cell tumors." | 2.75 | Lenalidomide in patients with cisplatin-refractory and multiply relapsed germ cell tumors. ( Bokemeyer, C; Honecker, F; Oechsle, K, 2010) |
| "Germ cell tumors are the most common malignancies in men under 50 years and also the most common cause of death from solid tumors in this age group." | 2.45 | Germ cell tumors of the gonads: a selective review emphasizing problems in drug resistance and current therapy options. ( Albers, P; Christoph, F; Hinz, S; Hoepfner, M; Jung, K; Kempkensteffen, C; Krause, H; Lein, M; Miller, K; Schostak, M; Schrader, M; Stephan, C; Weikert, S, 2009) |
| "Mediastinal nonseminomatous germ cell tumor (MNSGCT)-associated histiocytic proliferations are rare and rapidly fatal disorders." | 1.43 | Mediastinal Germ Cell Tumor-associated Histiocytic Proliferations Treated With Thalidomide Plus Chemotherapy Followed by Alemtuzumab-containing Reduced Intensity Allogeneic Peripheral Blood Stem Cell Transplantation: A Case Report. ( Chen, RL; Chen, WT; Fang, LH; Lee, PI; Shih, LS, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prince, SK | 1 |
| Forgeson, G | 1 |
| Fang, LH | 1 |
| Shih, LS | 1 |
| Lee, PI | 1 |
| Chen, WT | 1 |
| Chen, RL | 1 |
| Schrader, M | 1 |
| Kempkensteffen, C | 1 |
| Christoph, F | 1 |
| Hinz, S | 1 |
| Weikert, S | 1 |
| Lein, M | 1 |
| Krause, H | 1 |
| Stephan, C | 1 |
| Jung, K | 1 |
| Hoepfner, M | 1 |
| Albers, P | 1 |
| Miller, K | 1 |
| Schostak, M | 1 |
| Oechsle, K | 1 |
| Bokemeyer, C | 1 |
| Honecker, F | 1 |
| Rick, O | 1 |
| Braun, T | 1 |
| Siegert, W | 1 |
| Beyer, J | 1 |
1 review available for thalidomide and Cancer, Embryonal
| Article | Year |
|---|---|
Germ cell tumors of the gonads: a selective review emphasizing problems in drug resistance and current therapy options.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Cell | 2009 |
1 trial available for thalidomide and Cancer, Embryonal
| Article | Year |
|---|---|
Lenalidomide in patients with cisplatin-refractory and multiply relapsed germ cell tumors.
Topics: Adult; Antineoplastic Agents; Cisplatin; Compassionate Use Trials; Drug Resistance, Neoplasm; Humans | 2010 |
3 other studies available for thalidomide and Cancer, Embryonal
| Article | Year |
|---|---|
Bleeding from gastrointestinal tract recurrence of non-seminomatous germ cell tumour testis, showing temporary response to gemcitabine and oxaliplatin chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Gastrointestinal Hemorrhage; G | 2013 |
Mediastinal Germ Cell Tumor-associated Histiocytic Proliferations Treated With Thalidomide Plus Chemotherapy Followed by Alemtuzumab-containing Reduced Intensity Allogeneic Peripheral Blood Stem Cell Transplantation: A Case Report.
Topics: Alemtuzumab; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Fatal Outcome; Histiocytic Sa | 2016 |
Activity of thalidomide in patients with platinum-refractory germ-cell tumours.
Topics: Adult; Antineoplastic Agents; Drug Resistance, Neoplasm; Gonadal Disorders; Humans; Mediastinal Neop | 2006 |