Page last updated: 2024-11-05

thalidomide and Cachexia

thalidomide has been researched along with Cachexia in 44 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.

Research Excerpts

ExcerptRelevanceReference
"To determine the effects of thalidomide and placebo on anorexia-cachexia and its related symptoms, body composition, resting metabolic rate, and serum cytokines and their receptors in patients with advanced cancer."9.16The role of thalidomide and placebo for the treatment of cancer-related anorexia-cachexia symptoms: results of a double-blind placebo-controlled randomized study. ( Allo, J; Bruera, E; Cohen, EN; Del Fabbro, E; Palmer, JL; Reuben, JM; Tin, S; Willey, JS; Yennurajalingam, S, 2012)
"Thalidomide was well tolerated and effective at attenuating loss of weight and lean body mass in patients with cachexia due to advanced pancreatic cancer."9.11Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. ( Duncan, HD; Ellis, RD; Goggin, PM; Gordon, JN; Johns, T; Trebble, TM, 2005)
"Celgene Corporation initiated a phase II safety and efficacy trial for Synovir (thalidomide) in the treatment of chronic intractable diarrhea in HIV-positive patients."9.08Thalidomide used to treat chronic diarrhea in HIV-positive patients. ( , 1996)
"This review aimed to (1) evaluate the effectiveness of thalidomide, and (2) identify and assess adverse effects from thalidomide for cancer cachexia."8.88Thalidomide for managing cancer cachexia. ( Cantwell, M; Cardwell, CR; Donnelly, M; Mills, M; Murray, LJ; Reid, J, 2012)
"To discuss and assess the clinical value of treating lung cancer cachexia with thalidomide combined with cinobufagin."7.88Clinical study on thalidomide combined with cinobufagin to treat lung cancer cachexia. ( Bao, Y; Bu, K; Chen, X; Lu, Y; Qin, S; Xie, M, 2018)
"Using our rat cholangiocarcinoma model, we demonstrated that thalidomide inhibited tumor growth and was associated with a decrease in expression of reduced eIF4E and VEGF expression; in addition, thalidomide preserved fast-twitch skeletal muscle fibers and was associated with decreased expression of TNFalpha and TGFbeta1."7.74Thalidomide attenuates tumor growth and preserves fast-twitch skeletal muscle fibers in cholangiocarcinoma rats. ( Liao, LM; Liu, KH; Ro, LS; Wu, YL; Yeh, TS, 2008)
"The management of cancer-related anorexia/cachexia syndrome (CACS) is a great challenge in clinical practice."6.77Clinical studies on the treatment of cancer cachexia with megestrol acetate plus thalidomide. ( Cao, YZ; Li, X; Peng, LM; Shi, YM; Wen, HS; Yang, F; Zhang, CC, 2012)
"Thalidomide treatment appeared to reverse the loss of weight and lean body mass over the 2-week trial period."6.71Oesophageal cancer and cachexia: the effect of short-term treatment with thalidomide on weight loss and lean body mass. ( Austin, A; Cole, AT; Freeman, JG; Holt, M; Khan, ZH; MacDonald, I; Pye, D; Simpson, EJ, 2003)
"To determine the effects of thalidomide and placebo on anorexia-cachexia and its related symptoms, body composition, resting metabolic rate, and serum cytokines and their receptors in patients with advanced cancer."5.16The role of thalidomide and placebo for the treatment of cancer-related anorexia-cachexia symptoms: results of a double-blind placebo-controlled randomized study. ( Allo, J; Bruera, E; Cohen, EN; Del Fabbro, E; Palmer, JL; Reuben, JM; Tin, S; Willey, JS; Yennurajalingam, S, 2012)
"Three hundred thirty-two assessable patients with cancer-related anorexia/cachexia syndrome were randomly assigned to one of five treatment arms: arm 1, medroxyprogesterone (500 mg/day) or megestrol acetate (320 mg/day); arm 2, oral supplementation with eicosapentaenoic acid; arm 3, L-carnitine (4 g/day); arm 4, thalidomide (200 mg/day); and arm 5, a combination of the above."5.14Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia. ( Contu, P; Dessì, M; Macciò, A; Madeddu, C; Mantovani, G; Massa, E; Panzone, F; Serpe, R, 2010)
"Three hundred and thirty-two assessable patients with cancer-related anorexia/cachexia syndrome (CACS) were randomly assigned to one of five arms of treatment: 1--medroxyprogesterone 500 mg/d or megestrol acetate 320 mg/d; 2--oral supplementation with eicosapentaenoic acid (EPA); 3--L-carnitine 4 g/d; 4--thalidomide 200 mg/d; 5--a combination of the above."5.14Randomised phase III clinical trial of 5 different arms of treatment on 332 patients with cancer cachexia. ( Mantovani, G, 2010)
"Thalidomide was well tolerated and effective at attenuating loss of weight and lean body mass in patients with cachexia due to advanced pancreatic cancer."5.11Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. ( Duncan, HD; Ellis, RD; Goggin, PM; Gordon, JN; Johns, T; Trebble, TM, 2005)
"Celgene Corporation initiated a phase II safety and efficacy trial for Synovir (thalidomide) in the treatment of chronic intractable diarrhea in HIV-positive patients."5.08Thalidomide used to treat chronic diarrhea in HIV-positive patients. ( , 1996)
"This review aimed to (1) evaluate the effectiveness of thalidomide, and (2) identify and assess adverse effects from thalidomide for cancer cachexia."4.88Thalidomide for managing cancer cachexia. ( Cantwell, M; Cardwell, CR; Donnelly, M; Mills, M; Murray, LJ; Reid, J, 2012)
"To discuss and assess the clinical value of treating lung cancer cachexia with thalidomide combined with cinobufagin."3.88Clinical study on thalidomide combined with cinobufagin to treat lung cancer cachexia. ( Bao, Y; Bu, K; Chen, X; Lu, Y; Qin, S; Xie, M, 2018)
"Using our rat cholangiocarcinoma model, we demonstrated that thalidomide inhibited tumor growth and was associated with a decrease in expression of reduced eIF4E and VEGF expression; in addition, thalidomide preserved fast-twitch skeletal muscle fibers and was associated with decreased expression of TNFalpha and TGFbeta1."3.74Thalidomide attenuates tumor growth and preserves fast-twitch skeletal muscle fibers in cholangiocarcinoma rats. ( Liao, LM; Liu, KH; Ro, LS; Wu, YL; Yeh, TS, 2008)
"Thalidomide is being tested as an anti-HIV drug, a weight loss treatment, an immune system regulator, a tuberculosis treatment supplement, and a treatment for microsporidiosis."3.69Treatment for weight loss, tuberculosis and AIDS? ( , 1995)
"The management of cancer-related anorexia/cachexia syndrome (CACS) is a great challenge in clinical practice."2.77Clinical studies on the treatment of cancer cachexia with megestrol acetate plus thalidomide. ( Cao, YZ; Li, X; Peng, LM; Shi, YM; Wen, HS; Yang, F; Zhang, CC, 2012)
"Oesophageal cancer cachexia is a significant clinical problem, resulting in excessive morbidity and mortality."2.76Poor tolerability of thalidomide in end-stage oesophageal cancer. ( Cole, AT; Freeman, JG; Khan, ZH; Rennie, MJ; Selby, AL; Wilkes, EA, 2011)
"Thalidomide treatment appeared to reverse the loss of weight and lean body mass over the 2-week trial period."2.71Oesophageal cancer and cachexia: the effect of short-term treatment with thalidomide on weight loss and lean body mass. ( Austin, A; Cole, AT; Freeman, JG; Holt, M; Khan, ZH; MacDonald, I; Pye, D; Simpson, EJ, 2003)
" The Food and Drug Administration (FDA), Celgene, and AIDS activists eliminated the randomized dose portion of the program to allow physicians to determine the dosage to use."2.68Thalidomide's elusive access. ( Gilden, D, 1995)
"Studies have recruited heterogeneous cancer patient populations in late disease stages, and many had issues with accrual and attrition."2.61Anti-cytokines in the treatment of cancer cachexia. ( Prado, BL; Qian, Y, 2019)
"In patients with advanced cancer, AIDS and end-stage organ diseases, symptoms of cachexia syndrome include decrease in appetite, weight loss, decreased performance status, and an increase in the systemic inflammatory response."2.50Immunomodulatory agents for the treatment of cachexia. ( Bhargava, R; Chasen, M; Hirschman, S, 2014)
"Much of the success in the treatment of cachexia has come from agents capable of blocking protein degradation through the ubiquitin-proteasome proteolytic pathway."2.43Clinical anticachexia treatments. ( Tisdale, MJ, 2006)
"Thalidomide was first produced in Germany in the 1950s."2.42[Thalidomide--new prospective therapy in oncology]. ( Pałgan, I; Pałgan, K, 2003)
"Thalidomide was first used in the late 1950s but it was withdrawn from the market in the 1960s for its notorious teratogenic effects."2.42The promise of thalidomide: evolving indications. ( Joglekar, S; Levin, M, 2004)
"The activity of thalidomide in solid tumors is less prominent."2.42Thalidomide in cancer medicine. ( Bamias, A; Dimopoulos, MA; Eleutherakis-Papaiakovou, V, 2004)
"Thalidomide trials have been slow to recruit, therefore buyers clubs are working to make the drug available through their services."1.29Thalidomide and HIV: several possible uses. ( Smith, D, 1995)
"Thalidomide may cause birth defects, and larger doses can cause neuropathy or other adverse effects."1.29Wasting syndrome--affordable treatments. ( James, JS, 1995)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (38.64)18.2507
2000's17 (38.64)29.6817
2010's10 (22.73)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xie, M1
Chen, X1
Qin, S1
Bao, Y1
Bu, K1
Lu, Y1
Prado, BL1
Qian, Y1
Wen, HS1
Li, X1
Cao, YZ1
Zhang, CC1
Yang, F1
Shi, YM1
Peng, LM1
Ritchie, CS1
Currow, DC1
Abernethy, AP1
Kutner, JS1
Chasen, M1
Bhargava, R1
Hirschman, S1
Tassinari, D1
Santelmo, C1
Tombesi, P1
Sartori, S1
Mantovani, G2
Macciò, A1
Madeddu, C1
Serpe, R1
Massa, E1
Dessì, M1
Panzone, F1
Contu, P1
Wilkes, EA2
Selby, AL1
Cole, AT2
Freeman, JG3
Rennie, MJ1
Khan, ZH2
Reid, J1
Mills, M1
Cantwell, M1
Cardwell, CR1
Murray, LJ1
Donnelly, M1
Yennurajalingam, S1
Willey, JS1
Palmer, JL1
Allo, J1
Del Fabbro, E1
Cohen, EN1
Tin, S1
Reuben, JM1
Bruera, E5
Simpson, EJ1
Holt, M1
MacDonald, I1
Pye, D1
Austin, A1
Okafor, MC1
Gordon, JN2
Goggin, PM2
Fanelli, M1
Sarmiento, R1
Gattuso, D1
Carillio, G1
Capaccetti, B1
Vacca, A1
Roccaro, AM1
Gasparini, G1
Pałgan, K1
Pałgan, I1
Joglekar, S1
Levin, M1
Eleutherakis-Papaiakovou, V1
Bamias, A1
Dimopoulos, MA1
Stroud, M1
Trebble, TM1
Ellis, RD1
Duncan, HD1
Johns, T1
Argilés, JM1
Busquets, S1
López-Soriano, FJ1
Tisdale, MJ1
Powell, RJ1
Liu, KH1
Liao, LM1
Ro, LS1
Wu, YL1
Yeh, TS1
Weinroth, SE1
Parenti, DM1
Simon, GL1
Haslett, PA1
Larkin, M1
Neumann, CM1
Pituskin, E1
Calder, K2
Ball, G1
Hanson, J1
Peuckmann, V1
Fisch, M1
Smith, D1
Getty, J1
Grunfeld, C1
James, JS3
Gilden, D1
Baker, R1
Cooper, S1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Double-blind Clinical Trial of the Use of Mirtazapine Versus Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.[NCT03283488]Phase 252 participants (Actual)Interventional2019-03-26Completed
A Single-arm, Open, Prospective, Multi-center Study on Thalidomide Combined With First-line Chemotherapy and Monotherapy for Maintenance Treatment of Liver Metastases From Her2-negative Advanced Gastric Cancer[NCT05198856]Phase 1/Phase 2106 participants (Anticipated)Interventional2022-03-10Not yet recruiting
Nabilone Effect on the Attenuation of Anorexia, Nutritional Status and Quality of Life in Patients With Anorexia Associated With Advanced Lung Cancer: Randomized Double Blind Clinical Trial[NCT02802540]Phase 2/Phase 378 participants (Anticipated)Interventional2014-12-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

16 reviews available for thalidomide and Cachexia

ArticleYear
Anti-cytokines in the treatment of cancer cachexia.
    Annals of palliative medicine, 2019, Volume: 8, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cachexia; Cytokines; Etanercept; Forecast

2019
Immunomodulatory agents for the treatment of cachexia.
    Current opinion in supportive and palliative care, 2014, Volume: 8, Issue:4

    Topics: Adipose Tissue; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Appetite; C-Reacti

2014
Thalidomide for managing cancer cachexia.
    The Cochrane database of systematic reviews, 2012, Apr-18, Issue:4

    Topics: Adult; Anti-Inflammatory Agents; Cachexia; Humans; Immunosuppressive Agents; Neoplasms; Randomized C

2012
Thalidomide for erythema nodosum leprosum and other applications.
    Pharmacotherapy, 2003, Volume: 23, Issue:4

    Topics: Animals; Cachexia; Erythema Nodosum; Graft vs Host Disease; Humans; Leprosy, Lepromatous; Multiple M

2003
Thalidomide and its derivatives: emerging from the wilderness.
    Postgraduate medical journal, 2003, Volume: 79, Issue:929

    Topics: Adjuvants, Immunologic; Cachexia; Crohn Disease; Graft vs Host Disease; Hematologic Neoplasms; Human

2003
Thalidomide: a new anticancer drug?
    Expert opinion on investigational drugs, 2003, Volume: 12, Issue:7

    Topics: Animals; Antineoplastic Agents; Cachexia; Hematologic Neoplasms; Humans; Neoplasms; Thalidomide

2003
[Thalidomide--new prospective therapy in oncology].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2003, Volume: 56, Issue:9-10

    Topics: Analgesics; Angiogenesis Inhibitors; Antineoplastic Agents; Cachexia; Clinical Trials as Topic; Huma

2003
The promise of thalidomide: evolving indications.
    Drugs of today (Barcelona, Spain : 1998), 2004, Volume: 40, Issue:3

    Topics: Cachexia; Carcinoma, Renal Cell; Clinical Trials as Topic; Erythema Nodosum; Graft vs Host Disease;

2004
Thalidomide in cancer medicine.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:8

    Topics: Angiogenesis Inhibitors; Cachexia; Clinical Trials as Topic; Graft vs Host Disease; Humans; Multiple

2004
Thalidomide and cancer cachexia: old problem, new hope?
    Gut, 2005, Volume: 54, Issue:4

    Topics: Angiogenesis Inhibitors; Cachexia; Humans; Neoplasms; Pancreatic Neoplasms; Thalidomide

2005
The pivotal role of cytokines in muscle wasting during cancer.
    The international journal of biochemistry & cell biology, 2005, Volume: 37, Issue:10

    Topics: Animals; Anorexia; Antibodies; Cachexia; Cytokines; Humans; Models, Biological; Muscle, Skeletal; Mu

2005
Clinical anticachexia treatments.
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2006, Volume: 21, Issue:2

    Topics: Adipose Tissue; Adrenal Cortex Hormones; Cachexia; Eicosapentaenoic Acid; Energy Metabolism; Humans;

2006
Wasting syndrome in AIDS: pathophysiologic mechanisms and therapeutic approaches.
    Infectious agents and disease, 1995, Volume: 4, Issue:2

    Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Body Comp

1995
Pharmacological treatment of cachexia: any progress?
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1998, Volume: 6, Issue:2

    Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Antiemetics; Antioxidants; Appetite Stimulants; C

1998
Anticytokine approaches to the treatment of anorexia and cachexia.
    Seminars in oncology, 1998, Volume: 25, Issue:2 Suppl 6

    Topics: Anorexia; Cachexia; Humans; Immunosuppressive Agents; Interleukin-1; Interleukin-6; Pentoxifylline;

1998
Potential novel uses of thalidomide: focus on palliative care.
    Drugs, 2000, Volume: 60, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Cachexia; Cytokines; Erythema Nodosum; Graft vs Host Disease; Huma

2000

Trials

13 trials available for thalidomide and Cachexia

ArticleYear
Clinical studies on the treatment of cancer cachexia with megestrol acetate plus thalidomide.
    Chemotherapy, 2012, Volume: 58, Issue:6

    Topics: Aged; Appetite Stimulants; Body Weight; Cachexia; Drug Therapy, Combination; Fatigue; Female; Hand S

2012
Thalidomide in the treatment of cancer cachexia.
    Journal of palliative care, 2008,Autumn, Volume: 24, Issue:3

    Topics: Aged; Angiogenesis Inhibitors; Anorexia; Cachexia; Drug Monitoring; Female; Gastrointestinal Neoplas

2008
Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia.
    The oncologist, 2010, Volume: 15, Issue:2

    Topics: Appetite Stimulants; Cachexia; Carnitine; Eicosapentaenoic Acid; Female; Humans; Interleukin-6; Male

2010
Randomised phase III clinical trial of 5 different arms of treatment on 332 patients with cancer cachexia.
    European review for medical and pharmacological sciences, 2010, Volume: 14, Issue:4

    Topics: Aged; Body Composition; Cachexia; Carnitine; Contraceptives, Oral, Hormonal; Eicosapentaenoic Acid;

2010
Poor tolerability of thalidomide in end-stage oesophageal cancer.
    European journal of cancer care, 2011, Volume: 20, Issue:5

    Topics: Aged; Aged, 80 and over; Cachexia; Double-Blind Method; Esophageal Neoplasms; Female; Humans; Male;

2011
The role of thalidomide and placebo for the treatment of cancer-related anorexia-cachexia symptoms: results of a double-blind placebo-controlled randomized study.
    Journal of palliative medicine, 2012, Volume: 15, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Anorexia; Cachexia; Double-Blind Method; Female; Humans; Immunosuppr

2012
Oesophageal cancer and cachexia: the effect of short-term treatment with thalidomide on weight loss and lean body mass.
    Alimentary pharmacology & therapeutics, 2003, Mar-01, Volume: 17, Issue:5

    Topics: Aged; Aged, 80 and over; Basal Metabolism; Body Composition; Body Mass Index; Cachexia; Energy Intak

2003
Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial.
    Gut, 2005, Volume: 54, Issue:4

    Topics: Aged; Angiogenesis Inhibitors; Body Weight; Cachexia; Double-Blind Method; Female; Humans; Male; Nut

2005
Thalidomide in patients with cachexia due to terminal cancer: preliminary report.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:7

    Topics: Aged; Appetite; Cachexia; Female; Humans; Hypnotics and Sedatives; Male; Neoplasm Metastasis; Neopla

1999
Thalidomide: new expanded access for wasting.
    AIDS treatment news, 1995, Sep-01, Issue:no 230

    Topics: Acquired Immunodeficiency Syndrome; Cachexia; Costs and Cost Analysis; Female; Hotlines; Humans; Imm

1995
Thalidomide's elusive access.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1995, Volume: 9, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Cachexia; Clinical Trials as Topic; Humans; Randomized Controlle

1995
Thalidomide for mouth ulcers and wasting.
    BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation, 1995

    Topics: Cachexia; Double-Blind Method; HIV Infections; Humans; Placebos; Stomatitis, Aphthous; Thalidomide

1995
Thalidomide used to treat chronic diarrhea in HIV-positive patients.
    Journal of the International Association of Physicians in AIDS Care, 1996, Volume: 2, Issue:5

    Topics: Cachexia; Diarrhea; Double-Blind Method; HIV Infections; Humans; Thalidomide; Treatment Outcome

1996

Other Studies

15 other studies available for thalidomide and Cachexia

ArticleYear
Clinical study on thalidomide combined with cinobufagin to treat lung cancer cachexia.
    Journal of cancer research and therapeutics, 2018, Volume: 14, Issue:1

    Topics: Aged; Bufanolides; Cachexia; Drug Therapy, Combination; Female; Humans; Kaplan-Meier Estimate; Lung

2018
Multisite studies offer a solution to recruitment challenges in palliative care studies.
    Journal of palliative medicine, 2013, Volume: 16, Issue:3

    Topics: Anorexia; Cachexia; Female; Humans; Immunosuppressive Agents; Male; Neoplasms; Thalidomide

2013
Thalidomide: an effective anabolic agent in gastrointestinal cancer cachexia.
    Alimentary pharmacology & therapeutics, 2006, Feb-01, Volume: 23, Issue:3

    Topics: Anabolic Agents; Cachexia; Gastrointestinal Neoplasms; Humans; Thalidomide

2006
Thalidomide. Treat with caution!
    The Netherlands journal of medicine, 2006, Volume: 64, Issue:11

    Topics: Adult; Aged, 80 and over; Angiodysplasia; Angiogenesis Inhibitors; Cachexia; Drug Design; Female; Hu

2006
Thalidomide attenuates tumor growth and preserves fast-twitch skeletal muscle fibers in cholangiocarcinoma rats.
    Surgery, 2008, Volume: 143, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cachexia

2008
Thwarting the dwindling progression of cachexia.
    Lancet (London, England), 1998, May-02, Volume: 351, Issue:9112

    Topics: Cachexia; HIV Infections; Humans; Neoplasms; Thalidomide

1998
Thalidomide for night sweats in patients with advanced cancer.
    Palliative medicine, 2000, Volume: 14, Issue:1

    Topics: Adenocarcinoma; Cachexia; Colonic Neoplasms; Female; Humans; Hypnotics and Sedatives; Middle Aged; S

2000
Thalidomide, the FDA, and us -- what do you have? Underground compassionate use. Food and Drug Administration.
    Notes from the underground (New York, N.Y.), 1995,Winter, Issue:no 29

    Topics: Acquired Immunodeficiency Syndrome; Cachexia; Clinical Trials as Topic; Humans; Teratogens; Thalidom

1995
Thalidomide and HIV: several possible uses.
    AIDS treatment news, 1995, Apr-21, Issue:no 221

    Topics: AIDS-Related Opportunistic Infections; Cachexia; Clinical Trials as Topic; HIV Infections; Humans; N

1995
Turning the corner on wasting? A symposium on wasting disorders.
    BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation, 1995

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cachexia; Endocrine System Diseases; Humans; M

1995
State of the art in wasting: an interview with Carl Grunfeld, PhD. Interview by Jeff Getty.
    BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation, 1995

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Animals; Cachexia; Endocr

1995
Wasting syndrome--affordable treatments.
    AIDS treatment news, 1995, Jul-07, Issue:no 226

    Topics: Acquired Immunodeficiency Syndrome; Cachexia; Costs and Cost Analysis; Dronabinol; Exercise Therapy;

1995
Treatment for weight loss, tuberculosis and AIDS?
    Treatment review, 1995, Issue:no 20

    Topics: Acquired Immunodeficiency Syndrome; Cachexia; Clinical Trials as Topic; Humans; Stomatitis, Aphthous

1995
Thalidomide for wasting syndrome: progress toward compromise.
    AIDS treatment news, 1995, Nov-03, Issue:no 234

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Cachexia; Dose-Response R

1995
Thalidomide, gentrified.
    Notes from the underground (New York, N.Y.), 1996, Issue:no 31

    Topics: Acquired Immunodeficiency Syndrome; Cachexia; Drug Costs; Female; Humans; Male; Stomatitis, Aphthous

1996