Page last updated: 2024-11-05

thalidomide and Brain Edema

thalidomide has been researched along with Brain Edema in 5 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

ExcerptRelevanceReference
"Wallerian degeneration is a potent experimental model for studying reproducible cell proliferation in vivo."5.29Inhibitory effects of thalidomide on cellular proliferation, endoneurial edema and myelin phagocytosis during early wallerian degeneration. ( Kögel, B; Schröder, JM; Sellhaus, B; Wöhrmann, T; Zwingenberger, K, 1995)
"Wallerian degeneration is a potent experimental model for studying reproducible cell proliferation in vivo."1.29Inhibitory effects of thalidomide on cellular proliferation, endoneurial edema and myelin phagocytosis during early wallerian degeneration. ( Kögel, B; Schröder, JM; Sellhaus, B; Wöhrmann, T; Zwingenberger, K, 1995)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kwon, HY1
Han, YJ1
Im, JH1
Baek, JH1
Lee, JS1
Fan, QY1
Ramakrishna, S1
Marchi, N1
Fazio, V1
Hallene, K1
Janigro, D1
Rigual, D1
Qiu, J1
Fenstermaker, RA1
Fabiano, AJ1
Tan, DS1
Evanson, J1
Plowman, PN1
Chew, SL1
Schröder, JM1
Sellhaus, B1
Wöhrmann, T1
Kögel, B1
Zwingenberger, K1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Efficacy and Safety of Thalidomide in the Adjuvant Treatment of Moderate New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273529]Phase 2100 participants (Anticipated)Interventional2020-02-20Not yet recruiting
The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273581]Phase 240 participants (Anticipated)Interventional2020-02-18Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

5 other studies available for thalidomide and Brain Edema

ArticleYear
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
    International journal of STD & AIDS, 2019, Volume: 30, Issue:11

    Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do

2019
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
    International journal of STD & AIDS, 2019, Volume: 30, Issue:11

    Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do

2019
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
    International journal of STD & AIDS, 2019, Volume: 30, Issue:11

    Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do

2019
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
    International journal of STD & AIDS, 2019, Volume: 30, Issue:11

    Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do

2019
Combined effects of prenatal inhibition of vasculogenesis and neurogenesis on rat brain development.
    Neurobiology of disease, 2008, Volume: 32, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Blood Vessels; Blood-Brain Barrier; Brain; Brain Chemistry; Brain

2008
Tumoral Bing-Neel Syndrome presenting as a cerebellar mass.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:6

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplas

2013
Post-radiation inflammatory reaction controlled with thalidomide and rofecoxib.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2004, Volume: 16, Issue:8

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Brain Edema; Brain Neoplasms; Female; Hemangioblasto

2004
Inhibitory effects of thalidomide on cellular proliferation, endoneurial edema and myelin phagocytosis during early wallerian degeneration.
    Acta neuropathologica, 1995, Volume: 89, Issue:5

    Topics: Animals; Brain Edema; Cell Division; Myelin Sheath; Phagocytosis; Rats; Rats, Wistar; Schwann Cells;

1995