thalidomide has been researched along with Bone Marrow Diseases in 2 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Bone Marrow Diseases: Diseases involving the BONE MARROW.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lenalidomide has shown good activity in transfusion-dependent patients with the del(5q) cytogenetic abnormality and modest activity in other lower-risk patients." | 2.45 | Treatment of MDS: something old, something new, something borrowed... ( Sekeres, MA, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sekeres, MA | 1 |
| Gómez-Rangel, JD | 1 |
| Ruiz-Delgado, GJ | 1 |
| Ruiz-Argüelles, GJ | 1 |
1 review available for thalidomide and Bone Marrow Diseases
| Article | Year |
|---|---|
Treatment of MDS: something old, something new, something borrowed...
Topics: Azacitidine; Benzoates; Blood Transfusion; Bone Marrow Diseases; Chromosome Deletion; Chromosomes, H | 2009 |
1 other study available for thalidomide and Bone Marrow Diseases
| Article | Year |
|---|---|
Pegylated-interferon induced severe bone marrow hypoplasia in a patient with multiple myeloma receiving thalidomide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Diseases; Drug Interactions | 2003 |