thalidomide has been researched along with Bone Diseases, Developmental in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Bone Diseases, Developmental: Diseases resulting in abnormal GROWTH or abnormal MORPHOGENESIS of BONES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide was administered on the 12th day of pregnancy by the intraperitoneal route in a mixture of Tween 20 with saline (1:3) in doses of 25, 50 and 200 mg/kg to females with genetic background LEW that were purposely mated with males of the BN or BN." | 1.28 | The significance of genetic factors for thalidomide teratogenicity in the Norway rat. ( Bílá, V; Kren, V, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HUBER, A | 1 |
| Bílá, V | 1 |
| Kren, V | 1 |
| Schumacher, HJ | 1 |
| Terapane, J | 1 |
| Jordan, RL | 1 |
| Wilson, JG | 1 |
| Fixsen, JA | 1 |
| Lloyd-Roberts, GC | 1 |
4 other studies available for thalidomide and Bone Diseases, Developmental
| Article | Year |
|---|---|
[CHONDRODYSTROPHY AFTER THALIDOMIDE MEDICATION].
Topics: Abnormalities, Drug-Induced; Bone Diseases, Developmental; Drug Therapy; Ectromelia; Enchondromatosi | 1964 |
The significance of genetic factors for thalidomide teratogenicity in the Norway rat.
Topics: Animals; Bone Diseases, Developmental; Female; Male; Rats; Rats, Inbred BN; Rats, Inbred Lew; Terato | 1989 |
The teratogenic activity of a thalidomide analogue, EM 12 in rabbits, rats, and monkeys.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Bone Diseases, Developmental; Female; Fetal De | 1972 |
The natural history and early treatment of proximal femoral dysplasia.
Topics: Acetabulum; Arthrodesis; Bone Diseases, Developmental; Femur; Femur Head; Fibula; Humans; Ilium; Inf | 1974 |