thalidomide has been researched along with Besnier-Boeck Disease in 36 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Excerpt | Relevance | Reference |
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"Thalidomide use in cutaneous sarcoidosis is based on data from small case series or case reports." | 9.19 | A randomized, investigator-masked, double-blind, placebo-controlled trial on thalidomide in severe cutaneous sarcoidosis. ( Chevrant-Breton, J; Chosidow, O; Cosnes, A; D'Incan, M; Desseaux, K; Droitcourt, C; Dupin, N; Dupuy, A; Joly, P; Juillard, C; Lacour, JP; Lebrun-Vignes, B; Misery, L; Porcher, R; Revuz, J; Rybojad, M; Sassolas, B; Tazi, A; Valeyre, D, 2014) |
"Limited data report thalidomide improves cutaneous sarcoidosis; no benefit has been reported for pulmonary localization." | 9.16 | Thalidomide for improving cutaneous and pulmonary sarcoidosis in patients resistant or with contraindications to corticosteroids. ( Antonelli, A; Barachini, P; Calabrese, R; Carpi, A; Cei, G; Cristofani, R; Fazzi, P; Manni, E; Piazza, S; Siciliano, G, 2012) |
"Thalidomide efficacy and tolerance in patients with cutaneous sarcoidosis merits further evaluation in a controlled trial." | 9.11 | Treatment of cutaneous sarcoidosis with thalidomide. ( Cordoliani, F; Dupuy, A; Lebbé, C; Morel, P; Nguyen, YT; Rybojad, M; Vignon-Pennamen, MD, 2004) |
"Thalidomide was an effective form of treatment for chronic cutaneous sarcoidosis." | 9.10 | Thalidomide for chronic sarcoidosis. ( Baughman, RP; Judson, MA; Lower, EE; Moller, DR; Teirstein, AS, 2002) |
"Data from ten patients with sarcoidosis treated with thalidomide between January 1998 and March 1999 were collected from delivery authorizations and analyzed." | 7.71 | [Sarcoidosis: thalidomide treatment in ten patients]. ( Bressieux, JM; Cosnes, A; Estines, O; Revuz, J; Roujeau, JC; Wolkenstein, P, 2001) |
"A patient with sarcoidosis was treated with thalidomide for disfiguring and painful steroid unresponsive sarcoidal granulomas of the skin." | 7.70 | Disfiguring cutaneous manifestation of sarcoidosis treated with thalidomide: a case report. ( Koblenzer, PS; Lee, JB, 1998) |
" Because administration of low doses of thalidomide has been successful in treating other inflammatory diseases, it was used in a patient with systemic sarcoidosis who was unresponsive to corticosteroids and in a patient with pulmonary sarcoidosis, in whom Kaposi's sarcoma developed after a course of corticosteroid therapy." | 7.69 | Treatment of cutaneous and pulmonary sarcoidosis with thalidomide. ( Bonaccorsi, P; Calvieri, S; Carlesimo, M; Giustini, S; Rossi, A, 1995) |
"Thalidomide has a different toxicity profile than corticosteroids or immunosuppressives." | 6.42 | Newer therapies for cutaneous sarcoidosis: the role of thalidomide and other agents. ( Baughman, RP; Lower, EE, 2004) |
"Thalidomide was given to 2 patients with EOS (a 16-year-old girl and an 8-year-old boy) at an initial dosage of 2 mg/kg/day, and the dosage was increased if necessary." | 5.36 | Thalidomide dramatically improves the symptoms of early-onset sarcoidosis/Blau syndrome: its possible action and mechanism. ( Manki, A; Morishima, T; Takemoto, K; Tsuge, M; Yamamoto, M; Yashiro, M; Yasui, K, 2010) |
"Thalidomide is an immunomodulatory agent that acts to inhibit production of tumor-necrosis factor-alpha (TNF-alpha), an important mediator in CNS inflammation, by enhancing TNF-alpha mRNA degradation." | 5.34 | Thalidomide for acute treatment of neurosarcoidosis. ( Hammond, ER; Kaplin, AI; Kerr, DA, 2007) |
"Thalidomide was effective for muscular, cutaneous, and pulmonary involvement in our patient." | 5.32 | Successful treatment of muscle sarcoidosis with thalidomide. ( Lochmüller, H; Meindl, T; Müller-Felber, W; Schlotter-Weigel, B; Walter, MC, 2003) |
"Thalidomide use in cutaneous sarcoidosis is based on data from small case series or case reports." | 5.19 | A randomized, investigator-masked, double-blind, placebo-controlled trial on thalidomide in severe cutaneous sarcoidosis. ( Chevrant-Breton, J; Chosidow, O; Cosnes, A; D'Incan, M; Desseaux, K; Droitcourt, C; Dupin, N; Dupuy, A; Joly, P; Juillard, C; Lacour, JP; Lebrun-Vignes, B; Misery, L; Porcher, R; Revuz, J; Rybojad, M; Sassolas, B; Tazi, A; Valeyre, D, 2014) |
"Limited data report thalidomide improves cutaneous sarcoidosis; no benefit has been reported for pulmonary localization." | 5.16 | Thalidomide for improving cutaneous and pulmonary sarcoidosis in patients resistant or with contraindications to corticosteroids. ( Antonelli, A; Barachini, P; Calabrese, R; Carpi, A; Cei, G; Cristofani, R; Fazzi, P; Manni, E; Piazza, S; Siciliano, G, 2012) |
"Thalidomide efficacy and tolerance in patients with cutaneous sarcoidosis merits further evaluation in a controlled trial." | 5.11 | Treatment of cutaneous sarcoidosis with thalidomide. ( Cordoliani, F; Dupuy, A; Lebbé, C; Morel, P; Nguyen, YT; Rybojad, M; Vignon-Pennamen, MD, 2004) |
"Thalidomide was an effective form of treatment for chronic cutaneous sarcoidosis." | 5.10 | Thalidomide for chronic sarcoidosis. ( Baughman, RP; Judson, MA; Lower, EE; Moller, DR; Teirstein, AS, 2002) |
"The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids, antimalarials, and methotrexate." | 4.84 | Cutaneous sarcoidosis therapy updated. ( Badgwell, C; Rosen, T, 2007) |
"Data from ten patients with sarcoidosis treated with thalidomide between January 1998 and March 1999 were collected from delivery authorizations and analyzed." | 3.71 | [Sarcoidosis: thalidomide treatment in ten patients]. ( Bressieux, JM; Cosnes, A; Estines, O; Revuz, J; Roujeau, JC; Wolkenstein, P, 2001) |
"A patient with sarcoidosis was treated with thalidomide for disfiguring and painful steroid unresponsive sarcoidal granulomas of the skin." | 3.70 | Disfiguring cutaneous manifestation of sarcoidosis treated with thalidomide: a case report. ( Koblenzer, PS; Lee, JB, 1998) |
" Because administration of low doses of thalidomide has been successful in treating other inflammatory diseases, it was used in a patient with systemic sarcoidosis who was unresponsive to corticosteroids and in a patient with pulmonary sarcoidosis, in whom Kaposi's sarcoma developed after a course of corticosteroid therapy." | 3.69 | Treatment of cutaneous and pulmonary sarcoidosis with thalidomide. ( Bonaccorsi, P; Calvieri, S; Carlesimo, M; Giustini, S; Rossi, A, 1995) |
"Sarcoidosis is a systemic granulomatous disease that affects numerous organs, commonly manifesting at the lungs and skin." | 2.52 | TNF-α: a treatment target or cause of sarcoidosis? ( Amber, KT; Bloom, R; Hertl, M; Mrowietz, U, 2015) |
"Thalidomide was initially approved by the U." | 2.46 | Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders. ( Ladizinski, B; Levis, WR; Sanchez, MR; Shannon, EJ, 2010) |
"Thalidomide was developed in the 1950s as a sedative drug and withdrawn in 1961 because of its teratogenic effects, but has been rediscovered as an immuno-modulatory drug." | 2.46 | [Thalidomide as immunomodulatory drug: pharmacological actions and its indications]. ( Yasui, K, 2010) |
"Thalidomide was first introduced in the 1950s as a sedative but was quickly removed from the market after it was linked to cases of severe birth defects." | 2.43 | Thalidomide: dermatological indications, mechanisms of action and side-effects. ( Hsu, S; Huang, DB; Pang, KR; Tyring, SK; Wu, JJ, 2005) |
"Thalidomide has a different toxicity profile than corticosteroids or immunosuppressives." | 2.42 | Newer therapies for cutaneous sarcoidosis: the role of thalidomide and other agents. ( Baughman, RP; Lower, EE, 2004) |
"Thalidomide was given to 2 patients with EOS (a 16-year-old girl and an 8-year-old boy) at an initial dosage of 2 mg/kg/day, and the dosage was increased if necessary." | 1.36 | Thalidomide dramatically improves the symptoms of early-onset sarcoidosis/Blau syndrome: its possible action and mechanism. ( Manki, A; Morishima, T; Takemoto, K; Tsuge, M; Yamamoto, M; Yashiro, M; Yasui, K, 2010) |
"Thalidomide is an immunomodulatory agent that acts to inhibit production of tumor-necrosis factor-alpha (TNF-alpha), an important mediator in CNS inflammation, by enhancing TNF-alpha mRNA degradation." | 1.34 | Thalidomide for acute treatment of neurosarcoidosis. ( Hammond, ER; Kaplin, AI; Kerr, DA, 2007) |
"Thalidomide was effective for muscular, cutaneous, and pulmonary involvement in our patient." | 1.32 | Successful treatment of muscle sarcoidosis with thalidomide. ( Lochmüller, H; Meindl, T; Müller-Felber, W; Schlotter-Weigel, B; Walter, MC, 2003) |
"Our data suggest that thalidomide treatment of sarcoidosis results in granuloma differentiation to a Th1-type cellular immune response usually associated with protective immunity to tuberculosis and tuberculoid leprosy." | 1.31 | Thalidomide induces granuloma differentiation in sarcoid skin lesions associated with disease improvement. ( Kaplan, G; Kikuchi, T; Krueger, JG; Oliver, SJ, 2002) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (8.33) | 18.7374 |
1990's | 5 (13.89) | 18.2507 |
2000's | 16 (44.44) | 29.6817 |
2010's | 11 (30.56) | 24.3611 |
2020's | 1 (2.78) | 2.80 |
Authors | Studies |
---|---|
Wang, W | 2 |
Zhong, LQ | 1 |
Li, WD | 1 |
Wu, SJ | 1 |
Song, HM | 1 |
Droitcourt, C | 1 |
Rybojad, M | 2 |
Porcher, R | 1 |
Juillard, C | 1 |
Cosnes, A | 2 |
Joly, P | 1 |
Lacour, JP | 1 |
D'Incan, M | 1 |
Dupin, N | 1 |
Sassolas, B | 1 |
Misery, L | 1 |
Chevrant-Breton, J | 1 |
Lebrun-Vignes, B | 1 |
Desseaux, K | 1 |
Valeyre, D | 1 |
Revuz, J | 2 |
Tazi, A | 1 |
Chosidow, O | 1 |
Dupuy, A | 2 |
Huddleston, SM | 1 |
Houser, KH | 1 |
Walton, RC | 1 |
Amber, KT | 1 |
Bloom, R | 1 |
Mrowietz, U | 1 |
Hertl, M | 1 |
Xiong, X | 1 |
Ling, Y | 1 |
Yang, K | 1 |
Sun, W | 1 |
Su, Z | 1 |
Lu, Y | 1 |
Antoniu, SA | 1 |
Yasui, K | 2 |
Yashiro, M | 1 |
Tsuge, M | 1 |
Manki, A | 1 |
Takemoto, K | 1 |
Yamamoto, M | 1 |
Morishima, T | 1 |
Ladizinski, B | 1 |
Shannon, EJ | 1 |
Sanchez, MR | 1 |
Levis, WR | 1 |
Ahn, SW | 1 |
Kim, KT | 1 |
Youn, YC | 1 |
Kwon, OS | 1 |
Kim, YB | 1 |
Baughman, RP | 4 |
Judson, MA | 2 |
Ingledue, R | 1 |
Craft, NL | 1 |
Lower, EE | 3 |
Fazzi, P | 1 |
Manni, E | 1 |
Cristofani, R | 1 |
Cei, G | 1 |
Piazza, S | 1 |
Calabrese, R | 1 |
Antonelli, A | 1 |
Siciliano, G | 1 |
Barachini, P | 1 |
Carpi, A | 1 |
Teirstein, AS | 1 |
Moller, DR | 2 |
Lynch, JP | 1 |
Walter, MC | 1 |
Lochmüller, H | 1 |
Schlotter-Weigel, B | 1 |
Meindl, T | 1 |
Müller-Felber, W | 1 |
Vizel', AA | 1 |
Guryleva, ME | 1 |
Vizel', EA | 1 |
Nasretdinova, GP | 1 |
Nguyen, YT | 1 |
Cordoliani, F | 1 |
Vignon-Pennamen, MD | 1 |
Lebbé, C | 1 |
Morel, P | 1 |
Wu, JJ | 1 |
Huang, DB | 1 |
Pang, KR | 1 |
Hsu, S | 1 |
Tyring, SK | 1 |
Badgwell, C | 1 |
Rosen, T | 1 |
Hammond, ER | 1 |
Kaplin, AI | 1 |
Kerr, DA | 1 |
Barriere, H | 1 |
Prigent, F | 1 |
Ouazzani, W | 1 |
Carlesimo, M | 1 |
Giustini, S | 1 |
Rossi, A | 1 |
Bonaccorsi, P | 1 |
Calvieri, S | 1 |
Rousseau, L | 1 |
Beylot-Barry, M | 1 |
Doutre, MS | 1 |
Beylot, C | 1 |
Grasland, A | 1 |
Pouchot, J | 1 |
Chaumaizière, D | 1 |
Aitken, G | 1 |
Vinceneux, P | 1 |
Lee, JB | 1 |
Koblenzer, PS | 1 |
Saano, V | 1 |
Moraes, M | 1 |
Russo, G | 1 |
Estines, O | 1 |
Wolkenstein, P | 1 |
Bressieux, JM | 1 |
Roujeau, JC | 1 |
Hoch, O | 1 |
Müller, S | 1 |
Büttner, G | 1 |
Mensing, H | 2 |
Oliver, SJ | 1 |
Kikuchi, T | 1 |
Krueger, JG | 1 |
Kaplan, G | 1 |
Ochsendorf, F | 1 |
Kaufmann, R | 1 |
Picard, C | 1 |
Crickx, B | 1 |
Perron, J | 1 |
Lecerf, V | 1 |
Belaïch, S | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Randomized Controlled Trial of Thalidomide vs Placebo in Skin Sarcoidosis[NCT00305552] | Phase 3 | 40 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
The Efficacy and Safety of CC-10004 in Chronic Cutaneous Sarcoidosis[NCT00794274] | Phase 2/Phase 3 | 15 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
Clinical Biomarkers of Disease Activity and Treatment Responses in Patients With CNS Sarcoidosis Treated With H.P. Acthar Gel[NCT02298491] | Phase 4 | 4 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Total number of lesions assessed at 1 year (NCT02298491)
Timeframe: 1 year
Intervention | lesions (Number) |
---|---|
H.P. Acthar Gel | 5 |
13 reviews available for thalidomide and Besnier-Boeck Disease
Article | Year |
---|---|
TNF-α: a treatment target or cause of sarcoidosis?
Topics: Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Etanercept; Granuloma; Hum | 2015 |
Targeting the TNF-alpha pathway in sarcoidosis.
Topics: Adalimumab; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Eta | 2010 |
Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders.
Topics: Behcet Syndrome; Dermatitis; Erythema Nodosum; Humans; Immunomodulation; Lupus Erythematosus, Cutane | 2010 |
[Thalidomide as immunomodulatory drug: pharmacological actions and its indications].
Topics: Behcet Syndrome; Child; Female; Humans; Immunologic Factors; Male; NF-kappa B; Sarcoidosis; Thalidom | 2010 |
Treatment of sarcoidosis -- from a basic science point of view.
Topics: Etanercept; Granuloma; Humans; Immunoglobulin G; Immunosuppressive Agents; Interleukins; Pentoxifyll | 2003 |
Difficult treatment issues in sarcoidosis.
Topics: Antibodies, Monoclonal; Antimalarials; Azathioprine; Cyclophosphamide; Decision Making; Humans; Immu | 2003 |
[The role of tumor necrosis factor in pathogenesis and treatment of sarcoidosis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Humans; Immunosuppressive Agents; Infliximab; Sarcoido | 2003 |
Newer therapies for cutaneous sarcoidosis: the role of thalidomide and other agents.
Topics: Chronic Disease; Clinical Trials as Topic; Facial Dermatoses; Humans; Immunosuppressive Agents; Sarc | 2004 |
Thalidomide: dermatological indications, mechanisms of action and side-effects.
Topics: Adult; Behcet Syndrome; Dermatologic Agents; Erythema; Graft vs Host Disease; Histiocytosis, Langerh | 2005 |
Cutaneous sarcoidosis therapy updated.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents | 2007 |
[New therapeutic application of thalidomide].
Topics: Autoimmune Diseases; Colitis, Ulcerative; Erythema Multiforme; Female; Histiocytosis; Humans; Immuno | 1996 |
Thalidomide and its dermatologic uses.
Topics: Acquired Immunodeficiency Syndrome; Behcet Syndrome; Dermatologic Agents; Erythema Nodosum; Facial D | 2001 |
[Florid cutaneous sarcoidosis. Therapeutic difficulties].
Topics: Adrenal Cortex Hormones; Cyclosporins; Facial Dermatoses; Humans; Male; Middle Aged; PUVA Therapy; S | 1989 |
5 trials available for thalidomide and Besnier-Boeck Disease
Article | Year |
---|---|
A randomized, investigator-masked, double-blind, placebo-controlled trial on thalidomide in severe cutaneous sarcoidosis.
Topics: Adult; Aged; Double-Blind Method; Female; France; Humans; Immunosuppressive Agents; Male; Middle Age | 2014 |
Efficacy and safety of apremilast in chronic cutaneous sarcoidosis.
Topics: Female; Humans; Male; Phosphodiesterase 4 Inhibitors; Sarcoidosis; Severity of Illness Index; Skin D | 2012 |
Thalidomide for improving cutaneous and pulmonary sarcoidosis in patients resistant or with contraindications to corticosteroids.
Topics: Adult; Aged; Contraindications; Dose-Response Relationship, Drug; Drug Resistance; Feasibility Studi | 2012 |
Thalidomide for chronic sarcoidosis.
Topics: Adult; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; | 2002 |
Treatment of cutaneous sarcoidosis with thalidomide.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Male; Middle Aged | 2004 |
18 other studies available for thalidomide and Besnier-Boeck Disease
Article | Year |
---|---|
Thalidomide may be an effective drug for Blau syndrome: a case report.
Topics: Arthritis; Female; Humans; Nod2 Signaling Adaptor Protein; Sarcoidosis; Synovitis; Thalidomide; Uvei | 2022 |
Thalidomide for recalcitrant nodular scleritis in sarcoidosis.
Topics: Female; Humans; Immunosuppressive Agents; Middle Aged; Recurrence; Sarcoidosis; Scleritis; Thalidomi | 2014 |
Case of sarcoidosis presenting with symmetrical facial keratotic papules.
Topics: Cheek; Female; Hepatic Duct, Common; Humans; Keratosis; Lymph Nodes; Lymphadenopathy; Middle Aged; S | 2018 |
Thalidomide dramatically improves the symptoms of early-onset sarcoidosis/Blau syndrome: its possible action and mechanism.
Topics: Adolescent; Arthrography; Cells, Cultured; Child; Cytokines; Female; Humans; Immunosuppressive Agent | 2010 |
Isolated spinal cord neurosarcoidosis diagnosed by cord biopsy and thalidomide trial.
Topics: Adrenal Cortex Hormones; Biopsy; Central Nervous System Diseases; Female; Humans; Immunosuppressive | 2011 |
Successful treatment of muscle sarcoidosis with thalidomide.
Topics: Adult; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Muscular Diseases; Sarcoi | 2003 |
Thalidomide for acute treatment of neurosarcoidosis.
Topics: Adult; Brain; Granuloma; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Proprio | 2007 |
[Cutaneous sarcoidosis. Treatment with thalidomide].
Topics: Humans; Sarcoidosis; Skin Diseases; Thalidomide | 1983 |
[Cutaneous sarcoidosis. Treatment with thalidomide].
Topics: Humans; Leg Ulcer; Sarcoidosis; Thalidomide | 1983 |
Treatment of cutaneous and pulmonary sarcoidosis with thalidomide.
Topics: Aged; Female; Humans; Middle Aged; Sarcoidosis; Sarcoidosis, Pulmonary; Sarcoma, Kaposi; Skin Diseas | 1995 |
Cutaneous sarcoidosis successfully treated with low doses of thalidomide.
Topics: Adult; Cicatrix; Female; Fibrosis; Humans; Immunosuppressive Agents; Sarcoidosis; Skin Diseases; Tha | 1998 |
[Effectiveness of thalidomide treatment during cutaneous sarcoidosis].
Topics: Dermatologic Agents; Female; Humans; Middle Aged; Sarcoidosis; Skin Diseases; Thalidomide; Treatment | 1998 |
Disfiguring cutaneous manifestation of sarcoidosis treated with thalidomide: a case report.
Topics: Dermatologic Agents; Drug Administration Schedule; Facial Dermatoses; Female; Fingers; Glucocorticoi | 1998 |
[Sarcoidosis: thalidomide treatment in ten patients].
Topics: Chronic Disease; Dermatologic Agents; Drug Administration Schedule; Humans; Immunosuppressive Agents | 2001 |
[Thalidomide in the treatment of cutaneous and systemic sarcoidosis].
Topics: Adult; Dermatologic Agents; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Male; Middle | 2001 |
Thalidomide induces granuloma differentiation in sarcoid skin lesions associated with disease improvement.
Topics: Adult; Antigens, CD; Dendritic Cells; Dermatologic Agents; Female; Flow Cytometry; HLA-DR Antigens; | 2002 |
[New indication for thalidomide?].
Topics: Humans; Immunosuppressive Agents; Sarcoidosis; Thalidomide | 2002 |
[Comment on O. Hoch et al.: "Thalidomide in treatment of cutaneous and systemic sarcoidosis"].
Topics: Humans; Sarcoidosis; Skin Diseases; Thalidomide; Treatment Outcome | 2002 |