thalidomide has been researched along with Autism in 16 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism." | 7.69 | Autism in thalidomide embryopathy: a population study. ( Akerström, B; Gillberg, C; Miller, M; Nordin, V; Strömland, K, 1994) |
| "Auditory hypersensitivity in autism is frequently observed in clinics." | 5.56 | Altered neuronal activity in the auditory brainstem following sound stimulation in thalidomide-induced autism model rats. ( Ida-Eto, M; Narita, M; Noro, Y; Ohkawara, T; Tsugiyama, LE, 2020) |
| "Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests." | 5.36 | Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010) |
| "Morphologic abnormalities found in autism (e." | 5.31 | Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. ( Kato, M; Miyazaki, K; Narita, M; Narita, N; Okado, N; Tazoe, M, 2002) |
| "One third of Swedes with thalidomide embryopathy have sixth and seventh cranial nerve palsy, named Möbius syndrome/sequence, and some of them suffer from autism." | 4.80 | [Eye muscle paralysis can increase the knowledge on autism]. ( Strömland, K, 2000) |
| "Autism model rats were prepared by prenatal exposure to thalidomide on embryonic day 9 and 10 in pregnant rats." | 3.85 | Mechanism of auditory hypersensitivity in human autism using autism model rats. ( Hara, N; Ida-Eto, M; Narita, M; Ohkawara, T, 2017) |
| "Based on the fact that thalidomide, at a certain point in human pregnancy, produces autism, we propose administering thalidomide to pregnant monkeys at an appropriate point after conception." | 3.72 | A proposed primate animal model of autism. ( Teitelbaum, P, 2003) |
| "To review the association of autism spectrum disorder (ASD) in individuals manifesting thalidomide embryopathy and Möbius sequence and compare them with three new studies in which ASD was also associated with ocular and systemic malformations: (1) a Swedish study of individuals with CHARGE association (Coloboma, Heart, choanal Atresia, developmental or growth Retardation, Genital anomaly, and Ear involvement); (2) a Swedish study of Goldenhar syndrome; and (3) Brazilian Möbius syndrome (sequence) study." | 3.72 | Autism with ophthalmologic malformations: the plot thickens. ( Bandim, JM; Gillberg, C; Johansson, M; Miller, MT; Strömland, K; Ventura, L, 2004) |
| "The hypothesis that brain stem injury plays a role in the autism spectrum disorders was suggested by evidence that exposure to thalidomide during the earliest stages of brain development increases the risk of autism spectrum disorders." | 3.71 | Converging evidence for brain stem injury in autism. ( Rodier, PM, 2002) |
| "Autism has been linked to thalidomide exposure at 20-24 days gestation." | 3.71 | Is autism due to cerebral-cerebellum disconnection? ( Skoyles, JR, 2002) |
| "A previous study of 86 thalidomide-affected subjects with ophthalmic manifestations revealed the unexpected finding of autism in 4 of the 5 severely retarded individuals." | 3.70 | The puzzle of autism: an ophthalmologic contribution. ( Gillberg, C; Johansson, M; Miller, MT; Nilsson, EW; Strömland, K, 1998) |
| "Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism." | 3.69 | Autism in thalidomide embryopathy: a population study. ( Akerström, B; Gillberg, C; Miller, M; Nordin, V; Strömland, K, 1994) |
| "Thalidomide is a very potent teratogen capable of causing severe systemic malformations if the fetus is exposed during the sensitive period." | 2.45 | Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected. ( Miller, MT; Strömland, K; Ventura, L, 2009) |
| "Auditory hypersensitivity in autism is frequently observed in clinics." | 1.56 | Altered neuronal activity in the auditory brainstem following sound stimulation in thalidomide-induced autism model rats. ( Ida-Eto, M; Narita, M; Noro, Y; Ohkawara, T; Tsugiyama, LE, 2020) |
| "It is further posited that, in autism, the drugs act as "triggers" that disturb the pro-proliferative fetal milieu using the same, mainly epigenetic, mechanisms that they demonstrate in rapidly proliferating cancer cells." | 1.40 | Autism's cancer connection: the anti-proliferation hypothesis and why it may matter. ( Ward, CS, 2014) |
| "Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests." | 1.36 | Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010) |
| "Morphologic abnormalities found in autism (e." | 1.31 | Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. ( Kato, M; Miyazaki, K; Narita, M; Narita, N; Okado, N; Tazoe, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 9 (56.25) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lenart, J | 1 |
| Bratek, E | 1 |
| Lazarewicz, JW | 1 |
| Zieminska, E | 1 |
| Tsugiyama, LE | 1 |
| Ida-Eto, M | 2 |
| Ohkawara, T | 2 |
| Noro, Y | 1 |
| Narita, M | 4 |
| Ward, CS | 1 |
| Hara, N | 1 |
| Rout, UK | 1 |
| Clausen, P | 1 |
| Miller, MT | 3 |
| Ventura, L | 2 |
| Strömland, K | 5 |
| Oyabu, A | 1 |
| Imura, Y | 1 |
| Kamada, N | 1 |
| Yokoyama, T | 1 |
| Tano, K | 1 |
| Uchida, A | 1 |
| Narita, N | 2 |
| Rodier, PM | 1 |
| Kato, M | 1 |
| Tazoe, M | 1 |
| Miyazaki, K | 1 |
| Okado, N | 1 |
| Teitelbaum, P | 1 |
| Chudley, AE | 1 |
| Johansson, M | 2 |
| Bandim, JM | 1 |
| Gillberg, C | 3 |
| Nordin, V | 1 |
| Miller, M | 1 |
| Akerström, B | 1 |
| Nilsson, EW | 1 |
| Skoyles, JR | 1 |
3 reviews available for thalidomide and Autism
| Article | Year |
|---|---|
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected.
Topics: Abnormalities, Drug-Induced; Adult; Autistic Disorder; Child; Child, Preschool; Cranial Nerves; Embr | 2009 |
Genetic landmarks through philately - autism spectrum disorders: a genetic update.
Topics: Animals; Autistic Disorder; California; Cell Adhesion Molecules, Neuronal; Chromosomes, Human, X; Ex | 2004 |
[Eye muscle paralysis can increase the knowledge on autism].
Topics: Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Facial Nerve; Female; Humans; Hypnotics | 2000 |
13 other studies available for thalidomide and Autism
| Article | Year |
|---|---|
Changes in the Expression of SNAP-25 Protein in the Brain of Juvenile Rats in Two Models of Autism.
Topics: Animals; Autistic Disorder; Brain; Female; Male; Rats; Synaptosomal-Associated Protein 25; Thalidomi | 2020 |
Altered neuronal activity in the auditory brainstem following sound stimulation in thalidomide-induced autism model rats.
Topics: Acoustic Stimulation; Animals; Autistic Disorder; Brain Stem; Female; Hyperacusis; Immunosuppressive | 2020 |
Autism's cancer connection: the anti-proliferation hypothesis and why it may matter.
Topics: Antineoplastic Agents; Autistic Disorder; Epigenetic Repression; Gene Expression Regulation, Neoplas | 2014 |
Mechanism of auditory hypersensitivity in human autism using autism model rats.
Topics: Animals; Auditory Pathways; Auditory Perception; Autism Spectrum Disorder; Autistic Disorder; Hypera | 2017 |
Common increase of GATA-3 level in PC-12 cells by three teratogens causing autism spectrum disorders.
Topics: Animals; Autistic Disorder; Ethanol; GATA3 Transcription Factor; Gene Expression Profiling; PC12 Cel | 2009 |
Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat.
Topics: Age Factors; Animals; Autistic Disorder; Disease Models, Animal; Exploratory Behavior; Female; Inter | 2010 |
Converging evidence for brain stem injury in autism.
Topics: Autistic Disorder; Brain Stem; Child; Genetic Predisposition to Disease; Homeodomain Proteins; Human | 2002 |
Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism.
Topics: Animals; Autistic Disorder; Biogenic Monoamines; Brain; Female; Pregnancy; Rats; Rats, Sprague-Dawle | 2002 |
A proposed primate animal model of autism.
Topics: Animals; Animals, Newborn; Autistic Disorder; Child; Disease Models, Animal; Female; Haplorhini; Hum | 2003 |
Autism with ophthalmologic malformations: the plot thickens.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Autistic Disorder; Child; Child, P | 2004 |
Autism in thalidomide embryopathy: a population study.
Topics: Adult; Autistic Disorder; Deafness; Female; Humans; Intellectual Disability; Male; Pregnancy; Prenat | 1994 |
The puzzle of autism: an ophthalmologic contribution.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Autistic Disorder; Child; Eye Diseases; Facial Paral | 1998 |
Is autism due to cerebral-cerebellum disconnection?
Topics: Animals; Autistic Disorder; Axons; Brain Stem; Cerebellum; Cerebral Cortex; Female; Gestational Age; | 2002 |