thalidomide has been researched along with Atrial Septal Defect in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 7.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 3.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "We have recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on chromosome 20q13." | 1.32 | Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy. ( Becker, K; Kohlhase, J; Liebers, M; Mohammed, SN; Newbury-Ecob, R; Rauch, A; Reardon, W; Schubert, L, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donovan, KA | 1 |
| An, J | 1 |
| Nowak, RP | 1 |
| Yuan, JC | 1 |
| Fink, EC | 1 |
| Berry, BC | 1 |
| Ebert, BL | 1 |
| Fischer, ES | 1 |
| Gomes, JDA | 1 |
| Kowalski, TW | 1 |
| Fraga, LR | 1 |
| Macedo, GS | 1 |
| Sanseverino, MTV | 1 |
| Schuler-Faccini, L | 1 |
| Vianna, FSL | 1 |
| Kohlhase, J | 1 |
| Schubert, L | 1 |
| Liebers, M | 1 |
| Rauch, A | 1 |
| Becker, K | 1 |
| Mohammed, SN | 1 |
| Newbury-Ecob, R | 1 |
| Reardon, W | 1 |
| JORGENSEN, MB | 1 |
| KRISTENSEN, HK | 1 |
| BUCH, NH | 1 |
| Gilani, SH | 1 |
5 other studies available for thalidomide and Atrial Septal Defect
| Article | Year |
|---|---|
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
Topics: Abnormalities, Multiple; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; CYS2-HIS2 Zinc F | 2018 |
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C | 2019 |
Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy.
Topics: Abnormalities, Multiple; Base Sequence; Chromosomes, Human, Pair 20; DNA; DNA Mutational Analysis; D | 2003 |
THALIDOMIDE-INDUCED APLASIA OF THE INNER EAR.
Topics: Abnormalities, Drug-Induced; Ear Deformities, Acquired; Ear, External; Ear, Inner; Facial Paralysis; | 1964 |
Cardiovascular malformations in the chick embryo induced by thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Aortic Arch Syndromes; Aortic Valve Stenosis; Cardiovascular A | 1973 |