thalidomide has been researched along with Arthritis, Juvenile in 8 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Arthritis, Juvenile: Arthritis in children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Systemic onset juvenile idiopathic arthritis (SOJIA) is the most common autoimmune auto inflammatory disease in childhood." | 1.39 | Thalidomide for systemic onset juvenile idiopathic arthritis. ( Khubchandani, RP; Sathe, K, 2013) |
| "The average dosage of prednisone was reduced from 1." | 1.37 | [Efficacy of thalidomide for treatment of juvenile idiopathic arthritis]. ( Han, TX; Kuang, WY; Li, CF; Wang, J; Zhou, YF, 2011) |
| "Since a proportion of systemic-onset juvenile idiopathic arthritis (SOJIA) patients continue to require long-term corticosteroid therapy for disease control, an effective and safe therapeutic strategy for controlling the activity of refractory SOJIA remains to be established." | 1.34 | Treatment of difficult cases of systemic-onset juvenile idiopathic arthritis with tacrolimus. ( Ito, E; Kimura, S; Nonaka, K; Oki, ES; Suzuki, K; Tanaka, H; Tsugawa, K, 2007) |
| "Thalidomide is an immunomodulating agent which reverses many of the cytokine disturbances seen in systemic onset juvenile idiopathic arthritis (SoJIA) with inadequate response to other treatments." | 1.34 | Efficacy of thalidomide in systemic onset juvenile rheumatoid arthritis. ( Escárcega, RO; Escobar, LE; Fuentes-Alexandro, S; García-Carrasco, M; Rojas-Rodriguez, J, 2007) |
| "Systemic onset juvenile rheumatoid arthritis unresponsive to nonsteroidal anti-inflammatory drugs may be controlled with corticosteroids, but these drugs have significant side effects." | 1.31 | Thalidomide therapy for recalcitrant systemic onset juvenile rheumatoid arthritis. ( Lehman, TJ; Onel, KB; Striegel, KH, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sathe, K | 1 |
| Khubchandani, RP | 1 |
| Han, TX | 1 |
| Li, CF | 1 |
| Wang, J | 1 |
| Kuang, WY | 1 |
| Zhou, YF | 1 |
| Lehman, TJ | 2 |
| Schechter, SJ | 1 |
| Sundel, RP | 1 |
| Oliveira, SK | 1 |
| Huttenlocher, A | 1 |
| Onel, KB | 2 |
| Tanaka, H | 1 |
| Tsugawa, K | 1 |
| Suzuki, K | 1 |
| Oki, ES | 1 |
| Nonaka, K | 1 |
| Kimura, S | 1 |
| Ito, E | 1 |
| García-Carrasco, M | 1 |
| Fuentes-Alexandro, S | 1 |
| Escárcega, RO | 1 |
| Rojas-Rodriguez, J | 1 |
| Escobar, LE | 1 |
| Forrester, RM | 1 |
| Singer, NG | 1 |
| McCune, WJ | 1 |
| Striegel, KH | 1 |
1 review available for thalidomide and Arthritis, Juvenile
| Article | Year |
|---|---|
Update on immunosuppressive therapy.
Topics: Adult; Arthritis, Juvenile; Azathioprine; Behcet Syndrome; Child; Cladribine; Cyclophosphamide; Cycl | 1998 |
7 other studies available for thalidomide and Arthritis, Juvenile
| Article | Year |
|---|---|
Thalidomide for systemic onset juvenile idiopathic arthritis.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Female; Humans; Male; Thalidomid | 2013 |
[Efficacy of thalidomide for treatment of juvenile idiopathic arthritis].
Topics: Adolescent; Arthritis, Juvenile; Child; Female; Humans; Male; Prednisone; Retrospective Studies; Tha | 2011 |
Thalidomide for severe systemic onset juvenile rheumatoid arthritis: A multicenter study.
Topics: Arthritis, Juvenile; Blood Sedimentation; Child; Female; Humans; Immunosuppressive Agents; Male; Tha | 2004 |
Treatment of difficult cases of systemic-onset juvenile idiopathic arthritis with tacrolimus.
Topics: Arthritis, Juvenile; Child; Child, Preschool; Female; Humans; Immunosuppressive Agents; Male; Thalid | 2007 |
Efficacy of thalidomide in systemic onset juvenile rheumatoid arthritis.
Topics: Age of Onset; Arthritis, Juvenile; Child; Humans; Immunosuppressive Agents; Thalidomide; Treatment O | 2007 |
Motor handicap in children: a study of a population in 1965.
Topics: Abnormalities, Drug-Induced; Adolescent; Arthritis, Juvenile; Brain Damage, Chronic; Cerebral Palsy; | 1967 |
Thalidomide therapy for recalcitrant systemic onset juvenile rheumatoid arthritis.
Topics: Adolescent; Arthritis, Juvenile; Child; Humans; Male; Thalidomide | 2002 |