thalidomide has been researched along with Arthritis, Degenerative in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is a drug that has been reported to inhibit angiogenesis and reduce VEGF production by downregulating VEGF expression." | 5.48 | Intraperitoneal injection of thalidomide alleviates early osteoarthritis development by suppressing vascular endothelial growth factor expression in mice. ( Cai, DZ; Fang, H; Li, L; Song, JL, 2018) |
| "Thalidomide is a drug that has been reported to inhibit angiogenesis and reduce VEGF production by downregulating VEGF expression." | 1.48 | Intraperitoneal injection of thalidomide alleviates early osteoarthritis development by suppressing vascular endothelial growth factor expression in mice. ( Cai, DZ; Fang, H; Li, L; Song, JL, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Franco-Trepat, E | 1 |
| Guillán-Fresco, M | 1 |
| Alonso-Pérez, A | 1 |
| López-Fagúndez, M | 1 |
| Pazos-Pérez, A | 1 |
| Crespo-Golmar, A | 1 |
| Gualillo, O | 1 |
| Jorge-Mora, A | 1 |
| Bravo, SB | 1 |
| Gómez, R | 1 |
| Wang, Y | 1 |
| Xu, J | 1 |
| Zhang, X | 2 |
| Wang, C | 1 |
| Huang, Y | 1 |
| Dai, K | 1 |
| Song, JL | 1 |
| Li, L | 1 |
| Fang, H | 1 |
| Cai, DZ | 1 |
| Newman, RJ | 1 |
4 other studies available for thalidomide and Arthritis, Degenerative
| Article | Year |
|---|---|
Repurposing drugs to inhibit innate immune responses associated with TLR4, IL1, and NLRP3 signaling in joint cells.
Topics: Chondrocytes; Drug Repositioning; Humans; Immunity, Innate; Inflammasomes; Interleukin-1; Naloxone; | 2022 |
TNF-α-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis.
Topics: Animals; Cell Movement; Gene Expression Regulation; Glycoproteins; Human Umbilical Vein Endothelial | 2017 |
Intraperitoneal injection of thalidomide alleviates early osteoarthritis development by suppressing vascular endothelial growth factor expression in mice.
Topics: Animals; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Injections, Intrap | 2018 |
Shoulder joint replacement for osteoarthrosis in association with thalidomide-induced phocomelia.
Topics: Adult; Arm; Ectromelia; Female; Follow-Up Studies; Humans; Joint Prosthesis; Osteoarthritis; Pain Me | 1999 |