thalidomide has been researched along with Anorexia in 8 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Anorexia: The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We completed a two-stage Phase II dose titration study of thalidomide, the primary purpose of which was to assess appetite response to thalidomide in cancer-associated anorexia." | 9.16 | A Phase II dose titration study of thalidomide for cancer-associated anorexia. ( Bicanovsky, L; Davis, M; Lagman, R; Lasheen, W; Mahmoud, F; Walsh, D, 2012) |
| "To determine the effects of thalidomide and placebo on anorexia-cachexia and its related symptoms, body composition, resting metabolic rate, and serum cytokines and their receptors in patients with advanced cancer." | 9.16 | The role of thalidomide and placebo for the treatment of cancer-related anorexia-cachexia symptoms: results of a double-blind placebo-controlled randomized study. ( Allo, J; Bruera, E; Cohen, EN; Del Fabbro, E; Palmer, JL; Reuben, JM; Tin, S; Willey, JS; Yennurajalingam, S, 2012) |
| "Lenalidomide is a potent, novel thalidomide analog that has demonstrated promising clinical activity in patients with relapsed or refractory multiple myeloma (MM)." | 8.84 | Lenalidomide: a new agent for patients with relapsed or refractory multiple myeloma. ( Tariman, JD, 2007) |
| "We completed a two-stage Phase II dose titration study of thalidomide, the primary purpose of which was to assess appetite response to thalidomide in cancer-associated anorexia." | 5.16 | A Phase II dose titration study of thalidomide for cancer-associated anorexia. ( Bicanovsky, L; Davis, M; Lagman, R; Lasheen, W; Mahmoud, F; Walsh, D, 2012) |
| "To determine the effects of thalidomide and placebo on anorexia-cachexia and its related symptoms, body composition, resting metabolic rate, and serum cytokines and their receptors in patients with advanced cancer." | 5.16 | The role of thalidomide and placebo for the treatment of cancer-related anorexia-cachexia symptoms: results of a double-blind placebo-controlled randomized study. ( Allo, J; Bruera, E; Cohen, EN; Del Fabbro, E; Palmer, JL; Reuben, JM; Tin, S; Willey, JS; Yennurajalingam, S, 2012) |
| "Lenalidomide is a potent, novel thalidomide analog that has demonstrated promising clinical activity in patients with relapsed or refractory multiple myeloma (MM)." | 4.84 | Lenalidomide: a new agent for patients with relapsed or refractory multiple myeloma. ( Tariman, JD, 2007) |
| "Anorexia is the common symptom of malnutrition in cancer patients." | 2.72 | Appetite problem in cancer patients: Pathophysiology, diagnosis, and treatment. ( Hariyanto, TI; Kurniawan, A, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Hariyanto, TI | 1 |
| Kurniawan, A | 1 |
| Ritchie, CS | 1 |
| Currow, DC | 1 |
| Abernethy, AP | 1 |
| Kutner, JS | 1 |
| Tassinari, D | 1 |
| Santelmo, C | 1 |
| Tombesi, P | 1 |
| Sartori, S | 1 |
| Davis, M | 1 |
| Lasheen, W | 1 |
| Walsh, D | 1 |
| Mahmoud, F | 1 |
| Bicanovsky, L | 1 |
| Lagman, R | 1 |
| Yennurajalingam, S | 1 |
| Willey, JS | 1 |
| Palmer, JL | 1 |
| Allo, J | 1 |
| Del Fabbro, E | 1 |
| Cohen, EN | 1 |
| Tin, S | 1 |
| Reuben, JM | 1 |
| Bruera, E | 1 |
| Argilés, JM | 1 |
| Busquets, S | 1 |
| López-Soriano, FJ | 1 |
| Tariman, JD | 1 |
| Haslett, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nabilone Effect on the Attenuation of Anorexia, Nutritional Status and Quality of Life in Patients With Anorexia Associated With Advanced Lung Cancer: Randomized Double Blind Clinical Trial[NCT02802540] | Phase 2/Phase 3 | 78 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for thalidomide and Anorexia
| Article | Year |
|---|---|
Appetite problem in cancer patients: Pathophysiology, diagnosis, and treatment.
Topics: Anorexia; Appetite; Clinical Trials, Phase III as Topic; Eicosapentaenoic Acid; Growth Differentiati | 2021 |
The pivotal role of cytokines in muscle wasting during cancer.
Topics: Animals; Anorexia; Antibodies; Cachexia; Cytokines; Humans; Models, Biological; Muscle, Skeletal; Mu | 2005 |
Lenalidomide: a new agent for patients with relapsed or refractory multiple myeloma.
Topics: Anorexia; Antineoplastic Agents; Apoptosis; Constipation; Diarrhea; Drug Eruptions; Drug Monitoring; | 2007 |
Anticytokine approaches to the treatment of anorexia and cachexia.
Topics: Anorexia; Cachexia; Humans; Immunosuppressive Agents; Interleukin-1; Interleukin-6; Pentoxifylline; | 1998 |
3 trials available for thalidomide and Anorexia
| Article | Year |
|---|---|
Thalidomide in the treatment of cancer cachexia.
Topics: Aged; Angiogenesis Inhibitors; Anorexia; Cachexia; Drug Monitoring; Female; Gastrointestinal Neoplas | 2008 |
A Phase II dose titration study of thalidomide for cancer-associated anorexia.
Topics: Aged; Anorexia; Clinical Trials, Phase I as Topic; Dose-Response Relationship, Drug; Female; Humans; | 2012 |
The role of thalidomide and placebo for the treatment of cancer-related anorexia-cachexia symptoms: results of a double-blind placebo-controlled randomized study.
Topics: Adult; Aged; Aged, 80 and over; Anorexia; Cachexia; Double-Blind Method; Female; Humans; Immunosuppr | 2012 |
1 other study available for thalidomide and Anorexia
| Article | Year |
|---|---|
Multisite studies offer a solution to recruitment challenges in palliative care studies.
Topics: Anorexia; Cachexia; Female; Humans; Immunosuppressive Agents; Male; Neoplasms; Thalidomide | 2013 |