thalidomide has been researched along with Alloxan Diabetes in 8 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our aim was to compare the therapeutic effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats." | 7.72 | Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats. ( Bosco, AA; Lerario, AC; Santos, RF; Wajchenberg, BL, 2003) |
| "Our aim was to compare the therapeutic effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats." | 3.72 | Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats. ( Bosco, AA; Lerario, AC; Santos, RF; Wajchenberg, BL, 2003) |
| "Treatment with thalidomide markedly stimulated the phosphorylation of AMPKα." | 1.48 | Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway. ( Li, R; Wang, B; Wang, Y; Yang, Y; Zhang, H, 2018) |
| "Thermal hyperalgesia and mechanical allodynia were measured using planter test and dynamic aesthesiometer (Ugo-Basile, Italy), respectively." | 1.38 | Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats. ( Sharma, PL; Taliyan, R, 2012) |
| "Thalidomide treatment prevented hyperglycemia and preserved pancreatic insulin secretion in the diabetic mice." | 1.38 | Thalidomide attenuates multiple low-dose streptozotocin-induced diabetes in mice by inhibition of proinflammatory cytokines. ( Amirshahrokhi, K; Ghazi-Khansari, M, 2012) |
| "Thalidomide did not suppress the incidence of lymphocytic thyroiditis and serum anti-thyroglobulin antibodies or affect the serum concentrations of T4, T3 and TSH in this rat model." | 1.28 | Effect of thalidomide on the incidence of iodine-induced and spontaneous lymphocytic thyroiditis and spontaneous diabetes mellitus in the BB/Wor rat. ( Abend, S; Alex, S; Appel, MC; Braverman, LE; Lueprasitsakul, W; Reinhardt, W, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, HX | 1 |
| Yuan, J | 1 |
| Li, RS | 1 |
| Zhang, H | 1 |
| Yang, Y | 2 |
| Wang, Y | 1 |
| Wang, B | 1 |
| Li, R | 1 |
| Zhao, J | 1 |
| Wang, H | 1 |
| Song, T | 1 |
| Gu, K | 1 |
| Ma, P | 1 |
| Zhang, Z | 1 |
| Shen, L | 1 |
| Liu, J | 1 |
| Wang, W | 1 |
| Taliyan, R | 2 |
| Sharma, PL | 2 |
| Chauhan, N | 1 |
| Amirshahrokhi, K | 1 |
| Ghazi-Khansari, M | 1 |
| Bosco, AA | 1 |
| Lerario, AC | 1 |
| Santos, RF | 1 |
| Wajchenberg, BL | 1 |
| Lueprasitsakul, W | 1 |
| Abend, S | 1 |
| Alex, S | 1 |
| Reinhardt, W | 1 |
| Appel, MC | 1 |
| Braverman, LE | 1 |
8 other studies available for thalidomide and Alloxan Diabetes
| Article | Year |
|---|---|
Thalidomide Mitigates Apoptosis via Endoplasmic Reticulum Stress in Diabetic Nephropathy.
Topics: Animals; Apoptosis; Caspase 12; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic | 2022 |
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cytokines; Cytoprotection; Diabete | 2018 |
Thalidomide Promotes Morphine Efficacy and Prevents Morphine-Induced Tolerance in Rats with Diabetic Neuropathy.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Synergism; | 2016 |
Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabe | 2012 |
Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain.
Topics: Analgesics, Non-Narcotic; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropat | 2012 |
Thalidomide attenuates multiple low-dose streptozotocin-induced diabetes in mice by inhibition of proinflammatory cytokines.
Topics: Administration, Oral; Animals; Cytokines; Diabetes Mellitus, Experimental; Dose-Response Relationshi | 2012 |
Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats.
Topics: Angiogenesis Inhibitors; Animals; Aqueous Humor; Capillaries; Diabetes Mellitus, Experimental; Diabe | 2003 |
Effect of thalidomide on the incidence of iodine-induced and spontaneous lymphocytic thyroiditis and spontaneous diabetes mellitus in the BB/Wor rat.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Iodine; Male; Rats; Rat | 1990 |