Page last updated: 2024-11-05

thalidomide and Allergic Encephalomyelitis

thalidomide has been researched along with Allergic Encephalomyelitis in 8 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
"Lenalidomide treatment alone delayed symptom onset, while nanoceria treatment had no effect on symptom onset or severity, but did promote recovery; lenalidomide and nanoceria each significantly attenuated white matter pathology and associated inflammation."1.42Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity. ( Celik, H; Chigurapati, S; Chigurupati, S; Das, S; Eitan, E; Fishbein, KW; Ghosh, P; Ghosh, S; Greig, NH; Hutchison, ER; Mattson, MP; Raymick, J; Sarkar, S; Sasaki, CY; Seal, S; Spencer, RG; Tweedie, D, 2015)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Contino-Pépin, C3
Parat, A2
Périno, S1
Lenoir, C1
Vidal, M1
Galons, H1
Karlik, S1
Pucci, B2
Eitan, E1
Hutchison, ER1
Greig, NH1
Tweedie, D1
Celik, H1
Ghosh, S1
Fishbein, KW1
Spencer, RG1
Sasaki, CY1
Ghosh, P1
Das, S1
Chigurapati, S1
Raymick, J1
Sarkar, S1
Chigurupati, S1
Seal, S1
Mattson, MP1
Corrêa, JO1
Aarestrup, BJ1
Aarestrup, FM1
Patinote, C2
Roscoe, WA2
Karlik, SJ2
Owens, T1
Vladutiu, A1
Rosenthale, ME1
Datko, LJ1
Kassarich, J1
Schneider, F1

Reviews

2 reviews available for thalidomide and Allergic Encephalomyelitis

ArticleYear
Targeting vascular changes in lesions in multiple sclerosis and experimental autoimmune encephalomyelitis.
    Central nervous system agents in medicinal chemistry, 2012, Volume: 12, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Drug Delivery Systems; Encephalomyelitis, Autoimmune, Experimental

2012
Identification of new therapeutic targets for prevention of CNS inflammation.
    Expert opinion on therapeutic targets, 2002, Volume: 6, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antigens, CD; B7-2 Antigen; Cytokines; En

2002

Other Studies

6 other studies available for thalidomide and Allergic Encephalomyelitis

ArticleYear
Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application.
    Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Cell Line; Cell Proliferation; Chemistry, Pharmaceutical; Drug Des

2009
Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity.
    Experimental neurology, 2015, Volume: 273

    Topics: Analysis of Variance; Animals; Autoimmunity; Cells, Cultured; Central Nervous System; Cerium; Cytoki

2015
Effect of thalidomide and pentoxifylline on experimental autoimmune encephalomyelitis (EAE).
    Experimental neurology, 2010, Volume: 226, Issue:1

    Topics: Animals; Brain; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppressive

2010
Thalidomide derivatives for the treatment of neuroinflammation.
    ChemMedChem, 2010, Dec-03, Volume: 5, Issue:12

    Topics: Administration, Oral; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental;

2010
Another chance for thalidomide?
    Lancet (London, England), 1966, Apr-30, Volume: 1, Issue:7444

    Topics: Animals; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Immunosuppress

1966
Chemotherapy of experimental allergic encephalomyelitis (EAE).
    Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 179, Issue:2

    Topics: Allopurinol; Aminocaproates; Analgesics; Animals; Antineoplastic Agents; Azathioprine; Body Weight;

1969