thalidomide has been researched along with Allergic Encephalomyelitis in 8 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lenalidomide treatment alone delayed symptom onset, while nanoceria treatment had no effect on symptom onset or severity, but did promote recovery; lenalidomide and nanoceria each significantly attenuated white matter pathology and associated inflammation." | 1.42 | Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity. ( Celik, H; Chigurapati, S; Chigurupati, S; Das, S; Eitan, E; Fishbein, KW; Ghosh, P; Ghosh, S; Greig, NH; Hutchison, ER; Mattson, MP; Raymick, J; Sarkar, S; Sasaki, CY; Seal, S; Spencer, RG; Tweedie, D, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Contino-Pépin, C | 3 |
| Parat, A | 2 |
| Périno, S | 1 |
| Lenoir, C | 1 |
| Vidal, M | 1 |
| Galons, H | 1 |
| Karlik, S | 1 |
| Pucci, B | 2 |
| Eitan, E | 1 |
| Hutchison, ER | 1 |
| Greig, NH | 1 |
| Tweedie, D | 1 |
| Celik, H | 1 |
| Ghosh, S | 1 |
| Fishbein, KW | 1 |
| Spencer, RG | 1 |
| Sasaki, CY | 1 |
| Ghosh, P | 1 |
| Das, S | 1 |
| Chigurapati, S | 1 |
| Raymick, J | 1 |
| Sarkar, S | 1 |
| Chigurupati, S | 1 |
| Seal, S | 1 |
| Mattson, MP | 1 |
| Corrêa, JO | 1 |
| Aarestrup, BJ | 1 |
| Aarestrup, FM | 1 |
| Patinote, C | 2 |
| Roscoe, WA | 2 |
| Karlik, SJ | 2 |
| Owens, T | 1 |
| Vladutiu, A | 1 |
| Rosenthale, ME | 1 |
| Datko, LJ | 1 |
| Kassarich, J | 1 |
| Schneider, F | 1 |
2 reviews available for thalidomide and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Targeting vascular changes in lesions in multiple sclerosis and experimental autoimmune encephalomyelitis.
Topics: Angiogenesis Inhibitors; Animals; Drug Delivery Systems; Encephalomyelitis, Autoimmune, Experimental | 2012 |
Identification of new therapeutic targets for prevention of CNS inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antigens, CD; B7-2 Antigen; Cytokines; En | 2002 |
6 other studies available for thalidomide and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application.
Topics: Angiogenesis Inhibitors; Animals; Cell Line; Cell Proliferation; Chemistry, Pharmaceutical; Drug Des | 2009 |
Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity.
Topics: Analysis of Variance; Animals; Autoimmunity; Cells, Cultured; Central Nervous System; Cerium; Cytoki | 2015 |
Effect of thalidomide and pentoxifylline on experimental autoimmune encephalomyelitis (EAE).
Topics: Animals; Brain; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppressive | 2010 |
Thalidomide derivatives for the treatment of neuroinflammation.
Topics: Administration, Oral; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; | 2010 |
Another chance for thalidomide?
Topics: Animals; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Immunosuppress | 1966 |
Chemotherapy of experimental allergic encephalomyelitis (EAE).
Topics: Allopurinol; Aminocaproates; Analgesics; Animals; Antineoplastic Agents; Azathioprine; Body Weight; | 1969 |