Page last updated: 2024-11-05

thalidomide and Age-Related Osteoporosis

thalidomide has been researched along with Age-Related Osteoporosis in 4 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
"The methods used in treatment of osteoporosis induced by glucocorticosteroids are not effective enough."1.38Effects of thalidomide on the development of bone damage caused by prednisolone in rats. ( Kaczmarczyk-Sedlak, I; Rotko, K; Sedlak, L; Zych, M, 2012)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Otto, S1
Schreyer, C1
Hafner, S1
Mast, G1
Ehrenfeld, M1
Stürzenbaum, S1
Pautke, C1
Kaczmarczyk-Sedlak, I1
Zych, M1
Rotko, K1
Sedlak, L1
Hess, U1
McCarty, MF1

Reviews

1 review available for thalidomide and Age-Related Osteoporosis

ArticleYear
[The plasma cell myeloma--molecular pathogenesis and target therapies].
    Therapeutische Umschau. Revue therapeutique, 2006, Volume: 63, Issue:4

    Topics: Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols

2006

Other Studies

3 other studies available for thalidomide and Age-Related Osteoporosis

ArticleYear
Bisphosphonate-related osteonecrosis of the jaws - characteristics, risk factors, clinical features, localization and impact on oncological treatment.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2012, Volume: 40, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protoc

2012
Effects of thalidomide on the development of bone damage caused by prednisolone in rats.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:2

    Topics: Administration, Oral; Animals; Bone Remodeling; Dose-Response Relationship, Drug; Femur; Glucocortic

2012
Thalidomide may impede cell migration in primates by down-regulating integrin beta-chains: potential therapeutic utility in solid malignancies, proliferative retinopathy, inflammatory disorders, neointimal hyperplasia, and osteoporosis.
    Medical hypotheses, 1997, Volume: 49, Issue:2

    Topics: Animals; Antineoplastic Agents; Callithrix; Fish Oils; Gene Expression; Humans; Hyperplasia; Inflamm

1997