thalidomide has been researched along with Age-Related Memory Disorders in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two male patients (aged 41 and 70) with multiple myeloma developed severe, rapidly progressing cognitive impairment (mostly involving episodic memory) and loss of independence in activities of daily living during lenalidomide-based treatment." | 3.79 | Memory loss during lenalidomide treatment: a report on two cases. ( Delbeuck, X; Facon, T; Le Rhun, E; Leleu, X; Lenfant, P; Mackowiak, MA; Noel, MP; Pasquier, F; Pollet, M; Rollin-Sillaire, A, 2013) |
| "Thalidomide (5-50mg/kg) was intraperitoneally administered immediately after laparotomy." | 1.46 | Thalidomide alleviates postoperative pain and spatial memory deficit in aged rats. ( Guo, P; Hu, SP, 2017) |
| "Thalidomide treatment attenuated significantly STZ induced cognitive impairment and histopathological changes." | 1.39 | Thalidomide attenuates learning and memory deficits induced by intracerebroventricular administration of streptozotocin in rats. ( Alan, S; Elçioğlu, H; Kabasakal, L; Karan, M; Salva, E; Tufan, F, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, P | 1 |
| Hu, SP | 1 |
| Rollin-Sillaire, A | 1 |
| Delbeuck, X | 1 |
| Pollet, M | 1 |
| Mackowiak, MA | 1 |
| Lenfant, P | 1 |
| Noel, MP | 1 |
| Facon, T | 1 |
| Leleu, X | 1 |
| Pasquier, F | 1 |
| Le Rhun, E | 1 |
| Ren, WJ | 1 |
| Liu, Y | 1 |
| Zhou, LJ | 1 |
| Li, W | 1 |
| Zhong, Y | 1 |
| Pang, RP | 1 |
| Xin, WJ | 1 |
| Wei, XH | 1 |
| Wang, J | 1 |
| Zhu, HQ | 1 |
| Wu, CY | 1 |
| Qin, ZH | 1 |
| Liu, G | 1 |
| Liu, XG | 1 |
| Russo, I | 1 |
| Caracciolo, L | 1 |
| Tweedie, D | 1 |
| Choi, SH | 1 |
| Greig, NH | 1 |
| Barlati, S | 1 |
| Bosetti, F | 1 |
| Elçioğlu, H | 1 |
| Kabasakal, L | 1 |
| Alan, S | 1 |
| Salva, E | 1 |
| Tufan, F | 1 |
| Karan, M | 1 |
5 other studies available for thalidomide and Age-Related Memory Disorders
| Article | Year |
|---|---|
Thalidomide alleviates postoperative pain and spatial memory deficit in aged rats.
Topics: Acute Pain; Aging; Animals; Cytokines; Inflammation Mediators; Locomotion; Male; Memory Disorders; P | 2017 |
Memory loss during lenalidomide treatment: a report on two cases.
Topics: Adult; Aged; Angiogenesis Inhibitors; Humans; Immunologic Factors; Lenalidomide; Male; Memory Disord | 2013 |
Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-α in rodents.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocamp | 2011 |
3,6'-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit.
Topics: Amyloid beta-Peptides; Animals; Disease Models, Animal; Hippocampus; Injections, Intraventricular; M | 2012 |
Thalidomide attenuates learning and memory deficits induced by intracerebroventricular administration of streptozotocin in rats.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Brain; Disease Models, Animal; Injections, Intravent | 2013 |