thalidomide has been researched along with Age-Related Macular Degeneration in 7 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to determine the incidence of sensory symptoms (SS) that complicate thalidomide treatment of patients with age-related macular degeneration." | 9.14 | A prospective double-blind, placebo-controlled study of thalidomide sensory symptoms in an elderly population with age-related macular degeneration. ( Khella, SL; Souayah, N, 2010) |
| "We aimed to determine the incidence of sensory symptoms (SS) that complicate thalidomide treatment of patients with age-related macular degeneration." | 5.14 | A prospective double-blind, placebo-controlled study of thalidomide sensory symptoms in an elderly population with age-related macular degeneration. ( Khella, SL; Souayah, N, 2010) |
| ", 1991), we found that pentoxifylline and thalidomide potentiate each others antiangiogenic effect induced by human malignant melanoma cells in the cornea of Macaca arctoides monkeys." | 3.70 | Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration. ( Akhter, S; Ambrus, JL; Karakousis, CP; Kulaylat, M; Plavsic, L; Toumbis, CA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Souayah, N | 1 |
| Khella, SL | 1 |
| Ciardella, AP | 1 |
| Donsoff, IM | 1 |
| Guyer, DR | 1 |
| Adamis, A | 1 |
| Yannuzzi, LA | 1 |
| Verougstraete, C | 1 |
| Roodhooft, J | 1 |
| Ambrus, JL | 1 |
| Toumbis, CA | 1 |
| Karakousis, CP | 1 |
| Kulaylat, M | 1 |
| Akhter, S | 1 |
| Plavsic, L | 1 |
| François, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization[NCT00555594] | Phase 2/Phase 3 | 18 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for thalidomide and Age-Related Macular Degeneration
| Article | Year |
|---|---|
Antiangiogenesis agents.
Topics: Angiogenesis Inhibitors; Choroidal Neovascularization; Clinical Trials as Topic; Humans; Interferon | 2002 |
[Present and future treatment of age-related macular degeneration].
Topics: Animals; Clinical Trials as Topic; Diet Therapy; Forecasting; Humans; Interferon alpha-2; Interferon | 1999 |
No efficacious treatment for age-related macular degeneration.
Topics: Antioxidants; Choroid; Endothelial Growth Factors; Humans; Integrins; Interferon-alpha; Laser Therap | 2000 |
Embryological pigment epithelial dystrophies.
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Deafness; Female; Fluorescein Angiography; Human | 1976 |
1 trial available for thalidomide and Age-Related Macular Degeneration
| Article | Year |
|---|---|
A prospective double-blind, placebo-controlled study of thalidomide sensory symptoms in an elderly population with age-related macular degeneration.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Dose-Response Relationship, Drug; Double-Blind Met | 2010 |
2 other studies available for thalidomide and Age-Related Macular Degeneration
| Article | Year |
|---|---|
Rethinking thalidomide.
Topics: Animals; Diabetic Retinopathy; Eye; Humans; Macular Degeneration; Neovascularization, Pathologic; Ra | 1995 |
Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Cornea; Corneal Neovascularization; Drug Combinat | 2000 |