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thalidomide and Affective Disorders

thalidomide has been researched along with Affective Disorders in 2 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
"Thalidomide is a potent teratogen that causes dysmelia in humans."2.70A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer. ( Chen, CC; Dahut, W; Dixon, S; Duray, P; Figg, WD; Floeter, MK; Gubish, E; Hamilton, M; Jones, E; Kohler, DR; Krüger, EA; Linehan, WM; Pluda, JM; Premkumar, A; Reed, E; Steinberg, SM; Tompkins, A, 2001)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Juliusson, G1
Celsing, F1
Turesson, I1
Lenhoff, S1
Adriansson, M1
Malm, C1
Figg, WD1
Dahut, W1
Duray, P1
Hamilton, M1
Tompkins, A1
Steinberg, SM1
Jones, E1
Premkumar, A1
Linehan, WM1
Floeter, MK1
Chen, CC1
Dixon, S1
Kohler, DR1
Krüger, EA1
Gubish, E1
Pluda, JM1
Reed, E1

Trials

1 trial available for thalidomide and Affective Disorders

ArticleYear
A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:7

    Topics: Aged; Aged, 80 and over; Androgens; Angiogenesis Inhibitors; Dose-Response Relationship, Drug; Endot

2001

Other Studies

1 other study available for thalidomide and Affective Disorders

ArticleYear
Frequent good partial remissions from thalidomide including best response ever in patients with advanced refractory and relapsed myeloma.
    British journal of haematology, 2000, Volume: 109, Issue:1

    Topics: Adult; Aged; Angiogenesis Inhibitors; Bence Jones Protein; Drug Administration Schedule; Female; Hum

2000