thalidomide has been researched along with Acute Brain Injuries in 6 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved drug class is compromised by potential teratogenicity." | 8.31 | Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury. ( Baig, AM; Chiang, YH; Greig, NH; Hoffer, BJ; Hsueh, SC; Hwang, I; Kim, DS; Kim, S; Kim, YK; Lecca, D; Luo, W; Tweedie, D; Vargesson, N, 2023) |
| "Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved drug class is compromised by potential teratogenicity." | 4.31 | Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury. ( Baig, AM; Chiang, YH; Greig, NH; Hoffer, BJ; Hsueh, SC; Hwang, I; Kim, DS; Kim, S; Kim, YK; Lecca, D; Luo, W; Tweedie, D; Vargesson, N, 2023) |
| "Present knowledge of chromosomal aberrations associated with microphthalmia is surveyed, and some of the syndromes and phenocopies in the mentally retarded in which microphthalmia may be found are reviewed." | 2.35 | The heterogeneity of microphthalmia in the mentally retarded. ( Warburg, M, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, J | 1 |
| Jiang, J | 1 |
| He, B | 1 |
| Lin, WJ | 1 |
| Li, Y | 1 |
| Duan, J | 1 |
| Li, H | 1 |
| Huang, X | 1 |
| Cai, J | 1 |
| Xie, J | 1 |
| Zhang, Z | 1 |
| Yang, Y | 1 |
| Xu, Y | 1 |
| Hu, X | 1 |
| Wu, M | 1 |
| Zhuo, X | 1 |
| Liu, Q | 1 |
| Shi, Z | 1 |
| Yu, P | 1 |
| Rong, X | 1 |
| Ye, X | 1 |
| Saw, PE | 1 |
| Wu, LJ | 1 |
| Simone, CB | 1 |
| Chua, MLK | 1 |
| Mai, HQ | 1 |
| Tang, Y | 1 |
| Lecca, D | 2 |
| Hsueh, SC | 1 |
| Luo, W | 4 |
| Tweedie, D | 4 |
| Kim, DS | 2 |
| Baig, AM | 1 |
| Vargesson, N | 1 |
| Kim, YK | 1 |
| Hwang, I | 1 |
| Kim, S | 1 |
| Hoffer, BJ | 4 |
| Chiang, YH | 1 |
| Greig, NH | 4 |
| Lin, CT | 1 |
| Yang, LY | 1 |
| Scerba, MT | 1 |
| Huang, PS | 1 |
| Jung, YJ | 1 |
| Yang, CH | 1 |
| Wang, JY | 2 |
| Baratz, R | 2 |
| Rubovitch, V | 2 |
| Pick, CG | 2 |
| Yoon, JS | 1 |
| Warburg, M | 1 |
1 review available for thalidomide and Acute Brain Injuries
| Article | Year |
|---|---|
The heterogeneity of microphthalmia in the mentally retarded.
Topics: Abnormalities, Multiple; Abortifacient Agents; Adolescent; Adult; Brain Injuries; Child, Preschool; | 1971 |
1 trial available for thalidomide and Acute Brain Injuries
| Article | Year |
|---|---|
A phase 2 study of thalidomide for the treatment of radiation-induced blood-brain barrier injury.
Topics: Animals; Bevacizumab; Blood-Brain Barrier; Brain; Brain Injuries; Mice; Radiation Injuries; Thalidom | 2023 |
4 other studies available for thalidomide and Acute Brain Injuries
| Article | Year |
|---|---|
Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury.
Topics: Animals; Brain Injuries; Brain Injuries, Traumatic; Chick Embryo; Humans; Immunomodulating Agents; I | 2023 |
3,6'-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation.
Topics: Animals; Brain Injuries; Cytokines; Encephalitis; Male; Mice; Mice, Inbred C57BL; Microglia; Neurons | 2020 |
Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Cognition Disorders; Disease Models, Animal; Enzyme-Linke | 2015 |
Tumor necrosis factor-α synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Brain Injuries; Cell Line; Inflammat | 2011 |