thalidomide has been researched along with Acrorenoocular Syndrome in 10 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 7.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 3.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "We found that Duane syndrome and its variants were prominent in individuals who were exposed to thalidomide early in the sensitive period (days 20 to 26±)." | 2.47 | What can we learn from the thalidomide experience: an ophthalmologic perspective. ( Miller, MT; Strömland, KK, 2011) |
| "Most reported cases are associated with Duane syndrome." | 2.44 | Congenital aberrant tearing: a re-look. ( Miller, MT; Strömland, K; Ventura, L, 2008) |
| "We have recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on chromosome 20q13." | 1.32 | Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy. ( Becker, K; Kohlhase, J; Liebers, M; Mohammed, SN; Newbury-Ecob, R; Rauch, A; Reardon, W; Schubert, L, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donovan, KA | 1 |
| An, J | 1 |
| Nowak, RP | 1 |
| Yuan, JC | 1 |
| Fink, EC | 1 |
| Berry, BC | 1 |
| Ebert, BL | 1 |
| Fischer, ES | 1 |
| Gomes, JDA | 1 |
| Kowalski, TW | 1 |
| Fraga, LR | 1 |
| Macedo, GS | 1 |
| Sanseverino, MTV | 1 |
| Schuler-Faccini, L | 1 |
| Vianna, FSL | 1 |
| Parsa, CF | 1 |
| Robert, MP | 1 |
| Hoyt, CS | 1 |
| Miller, MT | 4 |
| Strömland, K | 2 |
| Ventura, L | 1 |
| Strömland, KK | 1 |
| Kohlhase, J | 2 |
| Schubert, L | 1 |
| Liebers, M | 1 |
| Rauch, A | 1 |
| Becker, K | 1 |
| Mohammed, SN | 1 |
| Newbury-Ecob, R | 1 |
| Reardon, W | 1 |
| Holmes, LB | 1 |
3 reviews available for thalidomide and Acrorenoocular Syndrome
| Article | Year |
|---|---|
Congenital aberrant tearing: a re-look.
Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Lacrimal | 2008 |
What can we learn from the thalidomide experience: an ophthalmologic perspective.
Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Limb Defo | 2011 |
Thalidomide embryopathy: a model for the study of congenital incomitant horizontal strabismus.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Duane Retraction Syndrome; Embryo, Mamm | 1991 |
7 other studies available for thalidomide and Acrorenoocular Syndrome
| Article | Year |
|---|---|
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
Topics: Abnormalities, Multiple; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; CYS2-HIS2 Zinc F | 2018 |
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C | 2019 |
Thromboembolism and congenital malformations: from Duane syndrome to thalidomide embryopathy.
Topics: Abducens Nerve; Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; F | 2013 |
No, not more talk about Duane syndrome.
Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Fetal Diseases; H | 2013 |
Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy.
Topics: Abnormalities, Multiple; Base Sequence; Chromosomes, Human, Pair 20; DNA; DNA Mutational Analysis; D | 2003 |
Mutations in SALL4 in malformed father and daughter postulated previously due to reflect mutagenesis by thalidomide.
Topics: Duane Retraction Syndrome; Fathers; Female; Hearing Loss; Humans; Male; Mutation; Pregnancy; Prenata | 2004 |
Thalidomide embryopathy: revisited 27 years later.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Duane Retraction Syndrome; Eye Abnormal | 1993 |