thalidomide has been researched along with Absence of Brain, Congenital in 6 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Head anomalies in fetuses (anencephaly, holoprosencephaly and hydrocephaly) were induced at a high frequency by the maternal administration of thalidomide on day 7, and also in a few fetuses on day 8." | 1.27 | [Teratogenic potentially of single dose of thalidomide in JW-NIBS rabbits]. ( Matsubara, Y; Mikami, T, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SALLER, K | 1 |
| INGALLS, TH | 1 |
| KLINGBERG, MA | 1 |
| Matsubara, Y | 1 |
| Mikami, T | 1 |
| Achs, R | 1 |
| Harper, RG | 1 |
| Bryan, EM | 1 |
| Kohler, HG | 1 |
| Tünte, W | 1 |
2 reviews available for thalidomide and Absence of Brain, Congenital
| Article | Year |
|---|---|
CONGENITAL MALFORMATIONS. CLINICAL AND COMMUNITY CONSIDERATIONS.
Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Achondroplasia; Anencephaly; Cleft Pala | 1965 |
Dermatoglyphics.
Topics: Abnormalities, Drug-Induced; Anemia, Sickle Cell; Anencephaly; Cerebral Palsy; Chromosome Aberration | 1968 |
4 other studies available for thalidomide and Absence of Brain, Congenital
| Article | Year |
|---|---|
[ON THE FREQUENCY OF MALFORMATIONS IN BAVARIA. 2].
Topics: Abnormalities, Drug-Induced; Anencephaly; Cleft Lip; Cleft Palate; Clubfoot; Congenital Abnormalitie | 1964 |
[Teratogenic potentially of single dose of thalidomide in JW-NIBS rabbits].
Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Brain; Female; Heart Defects, Congenital; Hydroce | 1985 |
The missing umbilical artery. I. Prospective study based on a maternity unit.
Topics: Adult; Anencephaly; Birth Weight; Congenital Abnormalities; Female; Gestational Age; Humans; Hydroce | 1974 |
[On the incidence of congenital malformations of the central nervous system and the alimentary tract during the years 1950-61].
Topics: Abnormalities, Drug-Induced; Anal Canal; Anencephaly; Esophageal Atresia; Esophagus; Female; Hand De | 1968 |