Compounds > thalidomide
Page last updated: 2024-11-05

thalidomide and Abnormality, Heart

thalidomide has been researched along with Abnormality, Heart in 38 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
"Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy."7.91The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019)
"The possibility of epilepsy resulting from maternal thalidomide ingestion was investigated by obtaining a telephoned neurological history from all suspect families in the United Kingdom in which the specific diagnosis was uncertain."7.65Epilepsy: a neurological complication of thalidomide embryopathy. ( Stephenson, JB, 1976)
"Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy."3.91The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019)
" The cats were given daily oral doses of thalidomide as follows: 10 mg/kg on days 10-20 of pregnancy, 240 mg/kg on days 10-14, and 120, 240, and 480 mg/kg on days 15-17 or 18-20 of pregnancy."3.65Fetal cardiovascular and other defects induced by thalidomide in cats. ( Khera, KS, 1975)
"The possibility of epilepsy resulting from maternal thalidomide ingestion was investigated by obtaining a telephoned neurological history from all suspect families in the United Kingdom in which the specific diagnosis was uncertain."3.65Epilepsy: a neurological complication of thalidomide embryopathy. ( Stephenson, JB, 1976)
"Thalidomide is a drug responsible to a spectrum of congenital anomalies known as Thalidomide Embryopathy (TE), which includes mainly limb and heart defects."1.72Genetic evaluation of HAND2 gene and its effects on thalidomide embryopathy. ( Bremm, JM; do Amaral Gomes, J; Fraga, LR; Kowalski, TW; Rengel, BD; Schüler-Faccini, L; Vianna, FSL, 2022)
"Thalidomide was used by pregnant women for morning sickness but was removed from the market because it caused severe malformations including CHDs."1.46A HAND to TBX5 Explains the Link Between Thalidomide and Cardiac Diseases. ( Bitar, F; Bouvagnet, P; El-Hachem, N; Khalil, A; Kurban, M; Nemer, G; Tanos, R, 2017)
"Head anomalies in fetuses (anencephaly, holoprosencephaly and hydrocephaly) were induced at a high frequency by the maternal administration of thalidomide on day 7, and also in a few fetuses on day 8."1.27[Teratogenic potentially of single dose of thalidomide in JW-NIBS rabbits]. ( Matsubara, Y; Mikami, T, 1985)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199031 (81.58)18.7374
1990's1 (2.63)18.2507
2000's0 (0.00)29.6817
2010's4 (10.53)24.3611
2020's2 (5.26)2.80

Authors

AuthorsStudies
Rengel, BD1
Kowalski, TW2
Bremm, JM1
do Amaral Gomes, J1
Schüler-Faccini, L2
Vianna, FSL2
Fraga, LR2
Kalisch-Smith, JI1
Ved, N1
Sparrow, DB1
Khalil, A1
Tanos, R1
El-Hachem, N1
Kurban, M1
Bouvagnet, P1
Bitar, F1
Nemer, G1
Donovan, KA1
An, J1
Nowak, RP1
Yuan, JC1
Fink, EC1
Berry, BC1
Ebert, BL1
Fischer, ES1
Gomes, JDA1
Macedo, GS1
Sanseverino, MTV1
Mukhtar, K1
Jayaseelan, S1
Allsop, E1
MENARGUEZ CARRETERO, L1
SOLER MONSALVE, JM1
MOREJON CHICO, J1
DALGAARD, JB1
MATTURRI, L1
NODARI, R1
D AVIGNON, M1
BARR, B1
INGALLS, TH1
KLINGBERG, MA1
Tikkanen, J1
Heinonen, OP1
Engle, MA1
Van Regemorter, N1
Haumont, D1
Kirkpatrick, C1
Viseur, P1
Jeanty, P1
Dodion, J1
Milaire, J1
Rooze, M1
Rodesch, F1
Hilgenberg, F1
Khera, KS1
Nora, JJ1
Nora, AH1
Taussig, H1
Stephenson, JB1
Matsubara, Y1
Mikami, T1
Onishi, T1
Hendrickx, AG1
Newman, L1
Achs, R1
Harper, RG1
Shiono, H1
Lenz, W2
Palmer, AK2
Shapiro, IuL1
Vaĭntrub, MIa1
Grinberg, KN1
Zhurkov, VS1
Smithells, RW1
Jackson, BT1
Shakibi, JG1
Simcha, A1
Keck, EW1
Roloff, D1
Markworth, P1
Poznanski, AK1
Garn, SM1
Holt, JF1
Kreipe, U1
Mongeau, M1
Gingras, G1
Sherman, ED1
Hebert, B1
Hutchison, J1
Corriveau, C1

Reviews

10 reviews available for thalidomide and Abnormality, Heart

ArticleYear
Environmental Risk Factors for Congenital Heart Disease.
    Cold Spring Harbor perspectives in biology, 2020, 03-02, Volume: 12, Issue:3

    Topics: Alcohol Drinking; Animals; Diabetes Mellitus; Environmental Exposure; Gene-Environment Interaction;

2020
CONGENITAL MALFORMATIONS. CLINICAL AND COMMUNITY CONSIDERATIONS.
    The American journal of the medical sciences, 1965, Volume: 249

    Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Achondroplasia; Anencephaly; Cleft Pala

1965
The evolution of specific genetic and environmental counseling in congenital heart diseases.
    Circulation, 1978, Volume: 57, Issue:2

    Topics: Chromosomes; Counseling; Ductus Arteriosus, Patent; Environmental Health; Heart Defects, Congenital;

1978
[Experimental congenital heart diseases].
    Nihon rinsho. Japanese journal of clinical medicine, 1972, Volume: 30, Issue:1

    Topics: Animals; Chickens; Cricetinae; Dactinomycin; Disease Models, Animal; Dogs; Female; Folic Acid Defici

1972
Dermatoglyphics.
    American journal of obstetrics and gynecology, 1968, Aug-01, Volume: 101, Issue:7

    Topics: Abnormalities, Drug-Induced; Anemia, Sickle Cell; Anencephaly; Cerebral Palsy; Chromosome Aberration

1968
[Diseases and dermatoglyphics].
    Nihon hoigaku zasshi = The Japanese journal of legal medicine, 1970, Volume: 24, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Chromosome Aberrations; Chromo

1970
Phenocopies.
    Journal of medical genetics, 1973, Volume: 10, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anemia, Aplastic; Anorexia Nervosa; Arm; Cleft

1973
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1972, Volume: 72, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent

1972
The pathogenesis of congenital cardiovascular anomalies.
    The New England journal of medicine, 1968, Jul-11, Volume: 279, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Embryology; Female; Heart; Heart Defects, Conge

1968
Etiology of congenital heart disease.
    Henry Ford Hospital medical journal, 1969,Summer, Volume: 17, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders;

1969

Other Studies

28 other studies available for thalidomide and Abnormality, Heart

ArticleYear
Genetic evaluation of HAND2 gene and its effects on thalidomide embryopathy.
    Birth defects research, 2022, 12-01, Volume: 114, Issue:20

    Topics: Abnormalities, Multiple; Basic Helix-Loop-Helix Transcription Factors; Female; Fetal Diseases; Genet

2022
A HAND to TBX5 Explains the Link Between Thalidomide and Cardiac Diseases.
    Scientific reports, 2017, 05-03, Volume: 7, Issue:1

    Topics: Basic Helix-Loop-Helix Transcription Factors; DNA; Female; Genotype; Heart Defects, Congenital; HEK2

2017
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
    eLife, 2018, 08-01, Volume: 7

    Topics: Abnormalities, Multiple; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; CYS2-HIS2 Zinc F

2018
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
    Scientific reports, 2019, 08-06, Volume: 9, Issue:1

    Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C

2019
Anaesthesia and orphan disease: phocomelia--a lesson from the past.
    European journal of anaesthesiology, 2012, Volume: 29, Issue:7

    Topics: Abdomen; Anesthesiology; Ectromelia; Heart Defects, Congenital; Hemodynamics; Humans; Intestines; Ma

2012
[Thalidomide and congenital heart diseases].
    Revista espanola de cardiologia, 1962, Volume: 15

    Topics: Heart Defects, Congenital; Humans; Thalidomide

1962
[Thalidomide syndrome without dysmelia. A case with a rare congenital heart lesion].
    Ugeskrift for laeger, 1963, Aug-02, Volume: 125

    Topics: Heart; Heart Defects, Congenital; Humans; Syndrome; Thalidomide

1963
[ANATOMOCLINICAL STUDY OF 19 CASES OF EMBRYOPATHY CAUSED BY THALIDOMIDE].
    Folia hereditaria et pathologica, 1963, Volume: 12

    Topics: Appendix; Congenital Abnormalities; Ectromelia; Female; Fetal Diseases; Heart Defects, Congenital; H

1963
EAR ABNORMALITIES AND CRANIAL NERVE PALSIES IN THALIDOMIDE CHILDREN.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1964, Volume: 80

    Topics: Abnormalities, Drug-Induced; Child; Cranial Nerve Diseases; Cranial Nerves; Deafness; Ear Deformitie

1964
[Maternal drug therapy as a risk factor for congenital heart disease].
    Duodecim; laaketieteellinen aikakauskirja, 1984, Volume: 100, Issue:11

    Topics: Anticonvulsants; Female; Heart Defects, Congenital; Hormones; Humans; Infant, Newborn; Lithium; Mate

1984
Biographies of great American pediatricians--Helen Brooke Taussig: the mother of pediatric cardiology.
    Pediatric annals, 1982, Volume: 11, Issue:7

    Topics: Cardiology; Female; Heart Defects, Congenital; History of Medicine; Humans; Infant, Newborn; Pediatr

1982
Holt Oram syndrome mistaken for thalidomide embryopathy--embryological considerations.
    European journal of pediatrics, 1982, Volume: 138, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Diagnosis, Differential; Ectromelia; Female; Genetic Counseling;

1982
[Misfortune at the beginning of life. Challenge and accomplishments].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 1998, Volume: 17, Issue:1

    Topics: Abnormalities, Drug-Induced; Heart Defects, Congenital; Humans; Infant, Newborn; Intensive Care Unit

1998
Fetal cardiovascular and other defects induced by thalidomide in cats.
    Teratology, 1975, Volume: 11, Issue:1

    Topics: Animals; Cardiomegaly; Cats; Coronary Vessels; Female; Fetal Heart; Heart Atria; Heart Defects, Cong

1975
A conversation with Helen Taussig. Interview by Dr. W. Proctor Harvey.
    Medical times, 1978, Volume: 106, Issue:11

    Topics: Abnormalities, Drug-Induced; Cardiology; Education, Medical; Forecasting; Heart Defects, Congenital;

1978
Epilepsy: a neurological complication of thalidomide embryopathy.
    Developmental medicine and child neurology, 1976, Volume: 18, Issue:2

    Topics: Adolescent; Ear; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Female; Heart Defects, C

1976
[Teratogenic potentially of single dose of thalidomide in JW-NIBS rabbits].
    Jikken dobutsu. Experimental animals, 1985, Volume: 34, Issue:3

    Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Brain; Female; Heart Defects, Congenital; Hydroce

1985
Appendicular skeletal and visceral malformations induced by thalidomide in bonnet monkeys.
    Teratology, 1973, Volume: 7, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Arm; Bone and Bones; Brain; Dose-Response Relationship, Drug;

1973
Problems associated with the screening of drugs for possible teratogenic activity.
    Experimental embryology and teratology, 1974, Volume: 1, Issue:0

    Topics: 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Aspirin; Dose-Response Rela

1974
Defects and disabilities of thalidomide children.
    British medical journal, 1973, Feb-03, Volume: 1, Issue:5848

    Topics: Abnormalities, Drug-Induced; Arm; Child; Coloboma; Ear; Ectromelia; Eye Abnormalities; Heart Defects

1973
Sporadic malformations in laboratory animals and their influence on drug testing.
    Advances in experimental medicine and biology, 1972, Volume: 27

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Laboratory; Aspirin; Bone and Bones; Congenital Abnor

1972
Congenital heart disease in radial clubbed hand syndrome.
    Archives of disease in childhood, 1971, Volume: 46, Issue:247

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Hand Deformities, Acquired; Heart Defe

1971
[Cardiovascular findings in children with the thalidomide-dysmelia-syndrome].
    Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung, 1971, Volume: 37

    Topics: Abnormalities, Drug-Induced; Child; Ectromelia; Female; Germany, West; Heart Defects, Congenital; Hu

1971
The thumb in the congenital malformation syndromes.
    Radiology, 1971, Volume: 100, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acrocephalosyndactylia; Anemia, Aplastic; Arm;

1971
Phenocopy.
    Humangenetik, 1970, Volume: 9, Issue:3

    Topics: Abnormalities, Multiple; Anemia, Aplastic; Arm; Congenital Hypothyroidism; Deafness; Female; Feminiz

1970
Report of Inter-Society Commission for Heart Disease Resources. Prevention of Cardiovascular Disease. Primary prevention of congenital heart disease.
    Circulation, 1970, Volume: 41, Issue:6

    Topics: Child; Chromosome Aberrations; Female; Fetal Death; Heart Defects, Congenital; Humans; Infant; Infan

1970
[Abnormalities of internal organs in thalidomide embryopathy. A contribution to the determination of the sensitivity phase in thalidomide administration during early pregnancy].
    Archiv fur Kinderheilkunde, 1967, Volume: 176, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Digestive System Abnormalities; Ear Deformities, Acquired; Femal

1967
Medical and psychosocial aspects of the habilitation of thalidomide children.
    Canadian Medical Association journal, 1966, Aug-27, Volume: 95, Issue:9

    Topics: Abnormalities, Drug-Induced; Adult; Artificial Limbs; Child, Preschool; Deafness; Ear Deformities, A

1966