thalidomide has been researched along with Abnormalities, Multiple in 108 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Abnormalities, Multiple: Congenital abnormalities that affect more than one organ or body structure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 7.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "One third of Swedes with thalidomide embryopathy have sixth and seventh cranial nerve palsy, named Möbius syndrome/sequence, and some of them suffer from autism." | 4.80 | [Eye muscle paralysis can increase the knowledge on autism]. ( Strömland, K, 2000) |
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 3.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "To review the association of autism spectrum disorder (ASD) in individuals manifesting thalidomide embryopathy and Möbius sequence and compare them with three new studies in which ASD was also associated with ocular and systemic malformations: (1) a Swedish study of individuals with CHARGE association (Coloboma, Heart, choanal Atresia, developmental or growth Retardation, Genital anomaly, and Ear involvement); (2) a Swedish study of Goldenhar syndrome; and (3) Brazilian Möbius syndrome (sequence) study." | 3.72 | Autism with ophthalmologic malformations: the plot thickens. ( Bandim, JM; Gillberg, C; Johansson, M; Miller, MT; Strömland, K; Ventura, L, 2004) |
| " Animal models of hemifacial microsomia and thalidomide-induced otomandibular dysostosis are described; the causal mechanism of malformation appeared to be closely related to the formation of a hematoma at the time of development of the stapedial arterial systems." | 3.65 | Hemorrhage in development of the face. ( Poswillo, D, 1975) |
| "Proteus syndrome is an overgrowth syndrome caused by a somatic activating mutation in AKT1." | 2.61 | Vascular malformations syndromes: an update. ( Arias-Santiago, S; Martinez-Lopez, A; Molina-Leyva, A; Montero-Vilchez, T; Salvador-Rodriguez, L; Tercedor-Sanchez, J, 2019) |
| "Present knowledge of chromosomal aberrations associated with microphthalmia is surveyed, and some of the syndromes and phenocopies in the mentally retarded in which microphthalmia may be found are reviewed." | 2.35 | The heterogeneity of microphthalmia in the mentally retarded. ( Warburg, M, 1971) |
| "Thirty-three patients (26%) reported neuropathic pain." | 1.91 | Age-related changes in patients with upper limb thalidomide embryopathy in the United Kingdom. ( Brennan, S; Hooper, G; Lam, W; Markiewicz, M; Stirling, P, 2023) |
| "Thalidomide is a drug responsible to a spectrum of congenital anomalies known as Thalidomide Embryopathy (TE), which includes mainly limb and heart defects." | 1.72 | Genetic evaluation of HAND2 gene and its effects on thalidomide embryopathy. ( Bremm, JM; do Amaral Gomes, J; Fraga, LR; Kowalski, TW; Rengel, BD; Schüler-Faccini, L; Vianna, FSL, 2022) |
| "Thalidomide is a known teratogen and it is estimated that more than ten thousand babies were affected by thalidomide embryopathy (TE), which is characterized mainly by limb defects, but can involve many organs and systems." | 1.42 | Thalidomide embryopathy: Follow-up of cases born between 1959 and 2010. ( Kowalski, TW; Sanseverino, MT; Schuler-Faccini, L; Vianna, FS, 2015) |
| "Thalidomide has a potent immunomodulatory property and has now a number of approved and off-label uses in dermatologic, oncologic, infectious and gastrointestinal conditions." | 1.34 | New cases of thalidomide embryopathy in Brazil. ( Castilla, EE; de Sousa, AC; Luna, E; Maximino, C; Schuler-Faccini, L; Schwartz, IV; Soares, RC; Waldman, C, 2007) |
| "We have recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on chromosome 20q13." | 1.32 | Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy. ( Becker, K; Kohlhase, J; Liebers, M; Mohammed, SN; Newbury-Ecob, R; Rauch, A; Reardon, W; Schubert, L, 2003) |
| "Cases with documented maternal alcohol abuse in pregnancy in this group were analyzed separately." | 1.28 | Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study. ( Baird, PA; Froster, UG, 1992) |
| "After surgical removal of the meningocele all bladder and rectal disorders disappeared." | 1.28 | [Presacral meningocele in thalidomide-induced embryopathy]. ( Bröcheler, J; Halfmann, R, 1990) |
| "For example, in the case of Congenital rubella syndrome (CRS), monitoring for the combination of cataracts with deafness and/or patent ductus arteriosus could have led to earlier detection of an epidemic than could monitoring for cataracts alone." | 1.27 | Monitoring for multiple malformations in the detection of epidemics of birth defects. ( Adams, MM; Erickson, JD; Khoury, MJ; Rhodes, P, 1987) |
| "A new case of Tetraphocomelia--cleft palatee syndrome is described." | 1.25 | The tetraphocomelia -- cleft palate syndrome: description of a new case. ( Grosse, FR; Pandel, C; Wiedemann, HR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (69.44) | 18.7374 |
| 1990's | 11 (10.19) | 18.2507 |
| 2000's | 5 (4.63) | 29.6817 |
| 2010's | 12 (11.11) | 24.3611 |
| 2020's | 5 (4.63) | 2.80 |
| Authors | Studies |
|---|---|
| Rengel, BD | 1 |
| Kowalski, TW | 6 |
| Bremm, JM | 1 |
| do Amaral Gomes, J | 1 |
| Schüler-Faccini, L | 7 |
| Vianna, FSL | 3 |
| Fraga, LR | 5 |
| Passarge, E | 2 |
| Markiewicz, M | 1 |
| Stirling, P | 2 |
| Brennan, S | 1 |
| Hooper, G | 2 |
| Lam, W | 2 |
| Farr, S | 1 |
| Vargesson, N | 1 |
| Giddins, G | 1 |
| Hunter, A | 1 |
| Martinez-Lopez, A | 1 |
| Salvador-Rodriguez, L | 1 |
| Montero-Vilchez, T | 1 |
| Molina-Leyva, A | 1 |
| Tercedor-Sanchez, J | 1 |
| Arias-Santiago, S | 1 |
| Croci, DM | 1 |
| Dalolio, M | 1 |
| Schaeren, S | 1 |
| Wasner, MG | 1 |
| Mariani, L | 1 |
| Jost, GF | 1 |
| Donovan, KA | 1 |
| An, J | 1 |
| Nowak, RP | 1 |
| Yuan, JC | 1 |
| Fink, EC | 1 |
| Berry, BC | 1 |
| Ebert, BL | 1 |
| Fischer, ES | 1 |
| Gomes, JDA | 1 |
| Macedo, GS | 1 |
| Sanseverino, MTV | 2 |
| Schulte-Wissermann, H | 2 |
| Shiga, T | 1 |
| Shimbo, T | 1 |
| Yoshizawa, A | 2 |
| Sanseverino, MT | 3 |
| Vianna, FS | 2 |
| Nicotra, A | 1 |
| Newman, C | 1 |
| Johnson, M | 1 |
| Eremin, O | 1 |
| Friede, T | 1 |
| Malik, O | 1 |
| Nicholas, R | 1 |
| Tajima, T | 1 |
| Wada, T | 1 |
| Masuda, T | 1 |
| Okafuji, T | 1 |
| Nakayama, T | 1 |
| Hasuo, K | 1 |
| Sales Luiz Vianna, F | 1 |
| Tovo-Rodrigues, L | 2 |
| Tagliani-Ribeiro, A | 1 |
| Godoy, BA | 1 |
| Hutz, MH | 2 |
| Kohlhase, J | 1 |
| Schubert, L | 1 |
| Liebers, M | 1 |
| Rauch, A | 1 |
| Becker, K | 1 |
| Mohammed, SN | 1 |
| Newbury-Ecob, R | 1 |
| Reardon, W | 1 |
| BERGSTROM, AL | 1 |
| NILSSON, L | 1 |
| PETTERSSON, G | 1 |
| SODERLING, B | 1 |
| VICTORIN, L | 1 |
| WINBERG, J | 2 |
| FARIZON, F | 1 |
| MASBERNARD, A | 1 |
| HIRSCH, M | 1 |
| SCHONENBERG, H | 2 |
| WEICKER, H | 3 |
| CUTHBERT, R | 1 |
| SPEIRS, AL | 1 |
| KASS, E | 1 |
| RAVAILLE, G | 1 |
| METZ, J | 1 |
| MAUER, ML | 1 |
| KELSEY, FO | 2 |
| TORRICELLI, C | 1 |
| MATTURRI, L | 1 |
| NODARI, R | 1 |
| PARTSCH, CJ | 1 |
| MAURER, H | 1 |
| VOGL, A | 1 |
| INGALLS, TH | 1 |
| CURLEY, FJ | 1 |
| ZAPPASODI, P | 1 |
| SCHMIDT, JG | 1 |
| GATZEK, H | 1 |
| DIPAOLO, JA | 1 |
| MAIER, WA | 1 |
| ERFURTH, F | 1 |
| KENEZ, J | 1 |
| LENZ, W | 5 |
| KNAPP, K | 1 |
| PLIESS, G | 1 |
| Miller, MT | 5 |
| Strömland, K | 4 |
| Ventura, L | 1 |
| Johansson, M | 1 |
| Bandim, JM | 1 |
| Gillberg, C | 1 |
| Soares, RC | 1 |
| de Sousa, AC | 1 |
| Maximino, C | 1 |
| Luna, E | 1 |
| Schwartz, IV | 1 |
| Waldman, C | 1 |
| Castilla, EE | 1 |
| Mühlenstedt, D | 1 |
| Schwarz, M | 1 |
| Schmidt, M | 1 |
| Salzano, FM | 1 |
| Cutler, J | 1 |
| McBride, WG | 2 |
| McFadyen, RE | 1 |
| Hoffmann, W | 1 |
| Grospietsch, G | 1 |
| Kuhn, W | 1 |
| Waring, GO | 1 |
| Shields, JA | 1 |
| Grosse, FR | 2 |
| Wiedemann, H | 1 |
| Klaas, D | 1 |
| Schütte, E | 1 |
| Lizin, F | 1 |
| Poswillo, D | 1 |
| Feldmann, U | 1 |
| Schaller, A | 1 |
| Edwards, DH | 1 |
| Nichols, PJ | 3 |
| McCredie, J | 2 |
| Pandel, C | 1 |
| Wiedemann, HR | 1 |
| Smithells, RW | 1 |
| Newman, CG | 2 |
| Froster, UG | 1 |
| Baird, PA | 2 |
| Froster-Iskenius, UG | 1 |
| Bröcheler, J | 1 |
| Halfmann, R | 1 |
| Jörgensen, G | 4 |
| Khoury, MJ | 1 |
| Adams, MM | 1 |
| Rhodes, P | 1 |
| Erickson, JD | 1 |
| Schärli, AF | 1 |
| Phelps, PD | 1 |
| Clarke, MS | 1 |
| McCay, G | 1 |
| Molden, FR | 1 |
| Shiono, H | 1 |
| Shapiro, IuL | 1 |
| Vaĭntrub, MIa | 1 |
| Grinberg, KN | 1 |
| Zhurkov, VS | 1 |
| Illum, P | 1 |
| Book, SA | 1 |
| Bustad, LK | 1 |
| Pasquet, J | 1 |
| Wilson, JG | 1 |
| Holt, SB | 1 |
| Elsahy, NI | 1 |
| Mörike, KD | 1 |
| Depaepe, E | 1 |
| Bouckaert, JI | 1 |
| Warburg, M | 1 |
| Miehlke, A | 1 |
| Gagliardi, V | 1 |
| Terrahe, K | 1 |
| Simcha, A | 1 |
| Poznanski, AK | 1 |
| Garn, SM | 1 |
| Holt, JF | 1 |
| Hirth, L | 1 |
| Döser, R | 1 |
| Vickers, TH | 1 |
| Wrba, H | 1 |
| Rett, A | 1 |
| von Massenbach, W | 1 |
| Severin, G | 1 |
| Kirchmair, H | 1 |
| Källén, B | 1 |
| Kida, M | 1 |
| Rogers, EE | 1 |
| Clark, MS | 1 |
| Stamp, WG | 1 |
19 reviews available for thalidomide and Abnormalities, Multiple
| Article | Year |
|---|---|
[Thalidomide embryopathy 60 years].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Female; Fetal Diseases; Humans; Teratog | 2022 |
[Thalidomide embryopathy 60 years].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Female; Fetal Diseases; Humans; Teratog | 2022 |
[Thalidomide embryopathy 60 years].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Female; Fetal Diseases; Humans; Teratog | 2022 |
[Thalidomide embryopathy 60 years].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Female; Fetal Diseases; Humans; Teratog | 2022 |
Thalidomide upper limb embryopathy - pathogenesis, past and present management and future considerations.
Topics: Abnormalities, Multiple; Adult; Child; Female; Fetal Diseases; Humans; Thalidomide; Upper Extremity | 2023 |
Vascular malformations syndromes: an update.
Topics: Abnormalities, Multiple; Bevacizumab; Class I Phosphatidylinositol 3-Kinases; Growth Disorders; Huma | 2019 |
[THALIDOMIDE EMBRYOPATHY. SURVEY AND PATHOGENIC MECHANISM].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Data Collection; Ectromelia; Embryology; Fetal | 1963 |
Ocular anomalies: embryological implications.
Topics: Abnormalities, Multiple; Eye Abnormalities; Humans; Syndrome; Teratology; Thalidomide | 1995 |
[Eye muscle paralysis can increase the knowledge on autism].
Topics: Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Facial Nerve; Female; Humans; Hypnotics | 2000 |
Syndromes with reduction and surplus anomalies of the hand.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Fanconi Syndrome; Female; Fingers; Hand Deform | 1977 |
Thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone and Bones; Disease Models, Anima | 1977 |
Thalidomide embryopathy: a model for the study of congenital incomitant horizontal strabismus.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Duane Retraction Syndrome; Embryo, Mamm | 1991 |
[Human genetic aspects of inborn ear, nose, and throat diseases].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acrocephalosyndactylia; Child, Preschool; Chro | 1985 |
[Diseases and dermatoglyphics].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Chromosome Aberrations; Chromo | 1970 |
Phenocopies.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anemia, Aplastic; Anorexia Nervosa; Arm; Cleft | 1973 |
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent | 1972 |
The Mondini type of cochlear malformation. A survey of the literature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Aged; Animals; Child, Presc | 1972 |
The fetal and neonatal pig in biomedical research.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anemia, Hypochromic; Animals; Animals, Laborat | 1974 |
[The fawn rabbit of Burgundy in teratology. Spontaneous malformations and malformations provoked by thalidomide].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Rabbits; Teratogens; Thalidomide | 1974 |
Abnormalities of intrauterine development in non-human primates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic | 1972 |
The heterogeneity of microphthalmia in the mentally retarded.
Topics: Abnormalities, Multiple; Abortifacient Agents; Adolescent; Adult; Brain Injuries; Child, Preschool; | 1971 |
[Combined abnormalities of the ear and eye].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Craniofacial Dysostosis; Ear; Embryology; Eye | 1967 |
1 trial available for thalidomide and Abnormalities, Multiple
| Article | Year |
|---|---|
Thalidomide in America: a brush with tragedy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Clinical Trials as Topic; Drug Evaluation; Fem | 1976 |
88 other studies available for thalidomide and Abnormalities, Multiple
| Article | Year |
|---|---|
Genetic evaluation of HAND2 gene and its effects on thalidomide embryopathy.
Topics: Abnormalities, Multiple; Basic Helix-Loop-Helix Transcription Factors; Female; Fetal Diseases; Genet | 2022 |
Age-related changes in patients with upper limb thalidomide embryopathy in the United Kingdom.
Topics: Abnormalities, Multiple; Female; Fetal Diseases; Humans; Neuralgia; Quality of Life; Thalidomide; Up | 2023 |
Commentary on Markiewicz et al. Age-related changes in patients with upper limb thalidomide embryopathy in the United Kingdom.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Fetal Diseases; Humans; Thalidomide; U | 2023 |
Thalidomide Embryopathy as Possible Cause of Anterior Sacral Meningocele: A Case Report.
Topics: Abnormalities, Multiple; Fetal Diseases; Humans; Magnetic Resonance Imaging; Male; Meningocele; Midd | 2017 |
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
Topics: Abnormalities, Multiple; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; CYS2-HIS2 Zinc F | 2018 |
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C | 2019 |
[Independence of former Contergan children compromised].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Humans; Hypnotics and Sedatives; Pregn | 2013 |
Multicenter investigation of lifestyle-related diseases and visceral disorders in thalidomide embryopathy at around 50 years of age.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Cross-Sectional Studies; Female; Fetal Disease | 2015 |
Thalidomide embryopathy: Follow-up of cases born between 1959 and 2010.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Brazil; Child, Preschool; F | 2015 |
Peripheral Nerve Dysfunction in Middle-Aged Subjects Born with Thalidomide Embryopathy.
Topics: Abnormalities, Multiple; Adult; Case-Control Studies; Female; Humans; Male; Middle Aged; Nerve Fiber | 2016 |
Internal anomalies in thalidomide embryopathy: results of imaging screening by CT and MRI.
Topics: Abnormalities, Multiple; Causality; Female; Gallbladder; Humans; Japan; Liver; Magnetic Resonance Im | 2016 |
The impact of thalidomide use in birth defects in Brazil.
Topics: Abnormalities, Multiple; Brazil; Congenital Abnormalities; Fetal Diseases; Humans; Leprosy; Teratoge | 2017 |
Genomic and in silico analyses of CRBN gene and thalidomide embryopathy in humans.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adaptor Proteins, Signal Transducing; Binding | 2016 |
Angiogenesis-related genes and thalidomide teratogenesis in humans: an approach on genetic variation and review of past in vitro studies.
Topics: Abnormalities, Multiple; beta Catenin; Brazil; Cyclooxygenase 2; Female; Genetic Variation; Humans; | 2017 |
Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy.
Topics: Abnormalities, Multiple; Base Sequence; Chromosomes, Human, Pair 20; DNA; DNA Mutational Analysis; D | 2003 |
[Thalidomide embryopathy].
Topics: Abnormalities, Multiple; Congenital Abnormalities; Fetal Diseases; Hypnotics and Sedatives; Syndrome | 1962 |
[Thalidomide embryopathy].
Topics: Abnormalities, Multiple; Ectromelia; Fetal Diseases; Humans; Syndrome; Thalidomide | 1962 |
[Chromosomal studies on so-called thalidomide embryopathy].
Topics: Abnormalities, Multiple; Ectromelia; Fetal Diseases; Humans; Syndrome; Thalidomide | 1963 |
Thalidomide embryopathy.
Topics: Abnormalities, Multiple; Fetal Diseases; Humans; Syndrome; Thalidomide | 1963 |
[Thalidomide embryopathy].
Topics: Abnormalities, Multiple; Ectromelia; Fetal Diseases; Humans; Syndrome; Thalidomide | 1963 |
Thalidomide induced malformations--a radiological survey.
Topics: Abnormalities, Multiple; Congenital Abnormalities; Data Collection; Radiology; Syndrome; Thalidomide | 1963 |
[THALIDOMIDE EMBRYOPATHY].
Topics: Abnormalities, Multiple; Fetal Diseases; Humans; Syndrome; Thalidomide | 1963 |
[1ST CASE OF THALIDOMIDE EMBRYOPATHY STUDIED IN FRANCE].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ectromelia; Fetal Diseases; France; Infant, Ne | 1963 |
PROBLEMS RAISED FOR THE FDA BY THE OCCURRENCE OF THALIDOMIDE EMBRYOPATHY IN GERMANY 1960-1961.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Fetal Diseases; Geriatrics; Germany; Germany, | 1964 |
[THALIDOMIDE EMBRYOPATHY IN ITALY].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Fetal Diseases; Italy; Statistics as Topic; Sy | 1963 |
[THALIDOMIDE EMBRYOPATHIES IN MILANO AND SUBURBS. ANATOMO-CLINICAL STUDY].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Biomedical Research; Ectromelia; Fetal Disease | 1963 |
[ON THE FORMAL GENESIS OF EAR ABNORMALITIES IN THALIDOMIDE EMBRYOPATHY].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Coenzymes; Ear; Fetal Diseases; Humans; Infant | 1963 |
THALIDOMIDE EMBRYOPATHY IN HYBRID RABBITS.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Extremities; Female; Fetal Diseases; Humans; K | 1964 |
[OCULOMOTOR PARALYSIS IN THALIDOMIDE EMBRYOPATHY].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Female; Fetal Diseases; Ophthalmoplegia | 1964 |
RADIOGRAPHIC STUDIES OF THALIDOMIDE-INDUCED MALFORMATIONS IN MICE.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Ectromelia; Female; Humans; Kyphosis; | 1965 |
THALIDOMIDE EMBRYOPATHY AND LIMB DEFECTS; ESPERIENCES IN HABILITATION OF CHILDREN WITH ECTROMELIAS.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Angiography; Artificial Limbs; Child; Ectromel | 1965 |
PROBLEMS RAISED FOR THE FDA BY THE OCCURRENCE OF THALIDOMIDE EMBRYOPATHY IN GERMANY, 1960-1961.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Drug Industry; Female; Fetal Diseases; Germany | 1965 |
[ROENTGENOLOGIC CHANGES IN RABBIT THALIDOMIDE EMBRYOPATHY].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Carbon Tetrachloride; Ectromelia; Fet | 1965 |
[SIMILARITIES AND PECULIARITIES OF FANCONI'S ANEMIA AND THALIDOMIDE EMBRYOPATHY].
Topics: Abnormalities, Multiple; Anemia; Anemia, Aplastic; Diagnosis, Differential; Ectromelia; Fanconi Anem | 1964 |
[Thalidomide embryopathy].
Topics: Abnormalities, Multiple; Extremities; Fetal Diseases; Hypnotics and Sedatives; Limb Deformities, Con | 1962 |
Thalidomide embryopathy.
Topics: Abnormalities, Multiple; Extremities; Fetal Diseases; Hypnotics and Sedatives; Limb Deformities, Con | 1962 |
[Contribution to the teratological analysis of the new Wiedemann dysmelia syndrome (thalidomide abnormalities)].
Topics: Abnormalities, Multiple; Beckwith-Wiedemann Syndrome; Hypnotics and Sedatives; Teratology; Thalidomi | 1962 |
Autism with ophthalmologic malformations: the plot thickens.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Autistic Disorder; Child; Child, P | 2004 |
New cases of thalidomide embryopathy in Brazil.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Brazil; Contraindications; | 2007 |
[Gynecological and endocrinological studies of thalidomide-damaged girls].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Amenorrhea; Female; Follicle Stimu | 1984 |
Clinical studies on teenage Brazilian victims of thalidomide.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Brazil; Child; Female; Gynecomasti | 1983 |
Thalidomide revisited.
Topics: Abnormalities, Multiple; Brazil; Drug Utilization; Female; Humans; Leprosy; Thalidomide | 1994 |
Thalidomide may be a mutagen.
Topics: Abnormalities, Multiple; Fathers; Female; Forearm; Hand Deformities, Congenital; Humans; Infant, New | 1994 |
Thalidomide embryopathy: revisited 27 years later.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Duane Retraction Syndrome; Eye Abnormal | 1993 |
[The Contergan (Thalidomide) case. Catastrophic consequences].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Humans; Hypnotics and Sedatives; Infan | 2000 |
Thalidomide and female genital malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Ectromelia; Female; Genitalia, Fem | 1976 |
Partial unilateral cryptophthalmos with syndactyly, brachycephaly, and renal anomalies.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child, Preschool; Eye Abnormalities; Eyelids; | 1975 |
[Atypical retinal detachment in an adolescent with thalidomide abnormalities].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Female; Humans; Retinal Degenerati | 1977 |
Hemorrhage in development of the face.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Arteries; Craniofacial Dysostosis; Di | 1975 |
Unilateral and asymmetric limb defects in man: delineation of the femur-fibula-ulna complex.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Arm; Consanguinity; Femur; Fibula; Fingers; Ge | 1977 |
[Epidemiology of congenital abnormalities].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Epidemiologic Method | 1977 |
The spinal abnormalities in thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child; Follow-Up Studies; Humans; | 1977 |
Neural crest defects. A neuroanatomic basis for classification of multiple malformations related to phocomelia.
Topics: Abnormalities, Multiple; Autonomic Nervous System; Ectromelia; Humans; Peripheral Nerves; Thalidomid | 1976 |
The tetraphocomelia -- cleft palate syndrome: description of a new case.
Topics: Abnormalities, Multiple; Arm; Child, Preschool; Cleft Palate; Diagnosis, Differential; Ectromelia; F | 1975 |
Comments on "Reply to 'Comments on "Moebius syndrome: animal model--human correlations and evidence for a brainstem vascular etiology"'".
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Brain Stem; Female; Humans; Pregnancy; Syndrom | 1992 |
Recognition of thalidomide defects.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnosis, Differential; Head; Humans; Limb De | 1992 |
Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Alcoholism; Animals; British Columbia; Cocaine | 1992 |
Refractive evaluation in thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cornea; Eye Abnormalities; Female; Huma | 1992 |
Amelia: incidence and associated defects in a large population.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; British Columbia; Diagnosis, Differential; Ect | 1990 |
[Presacral meningocele in thalidomide-induced embryopathy].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Humans; Laminectomy; Male; Meningocele; | 1990 |
Monitoring for multiple malformations in the detection of epidemics of birth defects.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Biometry; Female; Humans; Pregnancy; Rubella; | 1987 |
Teratogen update: clinical aspects of thalidomide embryopathy--a continuing preoccupation.
Topics: Abdomen; Abnormalities, Multiple; Cardiovascular Abnormalities; Cranial Nerves; Dentition; Embryo, M | 1985 |
[Congenital abnormalities of rectum and anus. Diagnosis, physiology and therapy].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anal Canal; Anus, Imperforate; Congenital Abno | 1971 |
Congenital lesions of the inner ear, demonstrated by tomography.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Child; Cochlea; Ear; Ear, I | 1974 |
Swivel walkers. Experiences in fitting swivel walkers to children with severe lower-limb deformities.
Topics: Abnormalities, Multiple; Aluminum; Ankle Joint; Arm; Artificial Limbs; Child; Child, Preschool; Cosm | 1969 |
[Abnormalities in the field of otorhinolaryngology. Genetic report].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acrocephalosyndactylia; Chromosome Aberrations | 1972 |
[Malformations in otorhinolaryngology. Genetic report].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Chromosome Aberrations; Chromosome Diso | 1972 |
[Genetic analysis of skeletal diseases. Genetic report].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Bone Diseases; Child; Chromoso | 1973 |
The effect of absence of thumb on palmar dermatoglyphics.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Dermatoglyphics; Hand Deformities, Congenital; | 1972 |
Moebius syndrome associated with the mother taking thalidomide during gestation. Case report.
Topics: Abducens Nerve; Abnormalities, Drug-Induced; Abnormalities, Multiple; Anxiety; Facial Expression; Fa | 1973 |
[Morphological findings in surgically treated, bilateral, tibial aplasia].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ankle; Ankle Joint; Autopsy; Child, Preschool; | 1973 |
[Surgical exploration of deafness due to thalidomide].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Audiometry; Child; Deafness; Ear; Ear, Inner; | 1974 |
[The first description of the Widemann-Beckwith syndrome?].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adrenal Gland Diseases; Endocrinology; Hernia, | 1971 |
[Teratogenic effects induced by N-phthaloylglutamic acid imide in the maxillofacial region].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Animals, Newborn; Cleft Lip; Cleft Pa | 1971 |
[Diagnosis of malformations of the ear and temporal bone].
Topics: Abducens Nerve; Abnormalities, Drug-Induced; Abnormalities, Multiple; Audiometry; Craniofacial Dysos | 1972 |
Congenital heart disease in radial clubbed hand syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Hand Deformities, Acquired; Heart Defe | 1971 |
[Malformation syndrome and urinary organs].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Chromosomes, Human, 1 | 1971 |
The thumb in the congenital malformation syndromes.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acrocephalosyndactylia; Anemia, Aplastic; Arm; | 1971 |
Phenocopy.
Topics: Abnormalities, Multiple; Anemia, Aplastic; Arm; Congenital Hypothyroidism; Deafness; Female; Feminiz | 1970 |
[Skin ridges and skin furrows in dysmelia].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Chromosome Aberration | 1970 |
Further observations on the thalidomide embryopathy in rabbits.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Cytogenetics; Embryo, Mammalian; Fore | 1970 |
[Symposium on congential malformations. Introduction].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Female; Humans; Infa | 1967 |
[Dysmelia from the view-point of the obstetrician].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ectromelia; Female; Germany, East; Germany, We | 1967 |
[Malformation and liver damage. On the necessary 2nd noxa in experimental thalidomide embryopathies].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Carbon Tetrachloride; Chemical and Dr | 1967 |
[The so-called dysmelia syndrome (Thalidomide embryopathy) and its differential diagnosis].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnosis, Differential; Ectromelia; Facial Ex | 1967 |
A Swedish register of congenital malformations. Experience with continuous registration during 2 years with special reference to multiple malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Female; Fetal Death; | 1968 |
[Thalidomide embryopathy in Japan].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ear; Ectromelia; Female; Fetal Diseases; Finge | 1968 |
The acceptance and rejection of prostheses by children with multiple congenital limb deformities.
Topics: Abnormalities, Multiple; Adaptation, Psychological; Age Factors; Arm; Artificial Limbs; Child, Presc | 1968 |