th-302 and Carcinoma--Hepatocellular

The tumor-derived and transcatheter arterial chemoembolization (TACE) induced hypoxia microenvironment is closely related to the poor prognosis of hepatocellular carcinoma (HCC). In this study, hypoxia-activated prodrug TH-302 loaded poly(lactic-co-glycolic acid) (PLGA)-based TACE microspheres were prepared to treat HCC through localized and sustained drug delivery. TH-302 microspheres with three different sizes were fabricated by an oil-in-water emulsion solvent evaporation method and characterized by scanning electron microscopy (SEM), infrared spectra (IR), X-ray diffractometer (XRD), and drug release profiles. The

Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Catheterization; Cell Hypoxia; Chemoembolization, Therapeutic; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver Neoplasms; Microspheres; Nitroimidazoles; Phosphoramide Mustards; Rabbits