tg6-10-1 has been researched along with Central-Nervous-System-Diseases* in 1 studies
1 other study(ies) available for tg6-10-1 and Central-Nervous-System-Diseases
| Article | Year |
|---|---|
Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models.
Activation of prostanoid EP2 receptor exacerbates neuroinflammatory and neurodegenerative pathology in central nervous system diseases such as epilepsy, Alzheimer's disease, and cerebral aneurysms. A selective and brain-permeable EP2 antagonist will be useful to attenuate the inflammatory consequences of EP2 activation and to reduce the severity of these chronic diseases. We recently developed a brain-permeable EP2 antagonist Topics: Animals; Anti-Inflammatory Agents; Cell Line; Central Nervous System Diseases; Humans; Indoles; Male; Mice; Microglia; Microsomes, Liver; Molecular Structure; Neuroprotective Agents; Receptors, Prostaglandin E, EP2 Subtype; Solubility; Structure-Activity Relationship; Water | 2020 |