tg-003 and Chemical-and-Drug-Induced-Liver-Injury

tg-003 has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 1 studies

Other Studies

1 other study(ies) available for tg-003 and Chemical-and-Drug-Induced-Liver-Injury

Article	Year
Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers. Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14 Autophagy inducers represent new promising agents for the treatment of a wide range of medical illnesses. However, safe autophagy inducers for clinical applications are lacking. Inhibition of cdc2-like kinase 1 (CLK1) was recently found to efficiently induce autophagy. Unfortunately, most of the known CLK1 inhibitors have unsatisfactory selectivity. Herein, we report the discovery of a series of new CLK1 inhibitors containing the 1H-[1,2,3]triazolo[4,5-c]quinoline scaffold. Among them, compound 25 was the most potent and selective, with an IC Topics: Acetaminophen; Animals; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Protective Agents; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinolines; Stereoisomerism; Structure-Activity Relationship; Triazoles	2017

Article

Year

Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.

Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14

Autophagy inducers represent new promising agents for the treatment of a wide range of medical illnesses. However, safe autophagy inducers for clinical applications are lacking. Inhibition of cdc2-like kinase 1 (CLK1) was recently found to efficiently induce autophagy. Unfortunately, most of the known CLK1 inhibitors have unsatisfactory selectivity. Herein, we report the discovery of a series of new CLK1 inhibitors containing the 1H-[1,2,3]triazolo[4,5-c]quinoline scaffold. Among them, compound 25 was the most potent and selective, with an IC

Topics: Acetaminophen; Animals; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Protective Agents; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinolines; Stereoisomerism; Structure-Activity Relationship; Triazoles

2017