tfc-007 has been researched along with Cardiomegaly* in 1 studies
1 other study(ies) available for tfc-007 and Cardiomegaly
| Article | Year |
|---|---|
Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design.
Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the exciting modalities for drug discovery and biological discovery. It is important to select an appropriate linker, an E3 ligase ligand, and a target protein ligand in the development; however, it is necessary to synthesize a large number of PROTACs through trial and error. Herein, using a docking simulation of the ternary complex of a hematopoietic prostaglandin D synthase (H-PGDS) degrader, H-PGDS, and cereblon, we have succeeded in developing Topics: Animals; Bone Marrow; Cardiomegaly; Cell Line, Tumor; Computer Simulation; Drug Discovery; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Ligands; Lipocalins; Male; Mice; Mice, Inbred mdx; Molecular Docking Simulation; Muscular Dystrophy, Duchenne; Proteolysis | 2021 |