tezosentan has been researched along with Disease Models, Animal in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 16 (66.67) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Bartnikowski, NJ; Bisht, K; Black, D; Boon, AC; Bouquet, M; Colombo, SM; Diab, SD; Fraser, JF; Hyslop, K; James, L; Macdonald, PS; Marshall, L; McGiffin, DC; Obonyo, NG; Passmore, MR; Pedersen, SE; Pimenta, LP; Platts, DG; Prabhu, DA; Reid, J; See Hoe, LE; Skeggs, K; Stevenson, AK; Suen, JY; Walweel, K; Wells, MA; Wood, ES | 1 |
| Abukar, Y; May, CN; Ramchandra, R | 1 |
| Beier, UH; Chin, A; Fornell, L; John, E; Pham, J; Radhakrishnan, J; Samuel, S | 1 |
| Andersson, A; Fenhammar, J; Forestier, J; Frithiof, R; Hjelmqvist, H; Sollevi, A; Weitzberg, E | 1 |
| Anselmo, D; Busuttil, RW; Clozel, M; Farmer, DG; Kaldas, F; Kaldas, M; Katori, M; Kupiec-Weglinski, J; Lassman, C; Shen, XD | 1 |
| Cho, KR; Jo, WM; Kim, HJ; Ryu, SM | 1 |
| Couchot, E; de Lagausie, P; de Magnée, C; Guys, JM; Héry, G; Leprêtre, O; Paut, O; Rolland, PH; Stathopoulos, E | 1 |
| Albu, G; Beghetti, M; Fontao, F; Habre, W; Janosi, TZ; Petak, F; von Ungern-Sternberg, BS | 1 |
| Hedelin, P; Kylhammar, D; Rådegran, G | 1 |
| Atalay, F; Yilmaz-Sipahi, E; Yurdakan, G | 1 |
| Hedelin, P; Kylhammar, D; Lundgren, J; Rådegran, G | 1 |
| Menger, MD; Plusczyk, T; Schilling, M; Witzel, B | 1 |
| Al-Jiffry, BO; Menadue, M; Oliver, J; Saccone, GT; Shaffer, EA; Thomas, AC; Toouli, J; Woods, CM; Young, F | 1 |
| Konrad, D; Oldner, A; Rossi, P; Rudehill, A; Wanecek, M; Weitzberg, E | 1 |
| Andreasen, T; Bjertnaes, L; Kuklin, V; Skogen, V; Sovershaev, M; Ytrehus, K | 1 |
| Fischer, V; Fratz, S; Geiger, R; Kleinsasser, A; Loeckinger, A; Maier, S; Navarro-Psiha, S; Neu, N; Pajk, W; Treml, B | 1 |
| Edston, E; Oldner, A; Walther, SM; Wang, J; Winskog, C | 1 |
| Hlastala, MP; Lamm, WJ; Neradilek, B; Polissar, NL; Tsang, JY | 1 |
| Haney, M; Johansson, G; Konrad, D; Oldner, A; Wanecek, M; Weitzberg, E | 1 |
| Boomsma, F; de Beer, VJ; Dekkers, DH; Duncker, DJ; Lamers, JM; Merkus, D; Pijnappels, DA; Sorop, O | 1 |
| Duchman, SM; Kalra, D; Thohan, V; Torre-Amione, G | 1 |
| Clozel, JP; Clozel, M; Hess, P; Qiu, C; Qiu, CS | 1 |
| Chin, A; Fornell, L; John, E; Radhakrishnan, J | 1 |
1 review(s) available for tezosentan and Disease Models, Animal
| Article | Year |
|---|---|
Endothelin-1: a new target of therapeutic intervention for the treatment of heart failure.
Topics: Animals; Disease Models, Animal; Disease Progression; Dogs; Drug Evaluation, Preclinical; Endothelin-1; Heart Failure; Hemodynamics; Humans; Oxygen Consumption; Prognosis; Pyridines; Rabbits; Rats; Survival Analysis; Tetrazoles | 2000 |
23 other study(ies) available for tezosentan and Disease Models, Animal
| Article | Year |
|---|---|
Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system.
Topics: Animals; Disease Models, Animal; Endothelin Receptor Antagonists; Lung; Perfusion; Pyridines; Respiratory Function Tests; Sheep, Domestic; Tetrazoles; Tissue Donors; Vasodilator Agents | 2020 |
Role of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failure.
Topics: Animals; Arterial Pressure; Baroreflex; Biomarkers; Cardiac Pacing, Artificial; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Female; Heart; Heart Failure; Heart Rate; Hemodynamics; Infusions, Intravenous; Pyridines; Sheep; Signal Transduction; Stroke Volume; Sympathetic Nervous System; Tetrazoles; Time Factors; Up-Regulation | 2016 |
The effect of tezosentan after cold ischemia and renal artery clamping as a model of reperfusion injury in newborn piglets.
Topics: Animals; Animals, Newborn; Blood Flow Velocity; Cardiovascular System; Disease Models, Animal; Femoral Artery; Heart Rate; Ischemia; Pyridines; Renal Artery; Reperfusion Injury; Swine; Tetrazoles; Vasodilator Agents | 2008 |
The endothelin receptor antagonist tezosentan improves renal microcirculation in a porcine model of endotoxemic shock.
Topics: Aldosterone; Angiotensin II; Animals; Disease Models, Animal; Endothelin Receptor Antagonists; Endotoxemia; Female; Hemodynamics; Interleukins; Kidney; Microcirculation; Osmolar Concentration; Pyridines; Random Allocation; Swine; Tetrazoles; Treatment Outcome; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2008 |
Tezosentan, a novel endothelin receptor antagonist, markedly reduces rat hepatic ischemia and reperfusion injury in three different models.
Topics: Animals; Disease Models, Animal; Endothelin Receptor Antagonists; Hemodynamics; Ischemia; Liver; Liver Transplantation; Male; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tetrazoles; Warm Ischemia | 2008 |
Myocardial protective effect of tezosentan, an endothelin receptor antagonist, for ischemia-reperfusion injury in experimental heart failure models.
Topics: Animals; Cardiomyopathies; Coronary Vessels; Disease Models, Animal; Doxorubicin; Endothelin Receptor Antagonists; Heart Failure; Hypertrophy; Male; Pressure; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Reperfusion Injury; Tetrazoles; Vasodilator Agents; Ventricular Function, Left | 2009 |
Acute effect of a dual ETA-ETB receptor antagonist on pulmonary arterial vasculature in preterm lamb fetuses with surgically induced diaphragmatic hernia.
Topics: Animals; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Female; Fetus; Hemodynamics; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Hypertension, Pulmonary; Pregnancy; Pulmonary Artery; Pyridines; Sheep; Statistics, Nonparametric; Tetrazoles | 2011 |
Prevention of bronchial hyperreactivity in a rat model of precapillary pulmonary hypertension.
Topics: Administration, Oral; Airway Resistance; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelins; Hypertension, Pulmonary; Iloprost; Infusion Pumps, Implantable; Infusions, Parenteral; Lung; Lung Volume Measurements; Male; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Piperazines; Prostaglandins I; Purines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Signal Transduction; Sildenafil Citrate; Sulfones; Tetrazoles; Time Factors; Vasoactive Intestinal Peptide; Vasodilator Agents | 2011 |
Dual endothelin receptor blockade with tezosentan markedly attenuates hypoxia-induced pulmonary vasoconstriction in a porcine model.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Female; Heart Rate; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Pulmonary Artery; Pyridines; Receptor, Endothelin A; Receptor, Endothelin B; Swine; Tetrazoles; Time Factors; Vascular Resistance; Vasoconstriction; Vasodilator Agents | 2012 |
Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in rats.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Endothelin Receptor Antagonists; Lung; Male; Pyridines; Rats; Rats, Wistar; Tetrazoles; Thiourea | 2012 |
sGC stimulation totally reverses hypoxia-induced pulmonary vasoconstriction alone and combined with dual endothelin-receptor blockade in a porcine model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelin Receptor Antagonists; Enzyme Activators; Female; Guanylate Cyclase; Hypertension, Pulmonary; Hypoxia; Lung; Morpholines; Pyridines; Pyrimidines; Receptors, Endothelin; Swine; Tetrazoles; Vascular Resistance; Vasoconstriction; Vasodilator Agents | 2012 |
ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury.
Topics: Animals; Blood Flow Velocity; Capillaries; Cholagogues and Choleretics; Disease Models, Animal; Endothelin Receptor Antagonists; Male; Pancreas; Pancreatitis, Acute Necrotizing; Pyridines; Rats; Rats, Inbred Lew; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Taurocholic Acid; Tetrazoles; Vasodilator Agents | 2003 |
Endogenous endothelin increases gallbladder tone and leads to acute cholecystitis in the Australian possum.
Topics: Animals; Cholecystitis, Acute; Disease Models, Animal; Endothelins; Escherichia coli; Female; Gallbladder; Immunohistochemistry; Leukocyte Count; Lipopolysaccharides; Male; Muscle Contraction; Muscle, Smooth; Opossums; Pyridines; Tetrazoles; Vasodilator Agents | 2004 |
Differentiated and dose-related cardiovascular effects of a dual endothelin receptor antagonist in endotoxin shock.
Topics: Animals; Cardiac Catheterization; Cardiovascular System; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Monitoring; Echocardiography; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Infusions, Intravenous; Pyridines; Resuscitation; Shock, Septic; Stroke Volume; Swine; Tetrazoles; Troponin I; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left | 2004 |
Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture.
Topics: Animals; Capillary Permeability; Cecum; Disease Models, Animal; Endothelin A Receptor Antagonists; In Vitro Techniques; Ligation; Lung; Protein Kinase C-alpha; Pulmonary Edema; Punctures; Pyridines; Rats; Rats, Wistar; Receptor, Endothelin A; Reference Values; Tetrazoles; Vasodilator Agents | 2005 |
Tezosentan decreases pulmonary artery pressure and improves survival rate in an animal model of meconium aspiration.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Infant, Newborn; Meconium Aspiration Syndrome; Pulmonary Artery; Pulmonary Gas Exchange; Pyridines; Survival Analysis; Sus scrofa; Tetrazoles; Vascular Resistance | 2006 |
Effects of endothelin receptor antagonism on acute lung injury induced by chlorine gas.
Topics: Animals; Chlorine; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Female; Lung Compliance; Pyridines; Respiratory Distress Syndrome; Swine; Tetrazoles; Treatment Outcome; Vascular Resistance; Vasodilator Agents | 2006 |
Endothelin receptor blockade does not improve hypoxemia following acute pulmonary thromboembolism.
Topics: Acute Disease; Animals; Disease Models, Animal; Endothelin Receptor Antagonists; Hypoxia; Imaging, Three-Dimensional; Lung; Microspheres; Pulmonary Embolism; Pulmonary Gas Exchange; Pulmonary Ventilation; Pyridines; Receptors, Endothelin; Regional Blood Flow; Swine; Tetrazoles; Vasodilator Agents; Ventilation-Perfusion Ratio | 2007 |
Cardiac effects of endothelin receptor antagonism in endotoxemic pigs.
Topics: Animals; Blood Pressure; Cardiovascular Agents; Coronary Circulation; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endotoxemia; Endotoxins; Female; Heart Rate; Myocardial Contraction; Oxygen Consumption; Pyridines; Receptor, Endothelin A; Receptor, Endothelin B; Sus scrofa; Tetrazoles; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2007 |
Integrative control of coronary resistance vessel tone by endothelin and angiotensin II is altered in swine with a recent myocardial infarction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Hemodynamics; Irbesartan; Myocardial Infarction; Oxygen; Physical Exertion; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Endothelin A; Receptor, Endothelin B; Swine; Tetrazoles; Time Factors; Vascular Resistance; Vasoconstriction; Vasodilation; Ventricular Function, Left; Ventricular Remodeling | 2008 |
RO 610612.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Investigational; Endothelin Receptor Antagonists; Pyridines; Rats; Tetrazoles | 1999 |
Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction.
Topics: Animals; Disease Models, Animal; Endothelin Receptor Antagonists; Hemodynamics; Lung; Male; Myocardial Infarction; Organ Size; Pulmonary Edema; Pyridines; Rats; Rats, Wistar; Tetrazoles; Vasodilator Agents | 2002 |
Effects of tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxic shock.
Topics: Animals; Animals, Newborn; Cardiovascular System; Disease Models, Animal; Endothelin Receptor Antagonists; Endotoxemia; Escherichia coli; Hemodynamics; Kidney; Pyridines; Shock, Septic; Swine; Tetrazoles; Vasodilator Agents | 2002 |