texas-red and Diabetic-Retinopathy

texas-red has been researched along with Diabetic-Retinopathy* in 2 studies

Other Studies

2 other study(ies) available for texas-red and Diabetic-Retinopathy

Article	Year
Fatty acid binding protein gene 2 polymorphism is not associated with diabetic retinopathy in Japanese type 2 diabetic patients. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2003, Volume: 35, Issue:10 Topics: Aged; Body Mass Index; Carrier Proteins; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Glycated Hemoglobin; Humans; Japan; Male; Middle Aged; Neoplasm Proteins; Polymerase Chain Reaction; Polymorphism, Genetic; Spectrometry, Fluorescence; Tumor Suppressor Proteins; Xanthenes	2003
Retinal vascular permeability determined by dual-tracer fluorescence angiography. Annals of biomedical engineering, 2001, Volume: 29, Issue:8 Diabetic retinopathy is the leading cause of blindness in working age individuals in the United States. Breakdown of the blood-retinal barrier is one of the earliest events in the progression of diabetic retinopathy. Ideally, therapeutic measures would be directed at this early stage, but there are few sensitive, quantitative methods to assess the retinal vascular barrier in vivo. We present here a method that combines fluorescence microangiography and the simultaneous use of two fluorescent tracers to quantitatively assess the retinal vascular barrier. PS/F (permeability x surface area/flow) describing the retinal vasculature of Long Evans rats was found to be 0.086+/-0.031 (n=13, avg.+/-s.d.). Based on estimates of flow and surface area, we estimate the permeability of sodium fluorescein to be approximately 1.2 x 10(-5) cm/s. Infusion of a hyperosmolar solution of 1.6 M mannitol for 5 min significantly increased PS/F in individual veins and significantly increased a flow weighted PS/F from 0.073+/-0.028 to 0.16+/-0.034 (n=3). In conclusion, we have adapted indicator dilution techniques to quantitatively assess the retinal vasculature in vivo. We have found dual-tracer fluorescence angiography to be a sensitive indicator of increases in the blood-retinal barrier produced by hyperosmolar mannitol. This methodology is a promising new minimally invasive strategy which may be adapted to quantitatively track retinal vascular permeability. Topics: Animals; Biomedical Engineering; Blood-Retinal Barrier; Capillary Permeability; Diabetic Retinopathy; Fluorescein; Fluorescein Angiography; Fluorescent Dyes; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Male; Mannitol; Rats; Retinal Vessels; Xanthenes	2001

Article

Year

Fatty acid binding protein gene 2 polymorphism is not associated with diabetic retinopathy in Japanese type 2 diabetic patients.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2003, Volume: 35, Issue:10

Topics: Aged; Body Mass Index; Carrier Proteins; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Glycated Hemoglobin; Humans; Japan; Male; Middle Aged; Neoplasm Proteins; Polymerase Chain Reaction; Polymorphism, Genetic; Spectrometry, Fluorescence; Tumor Suppressor Proteins; Xanthenes

2003

Retinal vascular permeability determined by dual-tracer fluorescence angiography.

Annals of biomedical engineering, 2001, Volume: 29, Issue:8

Diabetic retinopathy is the leading cause of blindness in working age individuals in the United States. Breakdown of the blood-retinal barrier is one of the earliest events in the progression of diabetic retinopathy. Ideally, therapeutic measures would be directed at this early stage, but there are few sensitive, quantitative methods to assess the retinal vascular barrier in vivo. We present here a method that combines fluorescence microangiography and the simultaneous use of two fluorescent tracers to quantitatively assess the retinal vascular barrier. PS/F (permeability x surface area/flow) describing the retinal vasculature of Long Evans rats was found to be 0.086+/-0.031 (n=13, avg.+/-s.d.). Based on estimates of flow and surface area, we estimate the permeability of sodium fluorescein to be approximately 1.2 x 10(-5) cm/s. Infusion of a hyperosmolar solution of 1.6 M mannitol for 5 min significantly increased PS/F in individual veins and significantly increased a flow weighted PS/F from 0.073+/-0.028 to 0.16+/-0.034 (n=3). In conclusion, we have adapted indicator dilution techniques to quantitatively assess the retinal vasculature in vivo. We have found dual-tracer fluorescence angiography to be a sensitive indicator of increases in the blood-retinal barrier produced by hyperosmolar mannitol. This methodology is a promising new minimally invasive strategy which may be adapted to quantitatively track retinal vascular permeability.

Topics: Animals; Biomedical Engineering; Blood-Retinal Barrier; Capillary Permeability; Diabetic Retinopathy; Fluorescein; Fluorescein Angiography; Fluorescent Dyes; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Male; Mannitol; Rats; Retinal Vessels; Xanthenes

2001