tetrodotoxin and Sensation-Disorders

tetrodotoxin has been researched along with Sensation-Disorders* in 2 studies

Other Studies

2 other study(ies) available for tetrodotoxin and Sensation-Disorders

Article	Year
Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels. Anesthesia and analgesia, 1995, Volume: 81, Issue:2 To investigate whether local anesthetic neurotoxicity results from sodium channel blockade, we compared the effects of intrathecally administered lidocaine, bupivacaine, and tetrodotoxin (TTX), the latter a highly selective sodium channel blocker, on sensory function and spinal cord morphology in a rat model. First, to determine relative anesthetic potency, 25 rats implanted with intrathecal catheters were subjected to infusions of lidocaine (n = 8), bupivacaine (n = 8), or TTX (n = 9). The three drugs produced parallel dose-effect curves that differed significantly from one another: the EC50 values for lidocaine, bupivacaine, and TTX were 28.2 mM (0.66%), 6.6 mM (0.19%), and 462 nM, respectively. Twenty-five additional rats were then given intrathecal lidocaine (n = 8), bupivacaine (n = 8), or TTX (n = 9) at concentrations 10 times the calculated EC50 for sensory block. Lidocaine and bupivacaine induced persistent sensory impairment, whereas TTX did not. Finally, 28 rats were given either intrathecal bupivacaine (n = 10) or TTX (n = 9) at 10 times the EC50, or normal saline (n = 9). Significant sensory impairment again occurred after infusion of bupivacaine, but not after infusion of TTX or saline. Neuropathologic evaluation revealed moderate to severe nerve root injury in bupivacaine-treated animals; histologic changes in TTX- and saline-treated animals were minimal, similar, and restricted to the area adjacent to the catheter. These results indicate that local anesthetic neurotoxicity does not result from blockade of the sodium channel, and suggest that development of a safer anesthetic is a realistic goal. Topics: Animals; Bupivacaine; Demyelinating Diseases; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channel Gating; Lidocaine; Male; Nerve Block; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Reaction Time; Sensation Disorders; Sodium Channel Blockers; Sodium Channels; Spinal Cord; Spinal Nerve Roots; Tetrodotoxin	1995
Puffer fish poisoning. Anaesthesia and intensive care, 1994, Volume: 22, Issue:3 Topics: Adult; Animals; Fishes, Poisonous; Foodborne Diseases; Headache; Humans; Male; Paralysis; Respiratory Insufficiency; Sensation Disorders; Tetrodotoxin	1994

Article

Year

Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels.

Anesthesia and analgesia, 1995, Volume: 81, Issue:2

To investigate whether local anesthetic neurotoxicity results from sodium channel blockade, we compared the effects of intrathecally administered lidocaine, bupivacaine, and tetrodotoxin (TTX), the latter a highly selective sodium channel blocker, on sensory function and spinal cord morphology in a rat model. First, to determine relative anesthetic potency, 25 rats implanted with intrathecal catheters were subjected to infusions of lidocaine (n = 8), bupivacaine (n = 8), or TTX (n = 9). The three drugs produced parallel dose-effect curves that differed significantly from one another: the EC50 values for lidocaine, bupivacaine, and TTX were 28.2 mM (0.66%), 6.6 mM (0.19%), and 462 nM, respectively. Twenty-five additional rats were then given intrathecal lidocaine (n = 8), bupivacaine (n = 8), or TTX (n = 9) at concentrations 10 times the calculated EC50 for sensory block. Lidocaine and bupivacaine induced persistent sensory impairment, whereas TTX did not. Finally, 28 rats were given either intrathecal bupivacaine (n = 10) or TTX (n = 9) at 10 times the EC50, or normal saline (n = 9). Significant sensory impairment again occurred after infusion of bupivacaine, but not after infusion of TTX or saline. Neuropathologic evaluation revealed moderate to severe nerve root injury in bupivacaine-treated animals; histologic changes in TTX- and saline-treated animals were minimal, similar, and restricted to the area adjacent to the catheter. These results indicate that local anesthetic neurotoxicity does not result from blockade of the sodium channel, and suggest that development of a safer anesthetic is a realistic goal.

Topics: Animals; Bupivacaine; Demyelinating Diseases; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channel Gating; Lidocaine; Male; Nerve Block; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Reaction Time; Sensation Disorders; Sodium Channel Blockers; Sodium Channels; Spinal Cord; Spinal Nerve Roots; Tetrodotoxin

1995

Puffer fish poisoning.

Anaesthesia and intensive care, 1994, Volume: 22, Issue:3

Topics: Adult; Animals; Fishes, Poisonous; Foodborne Diseases; Headache; Humans; Male; Paralysis; Respiratory Insufficiency; Sensation Disorders; Tetrodotoxin

1994