tetrodotoxin and Labyrinth-Diseases

tetrodotoxin has been researched along with Labyrinth-Diseases* in 1 studies

Other Studies

1 other study(ies) available for tetrodotoxin and Labyrinth-Diseases

Article	Year
Transtympanic tetrodotoxin alters the VOR and Fos labeling in the vestibular complex. Neuroreport, 2001, Oct-08, Volume: 12, Issue:14 The sodium channel blocker tetrodotoxin (TTX) is an effective tool for blockade of action potentials. Unilateral transtympanic administration of 3 mM TTX produced behavioral symptoms similar to those following unilateral peripheral vestibular ablation. Complete resolution of visible symptoms occurred between 48 and 72 h post-TTX. Eye-coil recordings indicated a spontaneous nystagmus and a decrease in the VOR in TTX-treated animals. Neuronal activity in the central vestibular complex (VC), as monitored with Fos immunocytochemistry, revealed an asymmetric pattern of Fos labeling in the medial, inferior and superior vestibular nuclei and the prepositus hypoglossal nucleus. Although the spatio-temporal pattern of Fos labeling was consistent and reproducible at each time-point, changes were noted among time-points. Transient blockade with TTX may be useful for studying the central vestibular response to recurrent or episodic vestibular disruption in the intact system. Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Administration Routes; Ear, Inner; Functional Laterality; Immunohistochemistry; Labyrinth Diseases; Male; Neurons; Nystagmus, Pathologic; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reflex, Vestibulo-Ocular; Tetrodotoxin; Time Factors; Tympanic Membrane; Vestibular Nuclei	2001

Article

Year

Transtympanic tetrodotoxin alters the VOR and Fos labeling in the vestibular complex.

Neuroreport, 2001, Oct-08, Volume: 12, Issue:14

The sodium channel blocker tetrodotoxin (TTX) is an effective tool for blockade of action potentials. Unilateral transtympanic administration of 3 mM TTX produced behavioral symptoms similar to those following unilateral peripheral vestibular ablation. Complete resolution of visible symptoms occurred between 48 and 72 h post-TTX. Eye-coil recordings indicated a spontaneous nystagmus and a decrease in the VOR in TTX-treated animals. Neuronal activity in the central vestibular complex (VC), as monitored with Fos immunocytochemistry, revealed an asymmetric pattern of Fos labeling in the medial, inferior and superior vestibular nuclei and the prepositus hypoglossal nucleus. Although the spatio-temporal pattern of Fos labeling was consistent and reproducible at each time-point, changes were noted among time-points. Transient blockade with TTX may be useful for studying the central vestibular response to recurrent or episodic vestibular disruption in the intact system.

Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Administration Routes; Ear, Inner; Functional Laterality; Immunohistochemistry; Labyrinth Diseases; Male; Neurons; Nystagmus, Pathologic; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reflex, Vestibulo-Ocular; Tetrodotoxin; Time Factors; Tympanic Membrane; Vestibular Nuclei

2001