tetrodotoxin and Hypesthesia

tetrodotoxin has been researched along with Hypesthesia* in 3 studies

Other Studies

3 other study(ies) available for tetrodotoxin and Hypesthesia

ArticleYear
Case Report of Tetrodotoxin Poisoning from
    International journal of environmental research and public health, 2022, 11-08, Volume: 19, Issue:22

    The Indo-Pacific pufferfish

    Topics: Animals; Hypesthesia; Lebanon; Male; Mediterranean Sea; Tetraodontiformes; Tetrodotoxin

2022
Antinociceptive action of carbamazepine on thermal hypersensitive pain at spinal level in a rat model of adjuvant-induced chronic inflammation.
    Journal of anesthesia, 2011, Volume: 25, Issue:1

    Systemic carbamazepine, a voltage-gated sodium channel blocker, has been reported to dose-dependently reduce inflammatory hyperalgesia. However, the antinociceptive effects of carbamazepine on the spinal cord in inflammatory conditions are unclear. The aim of the present study was to evaluate the antinociceptive effects of carbamazepine on the spinal cord in a chronic inflammatory condition.. In Sprague-Dawley rats, a chronic inflammatory condition was induced by complete Freund's adjuvant (CFA) inoculation into the tail. Tail flick (TF) latencies were measured following intraperitoneal carbamazepine, or intrathecal carbamazepine or tetrodotoxin injection in intact rats and in the chronic inflammatory rats. From the values of TF latency at 60 min after drug injection, the effective dose required to produce 50% response (ED(50)) of each drug was derived.. Carbamazepine attenuated thermal responses with both systemic and intrathecal administration. The effect was more evident in rats with chronic inflammation than in intact rats; the ED(50s) of intraperitoneal carbamazepine in intact and inflamed rats were 12.39 and 1.54 mg/kg, and those of intrathecal carbamazepine were 0.311 and 0.048 nmol, respectively. Intrathecal tetrodotoxin also clearly inhibited the response, with ED(50s) of 1.006 pmol in intact rats and 0.310 pmol in inflamed rats. The relative potencies of intrathecal carbamazepine versus tetrodotoxin for inhibition were approximately 1:150-1:300 in intact and inflamed rats.. These results indicate that the inhibition of voltage-gated sodium channels, at least tetrodotoxin-sensitive channels, may contribute to the antinociceptive effect of carbamazepine on CFA-induced inflammatory pain, since lower doses of intrathecal carbamazepine and tetrodotoxin attenuated thermal responses to a greater extent in inflamed rats than in intact rats.

    Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Arthritis, Experimental; Carbamazepine; Chronic Disease; Dose-Response Relationship, Drug; Freund's Adjuvant; Hypesthesia; Inflammation; Injections, Intraperitoneal; Injections, Spinal; Rats; Rats, Sprague-Dawley; Reaction Time; Sodium Channel Blockers; Spine; Tail; Tetrodotoxin

2011
Intoxication following minor stabs from the spines of a porcupine fish.
    Clinical toxicology (Philadelphia, Pa.), 2006, Volume: 44, Issue:4

    We report an unusual intoxication by tetrodotoxin (TTX). A curator of an aquarium sustained minor punctures in his finger from the spines of a porcupine fish during an autopsy of a dead porcupine fish. He developed paresthesias, numbness, paresis, dizziness and headache. The death of the fish might have caused some autolysis, leading to increased availability of TTX. In combination with direct contact with the organ fluids, this probably led to TTX exposure via minor wounds.

    Topics: Animals; Fish Venoms; Fishes, Poisonous; Headache; Humans; Hypesthesia; Male; Netherlands; Tetraodontiformes; Tetrodotoxin

2006