tetrodotoxin and Cognition-Disorders

tetrodotoxin has been researched along with Cognition-Disorders* in 2 studies

Reviews

1 review(s) available for tetrodotoxin and Cognition-Disorders

ArticleYear
Organic neurotoxins in seafoods.
    Clinical neurology and neurosurgery, 1995, Volume: 97, Issue:2

    Toxins formed by organic micro-organisms may accumulate within certain tissues of predacious sea animals, which may serve as a source of seafood poisoning for the higher food chain. Such toxins are distinct from inorganic chemicals or infectious agents which may have contaminated the seafoods. Distinct clinical syndromes have emerged, and the individual toxins have been identified. Clinical manifestations of each begin with a gastrointestinal prodrome and headache, followed by sensorimotor deficits. Bulbar and cognitive changes are associated with the more lethal tetrodotoxin, saxitoxin, and domoic acid toxin. Tetrodotoxin and saxitoxin block sodium channels, while ciguatoxin opens them. Domoic acid stimulates excitatory amino acids at the NMDA receptors.

    Topics: Brain Diseases; Bulbar Palsy, Progressive; Ciguatoxins; Cognition Disorders; Foodborne Diseases; Gastrointestinal Diseases; Headache; Humans; Mannitol; Psychomotor Disorders; Receptors, N-Methyl-D-Aspartate; Saxitoxin; Seafood; Sodium Channels; Tetrodotoxin

1995

Other Studies

1 other study(ies) available for tetrodotoxin and Cognition-Disorders

ArticleYear
Cognitive disorganization in hippocampus: a physiological model of the disorganization in psychosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jan-04, Volume: 26, Issue:1

    Cognitive coordination refers to processes that organize the timing of activity among neurons without altering individual discharge properties. Coordinating processes allow neural networks to coactivate related representations and prevent the coactivation of unrelated representations. Impaired cognitive coordination, also called cognitive disorganization, is hypothesized to be the core deficit in the disorganized syndrome of schizophrenia (Phillips and Silverstein, 2003), a condition characterized by hallucinations, disorganization, and thought disorder. This disorganization hypothesis is based on the observation that schizophrenic subjects are impaired at segregating relevant and irrelevant stimuli and selectively using associations between relevant cues. We report that injecting the neural activity blocker tetrodotoxin (TTX) into one hippocampus persistently coactivated pyramidal cells in the uninjected hippocampus that initially discharged independently. In accord with the definition of cognitive disorganization, pyramidal cell firing rates only changed for 15 min and did not accompany the coactivation. The TTX-induced coactivity was maximal at gamma periods, consistent with altered gamma oscillations and disorganization in schizophrenia. A network model confirmed that increasing the coupling of weakly associated cells impairs the selective activation and inhibition of stored spatial representations. This TTX-induced cognitive disorganization correctly predicted that the same TTX injection selectively impaired the ability of rats to segregate relevant associations among distal spatial stimuli from irrelevant local stimuli (Wesierska et al., 2005). The TTX-induced coactivity of hippocampal pyramidal cell discharge has construct and predictive validity as a physiological model of psychosis-related disorganization.

    Topics: Action Potentials; Animals; Cognition Disorders; Disease Models, Animal; Hippocampus; Psychotic Disorders; Rats; Tetrodotoxin

2006