tetrodotoxin has been researched along with Cholera* in 2 studies
2 other study(ies) available for tetrodotoxin and Cholera
| Article | Year |
|---|---|
The involvement of intramural nerves in cholera toxin induced intestinal secretion.
In previous reports we have suggested that nervous reflexes are involved in the pathophysiology of cholera secretion and that these nervous reflexes involve a cholinergic synapse and a neuron with vasoactive intestinal polypeptide (VIP) as neurotransmitter. These proposals were further analyzed in this study. Tetrodotoxin (TTX) and lidocaine applied on the serosal surface inhibited cholera secretion in segments of rat small intestine. Fluid absorption in control rats was not significantly changed. Hexamethonium given i.v. decreased cholera secretion in the cat. No additional inhibition of cholera secretion was observed after giving TTX close i.a. Furthermore, the intestinal secretion evoked by VIP was not influenced by hexamethonium given i.v. or TTX given close i.a. The present observations support the hypothesis of a role for nervous reflexes in cholera secretion. The results suggest that at least a major part of the proposed nervous reflex(es) in cholera have a cholinergic synapse. Furthermore, the VIP-ergic neuron is situated "distal" to the cholinergic neuron in the reflex(es) closer to the effector cells. Topics: Animals; Cats; Cholera; Cholera Toxin; Female; Hexamethonium Compounds; Intestinal Secretions; Intestine, Small; Lidocaine; Male; Neurons; Rats; Rats, Inbred Strains; Reflex; Tetrodotoxin; Vasoactive Intestinal Peptide | 1983 |
On the role of intramural nerves in the pathogenesis of cholera toxin-induced intestinal secretion.
Intestinal secretion was produced in anesthetized cats and rats by exposing isolated intestinal segments to cholera enterotoxin. Giving, for example, tetrodotoxin, a nerve-conduction-blocking agent, or adding lidocaine, a local anesthetic agent, to the solution in the intestinal segments markedly inhibited the rate of choleraic secretion, and in most experiments a net absorption of fluid was observed. The results suggest that intramural nervous mechanisms are involved in the pathogenesis of choleraic secretion. Topics: Anesthetics, Local; Animals; Cats; Celiac Plexus; Cholera; Cholera Toxin; Disease Models, Animal; Female; Intestinal Secretions; Jejunum; Lidocaine; Male; Poisons; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1981 |