tetrodotoxin has been researched along with Blindness* in 1 studies
1 other study(ies) available for tetrodotoxin and Blindness
| Article | Year |
|---|---|
Difference in sensory dependence of occ1/Follistatin-related protein expression between macaques and mice.
occ1/Follistatin-related protein (Frp) is strongly expressed in the primary visual cortex (V1) of macaque monkeys, and its expression is strongly down-regulated by intraocular tetrodotoxin (TTX) injection. The pronounced area selectivity of occ1/Frp mRNA expression occurs in macaques and marmosets, but not in mice, rabbits and ferrets, suggesting that occ1/Frp is an important clue to the evolution of the primate cerebral cortex. To further determine species differences, we examined the sensory-input dependency of occ1/Frp mRNA expression in mice in comparison with macaque V1. In macaque V1, occ1/Frp mRNA expression level significantly decreased with even 1-day monocular deprivation (MD) by TTX injection. In contrast to that in macaques, however, the occ1/Frp mRNA expression in the visual cortex in mice was not down-regulated by 1- to 7-day MD by TTX injection. Similarly, MD had no effect on occ1/Frp mRNA expression level in the dorsal lateral geniculate nucleus of mice. In addition, the extirpation of the cochlear or olfactory epithelium had no effect on occ1/Frp mRNA expression in either the cochlear nucleus or the olfactory bulb in mice. Thus, occ1/Frp mRNA expression is independent of sensory-input in mice. The results suggest that activity-dependent occ1/Frp mRNA expression is not common between mice and monkeys, and that primate V1 has acquired a unique gene regulatory mechanism that enables a rapid response to environmental changes. The characteristic feature of the activity dependency of occ1/Frp mRNA expression is discussed, in comparison with that of the expression of the immediate-early genes, c-fos and zif268. Topics: Animals; Auditory Pathways; Blindness; Denervation; Female; Follistatin-Related Proteins; Gene Expression Regulation; Geniculate Bodies; Macaca; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Neuronal Plasticity; Neurons, Afferent; Neurotoxins; Olfactory Pathways; Retinal Ganglion Cells; RNA, Messenger; Sensory Deprivation; Species Specificity; Tetrodotoxin; Visual Cortex; Visual Pathways | 2008 |