tetrocarcin-a and Neoplasms

tetrocarcin-a has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for tetrocarcin-a and Neoplasms

Article	Year
Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions. Bioorganic & medicinal chemistry letters, 2001, Apr-09, Volume: 11, Issue:7 Tetrocarcin A was recently identified as an inhibitor of the anti-apoptotic function of Bcl-2. We synthesized novel tetrocarcin derivatives in order to increase their selective inhibitory activity against Bcl-2. It was found that 21-acetoxy-9-glycosyloxy derivatives had potent Bcl-2 inhibitory activity without significant antimicrobial activity. Topics: Aminoglycosides; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Apoptosis; Caspases; Female; HeLa Cells; Humans; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Structure-Activity Relationship	2001

Article

Year

Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions.

Bioorganic & medicinal chemistry letters, 2001, Apr-09, Volume: 11, Issue:7

Tetrocarcin A was recently identified as an inhibitor of the anti-apoptotic function of Bcl-2. We synthesized novel tetrocarcin derivatives in order to increase their selective inhibitory activity against Bcl-2. It was found that 21-acetoxy-9-glycosyloxy derivatives had potent Bcl-2 inhibitory activity without significant antimicrobial activity.

Topics: Aminoglycosides; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Apoptosis; Caspases; Female; HeLa Cells; Humans; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Structure-Activity Relationship

2001