tetramic-acid and Staphylococcal-Skin-Infections

The potential for reutericyclin derivatives to be used as topical antibiotics to treat staphylococcal skin infections was investigated. All reutericyclins inhibited the growth of clinical isolates of drug-resistant Staphylococcus aureus. Unlike the standard topical agent mupirocin, most reutericyclin derivatives eradicated staphylococcal biofilms. Moreover, two compounds formulated in hydrophilic petrolatum (10%, wt/wt) were efficacious in treating S. aureus superficial skin infections in mice. These data exemplify the prospect of developing reutericyclins as new topical antibiotics.

Topics: Animals; Anti-Bacterial Agents; Biofilms; Cell Line; Fibroblasts; Humans; Male; Mice; Pyrrolidinones; Staphylococcal Skin Infections; Tenuazonic Acid