tetramic-acid and Hepatitis-C

tetramic-acid has been researched along with Hepatitis-C* in 1 studies

Other Studies

1 other study(ies) available for tetramic-acid and Hepatitis-C

Article	Year
An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. Bioorganic & medicinal chemistry letters, 2006, Apr-15, Volume: 16, Issue:8 An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids is reported. Starting from commercially available chiral Fmoc-protected alpha-amino acids loaded onto Wang resin, Fmoc removal, reductive amination followed by amide bond formation, and base-catalyzed cyclization with simultaneous cleavage from the resin provided the desired products. Compounds described are potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. Topics: Animals; Antiviral Agents; Benzothiadiazines; Catalysis; Cyclization; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Inhibitory Concentration 50; Pyrrolidinones; RNA-Dependent RNA Polymerase	2006

Article

Year

An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Bioorganic & medicinal chemistry letters, 2006, Apr-15, Volume: 16, Issue:8

An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids is reported. Starting from commercially available chiral Fmoc-protected alpha-amino acids loaded onto Wang resin, Fmoc removal, reductive amination followed by amide bond formation, and base-catalyzed cyclization with simultaneous cleavage from the resin provided the desired products. Compounds described are potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Topics: Animals; Antiviral Agents; Benzothiadiazines; Catalysis; Cyclization; Drug Resistance, Viral; Hepacivirus; Hepatitis C; Humans; Inhibitory Concentration 50; Pyrrolidinones; RNA-Dependent RNA Polymerase

2006