tetramethylpyrazine has been researched along with Liver Cirrhosis in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (84.62) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, Z; He, S; Hu, Z; Jiang, K; Lin, C; Su, H; Yuan, G; Zeng, Y; Zhong, F | 1 |
| Cao, HJ; Hu, HJ; Li, SG; Liu, J; Lv, B; Zhong, JH; Zhou, J; Zhu, L | 1 |
| Lian, N; Lu, C; Lu, Y; Wu, X; Xiong, X; Zhang, F; Zheng, S | 1 |
| Cai, B; Cai, H; Cao, G; Hu, J; Wu, X | 1 |
| Lu, C; Shao, J; Xu, W; Zhang, F; Zheng, S | 1 |
| Bian, M; Chen, A; Chen, X; Hao, M; Jia, Y; Jin, H; Lian, N; Lu, C; Shao, J; Wu, L; Yao, S; Zhang, C; Zhang, F; Zheng, S | 1 |
| Lin, Q; Qian, L; Shao, J; Zhang, C; Zhang, F; Zhang, Z; Zhao, S; Zheng, S | 1 |
| Chen, A; Hao, M; Jin, H; Lian, N; Shao, J; Wu, L; Yao, Z; Zhang, F; Zheng, S | 1 |
| Chen, A; Shao, J; Yao, Z; Zhang, F; Zhang, Z; Zhao, S; Zheng, S | 1 |
| Li, S; Lu, B; Si, S; Yu, L; Zeng, Y | 1 |
| Chen, L; Kong, D; Lu, Y; Ni, C; Zhang, F; Zhang, X; Zheng, S; Zhu, X | 1 |
| Chen, L; Kong, DS; Lei, N; Lu, Y; Zhang, F; Zhang, XP; Zhang, ZL; Zheng, SZ; Zhu, XJ | 1 |
| Fu, QL | 1 |
13 other study(ies) available for tetramethylpyrazine and Liver Cirrhosis
| Article | Year |
|---|---|
Tetramethylpyrazine ameliorates hepatic fibrosis through autophagy-mediated inflammation.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Line, Tumor; Chromones; Chronic Disease; Fibrinolytic Agents; Hepatic Stellate Cells; Inflammation; Liver Cirrhosis; Male; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Effects of miR-9 and tetramethylpyrazine on activation of hepatic stellate cells.
Topics: Actins; Collagen Type I; Gene Expression Regulation; Hepatic Stellate Cells; Humans; Janus Kinase 1; Leptin; Ligusticum; Liver Cirrhosis; MicroRNAs; Phosphorylation; Phytotherapy; Plant Extracts; Pyrazines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Transfection; Up-Regulation | 2015 |
Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP3 inflammasome pathway.
Topics: Animals; Carrier Proteins; Caspase 1; Cytokines; Hepatocytes; Inflammasomes; Inflammation; Inflammation Mediators; Liver Cirrhosis; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Platelet-Derived Growth Factor; Pyrazines; Rats; Rats, Sprague-Dawley | 2015 |
Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro.
Topics: Apoptosis; Cell Line; Cell Proliferation; Connective Tissue Growth Factor; Cyclin-Dependent Kinases; Gene Expression Regulation; Genetic Diseases, Inborn; Hedgehog Proteins; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Pyrazines; Signal Transduction | 2015 |
Nrf2 knockdown attenuates the ameliorative effects of ligustrazine on hepatic fibrosis by targeting hepatic stellate cell transdifferentiation.
Topics: Animals; beta Catenin; Carbon Tetrachloride; Cell Line; Cell Transdifferentiation; Gene Knockdown Techniques; Genetic Therapy; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Mice, Inbred ICR; NF-E2-Related Factor 2; Pyrazines | 2016 |
Inhibition of YAP signaling contributes to senescence of hepatic stellate cells induced by tetramethylpyrazine.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Proliferation; Cellular Senescence; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Phosphoproteins; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction; YAP-Signaling Proteins | 2017 |
Tetramethylpyrazine attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic angiogenesis in rats.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; bcl-2-Associated X Protein; Becaplermin; Carbon Tetrachloride; Down-Regulation; Endothelial Cells; Hepatocytes; Liver; Liver Cirrhosis; Male; Neovascularization, Pathologic; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-sis; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Topics: Animals; Benzoquinones; Carbon Tetrachloride; Disease Models, Animal; Hedgehog Proteins; Hepatic Stellate Cells; HSP90 Heat-Shock Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Lactams, Macrocyclic; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Mustard Compounds; Neovascularization, Pathologic; Phenylpropionates; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction; Smoothened Receptor | 2017 |
Tetramethylpyrazine attenuates sinusoidal angiogenesis via inhibition of hedgehog signaling in liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Gene Expression Regulation; Hedgehog Proteins; Humans; Liver Cirrhosis; Mice; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase; Primary Cell Culture; Pyrazines; Smoothened Receptor | 2017 |
Alleviation of CCl4-induced cirrhosis in rats by tetramethylpyrazine is associated with downregulation of leptin and TGF-beta1 pathway.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Down-Regulation; Fibrinolytic Agents; Histocytochemistry; Leptin; Liver Cirrhosis; Male; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Leptin; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1 | 2010 |
Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-β receptor-mediated ERK and p38 pathways.
Topics: Antioxidants; Apoptosis; Blotting, Western; Cell Proliferation; Flow Cytometry; Genetic Markers; Hepatic Stellate Cells; Hydrogen Peroxide; Indicators and Reagents; Liver Cirrhosis; MAP Kinase Signaling System; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polymerase Chain Reaction; Pyrazines; Reactive Oxygen Species; Receptor, Platelet-Derived Growth Factor beta; RNA | 2012 |
Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro.
Topics: Animals; Apoptosis; Caspases; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; G1 Phase Cell Cycle Checkpoints; Hepatic Stellate Cells; Hepatocytes; Liver Cirrhosis; Male; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Pyrazines; Rats; Tumor Suppressor Protein p53 | 2013 |
[Experimental study on yiqi-huoxue therapy of liver fibrosis].
Topics: Alanine Transaminase; Animals; Astragalus propinquus; Carbon Tetrachloride; Collagen; Drugs, Chinese Herbal; Female; Fibrinolytic Agents; Liver; Liver Cirrhosis; Male; Pyrazines; Rats; Rats, Inbred Strains | 1992 |