tetramethylpyrazine has been researched along with Inflammation in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.70) | 29.6817 |
| 2010's | 18 (48.65) | 24.3611 |
| 2020's | 18 (48.65) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J | 1 |
| Gao, P; Hao, X; Liu, X; Xu, H; Zhan, P; Zou, J | 1 |
| Le, G; Lin, X; Zhu, Y | 1 |
| Bian, Y; He, J; Hu, S; Wang, S | 1 |
| Chen, M; Chen, X; Jiang, R; Liu, J; Wang, Y; Xu, J; Yin, M; Zhang, Y | 1 |
| Gao, J; Liu, J; Ma, X; Ren, J; Shi, D; Song, L; Zhang, Y | 1 |
| Cheng, J; Dong, L; Ji, Y; Li, L; Wang, H; Wu, Z; Yao, W; Zhang, D; Zhao, C | 1 |
| Ji, K; Li, J; Luo, CC; Pan, QQ; Tian, Z; Yang, CK; Zhou, HY | 1 |
| Chen, X; Cheng, Q; Cui, L; Huang, C; Huang, H; Liu, X; Lu, Y; Luo, C; Luo, Z; Mu, Q; Sun, R; Syeda, MZ; Tang, L; Wu, S; Yao, K; Zhang, H; Zhang, M; Zhang, Y; Zhu, X | 1 |
| Dong, H; Feng, Y; Zheng, L | 1 |
| Chang, YR; Chen, MC; Chen, RJ; Huang, CY; Kuo, CH; Kuo, WW; Li, CC; Roy, R; Tsai, BC; Wang, TF; Yao, CH | 1 |
| He, Y; Li, Q; Sun, H; Wang, S; Wang, Y; Xing, W; Xu, X | 1 |
| Fan, X; Tang, W; Wang, S; Zhang, H; Zhang, J | 1 |
| Du, J; Jiao, Y; Zhang, J; Zhang, S | 1 |
| Alharbi, KS; Alotaibi, BS; Alotaibi, MR; Alotaibi, NH; Alotaibi, NM; Alruwaili, NK; Alzarea, AI; Bukhari, SNA | 1 |
| Dong, J; Fu, Y; Jing, F; Li, G; Liu, S; Pan, R; Tang, H; Wang, H; Wang, Y; Yan, X | 1 |
| An, W; Duan, Y; Wang, J; Wu, Y | 1 |
| Guo, Z; He, S; Hu, Z; Jiang, K; Lin, C; Su, H; Yuan, G; Zeng, Y; Zhong, F | 1 |
| Cui, L; Gong, L; Hou, G; Hou, Y; Jiang, P; Lu, X; Zhang, H; Zhang, L; Zhao, W | 1 |
| Gong, S; Li, B; Li, Y; Pan, J; Qian, J; Qu, H; Wang, Y; Xiong, D; Ye, T; Zhang, L | 1 |
| Huang, H; Kong, L; Luan, S; Qi, C; Wu, F | 1 |
| Chang, Y; Chen, Y; Li, J; Li, L; Li, Y; Wang, H; Wang, Q; Yang, D; Yu, B; Zhai, J; Zhang, H; Zhang, P; Zhao, X | 1 |
| Chen, L; Liu, J; Liu, T; Wang, Q | 1 |
| Jin, H; Qu, J; Wang, Y; Yu, T | 1 |
| Bai, XY; Cao, Z; Du, PC; Hou, Y; Wang, XF; Zhang, LS | 1 |
| Du, S; He, G; Sun, Z; Wu, Y; Zhang, X; Zhao, Y; Zhou, L; Zhou, P; Zhuo, LH | 1 |
| Li, Y; Zhang, T; Zhou, Y; Zhu, Z | 1 |
| Chen, B; Huang, DD; Huang, HH; Li, DG; Yang, Q; Yuan, CL; Zhang, LM | 1 |
| Lin, L; Liu, N; Wang, JP; Wang, JQ; Zhang, FK | 1 |
| Fu, X; Hao, B; Lei, B; Lin, R; Liu, J; Qiu, Y; Yang, L; Yu, P | 1 |
| Chen, J; Chen, Y; Fan, Y; Gao, C; Li, W; Liu, D; Pan, S; Wang, H | 1 |
| Kim, SY; Min, S; Yeom, GG | 1 |
| Chen, YJ; Gong, JY; Huang, CS; Pan, ZH; Wang, F | 1 |
| Lian, N; Lu, C; Lu, Y; Wu, X; Xiong, X; Zhang, F; Zheng, S | 1 |
| Luo, YC; Wang, Q; Xiang, QW | 1 |
| Chen, XB; Hao, J; Jin, BL; Wang, SQ; Wu, HJ | 1 |
| Hu, JZ; Huang, JH; Li, JH; Li, XM; Lu, HB; Xiao, ZM | 1 |
1 review(s) available for tetramethylpyrazine and Inflammation
| Article | Year |
|---|---|
Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Bacteria; Cardiovascular Diseases; Humans; Inflammation; Molecular Structure; Neoplasms; Neuroprotective Agents; Pyrazines | 2018 |
2 trial(s) available for tetramethylpyrazine and Inflammation
| Article | Year |
|---|---|
Effect of DLT-SML on Chronic Stable Angina Through Ameliorating Inflammation, Correcting Dyslipidemia, and Regulating Gut Microbiota.
Topics: Adult; Aged; Angina, Stable; Anti-Inflammatory Agents; Bacteria; Biomarkers; China; Cytokines; Drug Therapy, Combination; Drugs, Chinese Herbal; Dysbiosis; Dyslipidemias; Female; Gastrointestinal Microbiome; Humans; Hypolipidemic Agents; Inflammation; Inflammation Mediators; Lipids; Male; Methylamines; Middle Aged; Pyrazines; Time Factors; Treatment Outcome | 2021 |
[Effect of ligustrazine hydrochloride on coagulation reaction and inflammation reaction in single valve replacement patients with rheumatic heart disease undergoing cardiopulmonary bypass].
Topics: Blood Coagulation; C-Reactive Protein; Cardiopulmonary Bypass; Humans; Inflammation; Interleukin-10; Interleukin-6; Pyrazines; Rheumatic Heart Disease | 2014 |
34 other study(ies) available for tetramethylpyrazine and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature | 2010 |
Tetramethylpyrazine Alleviates Tight Junction Disruption of Bronchial Mucosal Epithelial Cells Caused by Interleukin-17 via Inhibiting Nuclear Factor-κB-p65/Tumor Necrosis Factor-α Signaling Pathway.
Topics: Acute Lung Injury; Bronchi; Cell Line; Cytokines; Epithelial Cells; Gene Expression Regulation; Humans; Inflammation; Interleukin-17; Mucous Membrane; Pyrazines; Signal Transduction; Tight Junctions; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein | 2021 |
Tetramethylpyrazine alleviates endoplasmic reticulum stress‑activated apoptosis and related inflammation in chondrocytes.
Topics: Animals; Apoptosis; Chondrocytes; Endoplasmic Reticulum Stress; Extracellular Matrix; Gene Expression; Gene Expression Regulation; Heat-Shock Proteins; Inflammation; Interleukin-1beta; Male; Osteoarthritis; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Transcription Factor CHOP | 2022 |
Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte.
Topics: Inflammation; Keratinocytes; Ligusticum; NF-kappa B; Psoriasis; Pyrazines; Signal Transduction; TNF Receptor-Associated Factor 6 | 2022 |
Ligustrazine prevents coronary microcirculation dysfunction in rats via suppression of miR-34a-5p and promotion of Sirt1.
Topics: Animals; Heart Diseases; Inflammation; Microcirculation; MicroRNAs; Pyrazines; Rats; Sirtuin 1 | 2022 |
Ligustrazine exerts neuroprotective effects via circ_0008146/miR-709/Cx3cr1 axis to inhibit cell apoptosis and inflammation after cerebral ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Brain Ischemia; CX3C Chemokine Receptor 1; Infarction, Middle Cerebral Artery; Inflammation; Mice; Mice, Inbred C57BL; MicroRNAs; Neuroprotective Agents; Reperfusion Injury; RNA, Messenger | 2022 |
[Protective mechanism of tetramethylpyrazine on cardiovascular system].
Topics: Animals; Apoptosis; Endothelial Cells; Inflammation; Mice; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Thrombosis | 2023 |
Ligustrazine Nanoparticle Hitchhiking on Neutrophils for Enhanced Therapy of Cerebral Ischemia-Reperfusion Injury.
Topics: Brain Ischemia; Humans; Inflammation; Ischemic Stroke; Nanoparticles; Neutrophils; Reperfusion Injury | 2023 |
Ligustrazine inhibits inflammatory response of human endometrial stromal cells through the STAT3/IGF2BP1/RELA axis.
Topics: Female; Humans; Inflammation; Interleukin-6; RNA; RNA, Messenger; STAT3 Transcription Factor; Stromal Cells; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2023 |
Ligustrazine improves the compensative effect of Akt survival signaling to protect liver Kupffer cells in trauma-hemorrhagic shock rats.
Topics: Animals; Inflammation; Kupffer Cells; Liver; Proto-Oncogene Proteins c-akt; Rats; Shock, Hemorrhagic | 2023 |
RETRACTED: Tetramethylpyrazine alleviates lipopolysaccharide-induced damage in ATDC5 cells via down-regulating MyD88.
Topics: Animals; Apoptosis; Cells, Cultured; Chondrocytes; Inflammation; Lipopolysaccharides; Mice; Myeloid Differentiation Factor 88; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyrazines; Signal Transduction; Vasodilator Agents | 2019 |
Tetramethylpyrazine Inhibits Platelet Adhesion and Inflammatory Response in Vascular Endothelial Cells by Inhibiting P38 MAPK and NF-κB Signaling Pathways.
Topics: Animals; Anti-Inflammatory Agents; Brain; Cell Adhesion Molecules; Cell Hypoxia; Cell Line; Cytokines; Endothelial Cells; Glucose; Inflammation; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Platelet Adhesiveness; Pyrazines; Reperfusion Injury; Signal Transduction | 2020 |
Tetramethylpyrazine attenuates placental oxidative stress, inflammatory responses and endoplasmic reticulum stress in a mouse model of gestational diabetes mellitus.
Topics: Administration, Oral; Animals; Diabetes, Gestational; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Female; Inflammation; Mice; Mice, Inbred C57BL; Oxidative Stress; Placenta; Pregnancy; Pyrazines | 2019 |
Pharmacological appraisal of ligustrazine based cyclohexanone analogs as inhibitors of inflammatory markers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanones; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Inflammation; Lipoxygenase Inhibitors; Pyrazines; Structure-Activity Relationship | 2020 |
Ligustrazine ameliorates lipopolysaccharide‑induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway.
Topics: Animals; Apoptosis; Autophagy; Down-Regulation; Female; Inflammation; Interleukin-1beta; Lipopolysaccharides; Male; Neurocognitive Disorders; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Tetramethylpyrazine reduces inflammation levels and the apoptosis of LPS‑stimulated human periodontal ligament cells via the downregulation of miR‑302b.
Topics: Apoptosis; Cell Differentiation; Cell Survival; Cells, Cultured; Down-Regulation; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; MicroRNAs; NF-kappa B; Osteogenesis; Periodontal Ligament; Periodontitis; Pyrazines; Signal Transduction; Stem Cells; Tumor Necrosis Factor-alpha | 2020 |
Tetramethylpyrazine ameliorates hepatic fibrosis through autophagy-mediated inflammation.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cell Line, Tumor; Chromones; Chronic Disease; Fibrinolytic Agents; Hepatic Stellate Cells; Inflammation; Liver Cirrhosis; Male; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Tetramethylpyrazine Protects Blood-Spinal Cord Barrier Integrity by Modulating Microglia Polarization Through Activation of STAT3/SOCS3 and Inhibition of NF-кB Signaling Pathways in Experimental Autoimmune Encephalomyelitis Mice.
Topics: Animals; Brain; Cell Polarity; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Endothelial Cells; Female; Humans; Inflammation; Interferon-gamma; Mice, Inbred C57BL; Microglia; Microvessels; Neuroprotection; NF-kappa B; Phenotype; Pyrazines; Signal Transduction; Spinal Cord; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein | 2021 |
Combination of Danshen and ligustrazine has dual anti-inflammatory effect on macrophages and endothelial cells.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; Pyrazines; Salvia miltiorrhiza | 2021 |
Ligustrazine Suppresses Platelet-Derived Growth Factor-BB-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Inflammation by Regulating the PI3K/AKT Signaling Pathway.
Topics: Animals; Becaplermin; Cell Cycle; Cell Proliferation; China; Disease Models, Animal; Inflammation; Male; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pyrazines; Rats; Rats, Sprague-Dawley | 2021 |
Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspartate Aminotransferases; Cartilage; Curcumin; Cytokines; Drug Combinations; Edema; Female; Inflammation; Joints; Kidney; Liver; Male; Mice; NF-kappa B; Phytotherapy; Plant Extracts; Pyrazines; Rats, Sprague-Dawley; Resveratrol; Stilbenes | 2017 |
Ligustrazine protects chondrocyte against IL-1β induced injury by regulation of SOX9/NF-κB signaling pathway.
Topics: Aged; Cells, Cultured; Chondrocytes; Female; Humans; Inflammation; Interleukin-1beta; Male; Middle Aged; NF-kappa B; Protective Agents; Pyrazines; Signal Transduction; SOX9 Transcription Factor | 2018 |
Tetramethylpyrazine ameliorates experimental autoimmune encephalomyelitis by modulating the inflammatory response.
Topics: Animals; Cytokines; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Inflammation; Mice; Mice, Inbred C57BL; Pyrazines | 2018 |
Tetramethylpyrazine‑2'O‑sodium ferulate provides neuroprotection against neuroinflammation and brain injury in MCAO/R rats by suppressing TLR-4/NF-κB signaling pathway.
Topics: Animals; Brain Edema; Brain Injuries; Chemokine CCL2; Cytokines; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA | 2019 |
Ligustrazine attenuates inflammation and oxidative stress in a rat model of arthritis via the Sirt1/NF-κB and Nrf-2/HO-1 pathways.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Heme Oxygenase (Decyclizing); Inflammation; Injections, Subcutaneous; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Sirtuin 1; Structure-Activity Relationship | 2019 |
Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway.
Topics: Animals; Cytokines; Glycogen Synthase Kinase 3 beta; Inflammation; Isoproterenol; Male; Myocardial Ischemia; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Tetramethylpyrazine supplementation reduced Salmonella Typhimurium load and inflammatory response in broilers.
Topics: Animal Feed; Animals; Body Weight; Chickens; Diet; Gastrointestinal Contents; Inflammation; Male; Permeability; Poultry Diseases; Pyrazines; Salmonella Infections, Animal; Salmonella typhimurium | 2019 |
Retinal Transcriptome Analysis in the Treatment of Endotoxin-Induced Uveitis with Tetramethylpyrazine Eye Drops.
Topics: Animals; Endotoxins; Female; Inflammation; Mice; Mice, Inbred BALB C; Ophthalmic Solutions; Protective Agents; Pyrazines; Retina; Transcriptome; Uveitis | 2019 |
Tetramethylpyrazine alleviates LPS-induced inflammatory injury in HUVECs by inhibiting Rho/ROCK pathway.
Topics: Acute Lung Injury; Amides; Apoptosis; Cell Survival; Cell-Derived Microparticles; Cytokines; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Platelet Endothelial Cell Adhesion Molecule-1; Protective Agents; Pyrazines; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases | 2019 |
2,3,5,6-Tetramethylpyrazine of Ephedra sinica regulates melanogenesis and inflammation in a UVA-induced melanoma/keratinocytes co-culture system.
Topics: Animals; Cell Line; Cell Line, Tumor; Coculture Techniques; Cytokines; Ephedra sinica; Humans; Inflammation; Keratinocytes; Melanins; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Nitric Oxide; Pyrazines; Ultraviolet Rays | 2014 |
Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP3 inflammasome pathway.
Topics: Animals; Carrier Proteins; Caspase 1; Cytokines; Hepatocytes; Inflammasomes; Inflammation; Inflammation Mediators; Liver Cirrhosis; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Platelet-Derived Growth Factor; Pyrazines; Rats; Rats, Sprague-Dawley | 2015 |
[Effect of ligustrazine on expression of RhoA mRNA, ROCK-II protein in the lung and airway inflammation of allergic asthma model mice].
Topics: Animals; Asthma; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Pyrazines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger | 2008 |
Protective effects of ligustrazine on TNF-α-induced endothelial dysfunction.
Topics: Autoimmunity; Biomarkers; Chaperonin 60; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Nitric Oxide; Pyrazines; Tumor Necrosis Factor-alpha | 2012 |
Tetramethylpyrazine accelerates the function recovery of traumatic spinal cord in rat model by attenuating inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cytokines; Hindlimb; I-kappa B Proteins; Immunohistochemistry; Inflammation; Macrophage Migration-Inhibitory Factors; Male; Motor Activity; Neutrophil Infiltration; NF-kappa B; Pyrazines; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries | 2013 |