tetramethylpyrazine has been researched along with Disease Models, Animal in 102 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (2.94) | 18.2507 |
| 2000's | 20 (19.61) | 29.6817 |
| 2010's | 65 (63.73) | 24.3611 |
| 2020's | 14 (13.73) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J; Dong, L; Dong, Y; Fu, X; Guo, T; Liu, M; Mao, Y; Qiao, C; Yang, Y; Zhang, J; Zhang, X; Zhao, Y | 1 |
| Li, Z; Tong, J; Wang, Y; Zhu, H | 2 |
| Du, M; Feng, X; Li, S; Liu, P; Wang, J; Wang, Y | 1 |
| Cai, Q; Huang, G; Li, W; Li, Z; Liu, W; Ma, G; Meng, X; Wang, S; Zhang, Y | 1 |
| Chen, H; Deng, C; Meng, S; Meng, Z | 1 |
| Birla, H; Kosuru, R; Prakash, S; Rai, U; Singh, S; Singh, SP; Tiwari, V | 1 |
| Cheng, H; Guo, S; Ke, G; Liu, M; Mao, Y; Mi, Y; Wang, M; Wei, P | 1 |
| Deng, F; Fang, S; Zhang, B; Zhang, Y | 1 |
| Chen, Y; Han, Y; Qian, X; Wu, J; Yang, Q; Ying, J; Zhang, Y; Zhu, H | 1 |
| Du, J; Jiao, Y; Zhang, J; Zhang, S | 1 |
| Black, SM; Chen, J; Chen, X; Chen, Y; Desai, AA; Duan, X; Garcia, JGN; He, W; Hong, C; Hou, C; Kuang, M; Li, M; Liao, J; Liu, C; Liu, S; Lu, W; Makino, A; Rischard, F; Tang, H; Vanderpool, RR; Wang, J; Wu, X; Yang, K; Yuan, JX; Zhang, J; Zhang, N; Zhang, Z; Zheng, Q; Zhong, N; Zou, G | 1 |
| Chen, P; Chen, S; Chen, X; Ge, J; Han, X; He, A; He, S; Liu, X; Luo, Q; Qiu, J; Wu, C; Wu, N; Wu, Y; Yang, M; Yang, Y; Yu, K; Zhuang, J | 1 |
| Cao, H; Cheng, Y; Ge, L; Xu, M; Zhang, J | 1 |
| Cheng, H; Deng, X; Du, H; Huang, H; Kuang, X; Ling, X; Long, C; Shen, H; Shi, K; Tang, H; Wang, L; Wang, R; Xing, Y; Yan, J; Zhang, H; Zhu, X; Zou, Y | 1 |
| Huang, H; Kong, L; Luan, S; Qi, C; Wu, F | 1 |
| Jiang, SJ; Liu, J; Qin, XH; Wang, J; Wang, LX; Zhang, Q; Zhu, L | 1 |
| Chai, H; Huang, Z; Lei, Z; Liu, Y; Qin, X; Wu, Z | 1 |
| Gu, J; Li, N; Sun, Y; Wang, Y; Wu, L; Yu, P; Zhang, G; Zhang, T; Zhang, Z | 1 |
| Shan, L; Sun, Y; Wang, Y; Xu, C; Yu, P; Zhang, G; Zhang, X; Zhang, Z | 1 |
| Gao, Y; Guan, S; He, L; Huang, L; Jin, Y; Li, G; Liang, S; Liu, S; Ou, X; Shen, Y; Tan, M; Xiong, W; Xu, C; Xu, H; Yang, G | 1 |
| Fan, Y; Wu, Y | 1 |
| Akerman, S; Goadsby, PJ; Martins-Oliveira, M; Zhao, Y | 1 |
| Bian, ZR; Che, XW; Liu, XM; Wang, YB; Wu, Q | 1 |
| Gong, X; He, X; Sun, M; Sun, Y; Wang, BO; Wang, M; Wang, X; Wang, Z; Wei, X; Yi, F; Zhang, Y; Zhou, Z | 1 |
| Chen, P; Ge, J; Qiu, J; Tang, M; Wang, Q; Wu, Y; Xu, Z; Yang, Y; Yu, J; Yu, K; Zhuang, J | 1 |
| Jin, M; Liu, S; Ma, X; Shao, Z; Shi, H; Wang, X; Wu, P | 1 |
| Du, S; He, G; Sun, Z; Wu, Y; Zhang, X; Zhao, Y; Zhou, L; Zhou, P; Zhuo, LH | 1 |
| Li, Y; Zhang, T; Zhou, Y; Zhu, Z | 1 |
| Ge, J; Lai, Z; Qiu, J; Tang, M; Wu, C; Wu, Y; Xu, Z; Yang, M; Yang, Y; Yu, K; Zhuang, J | 1 |
| Chen, B; Hu, G; Lin, Y; Ma, Y; Wei, J; Xue, X | 1 |
| Cheng, Y; Cheng, Z; Jin, H; Xia, H; Xu, Y | 1 |
| Gu, S; Hua, X; Mou, Z; Ni, J; Shen, H; Zheng, T; Zhou, Y | 1 |
| Gao, T; Jiang, JD; Li, T; Shi, T; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Fu, D; Gong, X; Lu, H; Norgren, S; Tang, X; Wang, G; Wang, Q; Wang, Y | 1 |
| Chen, YG; Huang, LL; Liu, B; Tao, XG; Wang, JQ; Wei, L; Zhang, L | 1 |
| Fan, X; Huang, C; Li, Y; Wang, W; Zhan, X | 1 |
| Gál, P; Guzy, J; Pekárová, T; Tomečková, V; Tóth, Š; Varga, J; Veselá, J | 1 |
| Du, J; Duan, H; Guo, B; Lee, SM; Wang, Y; Xu, D; Zhang, Z | 1 |
| Chen, N; Chen, W; Lu, Y; Yin, L; Zhu, J; Zhu, M | 1 |
| Bi, L; Lu, C; Miao, Q; Miao, S; Shi, X; Wang, S; Xie, Y; Yang, Q; Zhang, J; Zhang, M; Zhang, S; Zhou, X | 1 |
| Cheng, H; Huang, M; Ji, NF; Wang, H; Xie, YC; Yin, KS; Zhang, MS; Zhao, X | 1 |
| Guo, ZH; Li, YN; Peng, Y; Qu, ZY; Xu, ML; Zhang, Q; Zhao, H | 1 |
| Cai, J; Chen, X; Hou, Z; Huang, RY; Huang, S; Huang, Y; Jia, X; Li, Y; Pan, R; Sun, J; Yang, GY | 1 |
| Ma, P; Mu, H; Sun, K; Wang, A; Wei, J; Wu, Z; Zhang, L; Zhang, X | 1 |
| Chen, XF; Huang, C; Jiang, B; Tong, LJ; Zhang, W | 1 |
| Polat, H; Türk, Ö; Uysal, O; Yaşar, B | 1 |
| Chen, Y; Gao, C; Li, C; Li, W; Peng, H; Wang, H; Zhang, X | 1 |
| Chen, C; Hao, Y; Hong, Y; Lei, H; Li, G; Tian, Y; Wang, P; Zhang, Y | 1 |
| Fan, YX; Feng, GK; Jiang, J; Li, H; Ma, Z; Shi, W; Yang, X; Yin, YL | 1 |
| Cao, Y; Hu, J; Li, D; Lu, H; Wu, T | 1 |
| Cao, M; Cao, Y; Hu, JZ; Huang, JH; Lu, HB; Wang, G; Zeng, L | 1 |
| Dong, J; Du, X; Li, M; Liu, F; Liu, J; Luo, Q; Sun, J; Wei, K; Wei, Y; Xu, F; Zhang, H | 1 |
| Cao, W; Chen, J; Cui, M; Shi, Q; Wang, C; Wang, X; Zhang, B; Zhang, G; Zhao, Y | 1 |
| Ando, K; Cao, X; Enkhsaikhan, A; Izumi-Nakaseko, H; Kishie, T; Nakamura, Y; Sugiyama, A; Wada, T; Xu, B; Zhu, B | 1 |
| Abdel-Tawab, AM; Esmat, A; Khalifa, AE; Michel, HE; Tadros, MG | 1 |
| Chen, A; Hao, M; Jin, H; Lian, N; Shao, J; Wu, L; Yao, Z; Zhang, F; Zheng, S | 1 |
| Fei, A; Gao, C; Jing, L; Pan, S; Zhang, X | 1 |
| Cao, Y; Hu, JZ; Li, DZ; Lu, HB; Wang, XK; Wu, TD; Xu, DQ; Zhang, T | 1 |
| Chen, SY; Gong, G; Hu, S; Liu, ZG; Ma, X; Wang, Q; Xiong, LZ; Zhu, XL; Zhu, ZH | 1 |
| Chang, CC; Chen, CH; Cheng, CF; Chou, Y; Juan, SH; Sue, YM | 1 |
| Chen, LJ; Ding, S; Feng, Y | 1 |
| Jiao, BM; Li, ZL; Qian, HJ; Su, L; Zheng, JS | 1 |
| Cheng, F; Feng, L; Guo, Y; Ke, N; Li, Q; Li, S; Li, Y | 1 |
| Gao, Y; Li, G; Li, X; Liang, S; Lin, J; Liu, H; Liu, S; Wan, F; Xu, C; Yu, K; Zhang, J | 1 |
| Chen, G; Feng, B; Ma, Q; Xu, X; Zhang, J | 1 |
| Fan, C; Liu, W; Zhang, X; Zhou, J | 1 |
| Chen, X; Liu, Y; Qi, C; Qiu, F; Xiao, X; Yang, P; Zhang, J | 1 |
| Jiang, DM; Liang, Y; Yang, QH; Yu, XD | 1 |
| Gao, C; Li, J; Liu, X; Shao, Z; Sun, Z; Zhao, Z | 1 |
| Dong, J; Gong, G; Ren, M; Wen, N; Xu, Y | 1 |
| Ni, SR; Wang, WT; Xu, ZJ; Zhou, WB | 1 |
| Ma, ML; Ou, JM; Wang, C; Wu, DJ; Zhang, XP | 1 |
| Chen, Z; Huo, JR; Yang, L; Zhu, HY | 1 |
| Dang, X; Die, J; Fan, L; Shi, Z; Wang, C; Wang, K | 1 |
| Deng, X; Gao, Y; He, M; Li, N; Zhu, Y | 1 |
| Cheng, QH; Jiang, J; Li, WJ; Shen, JY; Ye, Q; Zhang, XP; Zhu, H | 1 |
| Li, J; Lu, J; Wan, H; Yang, J; Zhang, Y; Zhu, Z | 1 |
| Ge, WP; Liu, N; Lu, D; Ma, CM; Qin, C; Shao, HT; Zhang, LF; Zhang, X | 1 |
| Ding, Y; Li, J; Li, S; Liang, X; Liao, X; Luo, Y; Min, W; Sun, G; Yang, C; Zhou, H | 1 |
| Luo, G; Shi, J; Wang, Y | 1 |
| Sun, Y; Wang, L; Wang, Y; Yu, P; Zhai, Z; Zhang, G; Zhong, H | 1 |
| Liang, B; Peng, C; Wang, H; Wang, P | 1 |
| Han, R; Li, J; Luo, Q; Shen, J; Tang, Q; Xiao, H | 1 |
| Gao, XM; Leng, YF; Wang, SX; Xing, YH | 1 |
| Chen, DM; Shi, CG; Sun, MZ; Wang, GF; Wang, HF; Wang, L; Wu, SX; Xu, ZQ | 1 |
| Li, Y; Shi, J; Sun, L; Wang, X | 1 |
| Chen, JL; Chen, NW; Chen, WX; Wu, YL; Zhang, MJ; Zhou, T; Zhu, JS | 1 |
| Li, HL; Wang, WJ; Wang, XH; Yang, L | 1 |
| Cheng, B; Dang, XQ; Fan, LH; Wang, CS; Wang, KZ | 1 |
| Gao, Y; Guo, P; Li, YF; Liang, QD; Ma, BP; Ma, ZC; Tan, HL; Tan, W; Wang, SQ; Zhou, Z | 1 |
| Davey, AK; Evans, AM; Li, Y; Wang, J; Xu, D; Zhang, S | 1 |
| Chen, CH; Chen, TH; Chu, YL; Hou, CC; Hsu, YH; Juan, SH; Lin, H; Sue, YM | 1 |
| Dang, SC; Qu, JG; Wang, XQ; Zhang, JX | 1 |
| Fu, H; Li, J; Li, QX; Shao, L; Xia, L | 1 |
| Chiou, GC; Jiang, W; Zou, Y | 1 |
| Dang, SC; Fan, X; Qu, JG; Wang, XQ; Zhang, JX | 1 |
| Bai, M; Fang, ZY; Feng, G; Tao, XN; Xiong, L | 1 |
| Matsumoto, K; Ni, JW; Watanabe, H | 1 |
| Chang, FC; Chen, KJ; Hong, CY; Huang, YT; Lin, HC; Lin, JG | 1 |
| Chen, SJ; Liao, MH; Wu, CC; Yen, MH | 1 |
| Chen, S; Dong, H; Lu, Z; Sang, H; Wang, Q; Xiong, L; Zhu, Z | 1 |
1 review(s) available for tetramethylpyrazine and Disease Models, Animal
| Article | Year |
|---|---|
The role and mechanism of tetramethylpyrazine for atherosclerosis in animal models: A systematic review and meta-analysis.
Topics: Animals; Aortic Diseases; Atherosclerosis; Disease Models, Animal; Humans; Pyrazines | 2022 |
101 other study(ies) available for tetramethylpyrazine and Disease Models, Animal
| Article | Year |
|---|---|
Hybrid molecules of scutellarein and tertramethylpyrazine's active metabolites for ischemic stroke.
Topics: Animals; Apigenin; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Neurons; Neuroprotective Agents; PC12 Cells; Pyrazines; Rats; Reperfusion Injury; Stroke | 2019 |
Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Computational Biology; Disease Models, Animal; Immunoglobulin E; Lung; Male; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Rats; Rats, Sprague-Dawley; Respiratory Hypersensitivity; RNA, Messenger | 2022 |
Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognition; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Luciferases; Mice; Mice, Transgenic; Mitophagy; Piperazine; PPAR gamma; Presenilin-1; Protein Kinases; Pyrazines; Rats; Sequestosome-1 Protein; Ubiquitin-Protein Ligases | 2022 |
Tetramethylpyrazine ameliorates systemic streptozotocin-induced Alzheimer-like pathology.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hippocampus; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Streptozocin | 2023 |
Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Glucose Transporter Type 4; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Wistar; Signal Transduction; Vasodilator Agents | 2019 |
Pharmacokinetic comparative study of tetramethylpyrazine and ferulic acid and their compatibility with different concentration of gastrodin and gastrodigenin on blood-stasis migraine model by blood-brain microdialysis method.
Topics: Administration, Oral; Animals; Benzyl Alcohols; Blood-Brain Barrier; Cold Temperature; Coumaric Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Extracellular Fluid; Gastrodia; Glucosides; Humans; Ligusticum; Male; Microdialysis; Migraine Disorders; Permeability; Pyrazines; Rats; Specific Pathogen-Free Organisms; Vasoconstriction | 2020 |
Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling.
Topics: Angiotensin II; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelin-1; Hypertension, Renovascular; Ligation; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pyrazines; Rats, Sprague-Dawley; Renal Artery; Signal Transduction; Temporal Arteries; Vascular Remodeling | 2020 |
Ligustrazine suppresses renal NMDAR1 and caspase-3 expressions in a mouse model of sepsis-associated acute kidney injury.
Topics: Acute Kidney Injury; Animals; Caspase 3; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Pyrazines; Receptors, N-Methyl-D-Aspartate; Sepsis | 2020 |
Tetramethylpyrazine attenuates placental oxidative stress, inflammatory responses and endoplasmic reticulum stress in a mouse model of gestational diabetes mellitus.
Topics: Administration, Oral; Animals; Diabetes, Gestational; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Female; Inflammation; Mice; Mice, Inbred C57BL; Oxidative Stress; Placenta; Pregnancy; Pyrazines | 2019 |
Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Humans; Hypertension, Pulmonary; Monocrotaline; Myocytes, Smooth Muscle; Pharmaceutical Preparations; Pulmonary Artery; Pyrazines; Rats; Rats, Sprague-Dawley | 2020 |
Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Movement; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Male; Microglia; NF-kappa B; Pyrazines; Rats, Sprague-Dawley; Retinal Ganglion Cells; Signal Transduction; Toll-Like Receptor 4; Uveitis | 2020 |
The Effect of Umbilical Cord Mesenchymal Stem Cells Combined with Tetramethylpyrazine Therapy on Ischemic Brain Injury: A Histological Study.
Topics: Animals; Brain; Brain Ischemia; Cells, Cultured; Combined Modality Therapy; Disease Models, Animal; Humans; Male; Mesenchymal Stem Cell Transplantation; Motor Activity; Nerve Regeneration; Neurogenesis; Neuroprotective Agents; Pyrazines; Rats, Sprague-Dawley; Recovery of Function; Signal Transduction; Umbilical Cord | 2020 |
2,3,5,6-Tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation.
Topics: Activating Transcription Factor 4; Animals; Cell Line, Tumor; Disease Models, Animal; Drug Evaluation, Preclinical; Electroretinography; Endoplasmic Reticulum Stress; Eye Proteins; Fasting; Female; Glucose; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Prion Proteins; Protein Aggregates; Protein Aggregation, Pathological; Pyrazines; Retina; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Single-Blind Method; Solubility; Specific Pathogen-Free Organisms; Transcription, Genetic | 2021 |
Ligustrazine Suppresses Platelet-Derived Growth Factor-BB-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Inflammation by Regulating the PI3K/AKT Signaling Pathway.
Topics: Animals; Becaplermin; Cell Cycle; Cell Proliferation; China; Disease Models, Animal; Inflammation; Male; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Pulmonary Arterial Hypertension; Pyrazines; Rats; Rats, Sprague-Dawley | 2021 |
Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Hippocampus; Humans; Hyperhomocysteinemia; Memory Disorders; Neurons; Neuroprotective Agents; Phosphorylation; Pyrazines; Rats; Rats, Sprague-Dawley | 2021 |
Tetramethylpyrazine inhibits neutrophil extracellular traps formation and alleviates hepatic ischemia/reperfusion injury in rat liver transplantation.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cell-Free Nucleic Acids; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Extracellular Traps; In Situ Nick-End Labeling; Liver; Liver Transplantation; Male; NADPH Oxidases; Neutrophils; Onium Compounds; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome | 2021 |
Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia.
Topics: Animals; Axons; Caspase 3; Cell Hypoxia; Cells, Cultured; Cerebrovascular Circulation; Disease Models, Animal; Embryo, Mammalian; Glucose; Hippocampus; Hypoxia-Ischemia, Brain; Male; Maze Learning; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Recognition, Psychology | 2017 |
Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Lactates; Male; Molecular Structure; Myocardial Ischemia; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Solubility; Structure-Activity Relationship | 2017 |
Inhibitory effects of tetramethylpyrazine on pain transmission of trigeminal neuralgia in CCI-ION rats.
Topics: Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; HEK293 Cells; Humans; Hyperalgesia; Male; MAP Kinase Signaling System; Membrane Potentials; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Pyrazines; Random Allocation; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; RNA, Messenger; Trigeminal Ganglion; Trigeminal Neuralgia | 2017 |
Tetramethylpyrazine alleviates neural apoptosis in injured spinal cord via the downregulation of miR-214-3p.
Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Down-Regulation; Flow Cytometry; HEK293 Cells; Humans; In Situ Nick-End Labeling; Male; MicroRNAs; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord Injuries; Up-Regulation | 2017 |
Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation.
Topics: Animals; Benzyl Alcohols; Disease Models, Animal; Dura Mater; Glucosides; Levetiracetam; Male; Medicine, Chinese Traditional; Migraine Disorders; Neurons, Afferent; Nociceptive Pain; Pain Management; Propranolol; Pyrazines; Rats, Sprague-Dawley; Trigeminal Nerve | 2018 |
Effects of Ligustrazine on Airway Inflammation in A Mouse Model of Neutrophilic Asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Interleukin-10; Interleukin-17; Leukocyte Count; Lung; Mice, Inbred C57BL; Neutrophils; Pneumonia; Pyrazines; Respiratory Hypersensitivity | 2018 |
Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke.
Topics: Animals; Brain Ischemia; Carnitine; Disease Models, Animal; Male; NADPH Oxidase 2; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Stroke | 2017 |
Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization.
Topics: Animals; Blotting, Western; Burns, Chemical; Corneal Neovascularization; Disease Models, Animal; Eye Burns; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; NF-kappa B; Nuclear Respiratory Factor 1; Pyrazines; Real-Time Polymerase Chain Reaction; Receptors, CXCR4; Sodium Hydroxide; Vasodilator Agents | 2018 |
Tetramethylpyrazine Protects Against Early Brain Injury and Inhibits the PERK/Akt Pathway in a Rat Model of Subarachnoid Hemorrhage.
Topics: Animals; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; eIF-2 Kinase; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction; Subarachnoid Hemorrhage; Vasodilator Agents | 2018 |
Tetramethylpyrazine‑2'O‑sodium ferulate provides neuroprotection against neuroinflammation and brain injury in MCAO/R rats by suppressing TLR-4/NF-κB signaling pathway.
Topics: Animals; Brain Edema; Brain Injuries; Chemokine CCL2; Cytokines; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA | 2019 |
Ligustrazine attenuates inflammation and oxidative stress in a rat model of arthritis via the Sirt1/NF-κB and Nrf-2/HO-1 pathways.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Heme Oxygenase (Decyclizing); Inflammation; Injections, Subcutaneous; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Sirtuin 1; Structure-Activity Relationship | 2019 |
Tetramethylpyrazine (TMP) ameliorates corneal neovascularization via regulating cell infiltration into cornea after alkali burn.
Topics: Alkalies; Animals; Burns, Chemical; Cell Line; Cell Movement; Cornea; Corneal Neovascularization; Disease Models, Animal; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Pyrazines; Receptors, CXCR4; Signal Transduction; Up-Regulation | 2019 |
Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Biopsy; Blood Glucose; Cytokines; Diet, High-Fat; Disease Models, Animal; Female; Hepatitis; Inflammation Mediators; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Pyrazines; Reactive Oxygen Species | 2019 |
The Controlled Release and Anti-Inflammatory Activity of a Tetramethylpyrazine-Loaded Thermosensitive Poloxamer Hydrogel.
Topics: Acetic Acid; Adhesiveness; Administration, Cutaneous; Administration, Intranasal; Administration, Oral; Animals; Anti-Inflammatory Agents; Biological Availability; Blood-Brain Barrier; Capillary Permeability; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Liberation; Gastritis; Hydrogels; Poloxamer; Pyrazines; Rats, Sprague-Dawley; Temperature; Viscosity | 2019 |
Tetramethylpyrazine reduces the consequences of nitric oxide inhibition in pregnant rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Female; Gene Expression Regulation; Heat-Shock Proteins; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Placenta; Pre-Eclampsia; Pregnancy; Pyrazines; Rats; Transcription Factor CHOP; Vascular Endothelial Growth Factor Receptor-1 | 2019 |
Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Gabapentin; Male; Mice; Mice, Inbred C57BL; Morphinans; Neuralgia; Peripheral Nerve Injuries; Pyrazines; Spinal Cord Injuries | 2019 |
Tetramethylpyrazine prevents contrast-induced nephropathy by inhibiting p38 MAPK and FoxO1 signaling pathways.
Topics: Acute Kidney Injury; Animals; Apoptosis; Contrast Media; Disease Models, Animal; Forkhead Transcription Factors; Immunohistochemistry; Kidney Cortex Necrosis; Male; Microscopy, Electron, Transmission; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Pyrazines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Signal Transduction | 2013 |
Tetramethylpyrazine upregulates the aquaporin 8 expression of hepatocellular mitochondria in septic rats.
Topics: Animals; Aquaporins; Calcium Channel Blockers; Disease Models, Animal; Hepatocytes; Liver Diseases; Male; Mitochondria, Liver; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sepsis; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
[Effects of combination of Salvia and Ligustrazine on TNF-α and TGF-β1 in serum and BALF of rats with pulmonary fibrosis].
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drugs, Chinese Herbal; Idiopathic Pulmonary Fibrosis; Lung; Male; Pyrazines; Rats; Salvia; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2013 |
Intravenous administration of tetramethylpyrazine reduces intestinal ischemia-reperfusion injury in rats.
Topics: Administration, Intravenous; Animals; Apoptosis; Disease Models, Animal; Goblet Cells; Intestinal Mucosa; Jejunum; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Paneth Cells; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents | 2013 |
Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Humans; Ligusticum; Male; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxidopamine; Parkinson Disease; Phytotherapy; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Substantia Nigra; Zebrafish | 2014 |
Tetramethylpyrazine improves oxazolone-induced colitis by inhibiting the NF-κB pathway.
Topics: Animals; Caco-2 Cells; Colitis; Cytokines; Disease Models, Animal; Humans; Inflammation Mediators; Intestinal Mucosa; Male; Mice; NF-kappa B; Oxazolone; Oxidative Stress; Phytotherapy; Pyrazines; Signal Transduction | 2014 |
Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson's disease induced by MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cytochromes c; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Down-Regulation; Glutamate-Cysteine Ligase; Male; MPTP Poisoning; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rats, Wistar; Up-Regulation | 2014 |
Ligustrazine corrects Th1/Th2 and Treg/Th17 imbalance in a mouse asthma model.
Topics: Animals; Asthma; Cells, Cultured; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Eosinophils; Female; Gene Expression Regulation; Homeostasis; Humans; Mice; Mice, Inbred C57BL; Neutrophils; Ovalbumin; Pyrazines; T-Lymphocytes, Regulatory; Th1-Th2 Balance; Th17 Cells; Transcription Factors | 2014 |
Tetramethylpyrazine alleviated cytokine synthesis and dopamine deficit and improved motor dysfunction in the mice model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Benzofurans; Corpus Striatum; Cytokines; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Mice; Neurons; Parkinsonian Disorders; Patch-Clamp Techniques; Postural Balance; Psychomotor Performance; Pyrazines; Quinolines; Vasodilator Agents | 2014 |
The combination of astragalus membranaceus and ligustrazine ameliorates micro-haemorrhage by maintaining blood-brain barrier integrity in cerebrally ischaemic rats.
Topics: Animals; Astragalus Plant; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Intracranial Hemorrhages; Magnetic Resonance Imaging; Male; Microscopy, Electron, Transmission; Plant Extracts; Pyrazines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction | 2014 |
Preparation and evaluation of a novel biodegradable long-acting intravitreal implant containing ligustrazine for the treatment of proliferative vitreoretinopathy.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Female; Lactic Acid; Male; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Pyrazines; Rabbits; Retina; Vitreoretinopathy, Proliferative; Vitreous Body | 2015 |
Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through Promotion of BDNF Signaling Pathway.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurogenesis; Neuropsychological Tests; Pyrazines; Signal Transduction; Tryptophan Hydroxylase | 2015 |
[The effect of ligustrazin in intestinal ischemia reperfusion injury generated on rats].
Topics: Animals; Disease Models, Animal; Ileum; Jejunum; Male; Mesenteric Ischemia; Pyrazines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Vasodilator Agents | 2015 |
Ligustrazine effect on lipopolysaccharide-induced pulmonary damage in rats.
Topics: Animals; Blood Gas Analysis; Cell-Derived Microparticles; Disease Models, Animal; Endothelial Cells; Injections, Intraperitoneal; Lipopolysaccharides; Lung; Lung Injury; Male; Oxygen; Partial Pressure; Platelet Endothelial Cell Adhesion Molecule-1; Pyrazines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Sepsis; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2015 |
A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats.
Topics: Animals; Behavior, Animal; Brain Ischemia; Ca(2+) Mg(2+)-ATPase; Cell Differentiation; Cell Survival; Cyclooxygenase 2; Disease Models, Animal; Immunohistochemistry; Neuroprotective Agents; NF-kappa B; PC12 Cells; Pyrazines; Rats; Stroke; Superoxide Dismutase; Toxicity Tests, Acute; Vascular Endothelial Growth Factor A | 2015 |
Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Learning; Male; Memory; Pyrazines; Random Allocation; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A; Vasodilator Agents | 2015 |
Micro-CT as a Tool to Investigate the Efficacy of Tetramethylpyrazine in a Rat Spinal Cord Injury Model.
Topics: Animals; Disease Models, Animal; Hindlimb; Male; Motor Activity; Neuroprotective Agents; Pyrazines; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; X-Ray Microtomography | 2016 |
Ligustrazine improves blood circulation by suppressing Platelet activation in a rat model of allergic asthma.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Asthma; Blood Circulation; Blood Platelets; Cell Adhesion; Cytokines; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Male; Platelet Activation; Pneumonia; Pyrazines; Rats, Sprague-Dawley | 2016 |
Tetramethylpyrazine enhances functional recovery after contusion spinal cord injury by modulation of MicroRNA-21, FasL, PDCD4 and PTEN expression.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Contusions; Disease Models, Animal; Fas Ligand Protein; Male; MicroRNAs; Neuroprotective Agents; PTEN Phosphohydrolase; Pyrazines; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries | 2016 |
Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Chemokines; Disease Models, Animal; Female; Interleukins; Lung; MAP Kinase Signaling System; Mice, Inbred BALB C; Ovalbumin; Pyrazines; Receptors, CCR7; STAT3 Transcription Factor | 2016 |
Ligustrazine alleviates acute pancreatitis by accelerating acinar cell apoptosis at early phase via the suppression of p38 and Erk MAPK pathways.
Topics: Acinar Cells; Acute Disease; Amylases; Animals; Apoptosis; Cell Line; Cytokines; Disease Models, Animal; Down-Regulation; Inflammation Mediators; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pancreatitis; Peroxidase; Phosphorylation; Pyrazines; Rats, Sprague-Dawley | 2016 |
Assessment of the Anti-anginal Effect of Tetramethylpyrazine Using Vasopressin-Induced Angina Model Rats.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Heart Rate; Male; Myocardial Ischemia; Pyrazines; Rats; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins | 2016 |
Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson's Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain; Cyclooxygenase 2; Disease Models, Animal; Male; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Pyrazines; Rats, Sprague-Dawley; Rotenone; Vasodilator Agents | 2017 |
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Topics: Animals; Benzoquinones; Carbon Tetrachloride; Disease Models, Animal; Hedgehog Proteins; Hepatic Stellate Cells; HSP90 Heat-Shock Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Lactams, Macrocyclic; Liver Cirrhosis; Male; Mice; Mice, Inbred ICR; Mustard Compounds; Neovascularization, Pathologic; Phenylpropionates; Pyrazines; Rats; Rats, Sprague-Dawley; Signal Transduction; Smoothened Receptor | 2017 |
Increased Circulating Endothelial Microparticles Associated with PAK4 Play a Key Role in Ventilation-Induced Lung Injury Process.
Topics: Animals; beta Catenin; Bronchoalveolar Lavage Fluid; Cell Adhesion; Cell-Derived Microparticles; Cytoskeleton; Disease Models, Animal; Endothelium, Vascular; Lung; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Microscopy, Fluorescence; Neutrophils; p21-Activated Kinases; Pyrazines; Respiration, Artificial; Respiratory Function Tests; Tidal Volume; Toll-Like Receptor 4; Ventilator-Induced Lung Injury | 2017 |
Tetramethylpyrazine Facilitates Functional Recovery after Spinal Cord Injury by Inhibiting MMP2, MMP9, and Vascular Endothelial Cell Apoptosis.
Topics: Animals; Apoptosis; Disease Models, Animal; Endothelial Cells; Follow-Up Studies; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neurologic Examination; Platelet Aggregation Inhibitors; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; Time Factors | 2017 |
Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats.
Topics: Analysis of Variance; Animals; Brain Infarction; Disease Models, Animal; Ischemic Attack, Transient; Male; Neurologic Examination; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Thioredoxins; Time Factors; Vasodilator Agents | 2009 |
Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Culture Techniques; Cells, Cultured; Disease Models, Animal; Gentamicins; Heme Oxygenase-1; Kidney Cortex Necrosis; Kidney Tubules; Male; Mice; Pyrazines; Rats; Vasodilator Agents | 2009 |
[The efficacy of tetramethylpyrazine-eluting stents on inhibiting neointima formation in porcine coronary arteries].
Topics: Animals; Coronary Restenosis; Coronary Vessels; Disease Models, Animal; Double-Blind Method; Drug-Eluting Stents; Pyrazines; Swine; Tunica Intima | 2008 |
[The influence of JNK inhibitor on hemodynamics after ischemia/reperfusion injury to the heart in rats].
Topics: Animals; Anthracenes; Disease Models, Animal; Hemodynamics; JNK Mitogen-Activated Protein Kinases; Male; Myocardial Reperfusion Injury; Protein Kinase Inhibitors; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley | 2008 |
The protective mechanism of ligustrazine against renal ischemia/reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Disease Models, Animal; Gene Expression; Intercellular Adhesion Molecule-1; Kidney; Kidney Diseases; Kidney Transplantation; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Neutrophils; Oxidative Stress; Peroxidase; Pyrazines; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2011 |
Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Disease Models, Animal; Drug Evaluation, Preclinical; Ganglia, Spinal; Hyperalgesia; Male; Pain Threshold; Patch-Clamp Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Skin | 2010 |
[Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats].
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Gene Expression; Humans; Male; Pyrazines; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A | 2009 |
[Studies on protection and mechanism of tetramethylpyrazine on myocardial injury of rats with DHF].
Topics: Animals; Calcium; Calcium-Transporting ATPases; Disease Models, Animal; Drugs, Chinese Herbal; Female; Heart Failure, Diastolic; Humans; Male; Myocardium; Pyrazines; Random Allocation; Rats; Rats, Wistar; Ventricular Pressure | 2009 |
Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia.
Topics: Adult Stem Cells; Aging; Animals; Body Water; Brain; Brain Infarction; Brain Ischemia; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Neurogenesis; Neurons; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Stem Cell Niche | 2010 |
Additive effect of tetramethylpyrazine and deferoxamine in the treatment of spinal cord injury caused by aortic cross-clamping in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Deferoxamine; Disease Models, Animal; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Siderophores; Spinal Cord Ischemia | 2011 |
Effects of tetramethylpyrazine on nitric oxide/cGMP signaling after cerebral vasospasm in rabbits.
Topics: Animals; Basilar Artery; Blotting, Western; Calcium Signaling; Cerebral Angiography; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Endothelial Cells; Male; Microscopy, Confocal; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrazines; Rabbits; Signal Transduction; Subarachnoid Hemorrhage; Tomography, X-Ray Computed; Ultrasonography, Doppler, Transcranial; Vasodilator Agents; Vasospasm, Intracranial | 2010 |
Synthesis of novel ligustrazine derivatives as NA+/H+ exchange inhibitors.
Topics: Animals; Benzamides; Cardiotonic Agents; Creatine Kinase; Disease Models, Animal; Myocardial Infarction; Pyrazines; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Structure-Activity Relationship | 2010 |
[Effect of ligustrazine on the expression and activity of heme oxygenase-1 in the pulmonary ischemia/reperfusion injury in rabbits].
Topics: Animals; Disease Models, Animal; Heme Oxygenase-1; Lung; Pyrazines; Rabbits; Reperfusion Injury | 2005 |
Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Ginsenosides; Isoflavones; Kidney; Liver; Male; Panax; Pancreas; Pancreatitis; Pyrazines; Rats; Rats, Sprague-Dawley; Saponins; Severity of Illness Index | 2010 |
Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Gynura segetum.
Topics: Animals; Asteraceae; Bilirubin; Biomarkers; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Early Growth Response Protein 1; Female; Gene Expression Regulation; Hepatic Veno-Occlusive Disease; Liver; Mice; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Serum Albumin; Thromboplastin; Time Factors; Transaminases; Transcription Factor RelA | 2011 |
Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Male; Neurologic Examination; Neuroprotective Agents; Neutrophil Infiltration; NF-kappa B; Peroxidase; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Protective effects and mechanism of tetramethylpyrazine against lens opacification induced by sodium selenite in rats.
Topics: Administration, Topical; Animals; Calcium; Calcium Channel Blockers; Catalase; Cataract; Disease Models, Animal; Drugs, Chinese Herbal; Glutathione Peroxidase; Lens, Crystalline; Ligusticum; Malondialdehyde; Photometry; Pyrazines; Rats; Rats, Sprague-Dawley; Sodium Selenite; Superoxide Dismutase | 2011 |
Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis.
Topics: Animals; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Immunity; Intestine, Small; Isoflavones; Ligusticum; Lymphoid Tissue; Pancreatitis, Acute Necrotizing; Pyrazines; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Vasodilator Agents | 2011 |
Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.
Topics: Animals; Astragalus Plant; Cardiovascular Agents; Caspase 3; Disease Models, Animal; Drug Synergism; Glucose; Hippocampus; Ischemic Attack, Transient; Male; Malondialdehyde; Neuroprotective Agents; Nimodipine; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Positron-Emission Tomography; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Saponins; Superoxide Dismutase; Triterpenes | 2012 |
Ginsenoside-Rb1 and tetramethylpyrazine phosphate act synergistically to prevent dilated cardiomyopathy in cTnTR141W transgenic mice.
Topics: Animals; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cardiomyopathy, Dilated; Disease Models, Animal; Disease Progression; Drug Synergism; Drug Therapy, Combination; Echocardiography; Gene Expression Regulation; Ginsenosides; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
TMP prevents retinal neovascularization and imparts neuroprotection in an oxygen-induced retinopathy model.
Topics: Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Ligusticum; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nerve Tissue Proteins; Neuroprotective Agents; Oxygen; Pyrazines; Reperfusion Injury; Retinal Neovascularization; Retinal Neurons; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vasodilator Agents | 2012 |
Ligustrazine phosphate ethosomes for treatment of Alzheimer's disease, in vitro and in animal model studies.
Topics: Acrylic Resins; Administration, Cutaneous; Alzheimer Disease; Amnesia; Animals; Antioxidants; Behavior, Animal; Brain; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Escape Reaction; Ethanol; Glutathione Peroxidase; Lipid Peroxidation; Male; Malondialdehyde; Memory; Mice; Mice, Inbred ICR; Mice, Nude; Microscopy, Confocal; Permeability; Phosphatidylcholines; Pyrazines; Rats; Rats, Sprague-Dawley; Reaction Time; Scopolamine; Skin; Skin Absorption; Superoxide Dismutase; Technology, Pharmaceutical; Time Factors | 2012 |
Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Recovery of Function | 2012 |
[Effect of Ligustrazine on expressions of FoXO3a, MAFbx, and MuRF1 in denervated skeletal muscle atrophy rats].
Topics: Animals; Disease Models, Animal; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Injections, Intraperitoneal; Muscle Denervation; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Time Factors; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2012 |
Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Brain Ischemia; Calcium; Cerebral Cortex; Disease Models, Animal; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2012 |
Effects of tetramethylpyrazine on neuronal apoptosis in the superficial dorsal horn in a rat model of neuropathic pain.
Topics: Animals; Apoptosis; Caspase 3; Disease Models, Animal; Immunohistochemistry; In Situ Nick-End Labeling; Male; Neuralgia; Neurons; Posterior Horn Cells; Pyrazines; Rats | 2012 |
Tetramethylpyrazine attenuates atherosclerosis development and protects endothelial cells from ox-LDL.
Topics: Animals; Aorta, Abdominal; Atherosclerosis; Cell Adhesion; Cell Culture Techniques; Cell Movement; Cells, Cultured; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Endothelial Cells; Immunohistochemistry; Ligusticum; Lipoproteins, LDL; Male; Plaque, Atherosclerotic; Pyrazines; Rabbits; Rats; Rats, Sprague-Dawley; Triglycerides | 2013 |
Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.
Topics: Animals; Disease Models, Animal; Endothelin-1; Free Radical Scavengers; Kidney; Kidney Diseases; Malondialdehyde; Pyrazines; Random Allocation; Rats; Rats, Wistar; Renal Artery; Reperfusion Injury; Superoxide Dismutase | 2002 |
Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats.
Topics: Animals; Disease Models, Animal; Free Radical Scavengers; Kidney; Liver; Male; P-Selectin; Pyrazines; Rats; Rats, Wistar; Reperfusion Injury | 2003 |
[Effect of ligustrazine on airway remodeling in asthmatic rats].
Topics: Animals; Anti-Asthmatic Agents; Asthma; Collagen Type III; Disease Models, Animal; Drugs, Chinese Herbal; Immunohistochemistry; Male; Muscle, Smooth, Vascular; Ovalbumin; Pyrazines; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2004 |
Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Male; Malondialdehyde; Microscopy, Electron, Transmission; Motor Neurons; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rabbits; Spinal Cord; Spinal Cord Ischemia; Superoxide Dismutase; Treatment Outcome; Up-Regulation | 2006 |
Effects of four Si-Wu-Tang's constituents and their combination on irradiated mice.
Topics: Animals; Benzoates; Body Weight; Bone Marrow Cells; Bridged-Ring Compounds; Colony-Forming Units Assay; Coumaric Acids; Disease Models, Animal; Dose-Response Relationship, Radiation; Drugs, Chinese Herbal; Female; Fructose; Gamma Rays; Glucosides; Hematopoietic Stem Cells; Mice; Mice, Inbred C57BL; Monoterpenes; Pyrazines; Radiation-Protective Agents; Stem Cells; Thymus Gland | 2006 |
The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury.
Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Decanoic Acids; Disease Models, Animal; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Heart Rate; Hydroxy Acids; Injections, Intravenous; Myocardial Infarction; Myocardial Reperfusion Injury; Pyrazines; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Ventricular Fibrillation | 2007 |
Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Cytochromes c; Disease Models, Animal; DNA; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Expression; Gentamicins; In Situ Nick-End Labeling; Kidney Tubules, Proximal; Ligusticum; Male; NF-kappa B; Oxidative Stress; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2007 |
Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis.
Topics: Acute Disease; Animals; Disease Models, Animal; Kidney Diseases; Pancreatitis, Acute Necrotizing; Pyrazines; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasodilator Agents | 2006 |
Protective effect of ligustrazine on accelerated anti-glomerular basement membrane antibody nephritis in rats is based on its antioxidant properties.
Topics: Animals; Anti-Glomerular Basement Membrane Disease; Antibodies; Antioxidants; Autoantibodies; Blood Urea Nitrogen; Catalase; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Kidney; Male; Malondialdehyde; Proteinuria; Pyrazines; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2007 |
Effect of tetramethylpyrazine on rat experimental choroidal neovascularization in vivo and endothelial cell cultures in vitro.
Topics: Animals; Capillary Permeability; Cell Proliferation; Cells, Cultured; Choroidal Neovascularization; Dextrans; Disease Models, Animal; Endothelium, Vascular; Fluorescein Angiography; Fluorescein-5-isothiocyanate; Injections, Intraperitoneal; Laser Coagulation; Male; Platelet Aggregation Inhibitors; Pyrazines; Rats; Rats, Inbred BN; Umbilical Veins | 2007 |
Ligustrazine alleviates gastric mucosal injury in a rat model of acute necrotizing pancreatitis.
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Female; Gastric Mucosa; Inflammation Mediators; Interleukin-1beta; Ligusticum; Male; Microcirculation; Pancreas; Pancreatitis, Acute Necrotizing; Peroxidase; Phytotherapy; Pyrazines; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 2007 |
Effect and mechanism of ligustrazine on Th1/Th2 cytokines in a rat asthma model.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; GATA3 Transcription Factor; Interferon-gamma; Interleukin-4; Lung; Male; Ovalbumin; Pyrazines; Rats; T-Box Domain Proteins; Th1 Cells; Th2 Cells | 2007 |
Tetramethylpyrazine improves spatial cognitive impairment induced by permanent occlusion of bilateral common carotid arteries or scopolamine in rats.
Topics: Animals; Brain Ischemia; Carotid Arteries; Cognition; Disease Models, Animal; Male; Maze Learning; Pyrazines; Rats; Rats, Wistar; Scopolamine; Spatial Behavior; Vasodilator Agents | 1995 |
Beneficial effects of combined terlipressin and tetramethylpyrazine administration on portal hypertensive rats.
Topics: Animals; Antihypertensive Agents; Cholestasis; Disease Models, Animal; Drug Therapy, Combination; Hemodynamics; Hypertension, Portal; Lypressin; Male; Portal Vein; Pyrazines; Rats; Rats, Sprague-Dawley; Terlipressin; Vasodilator Agents | 1999 |
Tetramethylpyradizine prevents inducible NO synthase expression and improves survival in rodent models of endotoxic shock.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Heart Rate; In Vitro Techniques; Lipopolysaccharides; Lung; Male; Mice; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Norepinephrine; Pyrazines; Rats; Rats, Inbred WKY; Shock, Septic; Tumor Necrosis Factor-alpha; Vasodilator Agents | 1999 |
Tetramethylpyrazine attenuates spinal cord ischemic injury due to aortic cross-clamping in rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Cell Count; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Motor Activity; Neurologic Examination; Neurons; Paraplegia; Pyrazines; Rabbits; Spinal Cord; Spinal Cord Ischemia; Thoracic Surgical Procedures; Treatment Outcome | 2002 |