Page last updated: 2024-08-21

tetramethylpyrazine and Alzheimer Disease

tetramethylpyrazine has been researched along with Alzheimer Disease in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's6 (54.55)24.3611
2020's4 (36.36)2.80

Authors

AuthorsStudies
Cai, Q; Huang, G; Li, W; Li, Z; Liu, W; Ma, G; Meng, X; Wang, S; Zhang, Y1
Chen, H; Deng, C; Meng, S; Meng, Z1
Huang, S; Huang, Z; Liu, T; Weng, G; Zhou, B1
Jiang, SJ; Liu, J; Qin, XH; Wang, J; Wang, LX; Zhang, Q; Zhu, L1
Li, W; Li, X; Liang, X; Lu, F; Wei, K; Yao, Y; Zhang, J; Zhang, Q1
Feng, X; Hong, G; Li, G; Li, X; Liu, T; Mao, L; Xu, Z; Zhang, Y1
Amjad, MW; Bukhari, SNA; Hussain, MA; Leng, J; Qin, HL; Raja, MAG; Wang, M1
Cai, W; Chen, HY; Cui, W; Han, YF; Long, C; Sun, YW; Tan, GL; Tsim, KW; Wang, JZ; Wang, YQ; Xu, DP; Yu, P; Zhang, GX; Zhang, ZJ1
Cong, W; Liu, Q; Luo, G; Shi, J; Wang, Y1
Luo, G; Shi, J; Wang, Y1
Cai, J; Cui, X; Wang, SZ; Zhang, C; Zuo, PP1

Other Studies

11 other study(ies) available for tetramethylpyrazine and Alzheimer Disease

ArticleYear
Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice.
    Alzheimer's research & therapy, 2022, 10-11, Volume: 14, Issue:1

    Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cognition; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Luciferases; Mice; Mice, Transgenic; Mitophagy; Piperazine; PPAR gamma; Presenilin-1; Protein Kinases; Pyrazines; Rats; Sequestosome-1 Protein; Ubiquitin-Protein Ligases

2022
Tetramethylpyrazine ameliorates systemic streptozotocin-induced Alzheimer-like pathology.
    Journal of chemical neuroanatomy, 2023, Volume: 127

    Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hippocampus; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Streptozocin

2023
Tetramethylpyrazine Improves Cognitive Function of Alzheimer's Disease Mice by Regulating SSTR4 Ubiquitination.
    Drug design, development and therapy, 2021, Volume: 15

    Topics: Alzheimer Disease; Animals; Cognition; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrazines; Rats; Receptors, Somatostatin; Tumor Cells, Cultured; Ubiquitination

2021
Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats.
    Current medical science, 2021, Volume: 41, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Hippocampus; Humans; Hyperhomocysteinemia; Memory Disorders; Neurons; Neuroprotective Agents; Phosphorylation; Pyrazines; Rats; Rats, Sprague-Dawley

2021
Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3β.
    Acta biochimica et biophysica Sinica, 2017, Aug-01, Volume: 49, Issue:8

    Topics: Alzheimer Disease; Animals; Glycogen Synthase Kinase 3; Hippocampus; Injections, Intraventricular; Learning; Male; Memory; Memory Disorders; Neurons; Neuroprotective Agents; Pyrazines; Rats, Wistar; Streptozocin

2017
Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids.
    European journal of medicinal chemistry, 2018, Mar-25, Volume: 148

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cholinesterase Inhibitors; Humans; Hydroxybenzoates; Models, Molecular; PC12 Cells; Pyrazines; Rats; Tacrine

2018
Synthesis and biological evaluation of new tetramethylpyrazine-based chalcone derivatives as potential anti-Alzheimer agents.
    Chemical biology & drug design, 2018, Volume: 92, Issue:5

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Survival; Chalcones; Drug Design; Humans; Inhibitory Concentration 50; Monoamine Oxidase; PC12 Cells; Protective Agents; Pyrazines; Rats; Structure-Activity Relationship

2018
A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine.
    Journal of molecular neuroscience : MN, 2015, Volume: 56, Issue:4

    Topics: Alzheimer Disease; Animals; Antioxidants; Cells, Cultured; Hydrazones; Mice; Neurons; Neuroprotective Agents; PC12 Cells; Pyrazines; Rats; Rats, Sprague-Dawley

2015
Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.
    Drug development and industrial pharmacy, 2012, Volume: 38, Issue:6

    Topics: Administration, Cutaneous; Alkaloids; Alzheimer Disease; Animals; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Therapy, Combination; Emulsions; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Skin Absorption; Time Factors; Transdermal Patch; Vasodilator Agents

2012
Ligustrazine phosphate ethosomes for treatment of Alzheimer's disease, in vitro and in animal model studies.
    AAPS PharmSciTech, 2012, Volume: 13, Issue:2

    Topics: Acrylic Resins; Administration, Cutaneous; Alzheimer Disease; Amnesia; Animals; Antioxidants; Behavior, Animal; Brain; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Escape Reaction; Ethanol; Glutathione Peroxidase; Lipid Peroxidation; Male; Malondialdehyde; Memory; Mice; Mice, Inbred ICR; Mice, Nude; Microscopy, Confocal; Permeability; Phosphatidylcholines; Pyrazines; Rats; Rats, Sprague-Dawley; Reaction Time; Scopolamine; Skin; Skin Absorption; Superoxide Dismutase; Technology, Pharmaceutical; Time Factors

2012
Protective effect of tetramethylpyrazine on learning and memory function in D-galactose-lesioned mice.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2004, Volume: 19, Issue:3

    Topics: Alzheimer Disease; Animals; Galactose; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Pyrazines; Receptors, Muscarinic

2004
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