tetrahydroneopterin and Foot-Diseases

The therapeutic potency of 5,6,7,8-tetrahydroneopterin (NPH4) was investigated in ischemic paw edema, Adriamycin (ADR)-induced cardiotoxicity, and endotoxin [lipopolysaccharide (LPS)]- and carbon tetrachloride (CCl4)-induced hepatotoxicity in mice. Ischemic paw edema was completely suppressed by pre-administration of NPH4. ADR-induced cardiotoxicity and LPS-induced hepatotoxicity were significantly decreased by post-administration of NPH4. Furthermore, NPH4 ameliorated CCl4-induced hepatotoxicity. These results suggest that NPH4 may be useful for the treatment of free radical, especially superoxide radical, -related tissue injury.

Topics: Animals; Biopterins; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Doxorubicin; Edema; Foot; Foot Diseases; Forelimb; Free Radical Scavengers; Free Radicals; Hindlimb; Ischemia; Lipopolysaccharides; Liver Diseases; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Myocardial Ischemia; Superoxides