tetrahydrocortisol has been researched along with Intraocular Pressure in 4 studies
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effectiveness of 3 alpha, 5 beta-tetrahydrocortisol (3 alpha, 5 beta-THF), a metabolite of cortisol, in lowering intraocular pressure (IOP) in rabbits made ocular hypertensive with glucocorticoids suggested its use in patients with Primary Open Angle Glaucoma (POAG)." | 3.69 | Treatment of glaucoma with 3 alpha, 5 beta-tetrahydrocortisol: a new therapeutic modality. ( Gordon, GG; Southren, AL; Wandel, T; Weinstein, BI, 1994) |
| "Tetrahydrocortisol was unable to inhibit the dexamethasone (DEX)-induced systemic hypertension and decrease in body mass in rats and was unable to displace 3H-DEX from the soluble human glucocorticoid receptor." | 3.69 | Inhibition of dexamethasone-induced cytoskeletal changes in cultured human trabecular meshwork cells by tetrahydrocortisol. ( Clark, AF; Lane, D; McCartney, MD; Miggans, ST; Wilson, K, 1996) |
| "3 alpha, 5 beta-tetrahydrocortisol, previously considered an inactive metabolite of cortisol, was found to lower significantly the intraocular pressure (IOP) of rabbits made ocular hypertensive with dexamethasone alone or with threshold levels of dexamethasone plus 5 beta-dihydrocortisol." | 3.67 | Intraocular hypotensive effect of a topically applied cortisol metabolite: 3 alpha, 5 beta-tetrahydrocortisol. ( Gordon, GG; l'Hommedieu, D; Southren, AL; Weinstein, BI, 1987) |
| " Fluorometholone and tetrahydrocortisol seem to have neither toxicity to the retina nor adverse effect of elevating intraocular pressure when intravitreally injected with this amount." | 1.28 | [Retinal toxicity of intravitreally injected steroids on the rabbit eye]. ( Ishii, Y; Kamei, M; Nakazawa, F; Sakai, H; Shirasawa, E; Tano, Y, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Southren, AL | 2 |
| Wandel, T | 1 |
| Gordon, GG | 2 |
| Weinstein, BI | 2 |
| Clark, AF | 1 |
| Lane, D | 1 |
| Wilson, K | 1 |
| Miggans, ST | 1 |
| McCartney, MD | 1 |
| Kamei, M | 1 |
| Tano, Y | 1 |
| Sakai, H | 1 |
| Nakazawa, F | 1 |
| Shirasawa, E | 1 |
| Ishii, Y | 1 |
| l'Hommedieu, D | 1 |
4 other studies available for tetrahydrocortisol and Intraocular Pressure
| Article | Year |
|---|---|
Treatment of glaucoma with 3 alpha, 5 beta-tetrahydrocortisol: a new therapeutic modality.
Topics: Administration, Topical; Aged; Aged, 80 and over; Animals; Drug Administration Schedule; Female; Gla | 1994 |
Inhibition of dexamethasone-induced cytoskeletal changes in cultured human trabecular meshwork cells by tetrahydrocortisol.
Topics: Actins; Animals; Anti-Inflammatory Agents; Blood Pressure; Body Weight; Cell Line; Cells, Cultured; | 1996 |
[Retinal toxicity of intravitreally injected steroids on the rabbit eye].
Topics: Animals; Fluorometholone; Injections; Intraocular Pressure; Male; Rabbits; Retina; Tetrahydrocortiso | 1992 |
Intraocular hypotensive effect of a topically applied cortisol metabolite: 3 alpha, 5 beta-tetrahydrocortisol.
Topics: Animals; Dexamethasone; Glaucoma, Open-Angle; Humans; Hydrocortisone; Intraocular Pressure; Ocular H | 1987 |