tetragastrin and Atrophy

Spinocerebellar ataxias (SCAs) are a group of genetic diseases characterized by progressive ataxia and neurodegeneration, often in cerebellar Purkinje neurons. A SCA1 mouse model, Pcp2-ATXN1[30Q]D776, has severe ataxia in absence of progressive Purkinje neuron degeneration and death. Previous RNA-seq analyses identify cerebellar upregulation of the peptide hormone cholecystokinin (Cck) in Pcp2-ATXN1[30Q]D776 mice. Importantly, absence of Cck1 receptor (Cck1R) in Pcp2-ATXN1[30Q]D776 mice confers a progressive disease with Purkinje neuron death. Administration of a Cck1R agonist, A71623, to Pcp2-ATXN1[30Q]D776;Cck

Topics: Animals; Ataxin-1; Atrophy; Behavior, Animal; Calbindins; Chemokines, CC; Cholecystokinin; Disease Models, Animal; Female; Genetic Predisposition to Disease; Guanine Nucleotide Exchange Factors; Male; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nerve Degeneration; Neuropeptides; Purkinje Cells; Signal Transduction; Spinocerebellar Ataxias; Tetragastrin

It remains controversial whether or not Helicobacter pylori infection causes altered gastric acid secretion. A novel test for evaluating gastric acid secretion (endoscopic gastrin test; EGT) has recently been developed.. To investigate by EGT the effects of H pylori eradication on the state of gastric acid secretion in patients with peptic ulcer.. Twenty six patients with duodenal ulcer and 33 with gastric ulcer, for all of whom H pylori infection had been documented, were studied by EGT, histological examination of gastric mucosa, and measurement of plasma gastrin levels before and one and seven months after H pylori eradication.. In patients with duodenal ulcer, the mean EGT value before H pylori eradication was higher than that in H pylori negative controls, but it had decreased significantly seven months after the treatment. In contrast, the mean EGT value of patients with gastric ulcer before H pylori eradication was lower than that in H pylori negative controls, but it had increased one month after the treatment; this was followed by a slight decrease at seven months. In both groups, mean EGT values seven months after the treatment were not significantly different from the mean control value.. The reduced acid secretion in gastric ulcer patients and gastric acid hypersecretion in duodenal ulcer patients were both normalised after the clearance of H pylori.

Topics: Adult; Aged; Atrophy; Duodenal Ulcer; Female; Gastric Acid; Gastrins; Gastritis; Gastroscopy; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Stomach Ulcer; Tetragastrin

The relationships of two acid protease groups, alkali labile pepsin (ALP) and alkali stable pepsin (ASP), and gastric mucosal atrophy, were studied. ALP and ASP were determined separately by alkali treatment. The extent of fundic gland atrophy was detected by endoscopic congo red test. The subjects of the study were 10 normal subjects and 64 patients with gastroduodenal disease. In all subjects, both ALP and ASP outputs were increased by tetragastrin administration while ASP:ALP ratio was decreased by the provocation. ALP output was reduced in parallel with the extent of fundic gland atrophy whereas ASP output was kept until the atrophy became severe.

Topics: Adult; Alkalies; Atrophy; Congo Red; Female; Gastric Juice; Gastric Mucosa; Gastrointestinal Diseases; Gastroscopy; Humans; Male; Middle Aged; Pepsin A; Tetragastrin