tetraethylammonium has been researched along with Aura in 15 studies
Tetraethylammonium: A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Aksoz, E | 1 |
| Sara, Y | 1 |
| Onur, R | 1 |
| Kherani, ZS | 1 |
| Auer, RN | 1 |
| SALTER, WT | 1 |
| Rüschenschmidt, C | 2 |
| Köhling, R | 2 |
| Schwarz, M | 1 |
| Straub, H | 2 |
| Gorji, A | 2 |
| Siep, E | 2 |
| Ebner, A | 1 |
| Pannek, HW | 1 |
| Tuxhorn, I | 1 |
| Wolf, P | 1 |
| Speckmann, EJ | 2 |
| Yan, HD | 1 |
| Ishihara, K | 1 |
| Hanaya, R | 1 |
| Kurisu, K | 1 |
| Serikawa, T | 1 |
| Sasa, M | 1 |
| Chinestra, P | 1 |
| Leinekugel, X | 1 |
| Ben Ari, Y | 1 |
| Pollard, H | 1 |
| Fueta, Y | 1 |
| Avoli, M | 1 |
| Thorin, E | 1 |
| Nguyen, TD | 1 |
| Bouthillier, A | 1 |
| Gutschmidt, KU | 1 |
| Stenkamp, K | 2 |
| Buchheim, K | 2 |
| Heinemann, U | 2 |
| Meierkord, H | 2 |
| Bikson, M | 1 |
| Ghai, RS | 1 |
| Baraban, SC | 2 |
| Durand, DM | 1 |
| Jow, F | 1 |
| Wang, K | 1 |
| Castro, PA | 1 |
| Cooper, EC | 1 |
| Lowenstein, DH | 1 |
| Schuchmann, S | 1 |
| Breustedt, J | 1 |
| Windmüller, O | 1 |
| Rutecki, PA | 1 |
| Lebeda, FJ | 1 |
| Johnston, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment Efficacy of 1-Octanol Compared to Placebo in Adults With Essential Tremor[NCT00080366] | Phase 2 | 14 participants | Interventional | 2004-03-31 | Completed | ||
| Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor[NCT00102596] | Phase 2 | 21 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Octanoic Acid is a metabolite of 1-octanol. Blood plasma levels of octanoic acid were measured at 5, 20, 45, 70, 100, 130, 160, 210, 270 and 360 minutes post-dose. (NCT00102596)
Timeframe: 5, 20, 45, 70, 100, 130, 160, 210, 270 and 360 minutes post-dose
| Intervention | ng/ml (Mean) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Plasma Octanoic Acid Level at 5 min post-dose | Plasma Octanoic Acid Level at 20 min post-dose | Plasma Octanoic Acid Level at 45 min post-dose | Plasma Octanoic Acid Level at 70 min post-dose | Plasma Octanoic Acid Level at 100 min post-dose | Plasma Octanoic Acid Level at 130 min post-dose | Plasma Octanoic Acid Level at 160 min post-dose | Plasma Octanoic Acid Level at 210 min post-dose | Plasma Octanoic Acid Level at 270 min post-dose | Plasma Octanoic Acid Level at 360 min post-dose | |
| 64 mg/kg 1-Octanol Cellulose-based (CEL) Formulation | 62.94 | 5064.12 | 7967.97 | 6788.58 | 5701.60 | 5448.23 | 4662.88 | 3179.10 | 2248.74 | 1266.37 |
| 64 mg/kg 1-Octanol Soybean Oil Embedded (SOY) Formulation | 74.16 | 3885.52 | 9645.55 | 13315.26 | 9289.39 | 9605.68 | 6678.69 | 4307.74 | 2618.25 | 872.51 |
(NCT00102596)
Timeframe: 0 minutes, 15 minutes, 100 minutes and 24 hours post-dose
| Intervention | beats per minute (Least Squares Mean) | |||
|---|---|---|---|---|
| Heart Rate at 0 min | Heart Rate at 15 min | Heart Rate at 100 min | Heart Rate at 24 hours | |
| 1-Octanol Dose | 70.8 | 66.6 | 67.1 | 72.4 |
Spirography mean tremor amplitudes were measured in the right hand of each participant at 0, 15, 30, 60, 90, 120, 150, 180, 240 and 360 minutes post-dose. Then, the scores of each participant were normalized (i.e., divided by) by their baseline tremor severity scores so that all scores are expressed as a proportion of the baseline score. Therefore, 1 is the baseline tremor severity, and lower scores indicate tremor reduction. (NCT00102596)
Timeframe: 0, 15, 30, 60, 90, 120, 150, 180, 240 and 360 minutes post-dose
| Intervention | normalized score on a scale (Mean) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Normalized score at 0 minutes | Normalized score at 15 minutes post-dose | Normalized score at 30 minutes post-dose | Normalized score at 60 minutes post-dose | Normalized score at 90 minutes post-dose | Normalized score at 120 minutes post-dose | Normalized score at 150 minutes post-dose | Normalized score at 180 minutes post-dose | Normalized score at 240 minutes post-dose | Normalized score at 360 minutes post-dose | |
| 64 mg/kg 1-Octanol Cellulose-based (CEL) Formulation | 1 | 1.009 | 0.826 | 0.786 | 0.670 | 0.662 | 0.680 | 0.645 | 0.791 | 0.894 |
| 64 mg/kg 1-Octanol Soybean Oil Embedded (SOY) Formulation | 1 | 0.901 | 0.738 | 0.766 | 0.685 | 0.709 | 0.746 | 0.707 | 0.683 | 0.122 |
(NCT00102596)
Timeframe: 0 minutes, 15 minutes, 100 minutes and 24 hours post-dose
| Intervention | ms (Least Squares Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| PR Interval at 0 min | PR Interval at 15 min | PR Interval at 100 min | PR Interval at 24 hours | QTc Interval at 0 min | QTc Interval at 15 min | QTc Interval at 100 min | QTc Interval at 24 hours | |
| 1-Octanol Dose | 168.8 | 172.8 | 171.6 | 168.6 | 433.8 | 436.5 | 433.0 | 437.4 |
15 other studies available for tetraethylammonium and Aura
| Article | Year |
|---|---|
T-type Ca
Topics: Animals; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channels, T-Type; Epilepsy; Long | 2020 |
Pharmacologic analysis of the mechanism of dark neuron production in cerebral cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Artifacts; Biopsy; Brain Ischemia; Cerebral Cortex; D | 2008 |
Therapeutics and toxicology.
Topics: Anemia; Anemia, Pernicious; Antacids; Anti-Bacterial Agents; Arthritis; Arthritis, Rheumatoid; Blood | 1950 |
Characterization of a fast transient outward current in neocortical neurons from epilepsy patients.
Topics: Adolescent; Adult; Anesthetics, Local; Anti-Arrhythmia Agents; Cadmium; Child, Preschool; Epilepsy; | 2004 |
Reduction of human neocortical and guinea pig CA1-neuron A-type currents by organic calcium channel blockers.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Animals; Calcium Channel Blockers; Child; Epilepsy; Fem | 2004 |
Voltage-dependent calcium channel abnormalities in hippocampal CA3 neurons of spontaneously epileptic rats.
Topics: Action Potentials; Animals; Calcium; Calcium Channels; Epilepsy; Fluoresceins; Hippocampus; Membrane | 2007 |
Use of hippocampal slices to study mRNA changes in relation to synaptic plasticity.
Topics: Animals; Base Sequence; DNA-Binding Proteins; Early Growth Response Protein 1; Electric Stimulation; | 1994 |
Tetraethylammonium-induced epileptiform activity in young and adult rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Bicuculline; Dose-Response Relationship, Drug; | 1993 |
Control of vascular tone by endogenous endothelin-1 in human pial arteries.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Arteries; Brain Neoplasms; Cerebral Cortex; Endothelin | 1998 |
Anticonvulsant actions of furosemide in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Calcium; Electric Stimulation; Entorhi | 1999 |
Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity.
Topics: 4-Aminopyridine; Animals; Barium; Calcium; Calibration; Cesium; Electric Stimulation; Epilepsy; Evok | 1999 |
Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity.
Topics: 4-Aminopyridine; Animals; Barium; Calcium; Calibration; Cesium; Electric Stimulation; Epilepsy; Evok | 1999 |
Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity.
Topics: 4-Aminopyridine; Animals; Barium; Calcium; Calibration; Cesium; Electric Stimulation; Epilepsy; Evok | 1999 |
Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity.
Topics: 4-Aminopyridine; Animals; Barium; Calcium; Calibration; Cesium; Electric Stimulation; Epilepsy; Evok | 1999 |
Cloning and functional expression of rKCNQ2 K(+) channel from rat brain.
Topics: Animals; Benzoquinones; Brain Chemistry; Cells, Cultured; Cloning, Molecular; Enzyme Inhibitors; Epi | 2000 |
Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebral Cortex; Choristoma; Delayed Rectifier Potassiu | 2001 |
Synaptic and nonsynaptic ictogenesis occurs at different temperatures in submerged and interface rat brain slices.
Topics: Animals; Body Temperature; Brain; Calcium; Epilepsy; Hippocampus; Hydrogen-Ion Concentration; Magnes | 2002 |
Epileptiform activity in the hippocampus produced by tetraethylammonium.
Topics: Animals; Electric Stimulation; Electrodes; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techni | 1990 |