tetradecanoylphorbol acetate has been researched along with Skin Neoplasms in 1458 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 446 (30.59) | 18.7374 |
| 1990's | 426 (29.22) | 18.2507 |
| 2000's | 336 (23.05) | 29.6817 |
| 2010's | 226 (15.50) | 24.3611 |
| 2020's | 24 (1.65) | 2.80 |
| Authors | Studies |
|---|---|
| Hano, Y; Nomura, T; Okabe, S; Suganuma, M; Takahashi, K | 1 |
| González-Rodríguez, M; Hiihtola, L; Järvinen, TAH; Junttila, IS; Kummola, L; Määttä, J; Parviainen, L; Pemmari, T; Salomaa, T; Salonen, N; Vähätupa, M | 1 |
| Chou, P; Kong, AN; Kuo, HC; Li, S; Phadnis, A; Sargsyan, D; Sarwar, MS; Su, S; Su, X; Wang, L; Wang, Y; Wu, R | 1 |
| Araki, K; Hasegawa, Y; Isogai, E; Okumura, K; Saito, M; Tokunaga, Y; Wakabayashi, Y | 1 |
| Dang, Y; Guo, C; Li, Y; Liang, Y; Liu, M; Shi, Y; Wang, C; Xiang, W; Xu, P; Ye, X; Zhang, X | 1 |
| Ghadi, DS; Joshi, P; Waghmare, SK | 1 |
| Kong, AT; Kuo, HD; Sargsyan, D; Sarwar, MS; Suh, N; Wang, C; Wu, R; Zheng, M | 1 |
| Akira, S; Morisaka, H; Sano, S; Takaishi, M | 1 |
| Chou, P; Dina Kuo, HC; Kong, AN; Mary Peter, R; Ramirez, CN; Sargsyan, D; Sarwar, MS; Shannar, A; Su, X; Wang, Y; Wu, R; Yang, Y; Yin, R | 1 |
| Abd Hamid, R; Md Roduan, MR; Mohtarrudin, N | 1 |
| Dahlhoff, M; Fröhlich, T; Goebeler, M; Hoesl, C; Hundt, JE; Kneitz, H; Schneider, MR; Wolf, R | 1 |
| Alex, VV; Anto, RJ; Bava, SV; Chittalakkottu, S; Nisthul A, A; Retnakumari, AP; Shankar G, M; Sundaram, S | 1 |
| Järvinen, TAH; Junttila, I; Pemmari, T; Pesu, M; Vähätupa, M | 1 |
| Cai, H; Hua, Z; Huang, H; Shi, J; Wei, Y; Zhang, L | 1 |
| Bauer, J; Becker, M; Hahn, H; König, S; Müllen, A; Pyczek, J; Rabe, H; Schön, MP; Uhmann, A | 1 |
| Hudlikar, RR; Kong, AN; Sargsyan, D; Su, S; Wu, R; Zheng, M | 1 |
| Furukawa, F; Ishida, Y; Kimura, A; Kondo, T; Kuninaka, Y; Mukaida, N; Nosaka, M; Yamamoto, Y | 1 |
| Hu, X; Wang, L; Zhang, L; Zhang, T | 1 |
| Kreft, M; Krotenberg Garcia, A; Ramovs, V; Sonnenberg, A | 1 |
| Al Matouq, J; Bloom, C; Hansen, LA; Holmes, M; Holmes, TR; Lovas, S; Madson, JG; Nicola, L; Palermo, NY; Rudd, JC; Sioda, N | 1 |
| Athar, M; Elmets, CA; Nasti, TH; Sherwani, MA; Timares, L; Yusuf, N | 1 |
| Casbolt, LS; Combes, V; Das, A; Dixon, KM; Hua, S; Hung, TT; Lai, D; Laos, AJ; Laxman, P; Mason, RS; McRae, CR; Menounos, S; Shariev, A; Smith, G; Thordarson, P; Zinger, A | 1 |
| Chiou, YS; Chou, PY; Ho, CT; Lee, PS; Nagabhushanam, K; Pan, MH | 1 |
| Brakebusch, C; Li, H | 1 |
| Aida, E; Hara, S; Kamei, D; Kuwata, H; Nakatani, Y; Ochiai, T; Sasaki, Y | 1 |
| Bajpai, D; Brooks, SR; Cataisson, C; Hasneen, K; Inoue, Y; Kellett, M; Mehdizadeh, S; Morasso, MI; Motegi, SI; Overmiller, A; Palazzo, E; Sawaya, A; Uchiyama, A; Yuspa, SH | 1 |
| Aird, KM; Buj, R; Chen, CW; Dahl, ES; Hobbs, RP; Imamura-Kawasawa, Y; Kossenkov, AV; Leon, KE; Lesko, E; Tangudu, NK | 1 |
| Baek, M; DiGiovanni, J; Jang, IS; Kim, DJ; Kim, M; Lee, H; Morales, LD; Slaga, TJ | 1 |
| Callejas-Valera, JL; Cimas, FJ; Fernandez-Aroca, DM; Garcia-Gil, E; García-Olmo, DC; Gutkind, JS; Hernández-Losa, J; Marcos, P; Melgar-Rojas, P; Ortega-Muelas, M; Pascual-Serra, R; Ramón Y Cajal, S; Roche, O; Ruiz-Hidalgo, MJ; Sanchez-Prieto, R | 1 |
| Chugh, NA; Kaur, N; Koul, A | 1 |
| Anguish, LJ; Coonrod, SA; Horibata, S; McElwee, JL; McLean, D; Mohanan, S; Mukai, C; Sams, K; Yan, A | 1 |
| Hamid, RA; Md Roduan, MR; Mohtarrudin, N; Sulaiman, H | 1 |
| Patial, V; Sharma, S; Sk, UH | 1 |
| Aguilar-Pimentel, JA; Beck, PJ; Fuchs, H; Gailus-Durner, V; Garman, KA; Hrabe de Angelis, M; Lee, YG; Ollert, M; Riegel, AT; Schmidt, MO; Schmidt-Weber, C; Tan, M; Tassi, E; Wellstein, A; Zuo, C | 1 |
| Hongbo, T; Wu, M; Wu, Y; Xu, Y; Zeng, N | 1 |
| Jeong, WS; Kong, AN; Truong, VL | 1 |
| Liu, P; Wang, D | 1 |
| Faustino-Rocha, AI; Ferreira, L; Ferreira, R; Gama, A; Neuparth, MJ; Oliveira, PA; Rodrigues, D; Vitorino, R | 1 |
| Ahn, JS; Cha-Molstad, H; Choi, TW; Han, HJ; Hong, JT; Hwang, J; Kim, BY; Kim, HJ; Kwon, YT; Lee, HG; Lee, KH; Lee, Y; Mun, J; Soung, NK | 1 |
| Cleary, MP; Hao, J; Landers, VD; Li, B; Li, Q; Liu, L; Mandal, A; Morris, RJ; Rao, E; Sun, Y; Suttles, J; Zeng, J; Zhang, Y | 1 |
| Cao, M; Fang, M; Guo, Y; Kong, AN; Su, ZY; Wu, R; Yang, I; Yang, Y | 1 |
| Kong, YH; Xu, SP | 1 |
| Bai, F; Hofbauer, GFL; Mi, J; Michel-Dziunycz, PJ; Qin, J; Tommasi di Vignano, A; Wu, X; Zhou, Q; Zu, T | 1 |
| Chakraborty, B; Das, B; Ghosh, SK; Nath, A; Pal, R; Sengupta, M; Singh, LM | 1 |
| Balmain, A; Del Rosario, R; Harris, S; Kandyba, E; Reeves, MQ | 1 |
| Balaiya, V; Johnson, LK; Koster, MI; Lakshmanachetty, S | 1 |
| Boutros, M; Cano, A; Géraud, C; Kober, KI; Martin, A; Mobasseri, SA; Philippeos, C; Pisco, AO; Rognoni, E; Salvador, F; Santos, V; Sipilä, K; Stannard, A; Watt, FM | 1 |
| Carson, DA; Li, S; Liu, SS; Lu, D; Song, J; Su, Z; Sun, Q; Wang, Z; Wei, L; Xia, Y; Yu, S; Zhao, L; Zhou, L | 1 |
| Ha Thi, HT; Hong, S; Kim, HY; Kim, SJ; Lee, YJ | 1 |
| Arimoto-Kobayashi, S; Fujii, N; Hatano, T; Kamiya, T; Negishi, T; Suzuki, T; Tanimoto, Y | 1 |
| Hall, JR; House, JS; Jima, DD; Messenger, ZJ; Smart, RC; Tam, HW; Tokarz, DA | 1 |
| DiGiovanni, J; Rho, O; Slaga, TJ; Tremmel, L | 1 |
| Asfaha, S; Boland, K; Gordon, D; Jin, G; Johnson, K; Lad, S; Londono, D; Morris, RJ; Park, H; Patterson, KS; Readio, N; Singh, A; Trempus, C; Wang, TC; Yang, X | 1 |
| Banu, N; Bilal, N; Hasan, S; Suhail, N | 1 |
| Gubareva, EA; Maidin, MA; Panchenko, AV; Tyndyk, ML; Vinogradova, LA | 1 |
| Al Habeeb, A; Bai, X; Cho, HR; Liu, M; Lu, C; Post, A; Wang, Y; Xiang, YY | 1 |
| Kong, AN; Li, S; Raskin, I; Sargsyan, D; Su, S; Wang, C; Wu, R; Yin, R; Zheng, M | 1 |
| Hara, T; Kageyama, Y; Kawabe, M; Mera, Y; Suguro, M; Tsutsumi, H; Urano, K | 1 |
| Kong, AN; Kuo, HD; Li, S; Wu, R; Yang, AY | 1 |
| Ishibashi, T; Maoka, T; Ohmori, A; Osawa, A; Shindo, K; Suzuki, N; Tokuda, H; Yasui, H | 1 |
| Ahmed, SA; Fahmy, H; Ichiishi, E; Iida, A; Khalifa, S; Suzuki, N; Szymanski, PT; Tokuda, H | 1 |
| Arimoto-Kobayashi, S; Kamiya, T; Negishi, T; Okamoto, G; Yuhara, Y; Zhang, X | 1 |
| Colombo, D; Gagliardi, C; Konoshima, T; Ronchetti, F; Suzuki, N; Takasaki, M; Tokuda, H; Vetro, M | 1 |
| Furukawa, F; Kawabe, M; Numano, T; Suguro, M; Taguchi, F; Tsutsumi, H; Urano, K | 1 |
| Amaral, L; Engi, H; Hamilton, G; Hohmann, J; Maoka, T; Molnar, J; Mucsi, I; Olszewski, U; Suzuiki, N; Tokuda, H; Vasas, A | 1 |
| Cescon, D; Chio, II; Dominguez-Brauer, C; Elia, AJ; Ghazarian, D; Gorrini, C; Haight, J; Hao, Z; Harris, IS; Inoue, S; Itsumi, M; Li, WY; Mak, TW; McCracken, S; Melino, G; Penn, LJ; Sasaki, M; Silvester, J; Snow, B; Ueda, T; Wakeham, A; Yamamoto, K; You-Ten, A; Zhou, L | 1 |
| Arora, N; Bansal, MP; Koul, A | 4 |
| Sachs, N; Secades, P; Song, JY; Sonnenberg, A; van Hulst, L | 1 |
| Hong, JI; Jung, BG; Kim, TH; Ko, JH; Lee, BJ; Lee, JA; Park, YS | 1 |
| Hanausek, M; Junco, JJ; Kowalczyk, MC; Kowalczyk, P; Slaga, TJ; Tolstykh, O; Walaszek, Z | 1 |
| Nakae, D; Nakajima, J; Yasukawa, K | 1 |
| Ichiishi, E; Iida, A; Kapadia, GJ; Konoshima, T; Rao, GS; Sridhar, R; Suzuki, N; Takasaki, M; Tokuda, H | 1 |
| Hanausek, M; Junco, JJ; Kowalczyk, MC; Kowalczyk, P; Slaga, TJ; Sosnowska, R; Tolstykh, O; Walaszek, Z | 1 |
| Chen, L; Ghosh, S; Hayden, MS; Jimi, E; Pentland, AP; Poligone, B | 1 |
| Greenhalgh, DA; Macdonald, FH; Quinn, JA; Yao, D | 1 |
| DiGiovanni, J; Jiang, G; Kiguchi, K; Rho, O | 1 |
| Fujiwara, K; Ghosh, S; Liang, P; Morien, E; Nagase, H; Soma, M | 1 |
| Ahn, JS; Bode, AM; Choi, TW; Dong, Z; Erikson, RL; Huang, Z; Hwang, J; Jang, JH; Kim, BY; Lee, KW; Li, W; Liu, H; Liu, K; Ryoo, IJ; Thimmegowda, NR; Yang, Y; Zhou, X | 1 |
| Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O | 1 |
| Chen, LH; Ho, CT; Ho, YS; Hsieh, SC; Hsu, CH; Lai, CS; Lin, E; Pan, MH | 1 |
| Antsiferova, M; Feyerabend, TB; Förster, A; Hartmann, K; Hohl, D; Huber, M; Martin, C; Rodewald, HR; Werner, S | 1 |
| Chen, X; Fagin, JA; Johnson, LK; Knauf, JA; Makarewicz, JM | 1 |
| Ho, CT; Lai, CS; Pan, MH; Tsai, ML; Weerawatanakorn, M; Yang, JR | 1 |
| Ali, F; Khan, AQ; Khan, R; Lateef, MA; Maqbool, T; Sultana, S | 1 |
| Baban, B; Chandler, P; DuHadaway, JB; Keough, MP; Mandik-Nayak, L; Mellor, AL; Merlo, LM; Metz, R; Muller, AJ; Pigott, E; Prendergast, GC; Rust, S; Smith, C | 1 |
| Blankenstein, T; Bozrova, SV; Chashchina, AA; Drutskaya, MS; Kammertoens, T; Nedospasov, SA; Qin, Z; Quarcoo, D; Rothe, M | 1 |
| Hogg, N; McNeill, E | 1 |
| He, YY; Ming, M; Qiang, L; Zhao, B | 1 |
| Conney, AH; Khor, TO; Kong, AN; Lee, JH; Lu, YP; Shu, L; Su, ZY; Wu, TY; Zhang, C | 1 |
| Maurer, M; Metz, M; Siebenhaar, F | 1 |
| Abel, EL; Beltran, L; Bozeman, R; Cheng, T; DiGiovanni, J; Macias, E | 1 |
| Cline, JM; Endo, Y; Fonseca, LL; Ji, J; Lorenzo, PS; Rajani, C; Ramos, JW; Sharma, A; Stone, JC; Yanagida, JK | 1 |
| Chawsheen, HA; Colburn, NH; Gerard, M; Jiang, H; Mishra, M; Toledano, MB; Wei, Q; Wu, L; Young, MR | 1 |
| Becker, K; Kaina, B; Thomas, AD | 1 |
| Christiansen, H; Dittmann, K; Frommhold, A; Hahn, H; Heß, I; König, S; Lühder, F; Nitzki, F; Reifenberger, J; Schulz-Schaeffer, W; Uhmann, A; Zabel, S | 1 |
| Chen, W; Fan, F; Liu, Y; Liu, Z; Lu, Y; Pei, C; Ruan, J; Shan, Y; Shen, C; Tao, L; Tian, C; Wang, A; Wang, S; Wu, H; Zheng, S; Zhou, L | 1 |
| Guo, S; He, X; Lan, H; Lan, T; Li, J; Li, W; Qi, C; Wang, L; Wei, P; Yang, Y; Ye, J; Zhang, Q | 1 |
| Cipolat, S; Hoste, E; Natsuga, K; Quist, SR; Watt, FM | 1 |
| Argade, A; Chatterjee, A; Deshpande, SS; Jain, MR; Mohapatra, J; Shah, GB; Sharma, M | 1 |
| Aoto, Y; Goitsuka, R; Hachiya, T; Hirose, S; Isogai, E; Katsuragi, Y; Kominami, R; Nakamura, T; Okumura, K; Saito, M; Sakakibara, Y; Wakabayashi, Y | 1 |
| García-Fernández, RA; García-Iglesias, MJ; Pérez-Martínez, C | 1 |
| Catapang, A; Dennis, EA; Dumlao, DS; Fischer, SM; Herschman, HR; Ishikawa, TO; Jiao, J; Magyar, CE; Mikulec, C; Norris, PC | 1 |
| Hart, RP; Huang, MT; Huang, Y; Kong, AN; Lee, JH; Lu, Y; Pung, D; Ramirez, C; Shu, L; Su, ZY; Verzi, M; Yang, AY; Zhang, C | 1 |
| Asano, R; Iizuka, H; Nakae, Y; Nakajima, S; Ogasawara, K; Sakata, I; Takahashi, H | 1 |
| Becker, JC; Zur Hausen, A | 1 |
| Baybutt, R; Chen, J; Jiang, Y; King, B; Lu, L; Standard, J; Su, X; Tomich, J; Wang, W; Xu, J; Yu, M; Zhao, Z | 1 |
| Aggarwal, V; Monga, J; Nongalleima, K; Sharma, M; Suthar, SK | 1 |
| Bryant, CJ; Caddye, E; Caunt, CJ; Davidson, J; Delavaine, L; East, P; Keyse, SM; Kidger, AM; Rushworth, LK; Stewart, G; van Schelven, S | 1 |
| Bernabéu, C; del Castillo, G; Langa, C; Martín-Villar, E; Pérez-Gómez, E; Quintanilla, M; Renart, J; Sánchez-Blanco, E; Valbuena-Diez, AC | 1 |
| Naseem, I; Salman, M | 1 |
| Amberg, N; Glitzner, E; Holcmann, M; Novoszel, P; Sibilia, M; Stulnig, G | 1 |
| Celis, E; Condamine, T; Donthireddy, L; Gabrilovich, D; Knight, SC; Kumar, V; Lee, GH; Lenox, B; Luetteke, N; Malietzis, G; Martner, A; Mony, S; Moorghen, M; Ortiz, ML; Seykora, J | 1 |
| Fuchs, E; Oristian, D; Oshimori, N | 1 |
| Carr, TD; Feehan, RP; Hall, MN; Rüegg, MA; Shantz, LM | 1 |
| Anders, J; Blumenberg, M; Cataisson, C; Efimova, T; Kiss, A; Koppel, AC; Yuspa, SH | 1 |
| Athar, M; Cochran, JB; Elmets, CA; McKay, KM; Nasti, TH; Timares, L; Tsuruta, Y; Yusuf, N | 1 |
| Fartasch, M; Meischner, V; Schwarz, M; Thielmann, HW | 1 |
| Chen, C; Fan, F; Lin, C; Liu, Y; Liu, Z; Lu, Y; Shen, C; Sun, L; Tao, Y; Wang, A; Wang, S; Wei, Z; Wu, H; Zhao, L; Zhu, P; Zhu, Z | 1 |
| Hall, RP; He, Y; Huang, Q; Kato, TA; Li, CY; Li, F; Liu, X | 1 |
| Brady, M; Brennan-Crispi, DM; Hossain, C; Mahoney, MG; Riobo, NA; Sahu, J | 1 |
| Akihisa, M; Akihisa, T; Ebina, K; Feng, F; Kurita, M; Masters, ET; Shimizu, N; Tokuda, H; Ukiya, M; Yasukawa, K; Zhang, J | 1 |
| Amjad, A; Cai, X; Chen, H; Chen, T; Dang, Y; Fu, J; Gao, X; He, J; Huang, Q; Ji, L; Jiang, Z; Jing, T; Li, K; Li, L; Li, X; Liu, J; Liu, T; Moses, RE; Shi, K; Song, D; Tong, L; Xiao, J; Xu, W; Yan, W; Yang, C; Yang, X; Yao, L; Zhai, W; Zhang, J | 1 |
| Cao, Y; Chen, C; Fan, F; Lin, C; Liu, Z; Lu, Y; Shan, Y; Shen, C; Sun, L; Tao, Y; Wang, A; Wang, S; Wei, Z; Wu, H; Zheng, S; Zhu, P | 1 |
| DiGiovanni, J; Rho, O; Srivastava, J; Youssef, RM | 1 |
| Carbajal, S; Cho, J; DiGiovanni, J; Junco, J; Rho, O; Siegel, D; Slaga, TJ | 1 |
| Järvinen, TA; Laitinen, AM; May, U; Nieminen, K; Prince, S; Uusitalo-Järvinen, H; Vähätupa, M | 1 |
| Bao, R; Bechill, J; Bindokas, VP; Faber, PW; Lingen, MW; Spiotto, MT; Zhong, R | 1 |
| Bratton, SB; Cho, J; Dao, CK; DiGiovanni, J; Fischer, SM; Kohno, S; Lago, CU; Lee, S; Mills, EM; Nikawa, T; Nowinski, SM; Rho, O; Riley, CL; Rundhaug, JE; Solmonson, A; Wright, CW | 1 |
| Beck, A; Fletcher, S; Goldstein, J; Horsley, V; Lin, S; Roberts, N; Roth, E; Suárez-Fariñas, M; Tadeu, A; Wu, C; Zeiss, C; Zwick, R | 1 |
| Camelio, AM; Cho, J; DiGiovanni, J; Rho, O; Siegel, D; Slaga, TJ; Tremmel, L | 1 |
| Bauer, SJ; Havighurst, TC; Kim, K; Singh, A; Verma, AK; Wheeler, DL | 1 |
| Abdul Hamid, R; Khaza'ai, H; Mohtarrudin, N; Saiful Yazan, L; Yeong, LT | 1 |
| de Gruijl, F; Rebel, H; Tensen, K; van de Glind, G; van Kempen, M | 1 |
| Fukushima, K; Fukushima, N; Honoki, K; Takahashi, K; Tsujiuchi, T | 1 |
| Cataisson, C; Dubois, W; Dwyer, J; Hoover, S; Klosterman, M; Liu, F; Merlino, G; Michalowski, AM; Rodrigues, KB; Ryscavage, A; Shibuya, K; Simpson, MR; Wright, L; Yuspa, SH; Zhuang, A | 1 |
| Cho, J; DiGiovanni, J; Rho, O; Srivastava, J | 1 |
| Hermeking, H; Lodygin, D; Verdoodt, B; Winter, M | 1 |
| Garg, ML; Koul, A; Mohanty, BP; Sati, J | 1 |
| Baderca, F; Borcan, F; Coricovac, D; Danciu, C; Dehelean, CA; Pavel, I; Pinzaru, I; Soica, C; Spandidos, DA; Tsatsakis, AM | 1 |
| Hu, YQ; Wang, J; Wu, JH | 1 |
| Alitalo, K; Harjunen, V; Heljasvaara, R; Holopainen, T; Honkanen, HK; Izzi, V; Petäistö, T; Pihlajaniemi, T | 1 |
| Balmain, A; Del Rosario, R; Ginzinger, D; Halliwill, KD; Kang, HC; Quigley, DA | 1 |
| Dai, X; Dang, Y; Gu, J; Liu, M; Liu, X; Ren, X; Wang, L; Xu, P; Ye, X | 1 |
| Berx, G; Declercq, W; Denecker, G; Devos, M; Gilbert, B; Haigh, J; Hochepied, T; Lambert, J; Lemeire, K; Leurs, K; Libbrecht, L; Lippens, S; Mc Guire, C; Van Den Broecke, C; Vandenabeele, P; Vuylsteke, M | 1 |
| Asai, M; Asai, N; Enomoto, A; Kato, T; Mii, S; Murakumo, Y; Nagino, M; Shiraki, Y; Sunagawa, M; Takahashi, M | 1 |
| Bodman-Smith, K; Boukamp, P; Daher, CF; El-Sibai, M; Mroueh, MA; Shebaby, WN; Taleb, RI | 1 |
| Afaq, F; Mukhtar, H; Sarfaraz, S; Siddiqui, IA; Syed, DN | 1 |
| Bility, MT; Blazanin, N; Devlin-Durante, MK; Glick, AB; Gonzalez, FJ; Kang, BH; Kennett, MJ; Peters, JM; Ward, JM | 1 |
| Davidson, B; Flørenes, VA; Jørgensen, K; Rosnes, AK; Skrede, M; Slipicevic, A; Trøen, G | 1 |
| Chen, JS; Chiu, HC; Chu, CY; Dai, YS; Inoue, H; Jee, SH; Kuo, ML; Liao, YH; Lin, SJ; Shun, CT; Tjiu, JW; Tsai, TF; Yang, PC | 1 |
| Cannon, RE; Diwan, BA; Germolec, DR; Liu, J; Tennant, RW; Tokar, EJ; Trempus, CS; Waalkes, MP; Ward, JM | 1 |
| Chandler, PR; Duhadaway, JB; Everhart, ME; Johnson, BA; Kahler, DJ; Mellor, AL; Muller, AJ; Munn, DH; Pihkala, J; Prendergast, GC; Sharma, MD; Soler, AP | 1 |
| Hori, Y; Iigo, M; Imai, T; Kitahashi, T; Sugimura, T; Takahashi, M; Takasuka, N; Wakabayashi, K; Yoshimi, N | 1 |
| Anders, J; Berry, A; Cataisson, C; Flores-Obando, RE; Hansen, LA; Lo, YC; Patel, R; Strain, K; Virador, VM; Yuspa, SH; Zakhari, J | 1 |
| Ashton, GH; Baldeschi, C; Brunton, VG; Canel, M; Doyle, B; Frame, MC; Green, TP; Mackintosh, LJ; Mason, SM; Sansom, OJ; Serrels, A; Serrels, B | 1 |
| Karibasappa, GS; Pakhale, SS; Ramchandani, AG | 1 |
| Cataisson, C; Hennings, H; Jay, S; Ohman, R; Patel, G; Pearson, A; Tsien, M; Wright, L; Yuspa, SH | 1 |
| Bode, AM; Cho, YY; Dong, Z; Ericson, ME; Ma, WY; Yao, K; Zheng, D; Zhu, F | 1 |
| Katiyar, SK; Meeran, SM; Punathil, T; Vaid, M | 1 |
| Alam, MS; Athar, M; Chaudhary, SC; Siddiqui, MS | 3 |
| Fujiki, H; Suganuma, M | 1 |
| Li, Z; Qin, Z; Wang, C; Xiao, M; Zhang, J; Zhao, X | 1 |
| Arbeit, JM; Kladney, RD; Martin, RJ; Neumann, RG; Scortegagna, M | 1 |
| Bhui, K; George, J; Prasad, S; Shukla, Y | 1 |
| Abdul-Karim, FW; Fu, W; Gibbons, HE; Gorodeski, GI; Li, X; Luo, L; McCormick, T; Qi, X; Wang, BC; Zhou, L | 1 |
| Barragan, DI; Charron, J; Dumesic, PA; Harada, K; Khavari, PA; Scholl, FA | 1 |
| Asano, R; Iizuka, H; Nakae, Y; Nakajima, S; Sakata, I; Takahashi, H | 2 |
| Colburn, NH; Hou, DX; Murakami, A; Nishizawa, T; Ohigashi, H; Tanaka, T; Yasuda, M | 1 |
| Cheepala, SB; Clifford, JL; Cvek, U; Gill, JN; Kleiner, HE; Loganantharaj, R; Lynch, M; McMillian, A; Syed, Z; Trutschl, M; Yin, W | 1 |
| Glick, A; Moitra, J; Orosz, A; Rishi, V; Rozenberg, J; Vinson, C | 1 |
| Arthur, JS; Burns, CJ; Efimova, T; Gribben, EL; Hindes, A; Kissling, GE; Lin, MH; Longmore, GD; Owen, RJ; Schindler, EM; Yin, Y | 1 |
| Boily, G; He, XH; Jardine, K; McBurney, MW; Pearce, B | 1 |
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| Fischer, SM; Kim, E; Pavone, A; Rundhaug, JE | 1 |
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| Beltran, L; Digiovanni, J; Lu, J; Rho, O; Wilker, E | 1 |
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| Angel, P; Arnold, B; Bierhaus, A; Durchdewald, M; Enk, A; Fürstenberger, G; Gebhardt, C; Hess, J; Müller-Decker, K; Nawroth, PP; Németh, J; Riehl, A | 1 |
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| Gu, X; Liu, J; St Clair, DK; Zhao, Y | 1 |
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| Iversen, OH | 6 |
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| Klein-Szanto, AJ; Nelson, KG; Shah, Y; Slaga, TJ | 1 |
| Bhide, SV; Munir, KM; Rao, KV | 1 |
| Fischer, SM; Mills, GD; Slaga, TJ | 2 |
| Pashko, LL; Rovito, RJ; Schwartz, AG; Sobel, EL; Williams, JR | 1 |
| Ashendel, CL; Boutwell, RK; Takigawa, M; Verma, AK | 1 |
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| Kriegel, H; Schmahl, W; Senft, E | 1 |
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| Albert, RE; Burns, FJ | 1 |
| Eisinger, M; Greenebaum, E; Nicolaides, M; Vogel, RH; Weinstein, IB | 1 |
| Davidson, K; Mamrack, M; Nelson, K; Reiners, J; Slaga, T | 1 |
| Graff, DE; Miller, RE; O'Connell, JF; Pitt, JF; Weiss, HS | 1 |
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| Nesnow, S; Reiners, JJ; Slaga, TJ | 1 |
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| Bernfeld, P; Homburger, F | 1 |
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| Astrup, EG; Iversen, OH | 2 |
| Goerttler, K; Hesse, B; Loehrke, H; Schweizer, J | 6 |
| Klein-Szanto, AJ; Mamrack, MD; Reiners, JJ; Slaga, TJ | 1 |
| Aizu, E; Kato, R; Nakadate, T; Yamamoto, S | 7 |
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| Fürstenberger, G; Goerttler, K; Kinzel, V; Loehrke, H; Marks, F | 1 |
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| Fürstenberger, G; Marks, F | 4 |
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| Fischer, SM; Gleason, GL; Nelson, K; Slaga, TJ | 1 |
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| Donahoe, R; Ferguson, E; Geusz, S; Hennings, H; Spangler, EF; Wenk, M; Yuspa, SH | 1 |
| Ashendel, CL; Astrup, E; Boutwell, RK; Verma, AK | 1 |
| Berry, DL; Bertsch, S; Fürstenberger, G; Marks, F; Richter, H | 1 |
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| Goerttler, K; Hecker, E; Hesse, B; Loehrke, H; Schweitzer, J; Seip, H | 1 |
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| Herrmann, AL; Nelson, FR; Slaga, TJ; Weeks, CE | 1 |
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| Agarwal, R; Katiyar, SK; Korman, NJ; Mukhtar, H; Rupp, CO | 1 |
| Jiang, H; Kato, R; Nishikawa, K; Yamamoto, S | 1 |
| Aliyakparova, LM; Anisimov, VN; Vorobtsova, IE | 1 |
| Clifford, A; Gilmour, S; Morgan, D; Soler, AP; Yuspa, SH | 1 |
| Conti, CJ; Robles, AI | 1 |
| Iwashima, A; Konoshima, T; Kozuka, M; Nishino, H; Takasaki, M; Tokuda, H; Yoneyama, K; Yoshida, S | 1 |
| Ben-Ari, ET; Bernstein, LR; Birrer, MJ; Colburn, NH; Watts, RG; Wendel, E; Winterstein, D | 1 |
| Butler, AP; Kang, DC; Kennard, MD; Montgomery, RL | 1 |
| Fürstenberger, G; Marks, F; Müller-Decker, K; Scholz, K | 1 |
| Fischer, SM; Maldve, RE | 1 |
| Barth, H; Fürstenberger, G; Gschwendt, M; Kittstein, W; Kleinschroth, J; Leibersperger, H; Lindner, D; Marmé, D; Rudolph, C; Schächtele, C | 1 |
| Kopp-Schneider, A; Portier, CJ | 2 |
| Fürstenberger, G; Kopp-Schneider, A | 1 |
| Chang, MC; Lee, MJ; Lin, JK; Wang, CJ | 1 |
| Dwivedi, C; Tabbert, J | 1 |
| Barnes, S; Bowen, R; Cai, Q; Wang, Y; Wei, H | 1 |
| Eppley, RM; Hines, FA; Lambert, LA | 1 |
| Hansen, LA; Tennant, R | 1 |
| Balmain, A; Bremner, R; Kemp, CJ | 1 |
| Iwashima, A; Kasai, R; Konoshima, T; Kozuka, M; Nie, RL; Nishino, H; Takasaki, M; Tanaka, O; Tatsumoto, T; Tokuda, H | 1 |
| Boukamp, P; Fitzgerald, DJ; Fusenig, NE; Mesnil, M; Piccoli, C; Yamasaki, H | 1 |
| Asanoma, M; Kawazoe, Y; Miyabe, M; Mori, H; Takahashi, K; Yamamoto, K; Yoshimi, N | 1 |
| Hill, DL; Hosmer, CA; Riordan, JM; Rogers, TS; Shealy, YF; Wille, JW | 1 |
| Kakar, SS; Roy, D | 1 |
| Anderson, J; Barnett, T; Birt, DF; Pelling, JC | 1 |
| Chang, RL; Conney, AH; Huang, MT; Lou, YR; Lu, YP; Newmark, HL; Reuhl, KR | 1 |
| Chen, LC; De Luca, LM; Sly, L | 1 |
| Biozzi, G; Covelli, V; Doria, G; Mouton, D; Neveu, T; Pioli, C; Saran, A; Troiani, C | 1 |
| French, JE; Hansen, L; Libbus, BL; Mahler, J; Spalding, J; Tennant, RW; Tice, RR | 1 |
| Csuk-Glänzer, BI; Fürstenberger, G; Keppler, D; Marks, F | 1 |
| Kopp-Schneider, A | 1 |
| Meyer, SA; Monteiro-Riviere, NA; Moser, GJ; Smart, RC | 1 |
| Akihisa, T; Takido, M; Tamura, T; Yasukawa, K | 1 |
| Antony, M; Gupta, KP; Mehrotra, NK; Shukla, Y | 1 |
| Barat, N; Biozzi, G; Covelli, V; Mouton, D; Perin, F; Perin, O; Pioli, C; Plessis, MJ; Saran, A | 1 |
| Kornhauser, A; Lambert, LA; Lavu, S; Wamer, WG; Wei, RR | 1 |
| Kornhauser, A; Lambert, LA; Wamer, WG; Wei, RR | 1 |
| Bowden, GT; Domann, FE; Finch, JS; Levy, JP | 1 |
| Gembardt, C; Kühborth, B; Mellert, W; Munk, R | 1 |
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| Eckhardt, JN; Greenhalgh, DA; Roop, DR; Rothnagel, JA; Wang, XJ | 1 |
| Cmarik, JL; Colburn, NH; Dong, Z; Wendel, EJ | 1 |
| Bijur, GN; Boros, LG; Oberyszyn, AS; Oberyszyn, TM; Pellegrini, AE; Robertson, FM; Sabourin, CL | 1 |
| Jiang, H; Kato, R; Yamamoto, S | 1 |
| Bagwe, AN; Bhisey, RA; Ramchandani, AG | 1 |
| Agarwal, R; Katiyar, SK; Mukhtar, H | 3 |
| Colapietro, AM; Goodell, AL; Smart, RC | 1 |
| Haesen, S; Kirsch-Volders, M; Timmermans, M | 1 |
| Glick, AB; Hennings, H; Krsmanovic, LS; Lowry, DT; Sly, LM; Yuspa, SH | 1 |
| Inada, A; Iwashima, A; Konoshima, T; Kozuka, M; Nakanishi, T; Nishino, H; Tokuda, H | 1 |
| Elgjo, K; Iversen, OH; Paulsen, JE; Reichelt, KL | 1 |
| Mills, KJ; Reynolds, SH; Smart, RC | 1 |
| Bhisey, RA; Borges, AM; Ramchandani, AG | 1 |
| Kim, TW; Meyer, SA; Monteiro-Riviere, NA; Moser, GJ; Smart, RC | 1 |
| Jensen, TC; Johnson, TM; Majmudar, G; Nelson, BR; Voorhees, JJ | 1 |
| Kodari, E; Pavone, A; Reiners, JJ | 1 |
| Boone, CW; Kelloff, GJ; Steele, VE | 2 |
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| Ekström, T; Gimenez-Conti, I; Holmberg, B; Mild, KH; Rannug, A; Slaga, TJ | 2 |
| Beland, PE; Fischer, WH; Lutz, WK | 1 |
| Elwell, MR; Momma, J; Spalding, JW; Tennant, RW | 1 |
| Belury, MA; Fischer, SM; Lee, WY; Lo, HH; Locniskar, MF | 1 |
| Estes, JR; Kokumai, M; Konoshima, T; Kozuka, M; Lee, KH; Li, L; Terada, H; Tokuda, H; Wang, HK | 1 |
| Bijur, GN; Boros, LG; Oberyszyn, AS; Oberyszyn, TM; Robertson, FM; Sabourin, CL | 1 |
| Colburn, N; Dong, Z; Hegamyer, G; Nakamura, K; Sun, Y | 1 |
| Möller, L; Toftgård, R; Zeisig, M | 1 |
| Anderson, LM; Diwan, BA; Rehm, S; Rice, JM | 1 |
| Balmain, A; Bradley, A; Donehower, LA; Kemp, CJ | 1 |
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| Fujita, T; Iwashima, A; Nishino, H; Takaishi, Y; Tokuda, H; Ujita, K | 1 |
| Gali, HU; Gao, XM; Laks, PE; Perchellet, EM; Perchellet, JP | 1 |
| Belanger, AJ; Glick, AB; Hennings, H; Tennenbaum, T; Weiner, AK; Yuspa, SH | 1 |
| Aldaz, CM; Conti, CJ; DiGiovanni, J; Slaga, TJ; Walker, SE | 1 |
| Barnett, T; Birt, DF; Dimitroff, K; Phan, A; Pinch, HJ | 1 |
| Butler, AP; Fischer, SM; Lee, WY; Locniskar, MF | 1 |
| Dlugosz, AA; Hennings, H; Strickland, JE; Yuspa, SH | 1 |
| Fujiki, H; Okabe, S; Suganuma, M; Yatsunami, J; Yoshizawa, S | 1 |
| Cantu, A; Pavone, A; Reiners, JJ; Thai, G | 1 |
| Fischer, SM; Maldve, R; Pavone, A; Reiners, JJ | 1 |
| McCann, R; Mitchel, RE | 1 |
| Chen, LC; De Luca, LM; Jones, CS; Sly, L; Tarone, R | 1 |
| Bianchi, AB; Conti, CJ; Fischer, SM; Rinchik, EM; Robles, AI | 1 |
| Chang, PL; Prince, CW | 1 |
| Blumberg, PM; Krsmanovic, L; Szallasi, Z | 1 |
| DiBenedetto, PJ; Gilani, A; Gilchrest, BA; Harkness, DD; Yaar, M | 1 |
| Conti, CJ; DiGiovanni, J; Sagartz, JW; Sharma, S; Skisak, C; Slaga, TJ; Walborg, EF | 1 |
| Gschwendt, M; Marks, F | 1 |
| Kelleher, D; Long, A; Magnuson, NS; Wingett, D | 1 |
| DiGiovanni, J; Imamoto, A; Kiguchi, K; Rupp, T; Xian, W; Zilberstein, A | 1 |
| Bignami, GS; Kuroki, DW; Wattenberg, EV | 1 |
| Kim, SY; Lee, KJ; Lee, YH; Oh, SH; Park, KK | 1 |
| Ma, R; Yu, L; Yu, T | 1 |
| Mehrotra, NK; Ray, PK; Shukla, Y; Verma, AS | 1 |
| Jetten, AM; Owens, DM; Smart, RC; Zainal, TA | 1 |
| Das, UN; Ramesh, G | 1 |
| Kapadia, GJ; Konoshima, T; Nishino, H; Tokuda, H | 1 |
| Desai, KN; Lamartiniere, CA; Wei, H | 1 |
| Hennings, H; Li, L; Lowry, DT | 1 |
| Conney, AH; Frenkel, K; Grunberger, D; Han, J; Huang, MT; Ma, W; Xie, JG; Yen, P | 2 |
| Beland, PE; Candrian, R; Fekete, T; Fischer, WH; Lutz, WK | 1 |
| Herlyn, M; Montone, KT; Nesbit, M; Satyamoorthy, K; Soballe, PW | 1 |
| Chen, G; Davis, AW; Gao, XM; Hua, DH; Newell, SW; Perchellet, EM; Perchellet, JP | 1 |
| Murakami, N; Nagatsu, A; Nishino, H; Sakakibara, J; Shirahashi, H; Tokuda, H | 1 |
| Davis, AW; Gao, XM; Hua, DH; Newell, SW; Perchellet, EM; Perchellet, JP | 1 |
| Aldaz, CM; Battalora, MS; Conti, CJ; DiGiovanni, J; Johnston, DA; Slaga, TJ | 1 |
| Barnett, T; Birt, DF; Copenhaver, J; Pour, PM | 1 |
| Anisimov, VN; Sheiko, EV | 1 |
| Fujisawa, Y; Hirako, Y; Kitajima, Y; Owada, MK; Owaribe, K; Seishima, M; Yaoita, H | 1 |
| Huang, M; Tan, A; Wu, K | 1 |
| Long, BW; Oberyszyn, TM; Robertson, FM; Ross, MS; Tober, KL | 2 |
| Chen, LC; De Luca, LM; Huynh, M; Jones, CS; Tarone, R | 1 |
| Flug, M; Köpf-Maier, P | 1 |
| Athar, M; Giri, U; Iqbal, M | 1 |
| Belury, MA; Bird, CE; Nickel, KP; Wu, Y | 1 |
| Agarwal, R; Ahmad, N; Mohan, RR; Mukhtar, H | 1 |
| Ali, AM; el-Sharkawy, SH; Hamid, M; Intan-Safinar, I; Lajis, NH; Mackeen, MM; Murakoshi, M | 1 |
| Collins, SJ; Darwiche, N; De Luca, LM; Greenwald, E; Jones, C; Rutberg, S; Scita, G; Tennenbaum, T; Yuspa, SH | 1 |
| Birt, DF; Li, B; Pinch, H | 1 |
| Albert, RE; French, JE; Maronpot, R; Spalding, J; Tennant, R | 1 |
| Biozzi, G; Bouthillier, Y; Covelli, V; Doria, G; Mouton, D; Neveu, T; Pioli, C; Saran, A | 1 |
| Cano, A; Conti, CJ; Duran, H; Jorcano, JL; Larcher, F; Murillas, R; Quintanilla, M; Robles, AI | 1 |
| Koshimizu, K; Murakami, A; Nakamura, Y; Ohigashi, H | 1 |
| Albino, HE; Bowden, GT; Finch, JS | 1 |
| Balasubramanian, V; Kapadia, GJ; Konoshima, T; Koyama, J; Nishino, H; Tagahaya, K; Takasaki, M; Tokuda, H | 1 |
| Reiners, JJ; Singh, KP | 1 |
| Goddard, M; Lecuyer, D; McLean, JR; Thansandote, A | 1 |
| Conti, CJ; La, E; Locniskar, MF; McCarthy, AC | 1 |
| Park, KK; Surh, YJ | 1 |
| Huang, MT; Inouye, M; Lou, YR; Lu, YP; Mirochnitchenko, OI; Newmark, HL; Yen, P | 1 |
| Goodrow, T; Klein-Szanto, AJ; Liu, SC; Morris, R; Zhang, SY | 1 |
| Budunova, IV; Carbajal, S; Kang, H; Slaga, TJ; Viaje, A | 1 |
| Agarwal, R; Ahmad, N; Mukhtar, H; Srivastava, RC | 1 |
| Beltrán, L; DiGiovanni, J; Dubowski, A; Kiguchi, K | 1 |
| Bol, DK; DiGiovanni, J; Gimenez-Conti, I; Kiguchi, K; Rupp, T | 1 |
| Dawson, MI; Dong, Z; Flavell, RA; Huang, C; Ma, WY; Rincon, M | 1 |
| Gilliard, G; Megosh, LC; O'Brien, TG; Soler, AP | 1 |
| Colburn, NH; Dong, Z; Strickland, J; Sun, Y | 1 |
| Muller, HK; Qu, M; Woods, GM | 1 |
| Apisariyakul, A; Dunn, FW; Limtrakul, P; Lipigorngoson, S; Namwong, O | 1 |
| Inada, A; Nakanishi, T; Nishino, H; Sharma, OP; Tokuda, H | 1 |
| Koshimizu, K; Kuki, W; Murakami, A; Nakamura, Y; Ohigashi, H; Ohto, Y; Takahashi, Y; Yonei, H | 1 |
| Hamano, T; Konoshima, T; Takasaki, M; Tokuda, H; Yasuda, I | 1 |
| Becker, K; Gregel, CM; Kaina, B | 1 |
| Coulter, K; Morris, RJ; Steinberg, SR; Tryson, K | 1 |
| Bostic, S; Cai, Y; DiGiovanni, J; Dubowski, A; Ivie, W; Johnston, D; Kleiner, H | 1 |
| Bergoc, R; Cricco, G; Davio, C; Duran, H; Fitzsimons, C; Molinari, B; Palmieri, M; Rivera, E | 1 |
| Fischer, SM; Li-Stiles, B; Lo, HH | 1 |
| Beamer, WG; Sundberg, BA; Sundberg, JP | 1 |
| Conti, CJ; Reiners, JJ; Singh, KP; Yoon, HL | 1 |
| Haseman, JK; Tennant, RW; Trempus, CS | 1 |
| Foley, JF; Kim, TW; Maronpot, RR; Porter, KL; Smart, RC | 1 |
| Bol, DK; Budunova, IV; Coghlan, LG; Conti, CJ; DiGiovanni, J; Fischer, SM; Gimenez-Conti, I; Kiguchi, K; Rundhaug, JE; Slaga, TJ; Stern, MC; Winberg, LD | 1 |
| Binder, RL; Conti, CJ; Gallagher, PM; Johnson, GR; Smith, BJ; Stockman, SL; Sundberg, JP | 1 |
| Angel, JM; Beltrán, L; DiGiovanni, J; Minda, K; Rupp, T | 1 |
| Aldaz, CM; Bednarek, AK; Chu, Y; Slaga, TJ | 1 |
| Travis, CC; Watanabe, KH | 1 |
| Gupta, KP; Mehrotra, NK | 5 |
| Nishino, H; Takeshita, M; Tokuda, H; Zaizen, Y | 1 |
| Bhisey, RA; Borges, AM; D'Souza, AV; Ramchandani, AG | 1 |
| Budunova, I; Coghlan, L; Conti, CJ; DiGiovanni, J; Fischer, SM; Gimenez-Conti, IB; Slaga, TJ; Stern, MC | 1 |
| Bundman, D; Cho, S; Delehedde, M; Greenhalgh, D; McDonnell, TJ; Rodríguez-Villanueva, J; Roop, D; Wang, XJ | 1 |
| Aiba, S; Tagami, H | 1 |
| Conti, CJ; Oberyszyn, AS; Oberyszyn, TM; Rackoff, AI; Robertson, FM; Ross, MS; Tober, KL | 1 |
| Jung, B; Kerbel, RS; Kobayashi, H; Landthaler, M; McClelland, M; Stolz, W; Vogt, T; Welsh, J | 1 |
| Darwiche, N; De Luca, LM; Gartsbein, M; Hansen, L; Hennings, H; Lowry, D; Morgan, DL; Tennenbaum, T; Yuspa, SH | 1 |
| Fürstenberger, G; Lehmann, WD; Löschke, M; Marks, F; Müller-Decker, K; Scholz, K | 1 |
| Barnett, T; Birt, DF; Copenhaver, J; Luthra, R; Pelling, JC | 1 |
| Chou, FP; Chu, CY; Hsu, JD; Huang, CL; Lo, MH; Tseng, TH; Wang, CJ | 1 |
| Locniskar, MF; Mouat, MF | 1 |
| Brinkley, BR; Greenhalgh, DA; He, D; Jiang, A; Medina, D; Roop, DR; Wang, XJ; Zhong, L | 1 |
| Cavalieri, EL; Chakravarti, D; Franzen, J; Higginbotham, S; Mailander, P; Rogan, EG | 1 |
| Bolontrade, M; Conti, CJ; Jorcano, JL; Larcher, F; Murillas, R | 1 |
| Cmarik, JL; Colburn, NH; Li, Y; Min, H; Ogram, SA; Reeves, R | 1 |
| Haines, DC; Hursting, SD; Perkins, SN; Phang, JM | 1 |
| Chun, KS; Lee, JM; Lee, SS; Park, KK; Surh, YJ | 1 |
| Higashi-Okai, K; Okai, Y; Otani, S | 1 |
| Furedi-Machacek, EM; Schmitt, SS; Skisak, CM; Swanson, MS; Vernot, EH | 1 |
| Duc, NM; Kasai, R; Konoshima, T; Nishino, H; Takasaki, M; Tokuda, H; Yamasaki, K | 1 |
| Chun, KS; Kang, JY; Lee, E; Lee, JM; Lee, SS; Park, KK; Surh, YJ | 1 |
| Gilmour, SK; Smith, MK; Trempus, CS | 1 |
| Bowen, R; Lebwohl, M; Wei, H; Zhang, X | 1 |
| Higashi-Okai, K; Okai, Y | 1 |
| Fürstenberger, G; Kopp-Schneider, A; Marks, F; Müller-Decker, K; Seibert, K | 1 |
| Binder, RL; Conti, CJ; Gallagher, PM; Johnson, GR; Stockman, SL; Sundberg, JP | 1 |
| Anderson, LE; DiGiovanni, J; Johnston, DA; Kavet, R; Miller, DL; Morris, JE; Sasser, LB; Walborg, EF | 1 |
| Fischer, WH; Lutz, WK | 1 |
| Kiyosawa, S; Konishi, T; Konoshima, T; Takasaki, M; Tokuda, H | 1 |
| Baykut, F; Berkarda, B; Koyuncu, H; Soybir, G | 1 |
| Hansen, LA; Malarkey, DE; Rosenberg, M; Tennant, RW; Wilkinson, JE; Woychik, RE | 1 |
| Akihisa, T; Kimura, Y; Takido, M; Tamura, T; Yasukawa, K | 1 |
| Brinkley, BR; Greenhalgh, DA; He, D; Jiang, A; Roop, DR; Wang, XJ; Zhong, L | 1 |
| Boorman, GA; Bruccoleri, A; Chen, GS; Foley, JF; Germolec, DR; Humble, MC; Luster, MI; Simeonova, PP; Spalding, J; Yoshida, T; Yu, HS | 1 |
| DiGiovanni, J; Higo, R; Iwamori, M; Kagehara, M; Kiguchi, K | 1 |
| Baqar, SM; Mehrotra, NK; Shukla, Y | 1 |
| Bueso-Ramos, C; Duvic, M; Estrov, Z; Lee, BN; Reuben, JM; Tang, CK | 1 |
| Kaul, A; Khanduja, KL | 1 |
| Ablett, E; Dannoy, PA; Parsons, PG; Pedley, J; Sturm, RA | 1 |
| Fusenig, NE; Garlick, JA; Javaherian, A; Karen, J; Vaccariello, M; Wang, Y | 1 |
| Fürstenberger, G; Johannes, FJ; Marks, F; Rehberger, PA; Rennecke, J; Richter, KH; Stöhr, M | 1 |
| Agarwal, R; Katiyar, SK; Lahiri-Chatterjee, M; Mohan, RR | 1 |
| Spalding, JW; Tennant, RW; Tice, RR | 1 |
| Alkhalaf, M; Ganguli, G; Le Meur, M; Messaddeq, N; Wasylyk, B | 1 |
| Bilodeau, JF; Mirault, ME | 1 |
| Agarwal, MK; Athar, M; Giri, U; Iqbal, M; Khan, S | 1 |
| Bomser, JA; Singletary, KW; Smith, MA; Wallig, MA | 1 |
| Anderson, LE; DiGiovanni, J; Johnston, DA; Kavet, R; Miller, DL; Morris, JE; Rupp, T; Sasser, LB; Walborg, EF | 1 |
| Deng, C; Fernandez-Salas, E; Hennings, H; Mirosh, E; Morgan, DL; Shalizi, A; Stanulis, E; Weinberg, WC; Yuspa, SH | 1 |
| Fischer, SM; La, E; Locniskar, MF; Muga, SJ | 1 |
| Biozzi, G; Bouthillier, Y; Cabrera, WH; De Franco, M; Ibañez, OM; Mouton, D; Ribeiro, OG; Siqueira, M | 1 |
| Carlson, DM; Tesfaigzi, J | 1 |
| Amonkar, AJ; Balasubramanian, S; Dhawan, D; Singh, N | 1 |
| Beltrán, L; Bol, D; DiGiovanni, J; Kiguchi, K; Rupp, T; Wilker, E | 1 |
| Belury, MA; Kavanaugh, CJ; Liu, KL | 1 |
| Shukla, Y; Srivastava, B | 1 |
| Arnott, C; Balkwill, F; Burke, F; East, N; Holdsworth, H; Kollias, G; Moore, RJ; Owens, DM; Pasparakis, M; Rollins, B; Stamp, G; Turner, L | 1 |
| Ahmad, N; Balasubramanian, S; Mukhtar, H | 1 |
| Higashi-Okai, K; Hiqashi-Okaj, K; Okai, Y; Otani, S | 1 |
| Kawamoto, N; Murakami, A; Nakamura, Y; Ohigashi, H; Ohto, Y; Torikai, K | 1 |
| Ageta, H; Arai, Y; Konoshima, T; Masuda, K; Shiojima, K; Takasaki, M; Tokuda, H | 1 |
| Furukawa, H; Ichiishi, E; Ito, C; Itoigawa, M; Mukainaka, T; Nishino, H; Ogata, M; Okuda, M; Tokuda, H | 1 |
| Konoshima, T; Nishino, H; Takasaki, M; Tokuda, H | 1 |
| Conti, CJ; LaCava, M; Rodriguez-Puebla, ML | 1 |
| Colburn, N; Flavell, RA; Hunziker, R; Li, JJ; Rincón, M; Sathyanarayana, BK; Young, MR | 1 |
| Conti, CJ; Gimenez-Conti, IB; Johnson, DG; Pierce, AM; Russell, JL; Schneider-Broussard, R | 1 |
| Hatano, T; Ito, H; Konoshima, T; Kozuka, M; Miyake, M; Mori, K; Mukainaka, T; Nishino, H; Nishitani, E; Okuda, T; Takasaki, M; Tokuda, H; Yoshida, T | 1 |
| Gurley, KE; Kemp, CJ; Philipp, J; Seidel, K; Vo, K | 1 |
| Chang, RL; Conney, AH; Cui, XX; Gwynne, M; Huang, MT; Jerina, DM; Lou, YR; Lu, YP; Merkler, KA; Murthy, B; Wei, SJ; Xie, JG | 1 |
| Agarwal, R; Chen, Y; Wang, J; Zhao, J | 1 |
| Bowden, GT; Broome Powell, M; Gause, PR; Gregus, J; Hyman, P; Lluria-Prevatt, M; Nagle, R | 1 |
| Holmgren, A; Kumar, S | 1 |
| Owens, DM; Smart, RC; Wei, S | 1 |
| Fujiki, H; Marino, MW; Okabe, S; Sakai, A; Sueoka, E; Suganuma, M | 1 |
| Biozzi, G; Bouthillier, Y; Covelli, V; Doria, G; Mouton, D; Pazzaglia, S; Pioli, C; Rebessi, S; Saran, A | 1 |
| Bergman, J; Möller, L; Rozell, BL; Skarin, T; Toftgård, R | 1 |
| Chung, AS; Chung, WY; Kim, J; Lee, JM; Park, KK; Park, MY; Surh, YJ; Yook, JI | 1 |
| Gurley, KE; Kemp, CJ; Vo, K | 1 |
| Dwivedi, C; Zhang, Y | 1 |
| Greenhalgh, DA; Liefer, KM; Roop, DR; Wang, XJ | 1 |
| Agarwal, R; Sharma, Y; Zhao, J | 1 |
| Anderegg, U; Haustein, UF; Saalbach, A; Wetzig, T | 1 |
| Chu, CY; Hwang, JM; Lee, MJ; Lin, WL; Tsai, YY; Tseng, TH; Wang, CJ | 1 |
| Ahrens, H; Dreckschmidt, NE; Oberley, TD; Reddig, PJ; Simsiman, R; Tseng, CP; Verma, AK; Zou, J | 1 |
| Budunova, IV; Jorcano, JL; Perez, P; Slaga, TJ; Spiegelman, VS; Vaden, VR | 1 |
| Battalora, MS; Bishop, WR; Doll, RJ; Haseman, JK; Mahler, JF; Njoroge, FG; Tennant, RW; Trempus, CS | 1 |
| Cros, MP; Omori, Y; Yamakage, K; Yamasaki, H; Zaidan-Dagli, ML | 1 |
| Duc, NM; Ichiishi, E; Kasai, R; Konoshima, T; Murakami, T; Nishino, H; Takasaki, M; Tokuda, H; Yamasaki, K | 1 |
| Lambert, PF; Liem, A; Miller, JA; Song, S | 1 |
| Morris, RJ; Tryson, KA; Wu, KQ | 1 |
| Gupta, KP | 1 |
| Bourguignon, SE; Dreckschmidt, NE; Oberley, TD; Reddig, PJ; Verma, AK; Zou, J | 1 |
| Mehrotra, NK; Shukla, Y; Singh, A | 1 |
| Han, C; Qi, L | 1 |
| Fürstenberger, G; Manzow, S; Marks, F; Richter, KH; Stempka, L | 1 |
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| Beltrán, L; Bol, DK; Carbajal, S; DiGiovanni, J; Jorcano, J; Kiguchi, K; Moats, S; Ramirez, A; Wilker, E | 1 |
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| Fürstenberger, G; Krieg, P; Marks, F; Müller, K | 1 |
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| Affara, NI; Gali-Muhtasib, HU | 1 |
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| Biozzi, G; Covelli, V; Mancuso, M; Pazzaglia, S; Primerano, B; Rebessi, S; Saran, A | 1 |
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| Matsunaga, S; Minami, T; Nishino, H; Tanaka, R; Terada, Y; Tokuda, H; Tsujimoto, K; Yoshitake, A | 1 |
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| Furukawa, H; Ichiishi, E; Ito, C; Iwase, Y; Ju-ichi, M; Mukainaka, T; Nishino, H; Takemura, Y; Tokuda, H; Yano, M | 1 |
| Furukawa, H; Ito, C; Itoigawa, M; Nishino, H; Okuda, M; Tan, HT; Tokuda, H | 1 |
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| Fujiki, H; Iida, N; Kishimoto, T; Kurusu, M; Ohshima, S; Okabe, S; Saeki, Y; Suganuma, M | 1 |
| Conti, CJ; Gómez-Casero, E; Jorcano, JL; Larcher, F; Navarro, M; Paramio, JM; Rodríguez-Puebla, ML | 1 |
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| Bracken, WM; Gleason, GL; Hennings, H; Slaga, TJ; Weeks, CE | 1 |
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| Boutwell, RK; Fischer, SM; Gleason, GL; Mufson, RA; Slaga, TJ; Verma, AK | 1 |
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| Marks, F; Schweizer, J | 1 |
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| Chang, RL; Conney, AH; Jerina, DM; Lehr, RE; Levin, W; Thakker, DR; Wood, AW | 1 |
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| Bracken, WJ; Conney, AH; Gleason, G; Jerina, DM; Levin, W; Slaga, TJ; Yagi, H | 1 |
| Segal, A; Van Duuren, BL | 1 |
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| Slaga, TJ; Viaje, A; Weinstein, IB; Wigler, M | 1 |
| Chang, RL; Conney, AH; Jerina, DM; Levin, W; Slaga, TJ; Wood, AW; Yagi, H | 1 |
| Berry, DL; Bracken, WM; Fischer, SM; Leclerc, SM; Miller, DR; Slaga, TJ; Viaje, A | 1 |
| Bracken, WM; Conney, AH; Jerina, DM; Levin, W; Slaga, TJ; Viaje, A; Yagi, H | 1 |
| Chouroulinkov, I; Gentil, A; Grover, PL; Sims, P | 1 |
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| Bianchi, AB; Conti, CJ; Fischer, SM; Gimenez-Conti, IB; Reiners, JJ; Slaga, TJ | 1 |
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| Fujiki, H; Horiuchi, T; Nishiwaki, S; Nishiwaki-Matsushima, R; Okabe, S; Okuda, T; Suganuma, M; Sugimura, T; Yatsunami, J; Yoshizawa, S | 1 |
| Armbrust, AD; Gali, HU; Klish, DS; Perchellet, EM; Perchellet, JP | 1 |
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| Chang, R; Conney, AH; Ferraro, T; Ho, CT; Huang, MT; Ma, W; Reuhl, KR; Wang, ZY; Yang, CS | 1 |
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| Chen, LC; De Luca, LM; Jones, CS; Sly, L | 1 |
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| Adams, AK; Hanausek, M; Mirowski, M; Sherman, U; Slaga, TJ; Walaszek, Z | 1 |
| Chang, M; Fan, SX; He, WZ; Liu, WS; Ma, RD; Nishino, H; Takayasu, J; Wang, YQ; Yu, LJ; Zhen, J | 1 |
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| Bechtel, DH; Belury, MA; Fischer, SM; Lee, ML; Leyton, J; Locniskar, M; Maldve, RE; Slaga, TJ | 1 |
| Beltrán, L; Chenicek, KJ; DiGiovanni, J; Imamoto, A; Naito, M; Skow, L; Walker, SE | 1 |
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| Bechtel, D; Belury, MA; Fischer, SM; Lee, ML; Leyton, J; Locniskar, M; Slaga, TJ | 1 |
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| Koza, RA; Megosh, LC; O'Brien, TG; Palmieri, M | 1 |
| Fischer, SM; Slaga, TJ; Vo, TK | 1 |
| Baldwin, JK; Cameron, GS; Fischer, SM; Klann, RC; Patrick, KE | 1 |
| Belury, MA; Cumberland, AG; Fischer, SM; Locniskar, M; Patrick, KE | 2 |
| Lewbart, ML; Pashko, LL; Schwartz, AG | 1 |
| Balmain, A; Burns, PA; Haddow, S; Jack, A; Neilson, F | 1 |
| Crawford, CL; Smart, RC | 1 |
| Edashige, K; Utsumi, K; Utsumi, T | 1 |
| Connor, MJ | 1 |
| Devor, DE; Henneman, JR; Keefer, LK; Logsdon, DL; Rice, JM; Streeter, AJ; Ward, JM | 1 |
| Beltrán, LM; DiGiovanni, J; Imamoto, A | 1 |
| Aliiakparova, LM; Anisimov, VN; Vorobtsova, IE | 1 |
| Hayashi, Y; Kato, K; Miyakawa, Y; Nishi, Y; Sato, H; Takahashi, M | 1 |
| Albert, RE; Andringa, A; Baxter, CS; Cody, T; Miller, ML; Shukla, R | 1 |
| Cantu, AR; Pavone, A; Reiners, JJ; Rupp, T | 1 |
| Birt, DF; Bresnick, E; Tye, L; Wei, H | 1 |
| Balaschak, M; Hennings, H; Shores, R; Yuspa, SH | 1 |
| Hayashi, Y; Kakimoto, K; Miyakawa, Y; Sato, SI; Takahashi, M | 1 |
| Fujimoto, M; Hirono, I; Ito, K; Matsumoto, K; Tanaka, H | 1 |
| Baker, RS; Steinel, HH | 2 |
| Koch, WH; Kornhauser, A; Lambert, LA; Wamer, WG | 1 |
| Fischer, SM; Patamalai, B; Patrick, KE; Slaga, TJ | 1 |
| Bhisey, RA; Veturkar, PL | 1 |
| Glasø, M; Wetteland, P | 1 |
| Bangrazi, C; Biozzi, G; Covelli, V; Doria, G; Mouton, D; Neveu, T; Saran, A | 1 |
| Belman, S; Bosland, MC; Estensen, RD; Savarese, K; Sellakumar, A | 1 |
| Fialkow, PJ; Reddy, AL | 5 |
| Hashiba, H; Hashimoto, Y; Kuroki, T; Nose, K; Tajima, O | 1 |
| Fukuoka, M; Furukawa, F; Hasegawa, R; Hayashi, Y; Imaida, K; Sato, H; Takahashi, M; Takamura, N; Toyoda, K | 1 |
| Tabara, M; Watanabe, M | 1 |
| Ji, C; Marnett, LJ; Pruess-Schwartz, D; Reddy, A | 1 |
| Dietel, M; Hilz, H; Ludwig, A; Müller, K; Schäfer, G | 1 |
| Binder, RL; Cunniff, JJ; Maurer, JK; Newmann, EA; Sundberg, JP | 1 |
| Matsumoto, T; Tokuda, H | 1 |
| Hasegawa, T; Iwashima, A; Nishino, A; Nishino, H; Okuyama, T; Shibata, S; Takata, M; Takayasu, J; Tokuda, H; Ueyama, H | 1 |
| Burns, FJ | 2 |
| Hasegawa, T; Iwashima, A; Matsunaga, S; Nishino, A; Nishino, H; Takayasu, J; Tanaka, R; Tokuda, H; Ueyama, H | 1 |
| Burrill, C; LaVoie, EJ; Rice, JE; Weyand, EH | 1 |
| Cardiff, RD; Kuo, A; Leder, A; Leder, P; Sinn, E | 1 |
| Perchellet, JP; Satyamoorthy, K | 2 |
| Hatanaka, T; Hongyo, T; Kinuta, M; Nakajima, H; Nomura, T | 1 |
| Cotsarelis, G; Lavker, RM; Sun, TT | 1 |
| Beavis, AJ; Conney, AH; Gilmour, SK; Hietala, OA; Huang, MT; Laskin, JD; O'Brien, TG; Robertson, FM | 1 |
| Hansen, LA; Monteiro-Riviere, NA; Smart, RC | 1 |
| Kitano, Y; Okada, N | 1 |
| Roop, DR; Toftgard, R; Yuspa, SH | 2 |
| Parkinson, EK | 1 |
| DeLeo, VA; Hanson, D; Harber, LC; Horlich, H; Scheide, S; Southern, W; Weinstein, IB | 1 |
| Aglow, E; Gilmour, SK; O'Brien, TG | 1 |
| Duray, P; Ghosh, S; Halaban, R; Kirkwood, JM; Lerner, AB | 1 |
| Christensen, SB; Fujiki, H; Hakii, H; Nakayasu, M; Scheuer, PJ; Suganuma, M; Sugimura, T; Tahira, T | 1 |
| Ernst, SM; Johnson, JA; Nairn, RS; Pelling, JC; Slaga, TJ; Strawhecker, JM | 1 |
| Baird, WM; Carlson, GP; Morse, MA | 1 |
| Laskin, JD; Molloy, CJ | 1 |
| Cheng, CK; Krieg, TM; Mehrel, T; Roop, DR; Yuspa, SH | 1 |
| Aldaz, CM; Chesner, J; Conti, CJ; Larcher, F; Roop, DR; Slaga, TJ; Trono, D; Whitehead, T | 1 |
| Jaken, S; Yuspa, SH | 1 |
| Fischer, SM; Morris, RJ; Slaga, TJ; Tacker, KC | 1 |
| DiGiovanni, J; Kruszewski, FH; Naito, M; Naito, Y | 1 |
| Fitzgerald, DJ; Klann, RC; Piccoli, C; Slaga, TJ; Yamasaki, H | 1 |
| Inoue, S; Kitajima, Y; Nagao, S; Nagata, K; Nozawa, Y; Yaoita, H | 1 |
| Aldaz, CM; Conti, CJ | 1 |
| Glasø, M; Hovig, T; Iversen, OH | 1 |
| Birt, DF; Choi, B; Pelling, JC; White, LT | 1 |
| Bonfil, RD; Conti, CJ; Klein-Szanto, AJ; Larcher, F | 1 |
| Aldaz, CM; Conti, CJ; Miller, DR; Rotstein, J; Slaga, TJ; Viaje, A | 1 |
| Cantu, AR; Colby, A; Pavone, A; Reiners, JJ; Rupp, T | 1 |
| DiGiovanni, J; Naito, M | 1 |
| Akhurst, R; Bailleul, B; Balmain, A; Brown, K; Fee, F; Ramsden, M | 1 |
| Miller, DR; Morris, RJ; O'Connell, JF; Patskan, GP; Slaga, TJ; Tacker, K; Viaje, AV | 1 |
| Li, MH; Liu, JG | 1 |
| Amtmann, E; Fürstenberger, G; Marks, F; Sauer, G | 1 |
| Becher, H; Chouroulinkov, I; Day, NE; Lasne, C; Lowy, R; Wahrendorf, J; Yamasaki, H | 1 |
| Fürstenberger, G; Fusenig, NE; Kaina, B; Marks, F; Petrusevska, RT; Schurich, B | 1 |
| Conti, CJ; DiGiovanni, J; Ewing, MW; Phillips, JL; Slaga, TJ | 1 |
| Birt, DF; Pelling, JC; Schweickert, L; Tibbels, MG | 1 |
| Nakadate, T | 1 |
| Furukawa, F; Hasegawa, R; Hayashi, Y; Imaida, K; Sato, H; Takahashi, M; Toyoda, K | 1 |
| Fuwa, T; Itakura, Y; Iwashima, A; Matsuura, H; Nishino, H | 1 |
| Gill, TJ; Shinozuka, H; Yokota, K | 1 |
| Dlugosz, AA; Dzubow, L; Gilmour, SK; Hietala, O; O'Brien, TG; O'Donnell, K | 1 |
| De Luca, LM; Shores, RL; Spangler, EF; Wenk, ML | 1 |
| Athar, M; Bickers, DR; Lloyd, JR; Mukhtar, H | 1 |
| Blumberg, PM; Hennings, H; Sharkey, NA; Yuspa, SH | 1 |
| Anisimov, V; Likhachev, A; Loktionov, A; Napalkov, N; Tomatis, L; Zabezhinski, M | 2 |
| Kim, YS; Park, KK | 1 |
| Fairman, DK; Lewbart, ML; Pashko, LL; Polansky, M; Schwartz, AG | 1 |
| Irie, K; Iwashima, A; Koshimizu, K; Nishino, H; Okuno, S; Tokuda, H | 1 |
| Aizu, E; Hosoda, Y; Kato, R; Kiyoto, I; Nakadate, T; Yamamoto, S | 1 |
| Hirsch, JM; Johansson, SL; Larsson, PA; Vahlne, A | 1 |
| Hashiba, H; Hosoi, J; Karasawa, M; Kuroki, T; Nose, K; Yamada, S | 1 |
| Konoshima, T; Kozuka, M; Tanabe, M; Tokuda, H | 1 |
| Bonham, K; Bowden, GT; Cress, AE; Embry, T; Gibson, D; Jaffe, DR; Roberts, RA | 1 |
| Fürstenberger, G; Marks, F; Schweizer, J | 1 |
| Adams, LM; Fischer, SM; Klein-Szanto, AJ; Slaga, TJ | 1 |
| Bowden, GT; Jaffe, DR | 2 |
| Anderson, LM; Enomoto, T; Giner-Sorolla, A; Kovatch, RM; Perantoni, AO; Reed, CD; Rice, JM; Riggs, CW | 1 |
| Gill, TJ; Hattori, A; Kunz, HW; Shinozuka, H; Yokota, K | 1 |
| Bauer, G; Fürstenberger, G; Höfler, P; Marks, F; Rogers, M; Schnapke, R | 1 |
| Conney, AH; Hansen, LA; Mills, KJ; Smart, RC | 1 |
| Arita, I; Mitani, H; Sasaki, MS; Tachibana, A; Takebe, H; Tatsumi, K; Toyoda, M | 1 |
| Baldwin, JK; Butler, AP; Cameron, GS; Fischer, SM; Jasheway, DW; Klann, RC; Patrick, KE | 1 |
| Abney, NL; Maatta, EA; Perchellet, EM; Perchellet, JP; Thomas, RM | 1 |
| Greenhalgh, DA; Harper, JR; Lacal, JC; Reynolds, SH; Strickland, JE; Yuspa, SH | 1 |
| Baldwin, JK; Cameron, GS; Fischer, SM; Jasheway, DW; Patrick, KE | 1 |
| Orten, DK; Owen, MD; Perchellet, JP; Posey, TD; Schneider, BA | 1 |
| Lichti, U; Yuspa, SH | 1 |
| Chiba, M; Klein-Szanto, AJ; Maley, MA | 1 |
| Glasø, M; Hovig, T; Iversen, OH; Ree, K | 1 |
| Fujiki, H | 3 |
| Digiovanni, DM; Fries, JW; Klein-Szanto, AJ; O'Connell, JF; Slaga, TJ | 2 |
| Fujiki, H; Hakii, H; Horiuchi, T; Nakayasu, M; Suganuma, M; Sugimura, T; Takayama, S | 1 |
| Hennings, H; Kilkenny, A; Lichti, U; Michael, D; Morgan, D; Spangler, EF; Yuspa, SH | 1 |
| Blumberg, PM; Herald, CL; Pettit, GR; Sako, T; Yuspa, SH | 1 |
| Cabral, JR; Galendo, D; Hollstein, M; Martel, N; Tomatis, L; Yamasaki, H | 1 |
| Fürstenberger, G; Gross, M; Marks, F | 1 |
| Aitken, A; Brooks, G; Evans, AT; Evans, FJ | 1 |
| McCormick, DL; Moon, RC | 1 |
| Chuthaputti, A; Pfeifer, RW; Updyke, LW; Yim, GK | 1 |
| Colburn, NH; Gindhart, TD; Nakamura, Y | 1 |
| Pelling, JC; Slaga, TJ | 1 |
| Adams, LM; Fischer, SM | 1 |
| Konishi, S; Mizusaki, S; Saito, Y; Takizawa, H; Yoshida, D | 1 |
| Fujiki, H; Iwashima, A; Konishi, S; Nishino, H; Okabe, H; Okamoto, H; Shibata, S; Sugimura, T; Takizawa, H; Yoshioka, K | 1 |
| Adams, LM; Baldwin, JK; Fischer, SM | 1 |
| Chida, K; Kuroki, T; Munakata, K; Murakami, Y | 1 |
| Balmain, A; Brown, K; Kerr, IB; Quintanilla, M; Ramsden, M; Young, S | 1 |
| Young, AR | 1 |
| Czerniecki, B; Gad, SC; Reilly, C; Smith, AC; Witz, G | 1 |
| Mazzone, A; Ricevuti, G; Rizzo, SC; Sacchi, S | 1 |
| Inui, N; Iwata, K; Ohkawa, Y | 1 |
| Hsieh, JT; Pong, RC; Verma, AK | 1 |
| Graem, N | 1 |
| Hakaim, AG; Jacoby, WT; O'Connell, JF; Weiss, HS | 1 |
| Fujiki, H; Iwashima, A; Kitagawa, K; Nishino, H | 1 |
| Kanno, J; Kasuga, T; Matsubara, O | 2 |
| Kato, R; Nakadate, T; Yamamoto, S | 1 |
| Bowden, GT; Gensler, HL; Sim, DA | 1 |
| Fürstenberger, G; Kinzel, V; Loehrke, H; Marks, F | 1 |
| Ali, M; Duvick, L; Verma, AK | 1 |
| Fujiki, H; Hakii, H; Hirata, Y; Horiuchi, T; Iwashima, A; Nishino, H; Suganuma, M; Sugimura, T; Yamashita, K | 1 |
| Furukawa, F; Hasegawa, R; Hayashi, Y; Miyakawa, Y; Sato, H; Takahashi, M | 1 |
| Fujiki, H; Hakii, H; Horiuchi, T; Suganuma, M; Sugimura, T; Yamashita, K | 1 |
| Blumenson, L; Kulesz-Martin, M; Lisafeld, B | 1 |
| Gragtmans, NJ; Jevcak, JJ; Mitchel, RE; Morrison, DP | 1 |
| Colburn, NH; Heine, UI; Junker, JL; Rice, JM; Takahashi, K | 1 |
| Fujiki, H; Nitta, K; Takeuchi, M | 1 |
| Jacoby, WT; Weiss, HS | 1 |
| Ernst, SM; Hixson, DC; Nairn, RS; Patskan, G; Pelling, JC; Rhode, SL; Slaga, TJ | 1 |
| Devor, D; Hennings, H; Rehm, S; Ward, JM; Wenk, ML | 1 |
| Anderson, LM; Rice, JM | 2 |
| Danner, MW; Marian, B | 1 |
| Caldwell, M; Fialkow, PJ; Reddy, AL | 2 |
| Anisimov, V; Becher, H; Likhachev, A; Loktionov, A; Napalkov, N; Ovsyannikov, A; Tomatis, L; Wahrendorf, J; Zabezhinski, M | 1 |
| Marian, B | 2 |
| Aldaz, CM; Conti, CJ; Klein-Szanto, AJ; Slaga, TJ | 1 |
| Fujiki, H; Hecker, E; Hirota, M; Horiuchi, T; Suganuma, M; Sugimura, T; Suttajit, M; Wongchai, V; Yoshioka, A | 1 |
| Cohen, SM; Hasegawa, R; St John, M; Tibbels, TS | 1 |
| Fischer, SM; Fürstenberger, G; Marks, F; Slaga, TJ | 1 |
| Conti, CJ; DiGiovanni, J; Kruszewski, FH | 1 |
| Chouroulinkov, I; Lasne, C; Royer, R; Venegas, W | 1 |
| Scherneck, S; Wunderlich, V | 1 |
| Fischer, SM; Neades, R; Pelling, JC; Schweickert, L; Strawhecker, J | 1 |
| Brown, CC; Chu, KC; Tan, WY; Tarone, RE | 1 |
| Bhisey, RA; Borges, A; Veturkar, PL | 1 |
| Gragtmans, NJ; Mitchel, RE; Morrison, DP | 2 |
| DiGiovanni, J; Naito, M; Naito, Y | 1 |
| Balaschak, M; Greenhalgh, DA; Hennings, H; Koceva-Chyla, A; Restrepo, C; Strickland, JE; Yuspa, SH | 1 |
| Ootsuyama, A; Tanooka, H | 1 |
| Hibasami, H; Maekawa, S; Nakashima, K; Sakurai, M; Tsukada, T | 1 |
| Crysup, SE; DiGiovanni, J; Ewing, MW; Phillips, JL; Slaga, TJ | 1 |
| Fujiki, H; Hirota, M; Nakayasu, M; Ojika, M; Suganuma, M; Sugimura, T; Suguri, H; Wakamatsu, K; Yamada, K; Yoshizawa, S | 1 |
| Chenicek, KJ; DiGiovanni, J; Naito, M; Naito, Y | 1 |
| Chao, WR; Dawson, MI | 1 |
| Chenicek, KJ; DiGiovanni, J; Kruszewski, FH | 2 |
| Chouroulinkov, I; Grover, P; Lasne, C; Phillips, D | 1 |
| Conney, AH; Huang, MT; Smart, RC; Wong, CQ | 1 |
| Antony, M; Kumar, S; Mehrotra, NK | 1 |
| Conti, CJ; DiGiovanni, J; Ewing, MW; Kruszewski, FH; Slaga, TJ | 1 |
| Hashimura, T; Kanamaru, H; Yoshida, O | 1 |
| Nakagawa, S; Takeuchi, M; Takido, M; Yasukawa, K | 1 |
| Bowden, GT; Breathnach, R; Finch, J; Krieg, P; Matrisian, L; O'Connell, JF; Ostrowski, LE; Patskan, G; Phillips, J; Slaga, TJ | 1 |
| Burns, PD; Conway, T; Cope, FO; Johnston, D; Murphy, P; Triggs, G; Wagner, FJ; Wille, JJ | 1 |
| Colburn, NH; Gindhart, TD; Hegameyer, GA; Nakamura, Y; Smith, BM; Stevens, LA; West, MW | 1 |
| Bravo, R; Burckhardt, J; Curran, T; Müller, R | 1 |
| DiGiovanni, J; Kruszewski, FH | 1 |
| Conney, AH; Huang, MT; Mills, KJ; Monteiro-Riviere, NA; Smart, RC; Wong, CQ | 1 |
| Chida, K; Hirota, K; Kuroki, T; Yamada, S | 1 |
| Bhisey, RA; Borges, A; Jeyapaul, J; Veturkar, PL | 1 |
| Gschwendt, M; Kittstein, W; Marks, F | 2 |
| Fukao, K; Kayata, Y; Ohyama, Y; Okuda, K; Takada, K; Tanimoto, Y; Yoshiga, K | 1 |
| Bhisey, RA; Borges, AM; Notani, PN; Ramchandani, AG; Sirsat, SM; Veturkar, PL | 1 |
| Hasegawa, T; Hirabayashi, K; Iwashima, A; Iwata, S; Nishino, A; Nishino, H; Shibata, S; Takayasu, J | 1 |
| Fukao, K; Kayata, Y; Okuda, K; Takada, K; Tanimoto, Y; Yoshiga, K | 1 |
| Aizu, E; Kato, R; Kiyoto, I; Nakaki, T; Sasakawa, N; Yamamoto, S | 1 |
| Holmes, M; Madara, T; O'Brien, TG; Pyle, JA | 1 |
| Bowden, GT; Gensler, HL; Moriguchi, S; Watson, RR | 1 |
| Bowden, GT; Breathnach, R; Briand, JP; Fürstenberger, G; Krieg, P; Leroy, P; Matrisian, LM | 1 |
| Adams, LM; Conti, CJ; Fischer, SM; Fries, JW; O'Connell, JF; Patrick, KE; Slaga, TJ; Tacker, KC | 1 |
| Adams, DO; Lewis, JG | 1 |
| Birt, DF; Bresnick, E; Pelling, JC; Pour, PM; Schweickert, L; Tibbels, MG | 1 |
| Furukawa, F; Hasegawa, R; Hayashi, Y; Miyakawa, Y; Sato, H; Takahashi, M; Toyoda, K | 2 |
| Blumberg, PM; Hennings, H; Herald, CL; Pettit, GR; Shores, R; Yuspa, SH | 1 |
| Kumar, S; Mehrotra, NK; Shukla, Y | 1 |
| Bowden, GT; Jaffe, DR; Williamson, JF | 1 |
| Pence, BC; Reiners, JJ | 1 |
| Conney, AH; Focella, A; Han, ZT; Huang, MT; Kaplan, MC; Smart, RC | 1 |
| Bowden, GT; Jaffe, D | 1 |
| Baxter, CS; Miller, ML | 1 |
| Fischer, SM; Morris, RJ; Slaga, TJ | 1 |
| Abernethy, DJ; Boreiko, CJ; Dorman, BH; Sanchez, JH | 1 |
| Kuroki, T | 1 |
| Cerutti, PA; Kozumbo, WJ | 1 |
| Conney, AH; Huang, MT; Smart, RC | 1 |
| Erickson, D; Pong, RC; Verma, AK | 1 |
| Bull, RJ; Laurie, RD; Robinson, M | 1 |
| Bergman, H; Nesnow, S; Slaga, TJ | 1 |
| Melchionne, S; Seidman, I; Van Duuren, BL | 1 |
| Devor, D; Quander, R; Spangler, EF; Ward, JM; Wenk, ML | 1 |
| Ito, Y; Koshimizu, K; Ohigashi, H; Tokuda, H | 1 |
| Gilmour, SK; Madara, T; O'Brien, TG; Verma, AK | 1 |
| Aldaz, CM; Conti, CJ; Miller, DR; Slaga, TJ; Viaje, A | 1 |
| Hosoi, J; Kato, K; Kuroki, T | 1 |
| Baldwin, JK; Fischer, SM; Morris, RJ; Slaga, TJ; Tacker, KC | 1 |
| Ebbesen, P | 1 |
| Chida, K; Fukushima, M; Hashiba, H; Kuroki, T; Suda, T | 1 |
| Creasia, D; Kripke, ML; Strickland, PT | 1 |
| Boutwell, RK; Carbone, PP; Loprinzi, CL; Verma, AK | 1 |
| Wattenberg, LW | 1 |
| Noguchi, N | 1 |
| Diwan, BA; Henneman, J; Ward, JM; Wenk, ML | 1 |
| Colburn, NH; Diwan, BA; Rice, JM; Spangler, EF; Ward, JM | 1 |
| Hennings, H; Yuspa, SH | 1 |
| Agrawal, HP; Randerath, E; Randerath, K | 1 |
| Hashimura, T; Yoshida, O | 1 |
| Egner, PA; Kensler, TW | 1 |
| Baggiolini, E; Chang, RL; Conney, AH; Huang, MT; Partridge, JJ; Uskokovic, M; Wood, AW | 1 |
| Fürstenberger, G; Kinzel, V; Marks, F; Schwarz, M | 1 |
| Boutwell, RK; Cleaveland, JS; Ordman, AB | 1 |
| Arranto, A; Stenbäck, F | 1 |
| Autrup, H; Christensen, B; Skibshøj, I; Skouv, J | 1 |
| Yamasaki, H | 1 |
| Colburn, NH; Gindhart, TD; Srinivas, L | 1 |
| Aalfs, KK; Cantor, J; Coombs, MM; Decina, PC; DiGiovanni, J; Prichett, WP | 1 |
| Aldaz, CM; Conti, CJ; Gimenez, IB; Klein-Szanto, AJ; Slaga, TJ | 1 |
| Boreiko, CJ | 1 |
| Barrett, JC | 1 |
| Marian, B; Mazzucco, K | 1 |
| Gibson, NW; Hartley, JA; Yuspa, SH; Zwelling, LA | 1 |
| Agarwal, R; Antony, M; Kumar, S; Mehrotra, NK; Shukla, Y | 1 |
| Loprinzi, CL; Verma, AK | 1 |
| Barnhart, KM; Bowden, GT | 1 |
| Kishore, GS; Perchellet, EM; Perchellet, JP | 1 |
52 review(s) available for tetradecanoylphorbol acetate and Skin Neoplasms
| Article | Year |
|---|---|
Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors.
Topics: Animals; Carcinogens; Disease Progression; Enzyme Inhibitors; Humans; Marine Toxins; Mice; Models, Molecular; Neoplasms; Neoplasms, Experimental; Okadaic Acid; Oxazoles; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2009 |
Skin cancer chemoprevention by α-santalol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Mice; Mice, Mutant Strains; Phytotherapy; Plant Oils; Polycyclic Sesquiterpenes; Santalum; Sesquiterpenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Animal models of melanoma: a somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Avian Leukosis Virus; Avian Proteins; Cell Line, Tumor; Disease Models, Animal; Gene Transfer Techniques; Genetic Vectors; Humans; Melanocytes; Melanoma; Melanoma, Experimental; Mice; Mice, Transgenic; Neoplasm Transplantation; Receptors, Virus; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2011 |
Non-melanoma skin cancer in mouse and man.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Disease Progression; Genes, p53; Genes, ras; Humans; Melanoma; Mice; Mutation; Neoplasm Invasiveness; Neoplastic Stem Cells; Papilloma; Risk Assessment; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 2013 |
Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Brassica; Carcinogens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Isothiocyanates; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Skin; Skin Neoplasms; Sulfoxides; Tetradecanoylphorbol Acetate; Thiocyanates; Time Factors | 2006 |
Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Humans; Mice; Neoplasms, Radiation-Induced; Oncogenes; Ornithine Decarboxylase; Protein Kinase C-epsilon; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2006 |
Observations on the mechanism of skin tumor promotion by phorbol esters.
Topics: Adenosylmethionine Decarboxylase; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Protein Kinase C; Protein Kinases; Receptors, Drug; Receptors, Immunologic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Phorbol ester tumor promoters and lymphocyte proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Lymphocyte Activation; Lymphocytes; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Role of oxygen radicals in tumor promotion.
Topics: Animals; Antioxidants; Biotransformation; Carcinogens; Catalase; DNA Repair; DNA Replication; Free Radicals; Humans; Lipid Peroxides; Neoplasms; Oxygen; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1984 |
Molecular and cellular basis for tumor promotion in mouse skin.
Topics: Animals; Calcium; Cell Division; Cell Transformation, Neoplastic; Mice; Oncogenes; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Cellular and biochemical changes during multistage skin tumor promotion.
Topics: Animals; Antioxidants; Cell Transformation, Neoplastic; Free Radicals; Gene Amplification; Humans; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
The paradigm of two-stage carcinogenesis: a critical attitude.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Drug Interactions; Hyperplasia; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Nude; Models, Biological; Neoplasms; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Urethane | 1984 |
Multistage tumor promotion in skin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Humans; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Mouse skin: a useful model system for studying the mechanism of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Carcinogens; Cell Communication; Cell Differentiation; Cell Division; Cocarcinogenesis; DNA; Indomethacin; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Polyamines; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Studies on the multistage nature of radiation carcinogenesis.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Radiation; Harderian Gland; Humans; Lacrimal Apparatus Diseases; Methoxsalen; Mice; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Radiation, Ionizing; Sarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1982 |
Specificity and mechanism(s) of promoter inhibitors in multistage promotion.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diterpenes; Epidermal Cells; Fluocinolone Acetonide; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbol Esters; Polyamines; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin | 1982 |
Polyamines in mammalian tumors. Part I.
Topics: Adenosylmethionine Decarboxylase; Animals; Carcinogens; Cells, Cultured; Liver Neoplasms; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Polyamines; Rats; Skin Neoplasms; Spermidine Synthase; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Virus Infections | 1981 |
International Commission for Protection against Environmental Mutagens and Carcinogens ICPEMC working paper 2/8: An evaluation of assay procedures for detection of tumor promotors.
Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cocarcinogenesis; Mice; Mutagenicity Tests; Rats; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Transgenic approaches to the analysis of ras and p53 function in multistage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Genes, p53; Genes, ras; Mice; Mice, Transgenic; Mutation; Neoplasms, Radiation-Induced; Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Green tea and skin--anticarcinogenic effects.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Dermatitis; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1994 |
Histopathology of human intraepithelial neoplasia with implications for chemoprevention strategy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Anticarcinogenic Agents; Epithelium; Female; Humans; Mice; Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate; Uterine Cervical Neoplasms | 1993 |
Protein kinase C and skin tumor promotion.
Topics: Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Humans; Isoenzymes; Protein Kinase C; Receptors, Drug; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Expression, regulation, and function of the SPR family of proteins. A review.
Topics: Aging; Amino Acid Sequence; Animals; Calcium; Cell Count; Cell Division; CHO Cells; Consensus Sequence; Cornified Envelope Proline-Rich Proteins; Cricetinae; Cytokines; Digestive System; Epidermis; Gene Expression Regulation, Neoplastic; Humans; Intermediate Filament Proteins; Lung Neoplasms; Membrane Proteins; Molecular Sequence Data; Multigene Family; Neoplasms, Squamous Cell; Proteins; Respiratory System; Retinoids; Sequence Homology, Amino Acid; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1999 |
Upregulation of E2F transcription factors in chemically induced mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carrier Proteins; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; E2F3 Transcription Factor; E2F4 Transcription Factor; E2F5 Transcription Factor; Female; Mice; Papilloma; Retinoblastoma-Binding Protein 1; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor DP1; Transcription Factors; Up-Regulation | 1999 |
Cocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Viral; Cocarcinogenesis; Diet; Gastrointestinal Neoplasms; Hormones; Humans; Liver Neoplasms; Lung Neoplasms; Membranes; Methylcholanthrene; Models, Biological; Neoplasms; Nutritional Physiological Phenomena; Oncogenic Viruses; Propionibacterium acnes; Protein Biosynthesis; Retroviridae; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urinary Bladder Neoplasms; Vitamin A | 1979 |
Studies and perspectives of signal transduction in the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Communication; Humans; Keratinocytes; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Anticarcinogenic effects of (-)-epigallocatechin gallate.
Topics: Animals; Anticarcinogenic Agents; Catechin; Hydrolyzable Tannins; Male; Mice; Mice, Inbred C57BL; Skin; Skin Neoplasms; Tannins; Tea; Tetradecanoylphorbol Acetate | 1992 |
Natural history of intraepithelial neoplasia in humans with implications for cancer chemoprevention strategy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinoma; Epithelium; Humans; Papilloma; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Active oxygen species as factors in multistage carcinogenesis.
Topics: Animals; Carcinogens; DNA; Fluoresceins; Free Radicals; Glutathione; Mice; Oxygen; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Differential gene expression during tumor promotion and progression in the mouse skin model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Actins; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA; Gene Expression Regulation, Neoplastic; Matrix Metalloproteinase 3; Metalloendopeptidases; Methylnitronitrosoguanidine; Mice; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms, Multiple Primary; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ubiquitins | 1991 |
Modification of multistage skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; Mice; Precancerous Conditions; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1991 |
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin.
Topics: Arachidonic Acid; Arachidonic Acids; Carcinogens; Curcumin; Diet; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Carcinogens; Colonic Neoplasms; Eflornithine; Female; Mammary Neoplasms, Experimental; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Promotion and progression in carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Mice; Papilloma; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
The conversion stage of skin carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Mice; Models, Biological; Papilloma; Phorbol Esters; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Epidermis; In Vitro Techniques; Keratins; Mice; Mitosis; Oncogenes; Papilloma; Peptides; Phenotype; Phorbols; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1985 |
The premalignant nature of mouse skin papillomas: histopathologic, cytogenetic, and biochemical evidence.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Disorders; Karyotyping; Keratins; Mice; Papilloma; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Genetic background and development of skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cricetinae; Disease Susceptibility; Guinea Pigs; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Phorbol Esters; Rats; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1989 |
Development of murine skin neoplasia studied with enzymes used as cell markers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Carcinoma; Fibrosarcoma; Mice; Papilloma; Phosphoglycerate Kinase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
The action of oncogenes and growth factors in tumour initiation and promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Gene Expression Regulation; Genes, ras; Methylnitronitrosoguanidine; Mice; Mutation; Oncogenes; Restriction Mapping; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1989 |
Investigations of multistage carcinogenesis: applications of in vitro-in vivo studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Methylnitronitrosoguanidine; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
The mechanism of skin tumor promotion caused by phorbol esters: possible involvement of arachidonic acid cascade/lipoxygenase, protein kinase C and calcium/calmodulin systems.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calmodulin; Lipoxygenase; Mice; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Cellular mechanisms for tumor promotion and enhancement.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; ErbB Receptors; Humans; Kidney Neoplasms; Liver Neoplasms; Oncogenes; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Aspects of psoralen phototumorigenesis with emphasis on the possible role of tumour promotion.
Topics: Animals; Cross-Linking Reagents; DNA; Furocoumarins; Methoxsalen; Neoplasms, Experimental; Ornithine Decarboxylase; Oxygen; Photochemistry; PUVA Therapy; Singlet Oxygen; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1986 |
Screening for skin-tumor promoters.
Topics: Animals; Carcinogenicity Tests; Free Radicals; Mice; Nitroblue Tetrazolium; Oxygen; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tetrazolium Salts | 1988 |
Mechanisms involved in ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate, a potent mouse skin tumor promoter and an activator of protein kinase C.
Topics: Animals; Enzyme Induction; Epidermal Cells; Epidermis; Gene Expression Regulation; Humans; Ornithine Decarboxylase; Protein Kinase C; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Type C Phospholipases | 1988 |
[Tumor promoters].
Topics: Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cell Membrane; Lyngbya Toxins; Mice; Organ Specificity; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Inhibition of tumor promotion by flavonoids.
Topics: Animals; Antineoplastic Agents; Chick Embryo; Deoxyglucose; Enzyme Activation; Enzyme Induction; Fibroblasts; Flavonoids; HeLa Cells; Humans; Lyngbya Toxins; Mice; Ornithine Decarboxylase; Phospholipids; Platelet Aggregation; Protein Kinase C; Quercetin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tritium | 1986 |
SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Disease Models, Animal; Drug Evaluation, Preclinical; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1986 |
Inhibition of phorbol ester-induced ornithine decarboxylase gene transcription by retinoic acid: a possible mechanism of antitumor promoting activity of retinoids.
Topics: Animals; Humans; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin | 1988 |
Chemoprevention of cancer.
Topics: Animals; Antineoplastic Agents; Biotransformation; Carcinogens; Drug Administration Schedule; Humans; Neoplasms; Neoplasms, Experimental; Skin Neoplasms; Smoking; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1985 |
Regeneration and the mechanism of epidermal tumor promotion.
Topics: Acetates; Acetic Acid; Animals; Carcinogens; Cell Differentiation; Connective Tissue Cells; Diterpenes; Epidermal Cells; Humans; Hyperplasia; Inflammation; Models, Biological; Regeneration; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
1406 other study(ies) available for tetradecanoylphorbol acetate and Skin Neoplasms
| Article | Year |
|---|---|
28-deacetylbelamcandal, a tumor-promoting triterpenoid from Iris tectorum.
Topics: Animals; Carcinogens; Cell Adhesion; Female; HL-60 Cells; Humans; Mice; Plants; Protein Binding; Protein Kinase C; Skin; Skin Neoplasms; Triterpenes; Tumor Necrosis Factor-alpha | 1999 |
IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Interleukin-13; Interleukin-13 Receptor alpha1 Subunit; Mice; Mice, Knockout; Papilloma; Skin Neoplasms; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 2022 |
Nfe2l2 Regulates Metabolic Rewiring and Epigenetic Reprogramming in Mediating Cancer Protective Effect by Fucoxanthin.
Topics: Animals; Antioxidants; Cell Line; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation; Gene Knockdown Techniques; Mice; NF-E2-Related Factor 2; Oxidation-Reduction; Reactive Oxygen Species; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Xanthophylls | 2022 |
Functional Polymorphism in Pak1-3' Untranslated Region Alters Skin Tumor Susceptibility by Alternative Polyadenylation.
Topics: 3' Untranslated Regions; Animals; Carcinogenesis; Mice; Mice, Inbred Strains; p21-Activated Kinases; Polyadenylation; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2022 |
P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and β-Catenin Signaling Pathways.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Catenin; Carcinogenesis; Hyperplasia; Keratinocytes; Mice; Receptors, Purinergic P2; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wnt Signaling Pathway; YAP-Signaling Proteins | 2022 |
Isolation of cancer stem cells from skin squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Humans; Mice; Neoplastic Stem Cells; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2022 |
DNA Methylome and Transcriptome Study of Triterpenoid CDDO in TPA-Mediated Skin Carcinogenesis Model.
Topics: Cell Transformation, Neoplastic; Epigenome; Humans; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcriptome; Triterpenes; Ultraviolet Rays | 2022 |
Keratinocyte Regnase-1, a Downregulator of Skin Inflammation, Contributes to Protection against Tumor Promotion by Limiting Cyclooxygenase-2 Expression.
Topics: Acetates; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cyclooxygenase 2; Dermatitis; Humans; Inflammation; Keratinocytes; Lithostathine; Mice; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2023 |
The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model.
Topics: Animals; Benzo(a)pyrene; Carcinogenesis; Carcinogens, Environmental; Epigenesis, Genetic; Melatonin; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2023 |
Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinogens; Female; Furans; Kidney; Lactones; Liver; Mice; Mice, Inbred ICR; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2019 |
The transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis.
Topics: Aged; Aged, 80 and over; Animals; Carcinogenesis; Cell Differentiation; Cell Line, Tumor; Disease Progression; Epidermis; ErbB Receptors; Homeostasis; Humans; Hyperplasia; Inflammation; Membrane Glycoproteins; Mice, Inbred C57BL; Phenotype; Protein Binding; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thrombospondins | 2019 |
Pre-clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer.
Topics: Animals; Drug Screening Assays, Antitumor; gamma-Aminobutyric Acid; Ki-67 Antigen; Mice; Neoplasm Proteins; Proliferating Cell Nuclear Antigen; Quinazolines; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2020 |
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Female; Humans; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2019 |
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carcinogens; Cell Line; Cytokines; Female; Flavonoids; Mice, Inbred ICR; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor RelA | 2020 |
WIF1 Suppresses the Generation of Suprabasal Cells in Acanthotic Skin and Growth of Basal Cell Carcinomas upon Forced Overexpression.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinoma, Basal Cell; Cell Proliferation; Culture Media, Conditioned; Epidermis; Gene Knockdown Techniques; HEK293 Cells; Humans; Keratinocytes; Mice; Neoplasms, Experimental; Primary Cell Culture; Skin Neoplasms; Tamoxifen; Tetradecanoylphorbol Acetate; Tretinoin | 2020 |
Triterpenoid corosolic acid modulates global CpG methylation and transcriptome of tumor promotor TPA induced mouse epidermal JB6 P+ cells.
Topics: Animals; Carcinogens; Cell Line; Cell Survival; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Epidermal Cells; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Mice; Phytochemicals; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcriptome; Triterpenes | 2020 |
Pivotal Involvement of the CX3CL1-CX3CR1 Axis for the Recruitment of M2 Tumor-Associated Macrophages in Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Movement; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Humans; Male; Mice; Mice, Inbred C57BL; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor-Associated Macrophages; Wnt3A Protein | 2020 |
β-Elemene inhibits 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced skin tumorigenesis through suppression of NF-κB-associated signaling events in the mouse skin model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Disease Models, Animal; Mice; NF-kappa B; Sesquiterpenes; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2020 |
Integrin α3β1 Is a Key Regulator of Several Protumorigenic Pathways during Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Epidermis; Humans; Integrin alpha3beta1; Kalinin; Keratinocytes; Mice; Neoplasms, Experimental; Signal Transduction; Skin Neoplasms; Spheroids, Cellular; Tetradecanoylphorbol Acetate; Tetraspanin 24 | 2021 |
Targeting 14-3-3ε activates apoptotic signaling to prevent cutaneous squamous cell carcinoma.
Topics: 14-3-3 Proteins; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Carcinoma, Squamous Cell; cdc25 Phosphatases; Cell Line, Tumor; Cytoplasm; Female; Humans; Keratinocytes; Male; Mice; Mice, Knockout; Neoplasms, Experimental; Protein Multimerization; Skin Neoplasms; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays | 2021 |
Regulatory T Cells Play an Important Role in the Prevention of Murine Melanocytic Nevi and Melanomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; CD4 Antigens; CD8 Antigens; Female; Humans; Immune Tolerance; Male; Melanoma, Experimental; Mice; Mice, Knockout; Nevus, Pigmented; Skin; Skin Neoplasms; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 2021 |
Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic.
Topics: Animals; Epidermis; Mice; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2021 |
3'-Hydroxypterostilbene Inhibits 7,12-Dimethylbenz[a]anthracene (DMBA)/12-O-Tetradecanoylphorbol-13-Acetate (TPA)-Induced Mouse Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinogens; Cyclooxygenase 2; Drug Eruptions; Female; Gene Expression Regulation; Humans; Keratinocytes; Mice, Inbred ICR; Ornithine Decarboxylase; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate | 2021 |
Analyzing skin tumor development in mice by the DMBA/TPA model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Humans; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2021 |
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cyclooxygenase 2; Cytokines; Dinoprostone; Mice; Mice, Inbred BALB C; Prostaglandin-E Synthases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2021 |
Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR-ERBB2 pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aged; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; ErbB Receptors; Female; Homeodomain Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Grading; Receptor, ErbB-2; Signal Transduction; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Transcription Factors | 2021 |
DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Cycle Checkpoints; Cell Proliferation; Cellular Senescence; DNA Methylation; Epigenesis, Genetic; Female; Fibroblasts; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Interleukin-1alpha; Membrane Proteins; Mice; Microscopy, Fluorescence; Papilloma; Phenotype; Secretory Pathway; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2021 |
Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development.
Topics: Alleles; Animals; Apoptosis; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Epidermis; Gene Knockout Techniques; Gene Targeting; Hyperplasia; Keratinocytes; Mice; Mice, Knockout; Organ Specificity; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate | 2017 |
E1a is an exogenous in vivo tumour suppressor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenovirus E1A Proteins; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Female; HCT116 Cells; Humans; Melanoma, Experimental; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Burden; Tumor Suppressor Proteins | 2017 |
Folic Acid Modulates DMBA/TPA-Induced Changes in Skin of Mice: A Study Relevant to Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Epidermis; Folic Acid; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Proliferating Cell Nuclear Antigen; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin B Complex | 2018 |
PAD2 overexpression in transgenic mice augments malignancy and tumor-associated inflammation in chemically initiated skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Male; Mice; Mice, Transgenic; Papilloma; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2017 |
Annona muricata leaves extracts prevent DMBA/TPA-induced skin tumorigenesis via modulating antioxidants enzymes system in ICR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Annona; Antioxidants; Carcinogenesis; Furans; Lactones; Male; Mice, Inbred ICR; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2017 |
Dendrimer conjugated estramustine nanocrystalline 'Dendot': An effective inhibitor of DMBA-TPA induced papilloma formation in mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Carcinogens; Cell Proliferation; Dendrimers; Estramustine; Female; Intestines; Kidney; Liver; Mice; Nanoparticles; Papilloma; Skin Neoplasms; Stomach; Tetradecanoylphorbol Acetate | 2017 |
The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation.
Topics: Animals; Bone Marrow; Bone Marrow Transplantation; Carcinogenesis; Carcinogens; Carrier Proteins; Female; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation; Water Loss, Insensible; Wound Healing | 2018 |
Bryostatin 1 causes attenuation of TPA‑mediated tumor promotion in mouse skin.
Topics: Animals; Antineoplastic Agents; Bryostatins; Cyclooxygenase 2; Disease Models, Animal; Edema; Female; Mice; Ornithine Decarboxylase; Peroxidase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2018 |
Red Ginseng Oil Inhibits TPA-Induced Transformation of Skin Epidermal JB6 Cells.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Cell Line; Cell Transformation, Neoplastic; Cyclins; Cyclooxygenase 2; Epidermis; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinases; Heme Oxygenase-1; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; NF-E2-Related Factor 2; NF-kappa B; Panax; Plant Oils; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2018 |
Ingenol-3-Angelate Suppresses Growth of Melanoma Cells and Skin Tumor Development by Downregulation of NF-κB-Cox2 Signaling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinogenesis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Diterpenes; Down-Regulation; Epidermis; Female; Hyperplasia; Inflammation; Melanoma; Mice, Inbred ICR; NF-kappa B; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2018 |
Intense Pulsed Light: Friend or Foe? Molecular Evidence to Clarify Doubts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Disease Models, Animal; Female; Glycolysis; Intense Pulsed Light Therapy; Keratins; Mice; Mice, Inbred ICR; Oxidative Stress; Random Allocation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2018 |
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimetabolites, Antineoplastic; Benzofurans; Carcinogenesis; Colchicine; Disease Models, Animal; Fluorouracil; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tubulin; Tubulin Modulators | 2018 |
Epidermal FABP Prevents Chemical-Induced Skin Tumorigenesis by Regulation of TPA-Induced IFN/p53/SOX2 Pathway in Keratinocytes.
Topics: Animals; Carcinogenesis; Epidermis; Fatty Acid-Binding Proteins; Gene Expression Regulation, Neoplastic; Interferon-beta; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Neoplasms, Experimental; RNA, Neoplasm; Skin Neoplasms; SOXB1 Transcription Factors; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2018 |
Fucoxanthin Elicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells.
Topics: Animals; Antioxidant Response Elements; Cell Transformation, Neoplastic; CpG Islands; DNA Demethylation; Epidermal Cells; Epigenesis, Genetic; Gene Knockdown Techniques; Hep G2 Cells; Humans; Mice; NF-E2-Related Factor 2; RNA, Small Interfering; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Xanthophylls | 2018 |
Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Survival; Cytokines; Drug Administration Schedule; Gene Expression Regulation, Neoplastic; Glucosides; Humans; Mice; Phenols; Random Allocation; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2018 |
The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin.
Topics: Animals; Animals, Newborn; Calcineurin; Calcineurin Inhibitors; Carcinoma, Squamous Cell; Cells, Cultured; Cytokines; Female; Gene Expression; Humans; Inflammation Mediators; Keratinocytes; Mice, Inbred C57BL; Mice, Knockout; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tristetraprolin; Ultraviolet Rays | 2018 |
Anticancer efficacy of noble metal nanoparticles relies on reprogramming tumor-associated macrophages through redox pathways and pro-inflammatory cytokine cascades.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cellular Reprogramming; Cytokines; Gold; Humans; Inflammation Mediators; Macrophages; Metal Nanoparticles; Methylcholanthrene; Mice; Neoplasms, Experimental; Oxidation-Reduction; Signal Transduction; Silver; Skin Neoplasms; Tetradecanoylphorbol Acetate; Th1 Cells; Th2 Cells | 2018 |
Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Lineage; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Clonal Evolution; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Genetic Predisposition to Disease; Male; Mice, Transgenic; Mutation; Neoplasms, Experimental; Phenotype; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Burden | 2018 |
TRP63/TP63 loss accelerates skin tumorigenesis through activation of Wnt/β-catenin signaling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Mice, Knockout; Mice, Nude; Phosphoproteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators; Transcription Factors; Tumor Burden; Tumor Suppressor Proteins; Wnt Signaling Pathway | 2018 |
Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.
Topics: Amino Acid Oxidoreductases; Animals; Collagen; Dermis; Elastin; Extracellular Matrix; Humans; Mice; Mice, Knockout; Neoplasm Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2018 |
Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner.
Topics: Animals; Axin Protein; beta Catenin; Carcinogenesis; Carcinogens; Casein Kinase 1 epsilon; Casein Kinase Idelta; Cell Line, Tumor; Disease Models, Animal; Fibroblasts; HEK293 Cells; Humans; Low Density Lipoprotein Receptor-Related Protein-6; Mice; Phosphorylation; Protein Stability; Purines; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor 4; Wnt Proteins; Wnt Signaling Pathway | 2018 |
SMAD7 in keratinocytes promotes skin carcinogenesis by activating ATM-dependent DNA repair and an EGFR-mediated cell proliferation pathway.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Proliferation; DNA Repair; ErbB Receptors; Keratinocytes; Mice; Mice, Inbred C57BL; Signal Transduction; Skin Neoplasms; Smad7 Protein; Tetradecanoylphorbol Acetate | 2019 |
2,6-Dimethoxy-1,4-benzoquinone, isolation and identification of anti-carcinogenic, anti-mutagenic and anti-inflammatory component from the juice of Vitis coignetiae.
Topics: Aflatoxin B1; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antimutagenic Agents; Benzoquinones; Edema; Female; Male; Mice; Monocytes; Mutagens; Nitric Oxide; Phenols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitis | 2018 |
C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes; Mice; Mice, Knockout; ras Proteins; Receptors, Death Domain; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2018 |
Inhibition of skin tumor promotion by TPA using a combination of topically applied ursolic acid and curcumin.
Topics: Administration, Topical; Animals; Antineoplastic Combined Chemotherapy Protocols; Chemokine CXCL2; Curcumin; Female; Gene Expression Regulation, Neoplastic; Interleukin-1beta; Interleukin-22; Interleukin-6; Interleukins; Mice; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Treatment Outcome; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays | 2019 |
Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Bone Morphogenetic Protein 5; Cell Movement; Cell Plasticity; Cell Transformation, Neoplastic; Coculture Techniques; Epithelial Cells; Female; Hair Follicle; HMGB1 Protein; Keratinocytes; Keratins; Male; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Papilloma; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2018 |
Pre-Exposure to Chronic Unpredictable Stress Suppresses the Chemopreventive Potential of Aloe Vera (Av) Leaf Gel Against 7,12-Dimethylbenz(a)anthracene (DMBA) Induced Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; Chemoprevention; Male; Mice; Plant Preparations; Random Allocation; Skin Neoplasms; Stress, Physiological; Tetradecanoylphorbol Acetate | 2019 |
[Role of clock proteins in skin carcinogenesis in 14-month-old SHR mice maintained under disrupted light regimen].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; ARNTL Transcription Factors; Cell Transformation, Neoplastic; CLOCK Proteins; Cryptochromes; Gene Expression Regulation, Neoplastic; Lighting; Male; Mice; Neoplasm Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
XB130 deficiency enhances carcinogen-induced skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adaptor Proteins, Signal Transducing; Animals; Carcinogenesis; Carcinogens; Cell Proliferation; Female; Genes, Tumor Suppressor; Inflammation; Male; Mice; Mice, Knockout; Microfilament Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2019 |
CpG methyl-seq and RNA-seq epigenomic and transcriptomic studies on the preventive effects of Moringa isothiocyanate in mouse epidermal JB6 cells induced by the tumor promoter TPA.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Line; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Epidermal Cells; Epigenome; Isothiocyanates; Mice; Moringa; Sequence Analysis, RNA; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2019 |
Establishment and Validation of an Ultra-Short-Term Skin Carcinogenicity Bioassay Using Tg-rasH2 Mice.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Female; Genes, ras; Humans; Mice; Mice, Transgenic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2020 |
Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway.
Topics: Animals; Anthocyanins; Antioxidant Response Elements; Antioxidants; Cell Line; Epidermal Cells; Epigenesis, Genetic; Heme Oxygenase-1; Mice; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2019 |
Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Canthaxanthin; Carotenoids; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Lipid Peroxidation; Mice; Mice, Inbred ICR; Molecular Structure; Paracoccus; Singlet Oxygen; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Viral Matrix Proteins | 2013 |
Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice.
Topics: Animals; Anticarcinogenic Agents; Diterpenes; Female; Hydroxylamines; Mice; Mice, Hairless; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2013 |
Chemopreventive effects of the juice of Vitis coignetiae Pulliat on two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antimutagenic Agents; Antioxidants; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Fruit; Mice; Mice, Inbred SENCAR; Phenols; Phytotherapy; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitis | 2013 |
New 6-amino-6-deoxy-glycoglycerolipids derived from 2-O-β-D-glucopyranosylglycerol: insights into the structure-activity relationship of glycoglycerolipids as anti-tumor promoters.
Topics: Animals; Antigens, Viral; Antineoplastic Agents; Drug Screening Assays, Antitumor; Female; Glucosides; Glycolipids; Humans; Mice; Molecular Structure; Nasopharyngeal Neoplasms; Nitrogen; Oxygen; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2013 |
Tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in an ultra-short-term skin carcinogenesis bioassay using rasH2 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biological Assay; Carcinogenesis; Dose-Response Relationship, Drug; Female; Humans; Mice; Mice, Transgenic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2013 |
Effects of two disiloxanes ALIS-409 and ALIS-421 on chemoprevention in model experiments.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Breast Neoplasms; Carcinogens; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Female; Fibroblasts; Humans; Lung; Mice; Mice, Inbred ICR; Morpholines; Papilloma; Piperazines; Siloxanes; Skin Neoplasms; Stromal Cells; Tetradecanoylphorbol Acetate | 2013 |
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Female; Genes, ras; Keratinocytes; Male; Mice; Mice, Knockout; Nuclear Proteins; Oncogene Protein p21(ras); Protein Inhibitors of Activated STAT; Proto-Oncogene Proteins c-myc; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2013 |
Modulatory effects of Azadirachta indica leaf extract on cutaneous and hepatic biochemical status during promotion phase of DMBA/TPA-induced skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Antioxidants; Azadirachta; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Cytochromes b5; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Lipid Peroxidation; Liver; Male; Mice; Micronucleus Tests; Neoplasms, Experimental; Phytotherapy; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Xenobiotics | 2013 |
Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151.
Topics: Animals; Carcinogens; Cell Line; Epidermis; Female; Gene Deletion; Genetic Predisposition to Disease; Integrin alpha3; Keratinocytes; Male; Mice; Mice, Knockout; Neoplasm Staging; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tetraspanin 24 | 2014 |
Fermented Prunus mume with probiotics inhibits 7,12-dimethylbenz[a]anthracene and 12-o-tetradecanoyl phorbol-13-acetate induced skin carcinogenesis through alleviation of oxidative stress.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Antioxidants; Cell Proliferation; Cell Transformation, Neoplastic; Diet; Female; Fermentation; Lipid Peroxidation; Mice; Mice, Inbred BALB C; Oxidative Stress; Plant Preparations; Probiotics; Prunus; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2013 |
Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Cell Proliferation; Cyclooxygenase 2; Female; Gene Expression Regulation, Neoplastic; Glucaric Acid; Humans; Interleukin-6; Mice; Mice, Inbred SENCAR; Phytochemicals; Resveratrol; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid | 2013 |
Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cannabinoids; Cocarcinogenesis; Dermatitis, Contact; Female; Mice; Mice, Inbred ICR; Molecular Structure; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2013 |
Chemoprevention of skin cancer: effect of Lawsonia inermis L. (Henna) leaf powder and its pigment artifact, lawsone in the Epstein- Barr virus early antigen activation assay and in two-stage mouse skin carcinogenesis models.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Administration, Oral; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; B-Lymphocytes; Carcinogenesis; Cell Line, Tumor; Female; Herpesvirus 4, Human; Humans; Lawsonia Plant; Male; Naphthoquinones; Papilloma; Plant Extracts; Plant Leaves; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2013 |
The effects of dissociated glucocorticoids RU24858 and RU24782 on TPA-induced skin tumor promotion biomarkers in SENCAR mice.
Topics: Animals; Animals, Outbred Strains; Anticarcinogenic Agents; Biomarkers; Cell Proliferation; Cell Transformation, Neoplastic; Cyclooxygenase 2; Desoximetasone; Epidermis; Female; Gene Expression Regulation; Glucocorticoids; Hyperplasia; Interleukin-6; Mice; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-jun; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
A role for NF-κB activity in skin hyperplasia and the development of keratoacanthomata in mice.
Topics: Amino Acid Substitution; Animals; Cell Proliferation; Hyperplasia; Keratoacanthoma; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Papilloma; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor RelA | 2013 |
PTEN ablation in Ras(Ha)/Fos skin carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin D1/E2 inhibition.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Proliferation; Cyclin D1; Cyclins; Gene Expression Regulation, Neoplastic; Keratinocytes; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins p21(ras); PTEN Phosphohydrolase; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2014 |
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Chromones; ErbB Receptors; Female; Flavonoids; Hair Follicle; Hyperplasia; Keratinocytes; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred ICR; Mice, Transgenic; Morpholines; Multiprotein Complexes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2014 |
Genome-wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred C57BL; Papilloma; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-2 | 2015 |
A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1.
Topics: Animals; Anticarcinogenic Agents; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Flavones; Flavonoids; Histones; Male; Mice; p38 Mitogen-Activated Protein Kinases; Papilloma; Phenethylamines; Phosphorylation; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Metformin inhibits skin tumor promotion in overweight and obese mice.
Topics: Adenylate Kinase; Adiponectin; Animals; Body Weight; Carcinogenesis; Carcinoma, Squamous Cell; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Insulin; Insulin-Like Growth Factor I; Leptin; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Obese; Multiprotein Complexes; Neoplasms, Experimental; Obesity; Overweight; Papilloma; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2014 |
Hexahydro-β-acids potently inhibit 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Carboxylic Acids; Cyclooxygenase 2; Dermatitis; Edema; Extracellular Signal-Regulated MAP Kinases; Female; Humulus; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; Ornithine Decarboxylase; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2013 |
Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Activins; Animals; Carcinogens; Carcinoma, Squamous Cell; Chemotaxis; Female; Humans; Injections, Intralesional; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neovascularization, Pathologic; Neutrophil Infiltration; Papilloma; Proto-Oncogene Proteins c-kit; Recombinant Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wound Healing | 2013 |
Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line, Tumor; Enzyme Inhibitors; Farnesyltranstransferase; Gene Dosage; Gene Knock-In Techniques; Genes, ras; Humans; Mice, Mutant Strains; Mutation; Papilloma; Piperidines; Pyridines; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Inhibitory effects of Momordica grosvenori Swingle extracts on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mouse skin.
Topics: Animals; Anti-Inflammatory Agents; Drugs, Chinese Herbal; Edema; Female; Humans; In Vitro Techniques; Mice; Momordica; NF-kappa B; Ornithine Decarboxylase; Proto-Oncogene Proteins c-akt; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Assessment of Augmented Immune Surveillance and Tumor Cell Death by Cytoplasmic Stabilization of p53 as a Chemopreventive Strategy of 3 Promising Medicinal Herbs in Murine 2-Stage Skin Carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Apoptosis; Calendula; Carcinogenesis; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Chemoprevention; Eclipta; Female; Free Radicals; Immunologic Surveillance; Inflammation; Langerhans Cells; Mice; NF-kappa B; Phytotherapy; Plant Extracts; Proliferating Cell Nuclear Antigen; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trigonella; Tumor Suppressor Protein p53 | 2014 |
IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cytokines; Dendritic Cells; Female; Gene Expression Regulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Knockout; Papilloma; Signal Transduction; Skin Neoplasms; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate; Th1-Th2 Balance | 2014 |
IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cytokines; Interleukin-13 Receptor alpha1 Subunit; Methylcholanthrene; Mice; Mice, Inbred BALB C; Mice, Knockout; Papilloma; Receptors, Cell Surface; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2013 |
S100A9 has a protective role in inflammation-induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calgranulin A; Calgranulin B; Carcinogenesis; Cell Transformation, Neoplastic; Dimerization; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2014 |
Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin.
Topics: Animals; Antigens, CD34; Apoptosis; Carcinogenesis; Carcinoma, Squamous Cell; Cell Proliferation; DNA Repair; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Keratin-15; Keratin-19; Keratinocytes; Membrane Proteins; Mice; Mice, Knockout; RNA, Small Interfering; Sirtuin 2; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Burden; Up-Regulation | 2014 |
Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Isothiocyanates; Mice; NF-E2-Related Factor 2; Skin Neoplasms; Sulfoxides; Tetradecanoylphorbol Acetate | 2014 |
Mast cells protect from skin tumor development and limit tumor growth during cutaneous de novo carcinogenesis in a Kit-dependent mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adoptive Transfer; Animals; Carcinogenesis; Cell Count; Cell Degranulation; Cytoprotection; Disease Models, Animal; Female; Granulocytes; Macrophages; Mast Cells; Mice; Proto-Oncogene Proteins c-kit; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Burden | 2014 |
A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling.
Topics: Animals; Anthracenes; Cell Transformation, Neoplastic; Cells, Cultured; Female; Humans; Interferon Regulatory Factor-1; Interferon-gamma; Keratinocytes; Mice; Neoplasms, Experimental; Phosphorylation; Signal Transduction; Skin Neoplasms; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate | 2015 |
Targeted deletion of RasGRP1 impairs skin tumorigenesis.
Topics: Animals; Cell Transformation, Neoplastic; Codon; Gene Deletion; Gene Targeting; Genes, ras; Guanine Nucleotide Exchange Factors; Hyperplasia; Mice; Mice, Knockout; Mutation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2014 |
Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2014 |
Does increase in DNA repair allow "tolerance-to-insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice.
Topics: Animals; Carcinogenesis; Disease Resistance; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Gene Expression; Humans; Methylnitrosourea; Mice; Mice, Transgenic; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 2014 |
DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Carcinogenesis; Carcinogens; Carcinoma, Basal Cell; CD4-Positive T-Lymphocytes; Disease Models, Animal; Epidermis; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutation; Patched Receptors; Patched-1 Receptor; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Signal Transduction; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate | 2014 |
Chemomodulatory efficacy of lycopene on antioxidant enzymes and carcinogen-induced cutaneum carcinoma in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; Carotenoids; Chemoprevention; Female; Glutathione; Lipid Peroxidation; Lycopene; Mice, Inbred ICR; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Basement Membrane; Blood Vessels; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Collagen Type IV; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Neoplasm Invasiveness; Nerve Tissue Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Burden | 2014 |
Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Communication; Cell Differentiation; Cell Transformation, Neoplastic; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Epidermis; Keratinocytes; Membrane Proteins; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; NK Cell Lectin-Like Receptor Subfamily K; Papilloma; Permeability; Plakins; Protein Precursors; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymic Stromal Lymphopoietin; Time Factors | 2014 |
Chemopreventive effect of a novel, selective TACE inhibitor on DMBA- and TPA-induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; ADAM Proteins; ADAM17 Protein; Animals; Antineoplastic Agents; Cocarcinogenesis; Cytokines; Dose-Response Relationship, Drug; Edema; Female; Hydroxamic Acids; Mice, Inbred BALB C; Pyrrolidinones; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Meis1 regulates epidermal stem cells and is required for skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult Stem Cells; Animals; Carcinogens; Carcinoma; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Disease Progression; Gene Expression Regulation, Neoplastic; Hair Follicle; Homeodomain Proteins; Keratinocytes; Mice; Mice, Transgenic; Multipotent Stem Cells; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Papilloma; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
In vivo long-term effects of retinoic acid exposure in utero on induced tumours in adult mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Drug Administration Schedule; Female; Keratoacanthoma; Male; Mice; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Treatment Outcome; Tretinoin | 2014 |
Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Proliferation; Cyclooxygenase 2; Eicosanoids; Epidermis; Epithelial Cells; Gene Deletion; Gene Targeting; Hyperplasia; Keratinocytes; Lipid Metabolism; Macrophages; Mice; Myeloid Cells; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; CpG Islands; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome; Inflammation; Mice; Sequence Analysis, DNA; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2014 |
Photodynamic therapy using a novel irradiation source, LED lamp, is similarly effective to photodynamic therapy using diode laser or metal-halide lamp on DMBA- and TPA-induced mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Female; Lasers, Semiconductor; Mice; Mice, Hairless; Papilloma; Photochemotherapy; Photosensitizing Agents; Porphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Cells of origin in skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinoma, Basal Cell; CD4-Positive T-Lymphocytes; Epidermis; Patched Receptors; Receptors, Cell Surface; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Reduced signaling of PI3K-Akt and RAS-MAPK pathways is the key target for weight-loss-induced cancer prevention by dietary calorie restriction and/or physical activity.
Topics: Animals; Apolipoprotein A-I; Caloric Restriction; Computational Biology; Disease Models, Animal; Energy Intake; Female; Mice; Mice, Inbred SENCAR; Microarray Analysis; Mitogen-Activated Protein Kinase 1; Phosphatidylinositol 3-Kinases; Physical Conditioning, Animal; Proteomics; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcriptome; Up-Regulation; Weight Loss | 2014 |
Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acacia; Administration, Topical; Animals; Antioxidants; Biomarkers; Carcinoma, Squamous Cell; Catechin; Dinoprostone; Drug Evaluation, Preclinical; Emulsions; Humans; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Nucleus; Dual-Specificity Phosphatases; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Mice; Mice, Knockout; Plasminogen Activator Inhibitor 2; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2014 |
Soluble endoglin antagonizes Met signaling in spindle carcinoma cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Carcinogenesis; Cell Movement; Cell Proliferation; DNA, Complementary; Endoglin; Enzyme Activation; Female; HEK293 Cells; Hepatocyte Growth Factor; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Prognosis; Proto-Oncogene Proteins c-met; Receptors, Cell Surface; Sarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Transforming Growth Factor beta1; Tumor Cells, Cultured | 2015 |
Riboflavin as adjuvant with cisplatin: study in mouse skin cancer model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Antioxidants; Body Weight; Carcinoma, Squamous Cell; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Glutathione; Kidney; Liver; Male; Malondialdehyde; Mice; Photosensitizing Agents; Random Allocation; Riboflavin; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
Mouse models of nonmelanoma skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Culture Techniques; DNA; Epidermis; Humans; Keratinocytes; Mice; Skin Neoplasms; Staining and Labeling; Tamoxifen; Tetradecanoylphorbol Acetate | 2015 |
Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells.
Topics: Animals; Calgranulin B; CD4-Positive T-Lymphocytes; Cell Transformation, Neoplastic; Chemokine CCL4; Colitis; Female; Humans; Mice, Transgenic; Myeloid Cells; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cisplatin; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Glutathione; Head and Neck Neoplasms; Heterografts; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplastic Stem Cells; NF-E2-Related Factor 2; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 2015 |
Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Carrier Proteins; Caspase 3; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chemoprevention; Keratinocytes; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Ultraviolet Rays | 2015 |
Keratinocyte p38δ loss inhibits Ras-induced tumor formation, while systemic p38δ loss enhances skin inflammation in the early phase of chemical carcinogenesis in mouse skin.
Topics: Animals; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Inflammation; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 13; ras Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
A murine model for the development of melanocytic nevi and their progression to melanoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line, Tumor; Cell Separation; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Disease Progression; Melanoma; Mice; Mice, Nude; Mutation; Neoplasm Proteins; Nevus, Pigmented; ras Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Relevance of the mouse skin initiation-promotion model for the classification of carcinogenic substances encountered at the workplace.
Topics: Animals; Carcinogens; Disease Models, Animal; Humans; Mice; Occupational Exposure; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Workplace | 2015 |
Cancer-promoting effect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulating inflammation, Erk and p38 in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capsaicin; Carcinogenesis; Cyclooxygenase 2; Female; Hyperplasia; Inflammation; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2015 |
Caspase-3 promotes genetic instability and carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bone Marrow Cells; Breast; Caspase 3; Cells, Cultured; Endodeoxyribonucleases; Epithelial Cells; Female; Genome; Genomic Instability; Humans; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma in Situ; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Division; Cocarcinogenesis; Dermis; Desmoglein 2; Epidermis; Gene Knock-In Techniques; Genes, Reporter; Genetic Predisposition to Disease; Genotype; Hair Follicle; Hedgehog Proteins; Hyperplasia; Keratinocytes; Mice; Mice, Transgenic; Papilloma; Patched Receptors; Patched-1 Receptor; Receptors, Cell Surface; Signal Transduction; Skin Neoplasms; Stromal Cells; Tetradecanoylphorbol Acetate; Time Factors | 2015 |
Melanogenesis-inhibitory activity and cancer chemopreventive effect of glucosylcucurbic acid from shea (Vitellaria paradoxa) kernels.
Topics: alpha-MSH; Animals; Anticarcinogenic Agents; Antigens, Viral; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Glucosides; Humans; Melanins; Melanoma, Experimental; Mice, Inbred Strains; Molecular Structure; Monophenol Monooxygenase; Oxidoreductases; Oxylipins; Plant Extracts; Sapotaceae; Seeds; Skin Neoplasms; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays | 2015 |
REGγ is critical for skin carcinogenesis by modulating the Wnt/β-catenin pathway.
Topics: Animals; Autoantigens; Carcinogenesis; Carcinogens; Cell Line; Cell Proliferation; Cyclin D1; Gene Knockdown Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Keratinocytes; Mice; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-myc; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Wnt Signaling Pathway | 2015 |
Chemopreventive efficacy of menthol on carcinogen-induced cutaneous carcinoma through inhibition of inflammation and oxidative stress in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma; Chemoprevention; Cyclooxygenase 2; Dermatitis; Female; Glutathione; Inflammation; Menthol; Mice, Inbred ICR; Neoplasms, Experimental; Oxidative Stress; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
Twist1 regulates keratinocyte proliferation and skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Cycle; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Keratinocytes; Mice; Mice, Transgenic; Nuclear Proteins; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Twist-Related Protein 1 | 2016 |
Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate.
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Cell Nucleus; Cell Proliferation; Cytosol; Female; Inflammation; Male; Mice; Mice, Inbred ICR; Protein Binding; Resveratrol; Signal Transduction; Skin; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid | 2015 |
Resistance of R-Ras knockout mice to skin tumour induction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Proliferation; Dermis; Genetic Association Studies; Genetic Predisposition to Disease; Mice, Inbred C57BL; Mice, Knockout; Papilloma; ras Proteins; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; Carcinoma, Verrucous; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cocarcinogenesis; Disease Progression; DNA Transposable Elements; Female; Humans; Mice; Mice, Transgenic; Mouth Neoplasms; Mutagenesis, Insertional; Neoplasm Invasiveness; Oncogenes; Papilloma; Papillomaviridae; Receptor, Notch1; Skin Neoplasms; Specific Pathogen-Free Organisms; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Virus Infections; Uterine Cervical Neoplasms | 2015 |
Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Proliferation; Flow Cytometry; Gene Ontology; Humans; Immunoblotting; Ion Channels; Keratinocytes; Lipid Metabolism; Metabolome; Metabolomics; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Proteins; Neoplasms, Experimental; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Skin Neoplasms; Tetradecanoylphorbol Acetate; Uncoupling Protein 3 | 2015 |
Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Cytochrome P-450 CYP2E1; DNA Damage; Hair Follicle; Keratinocytes; Mice; Mice, Knockout; NFATC Transcription Factors; Papilloma; Skin; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate | 2015 |
Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Drug Interactions; Female; Mice; Mice, Inbred ICR; Pentacyclic Triterpenes; Perilla frutescens; Plant Extracts; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2015 |
Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Survival; Female; Male; Mice; Mice, Knockout; Mice, Transgenic; Protein Kinase C-epsilon; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2016 |
Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Ardisia; Cell Transformation, Neoplastic; Chemical Fractionation; Chemoprevention; Curcumin; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Male; Mice; Mice, Inbred ICR; Plant Extracts; Plant Roots; Quinones; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2015 |
Fractionation of a tumor-initiating UV dose introduces DNA damage-retaining cells in hairless mouse skin and renders subsequent TPA-promoted tumors non-regressing.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; DNA Damage; Epidermis; Female; Hyperplasia; Immunoenzyme Techniques; Male; Mice; Mice, Hairless; Mutation; Real-Time Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Ultraviolet Rays | 2016 |
Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells.
Topics: Carcinogens; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Melanoma; Receptors, G-Protein-Coupled; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis.
Topics: Animals; Carcinoma, Squamous Cell; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Keratinocytes; Mice; Proto-Oncogene Proteins c-met; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development.
Topics: Animals; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Keratinocytes; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Transgenic; Multiprotein Complexes; Phosphoproteins; Signal Transduction; Skin Neoplasms; Smad Proteins; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Wound Healing | 2016 |
Deletion of 14-3-3σ sensitizes mice to DMBA/TPA-induced papillomatosis.
Topics: 14-3-3 Proteins; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Cell Differentiation; Cell Proliferation; Codon, Nonsense; Disease Models, Animal; Down-Regulation; Epidermal Cells; Epidermis; Exons; Female; Gain of Function Mutation; Gene Deletion; Hair Follicle; Heterozygote; Immunohistochemistry; Integrases; Keratinocytes; Male; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Pro-Oxidant Role of Silibinin in DMBA/TPA Induced Skin Cancer: 1H NMR Metabolomic and Biochemical Study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Catalase; In Situ Nick-End Labeling; Magnetic Resonance Spectroscopy; Male; Metabolomics; Mice; Reactive Oxygen Species; Silybin; Silymarin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2016 |
Sex differences and pathology status correlated to the toxicity of some common carcinogens in experimental skin carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Female; Male; Mice; Mice, Hairless; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Administration of resveratrol enhances cell-cycle arrest followed by apoptosis in DMBA-induced skin carcinogenesis in male Wistar rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogenesis; Cell Cycle Checkpoints; Male; Rats; Rats, Wistar; Resveratrol; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate | 2016 |
Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Flow Cytometry; Lymph Nodes; Lymphangiogenesis; Lymphatic Metastasis; Lymphatic Vessels; Lymphocyte Count; Macrophages; Mast Cells; Mice; Mice, Knockout; Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor D | 2016 |
Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Mass Index; Carcinogenesis; Carcinogens; Connexins; Crosses, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genetic Predisposition to Disease; Humans; Inflammation; Lipid Metabolism; Male; Mice; Mice, Inbred Strains; Quantitative Trait Loci; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2016 |
Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1; Extracellular Signal-Regulated MAP Kinases; Genetic Predisposition to Disease; Humans; Keratinocytes; MAP Kinase Kinase 1; Mice, Knockout; Neoplasms, Experimental; Papilloma; Phenotype; Receptors, G-Protein-Coupled; RNA Interference; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transfection; Wnt Signaling Pathway | 2016 |
Elevated ΔNp63α Levels Facilitate Epidermal and Biliary Oncogenic Transformation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bile Duct Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Senescence; Hyperplasia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphoproteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trans-Activators | 2017 |
Suppression of skin tumorigenesis in CD109-deficient mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Apoptosis; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; DNA Damage; Genes, ras; Genetic Predisposition to Disease; Keratinocytes; Mice, Knockout; Mutation; Neoplasm Proteins; NF-E2-Related Factor 2; Papilloma; Phenotype; Phosphorylation; Signal Transduction; Skin Neoplasms; Smad2 Protein; Tetradecanoylphorbol Acetate; Time Factors; Transforming Growth Factor beta1 | 2016 |
Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Proliferation; Cyclin D1; Daucus carota; G1 Phase; Humans; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Protective Agents; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2017 |
Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Cyclooxygenase 2 Inhibitors; Edema; Female; Hyperplasia; I-kappa B Kinase; I-kappa B Proteins; MAP Kinase Signaling System; Mice; Mice, Inbred SENCAR; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Ornithine Decarboxylase Inhibitors; Phosphorylation; Pregnenediones; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) inhibits chemically induced skin tumorigenesis.
Topics: Acetone; Animals; Carcinogens; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Enzyme Activation; Female; Keratinocytes; Ligands; Mice; Mice, Mutant Strains; PPAR delta; PPAR-beta; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiazoles | 2008 |
The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells.
Topics: Biomarkers, Tumor; Carcinogens; Carrier Proteins; Cell Nucleus; Cell Proliferation; Cytoplasm; Disease Progression; Enzyme Inhibitors; Fatty Acid-Binding Protein 7; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunoenzyme Techniques; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Nevus, Pigmented; Oligonucleotide Array Sequence Analysis; Prognosis; RNA, Messenger; RNA, Small Interfering; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2008 |
Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction.
Topics: Carcinoma, Basal Cell; Cell Line, Tumor; Cell Polarity; Cyclooxygenase 2; Enzyme Induction; Fibroblast Growth Factor 2; Humans; Macrophages; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neovascularization, Pathologic; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2009 |
Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics.
Topics: Animals; Antigens, CD34; Arsenic; Carcinoma, Squamous Cell; Cell Cycle Proteins; Female; Fetus; Genes, ras; Mice; Neoplastic Stem Cells; Neuropeptides; Pregnancy; Proteins; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.
Topics: Animals; Dendritic Cells; Dermatitis, Contact; Disease Progression; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lymph Nodes; Mice; Mice, Inbred C57BL; Models, Animal; Papilloma; Signal Transduction; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2008 |
Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Diglycerides; Fatty Acids; Female; Fluocinolone Acetonide; Linoleic Acid; Mice; Oils; Oleic Acid; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinogens; DNA Primers; Genes, Tumor Suppressor; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Proteins; Polymerase Chain Reaction; Promyelocytic Leukemia Protein; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Suppressor Proteins | 2009 |
A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.
Topics: Adult; Aged; Animals; Anticarcinogenic Agents; Benzodioxoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Keratinocytes; Keratosis; Male; Mice; Middle Aged; Papilloma; Precancerous Conditions; Quinazolines; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate | 2009 |
Antitumor-promoting effects of polyphenolic extracts from seedless and seeded Indian grapes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Esophageal Neoplasms; Female; Flavonoids; India; Male; Mice; Mice, Inbred Strains; Phenols; Plant Extracts; Polyphenols; Seeds; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Vitis | 2008 |
Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Drug Eruptions; Enzyme Activation; Female; Hair Follicle; HeLa Cells; Humans; Keratinocytes; Ligands; Male; Mice; Neutrophils; Protein Kinase C-alpha; Receptors, Interleukin-8B; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.
Topics: Animals; Carcinogens; Cell Line, Tumor; Cell Transformation, Neoplastic; Down-Regulation; ErbB Receptors; Lysosomes; Mice; Mice, Knockout; Protein Structure, Tertiary; Proto-Oncogene Proteins c-cbl; Skin Neoplasms; Tetradecanoylphorbol Acetate; TRPV Cation Channels; Ubiquitin | 2009 |
Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cyclin D1; Cyclooxygenase 2; Dinoprostone; Female; Grape Seed Extract; Inflammation; Mice; Papilloma; Plant Extracts; Proanthocyanidins; Proliferating Cell Nuclear Antigen; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Drug Screening Assays, Antitumor; Edema; Extracellular Signal-Regulated MAP Kinases; Female; Hyperplasia; Inflammation; Mice; Monoterpenes; Oxidative Stress; ras Proteins; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2009 |
IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Inflammation; Interferon gamma Receptor; Interferon-gamma; Interleukin-17; Mice; Papilloma; Phosphorylation; Receptors, Interferon; Skin Neoplasms; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate | 2009 |
Hypoxia-inducible factor-1alpha suppresses squamous carcinogenic progression and epithelial-mesenchymal transition.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Cycle Proteins; Disease Progression; Epithelial Cells; Hypoxia-Inducible Factor 1, alpha Subunit; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Selenium-Binding Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2009 |
Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Bromelains; Cyclooxygenase 2 Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Mice; Mitochondria; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2009 |
Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Calcium; Caspase 3; Caspase 9; Caspase Inhibitors; Cells, Cultured; Dose-Response Relationship, Drug; Female; Immunohistochemistry; In Situ Nick-End Labeling; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Papilloma; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Survival Analysis; Tetradecanoylphorbol Acetate | 2009 |
Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Transformation, Neoplastic; Genotype; Hyperplasia; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oncogene Protein v-akt; Papilloma; Phosphorylation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Photodynamic therapy using a novel photosensitizer, EC036, is more effective compared with ATX-S10(Na) photodynamic therapy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Female; Lasers, Semiconductor; Mice; Mice, Hairless; Ointments; Papilloma; Photochemotherapy; Photosensitizing Agents; Porphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2009 |
Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis Regulatory Proteins; Cell Transformation, Neoplastic; Dermatitis; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Unsaturated; Female; Linoleic Acid; Lipopolysaccharides; Mice; Mice, Inbred ICR; RNA-Binding Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Suppressor Proteins | 2009 |
Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression; Immunohistochemistry; MAP Kinase Kinase Kinases; Mice; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins B-raf; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 2009 |
Inhibition of CREB function in mouse epidermis reduces papilloma formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Carcinogens; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Epidermis; Female; Genes, ras; In Situ Nick-End Labeling; Keratinocytes; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Mutation; Papilloma; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.
Topics: Animals; Animals, Newborn; Carcinoma; Cell Proliferation; Disease Progression; Epidermis; Female; Genes, ras; Genotype; Hyperplasia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 13; Mutation; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Chemoprevention; Cyclooxygenase 2; Disease Models, Animal; Drug Screening Assays, Antitumor; Extracellular Signal-Regulated MAP Kinases; Farnesol; Inflammation; Mice; Ornithine Decarboxylase; Oxidative Stress; ras Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Angiogenesis Inhibitors; Animals; Blood Vessels; Carcinogens; Cell Transformation, Neoplastic; Female; Genotype; Immunohistochemistry; Intestinal Polyps; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Neoplasms, Experimental; NIH 3T3 Cells; Resveratrol; Sirtuin 1; Sirtuins; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate; Transfection | 2009 |
Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Kaplan-Meier Estimate; Mice; Mice, Inbred Strains; Papilloma; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Catechin; Female; Hippophae; Inflammation; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Plant Stems; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Epidermis; Gene Deletion; Genes, Tumor Suppressor; Homeodomain Proteins; Mice; Mice, Knockout; Receptor, Notch1; Skin Neoplasms; Stromal Cells; Tetradecanoylphorbol Acetate | 2009 |
Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Carcinogens; Coumarins; Female; Ferula; Lactones; Mice; Mice, Inbred ICR; Monoterpenes; Papilloma; Phytotherapy; Plant Extracts; Plant Roots; Sesquiterpenes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Insights into the role of the calcium sensing receptor in epidermal differentiation in vivo.
Topics: Animals; Calcium Signaling; Carcinogens; Cell Differentiation; Epidermal Cells; Epidermis; Immunohistochemistry; Mice; Organ Specificity; Receptors, Calcium-Sensing; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development.
Topics: Animals; Arrestins; beta-Arrestins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Genes, ras; Mice; Mice, Inbred C57BL; Papilloma; Proto-Oncogene Proteins c-akt; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate | 2009 |
Cancer chemopreventive activity of oleanane-type triterpenoids from the stem bark of Betula ermanii.
Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Betula; Carcinogenicity Tests; Female; Mice; Mice, Inbred ICR; Oleanolic Acid; Papilloma; Plant Bark; Plant Stems; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2009 |
RIP4 regulates epidermal differentiation and cutaneous inflammation.
Topics: 14-3-3 Proteins; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Differentiation; Dermatitis, Contact; Epidermis; Female; Humans; I-kappa B Kinase; Keratin-14; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pregnancy; Promoter Regions, Genetic; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Receptors, Tumor Necrosis Factor, Type I; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Relative inhibitory activity of bile acids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, and chenodeoxycholic acid inhibition of tumour promotion in mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Bile Acids and Salts; Carcinogens; Chenodeoxycholic Acid; Disease Models, Animal; Edema; Female; Indomethacin; Inflammation; Inhibitory Concentration 50; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2009 |
The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Epidermis; Gene Deletion; Methylnitronitrosoguanidine; Mice; Receptors, Aryl Hydrocarbon; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2009 |
IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cyclin D1; Cyclooxygenase 2; Cytokines; Female; Inflammation; Interleukin-12 Subunit p40; Interleukin-6; Mice; Mice, Knockout; Proliferating Cell Nuclear Antigen; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2009 |
All-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Extracellular Signal-Regulated MAP Kinases; Female; Immunohistochemistry; MAP Kinase Kinase Kinases; Mice; Mice, Inbred SENCAR; Mice, Transgenic; raf Kinases; Signal Transduction; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Tretinoin | 2009 |
MK2 regulates the early stages of skin tumor promotion.
Topics: Animals; Apoptosis; Disease Progression; DNA Damage; Gene Expression Regulation, Neoplastic; Inflammation; Intracellular Signaling Peptides and Proteins; Keratinocytes; Mice; Mice, Transgenic; Phosphorylation; Protein Serine-Threonine Kinases; RNA, Small Interfering; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2009 |
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.
Topics: Acetylation; Animals; Carcinoma, Adenoid Cystic; Catalytic Domain; Cell Cycle; Cell Line, Tumor; Cytokinesis; Deubiquitinating Enzyme CYLD; Genes, Tumor Suppressor; Histone Deacetylase 6; Histone Deacetylases; Humans; Keratinocytes; Melanocytes; Melanoma; Mice; Microtubules; Mutation; Recombinant Fusion Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tubulin; Tumor Suppressor Proteins | 2010 |
Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model.
Topics: Animals; Blotting, Western; Cell Line; DNA, Complementary; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Keratinocytes; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2010 |
Basic fibroblast growth factor regulates persistent ERK oscillations in premalignant but not malignant JB6 cells.
Topics: Animals; Carcinogens; Cell Division; Cell Line, Tumor; Epidermal Cells; Epidermis; Fibroblast Growth Factor 2; Green Fluorescent Proteins; Humans; MAP Kinase Signaling System; Mesoderm; Mice; Mitogen-Activated Protein Kinase 3; Precancerous Conditions; Recombinant Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Wound Healing | 2010 |
Studies on glyphosate-induced carcinogenicity in mouse skin: a proteomic approach.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Glycine; Glyphosate; Herbicides; Mice; Proteomics; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2010 |
Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benz(a)Anthracenes; Benzo(a)pyrene; Blotting, Western; Caspase 3; Cyclin-Dependent Kinase Inhibitor p16; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); Ornithine Decarboxylase; Phosphoproteins; Proto-Oncogene Proteins c-bcl-2; Quinone Reductases; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators; Tumor Suppressor Protein p53 | 2010 |
The effect of c-myc on stem cell fate influences skin tumor phenotype.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma, Sebaceous; Animals; Carcinogens; Cell Differentiation; Cell Lineage; Crosses, Genetic; Female; Heterozygote; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Mice, Transgenic; Multipotent Stem Cells; Papilloma; Phenotype; Proto-Oncogene Proteins c-myc; Sebaceous Gland Neoplasms; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate; Transgenes | 2010 |
Hybrids of 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2) and various anti-oxidants as cancer chemopreventive agents.
Topics: Animals; Antigens, Viral; Antineoplastic Agents; Antioxidants; Cell Line; Drug Screening Assays, Antitumor; Female; Herpesvirus 4, Human; HIV Reverse Transcriptase; HIV-1; Humans; Mice; Mice, Inbred ICR; Neoplasms; Pyrones; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2010 |
Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Progression; Female; Fluorodeoxyglucose F18; Glucose; Mice; Papilloma; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tomography, X-Ray Computed | 2010 |
Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis.
Topics: Animals; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Mice; Mice, Inbred BALB C; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1 | 2010 |
Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Down-Regulation; Drug Interactions; Enzyme Activation; Enzyme Induction; Female; Humans; MAP Kinase Kinase 4; Mice; Mice, Inbred ICR; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin; Skin Neoplasms; Sulfides; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin.
Topics: Acetates; Alcohols; Animals; Anti-Inflammatory Agents; Cynara scolymus; Female; Flowers; Inflammation; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2010 |
Dietary energy restriction, in part through glucocorticoid hormones, mediates the impact of 12-O-tetradecanoylphorbol-13-acetate on jun D and fra-1 in Sencar mouse epidermis.
Topics: Animals; Body Weight; Caloric Restriction; Corticosterone; DNA; Epidermis; Female; Glucocorticoids; Mice; Mice, Inbred SENCAR; Protein Binding; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2010 |
Genetic heterogeneity of inflammatory response and skin tumorigenesis in phenotypically selected mouse lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Genetic Drift; Genetic Heterogeneity; Genetic Predisposition to Disease; Genome-Wide Association Study; Inflammation; Mice; Neutrophil Infiltration; Papilloma; Phenotype; Polymorphism, Single Nucleotide; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
The immunosuppressive surface ligand CD200 augments the metastatic capacity of squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Antigens, Surface; Carcinoma, Squamous Cell; Cell Growth Processes; Female; Gene Knockdown Techniques; Humans; Keratinocytes; Membrane Glycoproteins; Mice; Orexin Receptors; Receptors, Cell Surface; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Keratinocytes; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Neuropeptides; p21-Activated Kinases; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1.
Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Carbenoxolone; Carcinogens; Carcinoma, Squamous Cell; Caveolin 1; Cell Communication; Cell Proliferation; Connexin 43; Epidermal Cells; Epidermal Growth Factor; Epidermis; Epithelial Cells; Fluorescent Antibody Technique; Gap Junctions; Green Fluorescent Proteins; Humans; Immunoprecipitation; Keratinocytes; Mesoderm; Neoplasm Invasiveness; Rats; RNA, Small Interfering; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1 | 2010 |
The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.
Topics: Administration, Topical; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Line, Tumor; Diterpenes; Drug Eruptions; Enzyme Activation; Humans; Keratinocytes; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Protein Binding; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetates; Animals; Anti-Inflammatory Agents; Antigens, Viral; Antineoplastic Agents, Phytogenic; Carrageenan; Cell Line, Tumor; Cinnamates; Dose-Response Relationship, Drug; Edema; Female; Hindlimb; Mice; Mice, Inbred ICR; Sapotaceae; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Triterpenes | 2010 |
3,3'-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Chemokine CXCL5; Cyclooxygenase 2; Ear; Edema; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation; I-kappa B Kinase; Indoles; Inflammation; Inflammation Mediators; Interleukin-6; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adaptor Proteins, Signal Transducing; Animals; Bone Marrow; Bone Marrow Transplantation; Carcinogens; Drug Synergism; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-1beta; Keratinocytes; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Escape; Tumor Suppressor Proteins; U937 Cells; Whole-Body Irradiation | 2010 |
Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cocarcinogenesis; Cyclooxygenase 2; Drug Synergism; Enzyme Activation; ErbB Receptors; Female; Humans; Male; Mice; Mice, Knockout; Signal Transduction; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate; TRPV Cation Channels | 2010 |
Enhancement of ultraviolet B-induced skin tumor development in phospholipase Cε-knockout mice is associated with decreased cell death.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Interleukin-10; Interleukin-1beta; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Radiation-Induced; Phosphoinositide Phospholipase C; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2010 |
Chemopreventive activity of Azadirachta indica on two-stage skin carcinogenesis in murine model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Azadirachta; Carcinoma; Disease Models, Animal; Male; Mice; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
The potential use of protein kinase D inhibitors for prevention/treatment of epidermal tumors.
Topics: Animals; Anticarcinogenic Agents; Carbazoles; Cell Differentiation; Cell Proliferation; Cells, Cultured; Epidermis; Isoquinolines; Keratinocytes; Mice; Protein Kinase C; Protein Kinase Inhibitors; Resveratrol; Skin Neoplasms; Stilbenes; Sulfonamides; Tetradecanoylphorbol Acetate | 2010 |
Use of a TGFbeta type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFbeta signaling in tumor promotion and progression.
Topics: Animals; Benzamides; Dioxoles; Disease Progression; Genes, ras; Mice; Papilloma; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Skin Neoplasms; Smad2 Protein; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1 | 2010 |
Anti-tumor-initiating effects of spiro-biflavonoids from Abies sachalinensis.
Topics: Abies; Animals; Anticarcinogenic Agents; Biflavonoids; Carcinogenicity Tests; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Female; Humans; Mice; Mice, Inbred ICR; Molecular Structure; Peroxynitrous Acid; Plant Bark; Skin Neoplasms; Spiro Compounds; Tetradecanoylphorbol Acetate | 2010 |
Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cytokines; Female; Immunoblotting; Immunohistochemistry; Inflammation; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proto-Oncogene Proteins; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Embryo, Mammalian; Fibroblasts; Histones; Mice; Mice, Inbred C57BL; Mice, Knockout; Octamer Transcription Factor-3; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2010 |
Lack of skin carcinogenicity of topically applied titanium dioxide nanoparticles in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Body Weight; Carcinogenicity Tests; Metal Nanoparticles; Mice; Mice, Inbred ICR; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Titanium | 2011 |
Carcinogen-induced squamous papillomas and oncogenic progression in the absence of the SSeCKS/AKAP12 metastasis suppressor correlate with FAK upregulation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; A Kinase Anchor Proteins; Animals; Cell Cycle Proteins; Disease Progression; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2011 |
IL-17 enhances tumor development in carcinogen-induced skin cancer.
Topics: Aniline Compounds; Animals; Carcinogens; CD11b Antigen; Cell Growth Processes; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Interferon-gamma; Interleukin-17; Mice; Mice, Inbred C57BL; Mice, Knockout; Skin; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Tumor Microenvironment | 2010 |
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Binding Sites; Carcinogens; Clathrin; Drug Resistance, Neoplasm; Endocytosis; Female; Glutathione; GTPase-Activating Proteins; Humans; Male; Mice; Mice, Knockout; Protein Kinase C-alpha; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Suppressor Protein p53 | 2011 |
FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Chemokine CCL2; Chronic Disease; Fibroblasts; Humans; Inflammation; Macrophages; Mice; Mice, Inbred BALB C; Mice, Transgenic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Carcinogens; Cell Proliferation; Cyclooxygenase 2; Dinoprostone; Disease Progression; Epidermis; Female; Humans; Mice; Mice, Hairless; Mice, Transgenic; Receptors, Prostaglandin E, EP1 Subtype; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays; Up-Regulation | 2011 |
Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; Chemokines; Down-Regulation; Embryo, Mammalian; Epidermis; Hair Follicle; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; Keratosis; Male; Mice; Mice, Inbred BALB C; Skin Diseases, Papulosquamous; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wound Healing | 2011 |
Decreased incidence of papillomas in mice with impaired EGFR function during multi-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Proliferation; ErbB Receptors; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Papilloma; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2011 |
Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chemokine CCL2; Chemokine CXCL2; Cyclooxygenase 2; Female; Inflammation; Mice; Oligodeoxyribonucleotides; Ornithine Decarboxylase; Papilloma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Re-assessing K15 as an epidermal stem cell marker.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers; Cell Differentiation; Embryo, Mammalian; Embryonic Development; Epidermis; Gene Expression Regulation, Neoplastic; Homeostasis; Keratin-15; Mice; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate; Time Factors | 2011 |
The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Appetite; Arcuate Nucleus of Hypothalamus; Caloric Restriction; Female; Hunger; Male; Mice; Mice, Knockout; Neoplasms, Experimental; Neurons; Neuropeptide Y; Papilloma; RNA, Messenger; Skin Neoplasms; Sodium Glutamate; Tetradecanoylphorbol Acetate | 2011 |
Tumor necrosis factor-alpha-nuclear factor-kappa B-signaling enhances St2b2 expression during 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia.
Topics: Animals; Antibodies; Cholesterol Esters; Epidermis; Female; Hyperplasia; Inflammation; Mice; Mice, Inbred Strains; NF-kappa B; Nitriles; Protein Precursors; Receptors, Tumor Necrosis Factor; RNA, Small Interfering; Signal Transduction; Skin Neoplasms; Sulfones; Sulfotransferases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2011 |
Targeted expression of tumor necrosis factor-related apoptosis-inducing ligand TRAIL in skin protects mice against chemical carcinogenesis.
Topics: Animals; Benz(a)Anthracenes; beta Catenin; Cell Proliferation; Female; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; In Situ Hybridization; Keratin-14; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Precancerous Conditions; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; TNF-Related Apoptosis-Inducing Ligand; Wnt Proteins | 2011 |
CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Disease Progression; Epidermal Cells; Epidermis; Humans; Hyperplasia; Immunoblotting; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Lymphatic Metastasis; Mice; Mice, Transgenic; Mutation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitination | 2011 |
Potential O-acyl-substituted (-)-Epicatechin gallate prodrugs as inhibitors of DMBA/TPA-induced squamous cell carcinoma of skin in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Catechin; Female; Humans; Hydrolysis; Mice; Prodrugs; Skin; Skin Neoplasms; Solubility; Tea; Tetradecanoylphorbol Acetate | 2011 |
Protective role of cathepsin L in mouse skin carcinogenesis.
Topics: Administration, Topical; Alleles; Animals; Cathepsin L; CD4-Positive T-Lymphocytes; Cell Proliferation; Female; Genotype; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Knockout; Papilloma; Polymorphism, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Azadirachta indica exerts chemopreventive action against murine skin cancer: studies on histopathological, ultrastructural changes and modulation of NF-kappaB, AP-1, and STAT1.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Azadirachta; Male; Mice; NF-kappa B; Plant Extracts; RNA, Messenger; Skin Neoplasms; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2011 |
Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogenicity Tests; Cell Transformation, Neoplastic; Epstein-Barr Virus Infections; Flavanones; Genistein; Herpesvirus 4, Human; Hesperidin; Isoflavones; Mice; Oleanolic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2011 |
Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Epidermal Cells; Epidermis; Female; Gene Expression Regulation, Neoplastic; Keratinocytes; Mice; Mice, Knockout; MicroRNAs; ras Proteins; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Asphalt fume dermal carcinogenicity potential: II. Initiation-promotion assay of Type III built-up roofing asphalt.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Air Pollutants, Occupational; Animals; Body Weight; Carcinogens; Hydrocarbons; Male; Mice; Occupational Exposure; Skin; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.
Topics: Animals; Cell Respiration; Cell Transformation, Neoplastic; Humans; Malates; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitochondria; Protein Isoforms; Pyruvate Kinase; Pyruvic Acid; RNA, Small Interfering; Skin; Skin Neoplasms; Succinic Acid; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2011 |
Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma.
Topics: Animals; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Melanocytes; Melanoma; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Phosphorylation; Phosphothreonine; Proto-Oncogene Mas; Proto-Oncogene Protein c-ets-1; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2011 |
Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention.
Topics: Animals; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Carcinogens; Humans; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Blotting, Western; Carcinogens; Humans; Hyperplasia; Mice; Neoplasm Staging; Papilloma; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2011 |
CXCR3 enhances a T-cell-dependent epidermal proliferative response and promotes skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation, Neoplastic; Epidermis; Humans; Lymphocytes, Tumor-Infiltrating; Methylcholanthrene; Mice; Mice, Mutant Strains; Receptors, CXCR3; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2011 |
Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors.
Topics: Animals; Biomarkers, Tumor; Cattle; Cell Proliferation; Epidermis; I-kappa B Kinase; Immunohistochemistry; Integrin alpha6; Keratinocytes; Mice; Mice, Transgenic; NF-kappa B; Rabbits; Serpins; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Inhibitory effects of 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, β-diketone structural analogues of curcumin, on chemical-induced tumor promotion and inflammation in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Carcinogens; Curcumin; Dermatitis; Ear, External; Edema; Female; Ketones; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alphapapillomavirus; Animals; Carcinogens; Carcinoma, Squamous Cell; Cyclin-Dependent Kinase Inhibitor p21; Epidermis; Humans; Keratinocytes; Keratosis, Actinic; Mice; Mice, Transgenic; Oncogene Proteins, Viral; Papillomavirus Infections; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2011 |
Inhibitory effects of interferon-gamma plasmid DNA on DMBA-TPA induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Caspase 3; Cell Proliferation; Female; Genetic Therapy; Interferon-gamma; Mice; Mice, Inbred BALB C; Plasmids; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Drug Synergism; Genes, ras; Green Fluorescent Proteins; Humans; Long Interspersed Nucleotide Elements; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Animal; Mutagenesis, Insertional; Neoplasm Proteins; Receptors, Aryl Hydrocarbon; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2011 |
Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Female; Heme Oxygenase-1; Mice; Mice, Inbred Strains; Mice, Knockout; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Activation; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphorylation; Polyphenols; Proliferating Cell Nuclear Antigen; Protein Stability; Remission Induction; Resveratrol; Skin Neoplasms; Stilbenes; Tea; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2011 |
14-3-3σ and p63 play opposing roles in epidermal tumorigenesis.
Topics: 14-3-3 Proteins; 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinogens; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Gene Silencing; Homeostasis; Keratinocytes; Mice; Mice, Mutant Strains; Phosphoproteins; Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trans-Activators | 2011 |
Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Dedifferentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Increased skin papilloma formation in mice lacking glutathione transferase GSTP.
Topics: Animals; Apoptosis; Cell Proliferation; Glutathione S-Transferase pi; Mice; Oxidative Stress; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Human epithelial carcinoma cytotoxicity and inhibition of DMBA/TPA induced squamous cell carcinoma in Balb/c mice by Acacia catechu heartwood.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acacia; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutathione; Humans; Lipid Peroxidation; Liver; Mice; Mice, Inbred BALB C; Plant Preparations; Random Allocation; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2011 |
Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Disease Progression; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, Reporter; Genes, Synthetic; Humans; Mice; Mice, Transgenic; Neoplasm Proteins; Papilloma; Promoter Regions, Genetic; Recombinant Fusion Proteins; Skin Neoplasms; Sp1 Transcription Factor; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Suppressor Protein p53 | 2011 |
Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis.
Topics: Angiopoietin-Like Protein 2; Angiopoietin-like Proteins; Angiopoietins; Animals; Carcinogens; Carcinoma, Squamous Cell; Epithelial-Mesenchymal Transition; Female; Gene Expression; Immunoblotting; Immunohistochemistry; Inflammation; Inflammation Mediators; Kaplan-Meier Estimate; Lymph Nodes; Lymphangiogenesis; Male; Mice; Mice, Knockout; Mice, Transgenic; Neoplasm Metastasis; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents(†).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Dioxoles; Female; Humans; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosylmethionine Decarboxylase; Animals; Colon; Disease Models, Animal; Epidermis; Gene Expression Regulation, Enzymologic; Genes, APC; Intestinal Neoplasms; Mice; Mice, Transgenic; Ornithine Decarboxylase; Polyamines; Skin Neoplasms; Spermidine; Spermine; Spermine Synthase; Tetradecanoylphorbol Acetate | 2012 |
Prostaglandin modulation of phorbol ester skin tumor promotion.
Topics: Animals; Arachidonic Acid; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dinoprost; Dinoprostone; Female; Mice; Mice, Inbred SENCAR; Oxytocics; Papilloma; Prostaglandins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Effects of dose and duration of treatment with the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate on mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Female; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Catalase; Cyclohexenes; Cyclooxygenase 2; Female; Glutathione; Inflammation; Limonene; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; raf Kinases; ras Proteins; Signal Transduction; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 2012 |
Cytotoxic activities and anti-tumor-promoting effects of microbial transformation products of prenylated chalcones from Angelica keiskei.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Angelica; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Apoptosis; Aspergillus; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplastic; Chalcones; Humans; Mice; Molecular Structure; Prenylation; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2012 |
Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Glycosides; Humans; Mice; Molecular Structure; Momordica charantia; Plant Leaves; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes; Tumor Cells, Cultured | 2012 |
Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cell Transformation, Viral; Disease Models, Animal; Disease Progression; Gene Expression; Genes, ras; Keratin-14; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mutation; Papilloma; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Viral Matrix Proteins | 2012 |
A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Genes, ras; Hair Follicle; Humans; Integrases; Keratin-15; Keratinocytes; Laser Capture Microdissection; Mice; Mice, Transgenic; Mutation; Papilloma; Skin; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate | 2013 |
JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Blotting, Western; Carcinogens; Carrier Proteins; Cell Proliferation; Cells, Cultured; DNA Damage; ets-Domain Protein Elk-1; Heat-Shock Proteins; Immunohistochemistry; MAP Kinase Signaling System; Membrane Transport Proteins; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Papilloma; Phosphorylation; Proliferating Cell Nuclear Antigen; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Photodynamic therapy using a novel photosensitizer, TONS501, is similarly effective to ALA and EC036 photodynamic therapy on DMBA-and TPA-induced mouse skin papilloma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Aminolevulinic Acid; Animals; Disease Models, Animal; Female; Mice; Mice, Hairless; Ointments; Papilloma; Photochemotherapy; Photosensitizing Agents; Porphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Treatment Outcome | 2012 |
Epidermal α6β4 integrin stimulates the influx of immunosuppressive cells during skin tumor promotion.
Topics: Animals; Antigens, Surface; Carcinogens; Carcinoma, Squamous Cell; Chemokine CXCL5; Epidermis; Gene Expression; Humans; Inflammation Mediators; Integrin alpha6beta4; Keratinocytes; Lymphocyte Activation; Macrophage Colony-Stimulating Factor; Mice; Mice, Transgenic; Myeloid Cells; Orexin Receptors; Receptors, Cell Surface; Recombinant Proteins; Skin Neoplasms; T-Lymphocytes; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate; Tumor Microenvironment | 2012 |
Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Adhesion; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Female; Gene Expression Regulation, Neoplastic; Humans; Keratinocytes; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Mice, Transgenic; RNA Interference; RNA, Small Interfering; Skin Neoplasms; Tamoxifen; Tetradecanoylphorbol Acetate | 2012 |
Miz1 is a critical repressor of cdkn1a during skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p21; Mice; Mice, Transgenic; Neoplasms, Experimental; Nuclear Proteins; Protein Inhibitors of Activated STAT; Protein Structure, Tertiary; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ubiquitin-Protein Ligases | 2012 |
Inotilone suppresses phorbol ester-induced inflammation and tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Carcinogens; CCAAT-Enhancer-Binding Protein-beta; Cyclooxygenase 2; Dermatitis; Enzyme Activation; Female; Furans; Inflammation Mediators; Macrolides; Mice; Mice, Inbred ICR; NF-kappa B; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Tamoxifen-loaded novel liposomal formulations: evaluation of anticancer activity on DMBA-TPA induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antineoplastic Agents, Hormonal; Cocarcinogenesis; Drug Compounding; Drug Delivery Systems; Female; Liposomes; Mice; Skin Neoplasms; Tamoxifen; Tetradecanoylphorbol Acetate; Treatment Outcome | 2012 |
Anti-inflammatory and anti-tumor-promoting effects of 5-deprenyllupulonol C and other compounds from Hop (Humulus lupulus L.).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antigens, Viral; Carcinogens; Edema; Female; Humulus; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; Phloroglucinol; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alpinia; Animals; Benzyl Alcohols; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Fluocinolone Acetonide; Humans; Mice; Mice, Transgenic; NF-kappa B; Plant Extracts; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Zingiber officinale | 2012 |
The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.
Topics: Animals; Carcinoma, Squamous Cell; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Laryngeal Neoplasms; Mice; Mice, Knockout; Mouth Neoplasms; Protein Disulfide-Isomerases; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Reference Values; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2013 |
Nexrutine(R) inhibits tumorigenesis in mouse skin and induces apoptotic cell death in human squamous carcinoma A431 and human melanoma A375 cells.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Melanoma; Mice; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Anti-tumor-promoting activities of agaro-oligosaccharides on two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Agar; Animals; Antineoplastic Agents; Carcinogens; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Edema; Humans; Intramolecular Oxidoreductases; Leukocytes, Mononuclear; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitrites; Oligosaccharides; Prostaglandin-E Synthases; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
A transposon-based analysis of gene mutations related to skin cancer development.
Topics: Animals; Carcinogens; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Carrier Proteins; Cell Transformation, Neoplastic; DNA Mutational Analysis; DNA Transposable Elements; Genes, ras; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Intracellular Signaling Peptides and Proteins; Keratin-15; Keratin-5; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Receptor, Notch1; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transposases | 2013 |
Pterostilbene, a natural analogue of resveratrol, potently inhibits 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Cell Proliferation; Cyclooxygenase 2; Down-Regulation; Female; Inflammation; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; Protein Kinase Inhibitors; Resveratrol; Skin; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate | 2012 |
Independent genetic control of early and late stages of chemically induced skin tumors in a cross of a Japanese wild-derived inbred mouse strain, MSM/Ms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Crosses, Genetic; Female; Genetic Linkage; Japan; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2012 |
Topical 5-fluorouracil elicits regressions of BRAF inhibitor-induced cutaneous squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Cell Line; Cell Proliferation; Fluorouracil; Humans; Imidazoles; Indoles; Melanoma; Mice; Oximes; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate; Vemurafenib | 2013 |
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma; Animals; Animals, Inbred Strains; Azoxymethane; Cell Transformation, Neoplastic; Chemokines, CXC; Colitis; Colonic Neoplasms; Dermatitis, Contact; Dextran Sulfate; Gene Expression; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Papilloma; Peroxidase; Precancerous Conditions; Receptors, Interleukin-8B; Skin Neoplasms; Statistics, Nonparametric; Tetradecanoylphorbol Acetate; Tumor Burden | 2012 |
Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.
Topics: Animals; beta Catenin; Focal Adhesion Protein-Tyrosine Kinases; Hair Follicle; Hematopoietic Stem Cell Mobilization; Hyperplasia; Mice; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate | 2012 |
Effects of C-Phycocyanin on the representative genes of tumor development in mouse skin exposed to 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Carcinogens; Cyclooxygenase 2; Female; Gene Expression; Interleukin-6; Mice; Ornithine Decarboxylase; Phycocyanin; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2012 |
Azadirachta indica acts as a pro-oxidant and modulates cell cycle associated proteins during DMBA/TPA induced skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Azadirachta; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression; Lipid Peroxidation; Male; Mice; Plant Extracts; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2013 |
Evaluation of skin cancer chemoprevention potential of sunscreen agents using the Epstein-Barr virus early antigen activation in vitro assay.
Topics: Antigens, Viral; Carcinogens; Humans; In Vitro Techniques; Skin Neoplasms; Sunscreening Agents; Tetradecanoylphorbol Acetate | 2013 |
Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Caspase 1; Cell Proliferation; Cell Transformation, Neoplastic; Cytokines; Cytoskeletal Proteins; Down-Regulation; Epithelium; Humans; Inflammasomes; Inflammation; Keratinocytes; Mice; Mice, Knockout; Myeloid Cells; Neoplasms, Squamous Cell; Organ Specificity; Receptors, Interleukin-1; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Microenvironment; Tumor Suppressor Protein p53 | 2012 |
Baicalein inhibits DMBA/TPA-induced skin tumorigenesis in mice by modulating proliferation, apoptosis, and inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Cell Proliferation; Cell Transformation, Neoplastic; Female; Flavanones; Hyperplasia; Inflammation; Mice; Mice, Inbred C57BL; Plant Extracts; Scutellaria baicalensis; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2013 |
Inhibitory effects of Opuntia humifusa on 7, 12-dimethyl- benz[a]anthracene and 12-O-tetradecanoylphorbol-13- acetate induced two-stage skin carcinogenesis.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Apoptosis; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Female; Glutathione Transferase; Lipid Peroxidation; Mice; Mice, Inbred BALB C; Opuntia; Oxidative Stress; Phytotherapy; Plant Preparations; Skin; Skin Neoplasms; Statistics, Nonparametric; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2012 |
Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells.
Topics: Acetylation; Cell Line, Tumor; Cell Proliferation; DNA-Directed RNA Polymerases; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Interleukin-8; Melanoma; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; Pyrroles; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factor TFIIB; Transcription, Genetic; Uveal Neoplasms | 2013 |
Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetates; Animals; Antigens, CD34; Catechin; CCAAT-Enhancer-Binding Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitotic Index; Nitric Oxide Synthase Type II; Ornithine Decarboxylase; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2013 |
The effect of beta-carotene on lung and skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Carcinogens; Dose-Response Relationship, Drug; Ferrets; Lung Neoplasms; Mice; Nicotiana; Papilloma; Precancerous Conditions; Skin Neoplasms; Smoke; Tetradecanoylphorbol Acetate | 2002 |
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Artemia; Benzodioxoles; Biphenyl Compounds; Cocarcinogenesis; Female; Free Radical Scavengers; Herpesvirus 4, Human; Lethal Dose 50; Mice; Mice, Inbred ICR; Phenols; Picrates; Plant Oils; Resveratrol; Sesame Oil; Skin Neoplasms; Stilbenes; Sunflower Oil; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 2002 |
Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation.
Topics: Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2002 |
Modulation of epidermal tumor development caused by targeted overexpression of epidermis-type 12S-lipoxygenase.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonate 12-Lipoxygenase; Carcinogens; Down-Regulation; Female; Gene Expression; Isoenzymes; Linoleic Acids; Male; Mice; Mice, Inbred DBA; Mice, Transgenic; Papilloma; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2002 |
Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aloe; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Ear; Edema; Female; Mice; Mice, Inbred ICR; Plant Extracts; Plant Leaves; Plants, Medicinal; Putrescine; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2002 |
Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Celecoxib; Cocarcinogenesis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Gene Expression; Isoenzymes; Mice; Mice, Transgenic; Papilloma; Phenotype; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Skin; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate | 2002 |
Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis.
Topics: Animals; Chromosome Mapping; DNA Helicases; Exodeoxyribonucleases; Genes, ras; Genotype; Mice; Mice, Transgenic; Mutation; Papilloma; RecQ Helicases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes; Werner Syndrome; Werner Syndrome Helicase | 2002 |
Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis.
Topics: Animals; Base Sequence; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; DNA Primers; Gene Expression Profiling; Gene Expression Regulation; In Situ Hybridization; Keratinocytes; Male; Mice; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Subcellular Fractions; Tetradecanoylphorbol Acetate | 2003 |
Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Diterpenes; Diterpenes, Kaurane; Drug Screening Assays, Antitumor; Female; Glucosides; Mice; Mice, Inbred ICR; Skin Neoplasms; Stevia; Tetradecanoylphorbol Acetate | 2002 |
Inhibition by ajoene of skin-tumor promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Disulfides; Garlic; Male; Mice; Mice, Inbred ICR; Plant Extracts; Skin Neoplasms; Solvents; Sulfoxides; Tetradecanoylphorbol Acetate | 2002 |
Chemopreventive effect of Vitis vinifera extract on 12-O-tetradecanoyl-13-phorbol acetate-induced cutaneous oxidative stress and tumor promotion in murine skin.
Topics: Animals; Carcinogens; Chemoprevention; Female; Lipid Peroxidation; Mice; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Structures; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitis | 2002 |
Progressive iron overload enhances chemically mediated tumor promotion in murine skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Benzoyl Peroxide; Carcinogens; Catalase; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Induction; Enzyme Repression; Glutathione; Iron; Iron Overload; Lipid Peroxidation; Mice; Ornithine Decarboxylase; Oxidative Stress; Papilloma; Reactive Oxygen Species; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Matrix metalloproteinase-19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation.
Topics: Blotting, Northern; Blotting, Western; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Down-Regulation; Female; Fibroblasts; Humans; Immunoenzyme Techniques; Keratinocytes; Male; Matrix Metalloproteinases, Secreted; Metalloendopeptidases; Middle Aged; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
A 60 Hz magnetic field does not affect the incidence of squamous cell carcinomas in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Back; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Drug Tolerance; Electricity; Electromagnetic Fields; Mice; Mice, Inbred SENCAR; Neoplasms, Radiation-Induced; Radiation Tolerance; Reference Values; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer.
Topics: Animals; Base Pair Mismatch; Carcinogens; DNA Repair; DNA-Binding Proteins; Genetic Predisposition to Disease; Heterozygote; Homozygote; Mice; Mice, Knockout; MutS Homolog 2 Protein; Neoplasms, Radiation-Induced; Proto-Oncogene Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2002 |
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Beta vulgaris; Betacyanins; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Hydroxylamines; Indoles; Liver Neoplasms, Experimental; Mice; Mice, Inbred ICR; Neoplasms, Radiation-Induced; Phenobarbital; Plant Extracts; Plant Roots; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2003 |
Circadian rhythm of tumor promotion in the two-stage model of mouse tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Circadian Rhythm; Disease Models, Animal; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Female; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neoplasm Proteins; Papilloma; Skin; Skin Neoplasms; Survivin; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2003 |
Chemopreventive effects of alpha-santalol on skin tumor development in CD-1 and SENCAR mice.
Topics: Administration, Topical; Animals; Carcinogens; Chemoprevention; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Incidence; Mice; Mice, Inbred SENCAR; Ornithine Decarboxylase; Papilloma; Plant Oils; Sesquiterpenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Treatment Outcome; Women's Health | 2003 |
Tumor initiating activity of Helicobacter pylori water extract on mouse skin carcinogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alleles; Animals; Carcinogens; Cell Fractionation; Cocarcinogenesis; Codon; Deoxyguanosine; Disease Progression; DNA; DNA Adducts; DNA Damage; Female; Genes, ras; Helicobacter pylori; Luminescent Measurements; Mice; Mice, Inbred SENCAR; Oxidative Stress; Papilloma; Peroxidase; Point Mutation; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Water | 2003 |
Profile of gene expression induced by the tumour promotor TPA in murine epithelial cells.
Topics: Animals; Biomarkers, Tumor; Blotting, Northern; Carcinogens; DNA Primers; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Library; In Situ Hybridization; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Nucleic Acid Hybridization; Polymerase Chain Reaction; RNA, Neoplasm; Skin; Skin Neoplasms; Subtraction Technique; Tetradecanoylphorbol Acetate | 2003 |
Palm oil alleviates 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion response in murine skin.
Topics: Administration, Topical; Animals; Cell Division; Dose-Response Relationship, Drug; Mice; Palm Oil; Plant Oils; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Expression of enhancing factor/phospholipase A2 in skin results in abnormal epidermis and increased sensitivity to chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Multiple; Animals; Carcinogens; Carcinoma, Squamous Cell; Epidermis; Fibrosarcoma; Genetic Predisposition to Disease; Genotype; Group II Phospholipases A2; Humans; Keratins; Mice; Mice, Transgenic; Neoplasms, Basal Cell; Papilloma; Phenotype; Phospholipases A; Promoter Regions, Genetic; Recombinant Fusion Proteins; Skin; Skin Neoplasms; Tail; Tetradecanoylphorbol Acetate; Transgenes; Vibrissae | 2003 |
SCCA2-like serpins mediate genetic predisposition to skin tumors.
Topics: Adult; Aged; Animals; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cell Division; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Middle Aged; Oligonucleotide Array Sequence Analysis; Serpins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2003 |
Cancer chemopreventive activity of acridone alkaloids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Topics: Acridines; Acridones; Alkaloids; Animals; Anticarcinogenic Agents; Biological Assay; Carcinogens; Female; Herpesvirus 4, Human; Mice; Mice, Inbred ICR; Models, Chemical; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Blue light inhibits the growth of skin tumors in the v-Ha-ras transgenic mouse.
Topics: Animals; Epidermis; Female; Genes, ras; Hyperplasia; Keratins; Mice; Mice, Transgenic; Oncogene Protein p21(ras); Papilloma; Phototherapy; Precancerous Conditions; Recombinant Fusion Proteins; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Weight Gain | 2003 |
An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibodies, Monoclonal; Carcinogens; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Immunity, Innate; Keratinocytes; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Staging; Papilloma; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 2003 |
Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Hyperplasia; Mice; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wound Healing | 2003 |
Cancer preventive potential of trichothecenes from Trichothecium roseum.
Topics: Animals; Anti-Infective Agents; Anticarcinogenic Agents; Antigens, Viral; Carcinogenicity Tests; Cell Survival; Humans; Mice; Mitosporic Fungi; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trichothecenes; Tumor Cells, Cultured | 2003 |
IL-1 alpha, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1 alpha in epidermis on chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; DNA-Binding Proteins; Epidermis; Female; Humans; Immunity, Innate; Interleukin-1; Keratin-14; Keratins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nuclear Proteins; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2003 |
Evaluation of the Tg.AC assay: specificity testing with three noncarcinogenic pharmaceuticals that induce selected stress gene promoters in vitro and the inhibitory effects of solvent components.
Topics: Acetone; Administration, Topical; Amiloride; Animal Testing Alternatives; Animals; Carcinogenicity Tests; Carcinogens; CCAAT-Enhancer-Binding Proteins; Dimethyl Sulfoxide; Dipyridamole; Dose-Response Relationship, Drug; Drug Antagonism; Drug-Related Side Effects and Adverse Reactions; Female; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Papilloma; Pharmaceutical Preparations; Predictive Value of Tests; Promoter Regions, Genetic; Pyrimethamine; Skin Neoplasms; Solvents; Tetradecanoylphorbol Acetate; Transcription Factor CHOP; Transcription Factors; Transgenes | 2003 |
Vascular expression of matrix metalloproteinase-13 (collagenase-3) in basal cell carcinoma.
Topics: Blotting, Southern; Blotting, Western; Capillaries; Carcinoma, Basal Cell; Cell Division; Cells, Cultured; Collagenases; Culture Media, Conditioned; Dermis; Endothelium, Vascular; Humans; Immunoenzyme Techniques; Matrix Metalloproteinase 13; Organ Culture Techniques; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Identification of novel genetic loci contributing to 12-O-tetradecanoylphorbol-13-acetate skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice.
Topics: Animals; Carcinogens; Chromosome Mapping; Chromosomes, Mammalian; Cocarcinogenesis; Crosses, Genetic; Female; Genetic Linkage; Genetic Predisposition to Disease; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
c-Jun regulates eyelid closure and skin tumor development through EGFR signaling.
Topics: Animals; Apoptosis; Carcinogens; Cell Division; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Eyelids; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Genes, jun; Genetic Predisposition to Disease; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Models, Biological; Papilloma; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2003 |
Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Female; Genes, ras; Metallothionein; Mice; Mice, Inbred C57BL; Mutation; Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Topics: Administration, Oral; Alopecia; Animals; Benz(a)Anthracenes; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Eflornithine; Enzyme Inhibitors; Epidermis; Hair Follicle; Isoenzymes; Mice; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Kinase C; Protein Kinase C-epsilon; Putrescine; Recombinant Fusion Proteins; Skin Neoplasms; Skin Ulcer; Tetradecanoylphorbol Acetate | 2003 |
Toxicological evaluation of honey as an ingredient added to cigarette tobacco.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Inhalation; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Female; Honey; In Vitro Techniques; Male; Mutagenicity Tests; Nicotiana; Organ Size; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Sister Chromatid Exchange; Skin Neoplasms; Smoke; Smoking; Tetradecanoylphorbol Acetate | 2003 |
The 'Abtropfung phenomenon' revisited: Dermal nevus cells from congenital nevi cannot activate matrix metalloproteinase 2 (MMP-2).
Topics: Adolescent; Cell Line, Tumor; Cell Movement; Cells, Cultured; Child; Child, Preschool; Dermis; Enzyme Activation; Epidermal Growth Factor; Gelatinases; Humans; Infant; Infant, Newborn; Isoenzymes; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinases; Melanoma; Nevus; Nevus, Pigmented; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2 | 2003 |
Cancer chemopreventive activity of serratane-type triterpenoids on two-stage mouse skin carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Cocarcinogenesis; Female; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2003 |
H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinogens; Codon; Female; Genes, ras; Mice; Mutation; Nitric Oxide; Nitro Compounds; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage.
Topics: Antimetabolites; Down-Regulation; Gene Expression Regulation, Neoplastic; Glycosylation; Humans; Hyaluronan Receptors; Hyaluronic Acid; Melanoma; Metalloproteases; Mutagenesis, Site-Directed; Neoplasm Proteins; Protein Binding; Protein Processing, Post-Translational; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cells, Cultured; Cocarcinogenesis; Female; Lymphocytes; Mice; Mice, Inbred ICR; Momordica; Peroxynitrous Acid; Skin Neoplasms; Sweetening Agents; Tetradecanoylphorbol Acetate; Triterpenes | 2003 |
Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Carcinoma, Squamous Cell; CSK Tyrosine-Protein Kinase; Female; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Neoplasm Metastasis; Protein-Tyrosine Kinases; Skin; Skin Neoplasms; src-Family Kinases; Tetradecanoylphorbol Acetate | 2003 |
The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Hematopoietic Stem Cells; Liver; Mice; Mice, Knockout; Neoplasm Staging; Papilloma; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Carcinoma; Cells, Cultured; Endoglin; Epidermal Cells; Epidermis; Humans; Keratinocytes; Mice; Mice, Mutant Strains; Neoplasms, Experimental; Papilloma; Receptors, Cell Surface; Reference Values; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Vascular Cell Adhesion Molecule-1 | 2003 |
The carcinogenic potential of extractable organic matter from urban airborne particles in Shanghai, China.
Topics: 3T3 Cells; Air Pollutants; Air Pollution; Animals; Biotransformation; Carcinogens; Cell Survival; China; Cricetinae; DNA Adducts; Female; Fibroblasts; Male; Mesocricetus; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Occupational Exposure; Organic Chemicals; Phosphorus Radioisotopes; Polycyclic Compounds; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers.
Topics: Adrenal Gland Neoplasms; Animals; Arsenic; Female; Fetus; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Organ Specificity; Ovarian Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes.
Topics: Animals; Annexin A5; Apoptosis; Blotting, Western; Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Epidermal Cells; Epidermis; Flow Cytometry; Guanine Nucleotide Exchange Factors; Guanosine Triphosphate; Immunoblotting; Keratin-10; Keratinocytes; Keratins; Mice; Neoplasms, Experimental; Phorbol Esters; Precipitin Tests; Protein Kinase C; Protein Transport; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Pentoxifylline; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Reactive Oxygen Species; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2003 |
RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Genes, p53; Head and Neck Neoplasms; Humans; Keratinocytes; Mice; Mice, Nude; RNA, Messenger; Skin Neoplasms; Skin Transplantation; Tetradecanoylphorbol Acetate; Transcription Factors; Transduction, Genetic; Tripartite Motif Proteins; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases; Ultraviolet Rays | 2004 |
Absence of tumor promoting activity of Euphorbia milii latex on the mouse back skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Euphorbia; Female; Latex; Male; Mice; Mice, Inbred DBA; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Female; Lythraceae; Mice; Mice, Inbred Strains; Plant Oils; Random Allocation; Seeds; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2003 |
12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells.
Topics: Animals; Antigens, CD34; Arginine; Aspartic Acid; Cell Transformation, Neoplastic; Cells, Cultured; Cloning, Molecular; Culture Media, Serum-Free; DNA, Complementary; Epidermal Cells; Epidermis; Female; Gene Dosage; Glycine; Homozygote; Humans; Immunoblotting; In Situ Hybridization; Keratinocytes; Kinetics; Mice; Mutagenesis, Site-Directed; Mutation; Nucleoside-Diphosphate Kinase; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tissue Distribution; Transfection; Ultraviolet Rays; Up-Regulation | 2004 |
Free radical generating agents lead to the rapid progression of benign skin tumors to carcinoma in iron-overloaded mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzene Derivatives; Benzoyl Peroxide; Carcinogens; Carcinoma, Squamous Cell; Disease Progression; Female; Free Radicals; Hydrogen Peroxide; Iron; Iron Overload; Iron-Dextran Complex; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development.
Topics: Animals; Animals, Newborn; Antigens, CD; Cells, Cultured; Epidermis; Gene Expression Regulation; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinogens; Cinnamates; Depsides; DNA Primers; Male; Mice; Mice, Inbred BALB C; Perilla frutescens; Phytotherapy; Polymerase Chain Reaction; RNA, Messenger; Rosmarinic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Two new anti-tumor promoting serratane-type triterpenoids from the stem bark of Picea jezoensis var. jezoensis.
Topics: Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Female; Herpesvirus 4, Human; Inhibitory Concentration 50; Mice; Mice, Inbred ICR; Papilloma; Phytotherapy; Picea; Plant Bark; Plant Extracts; Plant Stems; Skin Neoplasms; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate; Triterpenes | 2003 |
E6 and E7 oncoproteins induce distinct patterns of chromosomal aneuploidy in skin tumors from transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Carcinogens; Cell Line, Tumor; Chromosome Mapping; Chromosomes; DNA Primers; Genes, p53; Genes, ras; Genes, Retinoblastoma; Karyotyping; Mice; Mice, Transgenic; Mutation; Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus E7 Proteins; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Repressor Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antigens, Viral; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Mice; Mice, Inbred ICR; Otitis; Papilloma; Perilla frutescens; Plant Leaves; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2004 |
Pro/antioxidant status in murine skin following topical exposure to cumene hydroperoxide throughout the ontogeny of skin cancer.
Topics: Animals; Antioxidants; Benzene Derivatives; Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Female; Glutathione; Humans; Inflammation; Isoenzymes; Keratinocytes; Lipid Peroxidation; Membrane Proteins; Mice; Mice, Inbred SENCAR; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Skin Neoplasms; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate | 2004 |
Low iron diet retards 12-O-tetradecanoyl phorbol-13-acetate-mediated tumor promotion in murine skin.
Topics: Animals; Benz(a)Anthracenes; Carcinogens; Carcinoma; Catalase; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Iron, Dietary; Mice; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate.
Topics: Animals; Animals, Genetically Modified; Benz(a)Anthracenes; Carcinogens; Female; Genes, ras; Humans; Male; Mammary Neoplasms, Experimental; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proto-Oncogene Mas; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis.
Topics: Animals; Carcinogens; Cell Division; Cells, Cultured; DNA-Binding Proteins; Epidermal Growth Factor; Epidermis; ErbB Receptors; Female; Keratinocytes; Mice; Mice, Inbred SENCAR; Mice, Transgenic; Signal Transduction; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators | 2004 |
Only a subset of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papillomas are promotable by benzoyl peroxide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinogens; Cocarcinogenesis; DNA Primers; Drug Resistance, Neoplasm; Female; Genes, ras; Genetic Predisposition to Disease; Male; Mice; Mutation; Papilloma; Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Study on prevention of two-stage skin carcinogenesis by Hibiscus rosa sinensis extract and the role of its chemical constituent, gentisic acid, in the inhibition of tumour promotion response and oxidative stress in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinogens; Croton Oil; Dose-Response Relationship, Drug; Female; Gentisates; Glutathione; Hibiscus; Hydrogen Peroxide; Lipid Peroxidation; Malondialdehyde; Mice; Ornithine Decarboxylase; Oxidative Stress; Phytotherapy; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Binding Sites; Carcinogens; Cell Division; Disease Progression; Enzyme Activation; Epidermis; Epithelium; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Mitosis; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2004 |
Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Hepatocellular; Carrageenan; Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; Edema; Female; Hindlimb; Humans; Hydroquinones; Indomethacin; Inflammation; Isoenzymes; Liver Neoplasms; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenylbutazone; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tyrphostins | 2004 |
Salix caprea inhibits skin carcinogenesis in murine skin: inhibition of oxidative stress, ornithine decarboxylase activity and DNA synthesis.
Topics: Administration, Cutaneous; Animals; Anticarcinogenic Agents; Dose-Response Relationship, Drug; Female; Flowers; Mice; Ornithine Decarboxylase; Oxidative Stress; Phytotherapy; Plant Extracts; Salix; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Xanthine Oxidase | 2004 |
Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice.
Topics: Administration, Topical; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Blotting, Western; Cyclooxygenase 2; Dose-Response Relationship, Drug; Edema; Enzyme Activation; Female; Hyperplasia; I-kappa B Kinase; Isoenzymes; Mice; Mice, Inbred Strains; Molecular Structure; NF-kappa B; Nitric Oxide Synthase; Ornithine Decarboxylase Inhibitors; Pentacyclic Triterpenes; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Triterpenes | 2004 |
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice.
Topics: Animals; Anticarcinogenic Agents; Cyclooxygenase 2; Enzyme Induction; Female; Glutathione S-Transferase pi; Glutathione Transferase; Isoenzymes; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Sesquiterpenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Nucleus; Cytoplasm; DNA, Complementary; Female; Humans; Immunohistochemistry; Keratinocytes; Kinetics; Mice; Mice, Transgenic; Microscopy, Electron; Mitochondria; Oxygen; Signal Transduction; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors | 2004 |
Increased skin carcinogenesis in a keratinocyte directed thioredoxin-1 transgenic mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Humans; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papilloma; Promoter Regions, Genetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thioredoxins; Ultraviolet Rays | 2004 |
Modulation of patched-associated susceptibility to radiation induced tumorigenesis by genetic background.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allelic Imbalance; Animals; Carcinogens; Carcinoma, Basal Cell; Female; Genetic Predisposition to Disease; Inbreeding; Intracellular Signaling Peptides and Proteins; Loss of Heterozygosity; Male; Membrane Proteins; Mice; Neoplasms, Radiation-Induced; Patched Receptors; Patched-1 Receptor; Proteins; Receptors, Cell Surface; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development.
Topics: Animals; Base Sequence; Carcinogens; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Nude; Molecular Sequence Data; Phosphorylation; RNA, Small Interfering; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors | 2004 |
Experimental study to test the potential tumor promotion effect of a tooth bleaching agent.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carbamide Peroxide; Carcinogens; Cricetinae; Disease Models, Animal; Drug Combinations; Female; Hyperplasia; Male; Mesocricetus; Mice; Mice, Inbred SENCAR; Mouth Mucosa; Mouth Neoplasms; Oxidants; Peroxides; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tooth Bleaching; Urea | 2001 |
Alpha 2-HS glycoprotein (fetuin-A) modulates murine skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; alpha-2-HS-Glycoprotein; Animals; Apoptosis; Blood Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Mice; Mice, Inbred C57BL; Mutation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechols; Dermatitis; Fatty Alcohols; Female; Guaiacol; HL-60 Cells; Humans; Ketones; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Papilloma; Plant Extracts; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zingiber officinale | 1999 |
Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Progression; Genes, ras; Heterozygote; Homozygote; Loss of Heterozygosity; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Mutation; Papilloma; Protein Tyrosine Phosphatases; PTEN Phosphohydrolase; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 2004 |
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis.
Topics: Animals; Carcinogens; Cell Division; DNA-Binding Proteins; Epidermis; Mice; Neoplasms, Glandular and Epithelial; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators | 2004 |
Effect of Onosma echioides on DMBA/croton oil mediated carcinogenic response, hyperproliferation and oxidative damage in murine skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Boraginaceae; Carcinogens; Catalase; Cell Division; Croton Oil; DNA; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hydrogen Peroxide; Malondialdehyde; Mice; Ornithine Decarboxylase; Oxidative Stress; Phytotherapy; Plant Extracts; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2004 |
Modulatory effect of soy isoflavones on biochemical alterations mediated by TPA in mouse skin model.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Biomarkers, Tumor; Carcinogens; Catalase; DNA; Dose-Response Relationship, Drug; Female; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Glycine max; Hydrogen Peroxide; Isoflavones; Lipid Peroxidation; Mice; Ornithine Decarboxylase; Oxidation-Reduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine | 2004 |
A novel ATX-S10(Na) photodynamic therapy for human skin tumors and benign hyperproliferative skin.
Topics: Animals; Bowen's Disease; Carcinogens; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Humans; Laser Therapy; Mice; Mice, Hairless; Mice, Inbred BALB C; Mice, SCID; Neoplasm Transplantation; Ointments; Photochemotherapy; Porphyrins; Psoriasis; Radiation-Sensitizing Agents; Skin; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transplantation, Heterologous | 2004 |
Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anthocyanins; Carcinogens; Cyclooxygenase 2; Edema; Epidermis; Female; Fruit; Hydrolyzable Tannins; Hyperplasia; I-kappa B Kinase; Isoenzymes; Lythraceae; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Ornithine Decarboxylase; Phosphorylation; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Signal Transduction; Skin Neoplasms; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetradecanoylphorbol Acetate | 2005 |
Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis.
Topics: Animals; Apoptosis; Blotting, Western; Calcium; Carbazoles; Caspase 3; Caspases; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Survival; Cell Transformation, Neoplastic; Chelating Agents; COS Cells; Cytosol; Dose-Response Relationship, Radiation; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Estrenes; Flow Cytometry; Genes, Dominant; Golgi Apparatus; Humans; Indoles; Keratinocytes; Mitogen-Activated Protein Kinase 3; Models, Biological; Neoplasms; Plasmids; Protein Kinase C; Pyrrolidinones; ras Proteins; Skin Neoplasms; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Ultraviolet Rays | 2004 |
Modulatory effect of Morus indica against two-stage skin carcinogenesis in Swiss albino mice: possible mechanism by inhibiting aryl hydrocarbon hydroxylase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Antioxidants; Aryl Hydrocarbon Hydroxylases; Carcinogens; Croton Oil; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA Damage; Enzyme Inhibitors; Female; Lipid Peroxidation; Male; Mice; Morus; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2004 |
Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis.
Topics: Animals; Apoptosis; Disease Susceptibility; DNA-Binding Proteins; Epidermis; Female; Inflammation; Keratinocytes; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Skin Neoplasms; Smad3 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factor AP-1; Transforming Growth Factor alpha | 2004 |
An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis.
Topics: Animals; Arachidonate Lipoxygenases; Carcinoma; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Female; Gene Expression; Genes, Tumor Suppressor; Hydroxyeicosatetraenoic Acids; Linoleic Acids, Conjugated; Membrane Proteins; Mice; Mice, Transgenic; Papilloma; Promoter Regions, Genetic; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2005 |
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Mice; Mice, Inbred C57BL; Mutation; Phosphoinositide Phospholipase C; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2004 |
Cancer prevention by antioxidants.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Beverages; Carotenoids; Curcumin; Lycopene; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Peroxynitrous Acid; Skin Neoplasms; Solanum lycopersicum; Tetradecanoylphorbol Acetate | 2004 |
Potential anti-tumor promoting activity of lupane-type triterpenoids from the stem bark of Glochidion zeylanicum and Phyllanthus flexuosus.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Female; Herpesvirus 4, Human; Inhibitory Concentration 50; Mice; Mice, Inbred ICR; Papilloma; Phyllanthus; Phytotherapy; Plant Bark; Plant Extracts; Skin Neoplasms; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate; Triterpenes | 2004 |
The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.
Topics: Animals; Cell Transformation, Neoplastic; Chromosomal Instability; Chromosome Aberrations; DNA-Binding Proteins; Gene Deletion; In Situ Hybridization, Fluorescence; Keratinocytes; Mice; Mice, Knockout; Mutation; Neoplasms; Protein Subunits; RNA; Skin Neoplasms; Telomerase; Tetradecanoylphorbol Acetate; Wound Healing | 2005 |
Haploinsufficiency for odc modifies mouse skin tumor susceptibility.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biogenic Polyamines; Carcinogens; Cocarcinogenesis; Enzyme Induction; Female; Genetic Predisposition to Disease; Haploidy; Male; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
A mechanism-based antioxidant approach for the reduction of skin carcinogenesis.
Topics: Animals; Apoptosis; Biomimetic Materials; Carcinogens; Cell Growth Processes; Female; Metalloporphyrins; Mice; Mice, Inbred DBA; Mice, Knockout; Oxidation-Reduction; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2005 |
Photodynamic therapy using a novel photosensitizer, ATX-S10(Na): comparative effect with 5-aminolevulinic acid on squamous cell carcinoma cell line, SCC15, ultraviolet B-induced skin tumor, and phorbol ester-induced hyperproliferative skin.
Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Line, Tumor; Mice; Neoplasms, Radiation-Induced; Neoplasms, Squamous Cell; Photochemotherapy; Porphyrins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2005 |
Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Apoptosis; Benzo(a)pyrene; Carcinogens; Female; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; NAD; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; Oxidation-Reduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2005 |
The effect of PPARgamma ligands on UV- or chemically-induced carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Chromans; Diet; Female; Keratinocytes; Ligands; Mice; PPAR gamma; RNA, Messenger; Rosiglitazone; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiazolidinediones; Troglitazone; Ultraviolet Rays | 2005 |
p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Biomimetic Materials; Cell Line; Cell Nucleus; DNA; Immunohistochemistry; Metalloporphyrins; Mice; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Suppressor Protein p53 | 2005 |
Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Growth Processes; Cell Transformation, Neoplastic; Chromosome Mapping; DNA Damage; DNA-Binding Proteins; Early Growth Response Protein 1; Female; Fibroblasts; Gene Expression Profiling; Genes, Tumor Suppressor; Immediate-Early Proteins; Male; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Suppressor Protein p53; Up-Regulation | 2005 |
c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis.
Topics: Animals; Blotting, Northern; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Electrophoretic Mobility Shift Assay; Female; Fibroblasts; Fluorescent Antibody Technique; Humans; In Situ Hybridization; Keratinocytes; Mice; Mice, Transgenic; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; rab GTP-Binding Proteins; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Carcinogens; Caspase 3; Caspases; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; DNA, Antisense; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Papilloma; Phosphoproteins; Sarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2005 |
Differential gene expression in epidermis of mice sensitive and resistant to phorbol ester skin tumor promotion.
Topics: Acetone; Animals; Cocarcinogenesis; Epidermis; Gene Expression Profiling; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oligonucleotide Array Sequence Analysis; Phorbol Esters; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cadherins; Carcinoma, Squamous Cell; Female; Incidence; Keratoacanthoma; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Treatment Outcome | 2005 |
Mice lacking the p53/p63 target gene Perp are resistant to papilloma development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Adhesion; Cell Differentiation; Cell Growth Processes; Female; Gene Silencing; Genes, p53; Genetic Predisposition to Disease; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Papilloma; Phosphoproteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trans-Activators | 2005 |
Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Diterpenes; DNA Methylation; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Methylnitronitrosoguanidine; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Papilloma; Promoter Regions, Genetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression.
Topics: Animals; Basement Membrane; Cell Growth Processes; Disease Progression; Female; Keratinocytes; Male; Matrix Metalloproteinase 14; Matrix Metalloproteinase 15; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Mice, Transgenic; Proprotein Convertases; Serine Endopeptidases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Cytokines; DNA; Female; Hyperplasia; Keratinocytes; Mice; Protein Kinase C; Protein Kinase C-alpha; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cell Line, Tumor; Disease Susceptibility; Down-Regulation; Female; Immunologic Surveillance; Killer Cells, Natural; Ligands; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NK Cell Lectin-Like Receptor Subfamily K; Papilloma; Receptors, Immunologic; Receptors, Natural Killer Cell; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Burden | 2005 |
Inhibitory effect of 18beta-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Disease Models, Animal; Female; Free Radical Scavengers; Glycyrrhetinic Acid; Glycyrrhiza; Mice; Oxidation-Reduction; Oxidative Stress; Plant Extracts; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Viral; DNA; Human papillomavirus 16; Humans; Membrane Proteins; Mice; Mice, Transgenic; Oncogene Proteins, Viral; Protein Structure, Tertiary; Repressor Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Mechanisms of SEPA 0009-induced tumorigenesis in v-rasHa transgenic Tg.AC mice.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Death; Cell Proliferation; Dermatitis, Irritant; Dioxolanes; Dose-Response Relationship, Drug; Epidermis; Female; Gene Expression; Genes, ras; Hyperplasia; Keratin-6; Keratinocytes; Keratins; Mice; Mice, Transgenic; Papilloma; Precancerous Conditions; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Chromatography, High Pressure Liquid; Eriobotrya; Magnetic Resonance Spectroscopy; Mice; Papilloma; Plant Leaves; Skin Neoplasms; Spectrometry, Mass, Electrospray Ionization; Tetradecanoylphorbol Acetate; Triterpenes | 2005 |
Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; CCAAT-Enhancer-Binding Protein-beta; Female; Integrases; Keratin-15; Keratin-5; Keratinocytes; Keratins; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway.
Topics: Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; E2F1 Transcription Factor; Genes, Tumor Suppressor; Hyperplasia; Mice; Mice, Transgenic; Promoter Regions, Genetic; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53; Ultraviolet Rays | 2006 |
Lack of expression of the EP2 but not EP3 receptor for prostaglandin E2 results in suppression of skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Cyclic AMP; Dinoprostone; Drug Eruptions; Female; Hyperplasia; Keratinocytes; Mice; Mice, Knockout; Neovascularization, Pathologic; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Death; Cell Differentiation; Cell Proliferation; Chemotaxis, Leukocyte; Cocarcinogenesis; Disease Models, Animal; Epidermis; Female; Hair Follicle; Hyperplasia; Keratin-10; Keratinocytes; Keratins; Mice; Mice, Transgenic; Neutrophils; Phenotype; Precancerous Conditions; Protein Kinase C-epsilon; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Cancer chemopreventive effect of orally administrated lupane-type triterpenoid on ultraviolet light B induced photocarcinogenesis of hairless mouse.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Female; Hamamelidaceae; Mice; Mice, Inbred SENCAR; Neoplasms, Radiation-Induced; Papilloma; Seeds; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Triterpenes; Ultraviolet Rays | 2006 |
Skin tumorigenic potential of aflatoxin B1 in mice.
Topics: Administration, Topical; Aflatoxin B1; Animals; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Female; Glutathione Transferase; Lipid Peroxidation; Liver; Liver Neoplasms; Mice; Poisons; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Keratin-13; Keratins; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mifepristone; Oncogene Protein v-akt; Papilloma; PTEN Phosphohydrolase; ras Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2006 |
Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppression.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Chemoprevention; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fenretinide; G1 Phase; Gene Expression Profiling; In Vitro Techniques; Keratinocytes; Mice; Mice, Inbred SENCAR; Oligonucleotide Array Sequence Analysis; Retinoid X Receptors; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Suppressor Proteins | 2006 |
Overexpression of extracellular superoxide dismutase (EC-SOD) in mouse skin plays a protective role in DMBA/TPA-induced tumor formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Proliferation; DNA Damage; Mice; Mice, Inbred C57BL; Mice, Transgenic; Reactive Oxygen Species; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 2005 |
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Growth Processes; Cocarcinogenesis; Keratinocytes; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mice; Mice, Transgenic; Minichromosome Maintenance Complex Component 7; Mutation; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Effect of radiofrequency radiation exposure on mouse skin tumorigenesis initiated by 7,12-dimethybenz[alpha]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Phone; Dose-Response Relationship, Radiation; Electromagnetic Fields; Male; Mice; Mice, Inbred ICR; Neoplasms, Radiation-Induced; Random Allocation; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2005 |
Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers; Carcinogens; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Female; Filaggrin Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mice; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Papilloma; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin.
Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Dexamethasone; Epidermis; Epithelium; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2006 |
Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development.
Topics: Animals; Animals, Newborn; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cattle; Cell Culture Techniques; Cell Proliferation; Female; Humans; Hyperplasia; Inflammation; Keratinocytes; Keratins; Mice; Mice, Transgenic; Neovascularization, Pathologic; Polymerase Chain Reaction; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2006 |
Ras mutation promotes p53 activation and apoptosis of skin keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Transformation, Neoplastic; Enzyme Inhibitors; Genes, ras; Keratinocytes; Mice; Mice, Inbred C57BL; Mitochondria; Mutation; NADPH Oxidases; Onium Compounds; Protein Transport; rac1 GTP-Binding Protein; Reactive Oxygen Species; RNA, Small Interfering; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2006 |
Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity.
Topics: Animals; Anthocyanins; Anticarcinogenic Agents; Antineoplastic Agents; Benz(a)Anthracenes; Carcinogens; Cell Line, Tumor; Fruit; Glucosides; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcriptional Activation; Ultraviolet Rays; Wound Healing | 2006 |
Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaline Phosphatase; Animals; Blotting, Western; Carcinogenicity Tests; Carcinogens; Cell Culture Techniques; Cells, Cultured; Chlorocebus aethiops; COS Cells; Eosine Yellowish-(YS); Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Hematoxylin; Histocytochemistry; Hydroquinones; Keratinocytes; Mice; Mice, Transgenic; Microscopy, Fluorescence; Models, Biological; NF-E2-Related Factor 2; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wound Healing | 2006 |
Assessment of carcinogenic potential of repeated fish fried oil in mice.
Topics: Administration, Topical; Albinism; Animals; Biomarkers; Carcinogens; Enzyme Induction; Female; Fish Oils; Lipid Peroxidation; Methylcholanthrene; Mice; Ornithine Decarboxylase; Oxidative Stress; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2006 |
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling.
Topics: Animals; B-Cell Lymphoma 3 Protein; Carcinogens; Cell Nucleus; Cell Proliferation; Cyclin D1; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Female; Humans; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Proto-Oncogene Proteins; RNA, Small Interfering; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; TNF Receptor-Associated Factor 2; Transcription Factors; Tumor Suppressor Proteins; Ultraviolet Rays | 2006 |
Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Hypoxia-Inducible Factor 1, alpha Subunit; Isoquinolines; Mice; Mice, Inbred C57BL; NF-kappa B; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2006 |
Involvement of the paxillin pathway in JB6 Cl41 cell transformation.
Topics: Animals; Base Sequence; Cell Growth Processes; Cell Line; Cell Transformation, Neoplastic; Down-Regulation; Epidermal Growth Factor; MAP Kinase Kinase 4; Mice; Molecular Sequence Data; Paxillin; Phosphorylation; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Serine; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2006 |
Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Enzyme Activation; Ephrin-A1; Female; Genetic Predisposition to Disease; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptor, EphA2; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Papilloma development is delayed in osteopontin-null mice: implicating an antiapoptosis role for osteopontin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Growth Processes; Epidermis; Female; Male; Mice; Osteopontin; Papilloma; Sialoglycoproteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2006 |
Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p21; Epidermis; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Proto-Oncogene Proteins c-myc; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2006 |
Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cell Line; Cocarcinogenesis; Cyclooxygenase 2; Female; Flavones; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2006 |
Inhibitory effect of ailanthoidol on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Benzo(a)pyrene; Benzofurans; Carcinogens; Female; Mice; Mice, Inbred ICR; Neoplasms; Peroxidase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2006 |
Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis.
Topics: Alopecia; Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Disease Models, Animal; Disease Progression; DNA Damage; Female; Genes, ras; Genotype; Hair; Hair Follicle; Homozygote; Integrases; Keratin-15; Keratin-5; Keratinocytes; Male; Mammary Glands, Animal; Mice; Mice, Transgenic; Papilloma; Recombination, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Inhibitory effects of asiatic acid on 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Induction; Female; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type II; Papilloma; Pentacyclic Triterpenes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Triterpenes | 2007 |
Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-acti
Topics: Acute Disease; Animals; Anticarcinogenic Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Ear; Edema; Female; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Neoplasm Staging; NF-kappa B; Nitric Oxide Synthase Type II; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phenols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzene Derivatives; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Glutathione; Mice; Mice, Transgenic; Oxidation-Reduction; Oxidative Stress; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2007 |
Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Epidermis; Gene Expression Regulation, Neoplastic; Keratinocytes; Mice; Mice, Transgenic; Nevus, Pigmented; Papilloma; PPAR gamma; Retinoid X Receptor alpha; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Transplacental arsenic carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Arsenic; Arsenicals; Carcinogens; Carcinoma, Transitional Cell; Data Interpretation, Statistical; Diethylstilbestrol; Dose-Response Relationship, Drug; Drug Synergism; Estrogens; Female; Gene Expression Regulation, Neoplastic; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C3H; Neoplasms; Pregnancy; Prenatal Exposure Delayed Effects; Signal Transduction; Skin Neoplasms; Tamoxifen; Tetradecanoylphorbol Acetate; Urinary Bladder Neoplasms | 2007 |
Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice.
Topics: 4-Butyrolactone; 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Caspase 3; Caspase 8; Caspase 9; Cell Proliferation; Cyclooxygenase 2; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; CCAAT-Enhancer-Binding Proteins; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Transgenic; NF-kappa B; Oncogene Proteins, Viral; Osteopontin; Papillomavirus E7 Proteins; Peptide Fragments; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2007 |
The ends of a conundrum?
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Binding Sites; Carcinogens; Cell Proliferation; Cells, Cultured; Disease Susceptibility; Epidermal Cells; Intermediate Filaments; Keratin-10; Keratin-14; Keratin-5; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; Protein Binding; Protein Structure, Tertiary; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Codon; Crosses, Genetic; DNA Helicases; Female; Genes, ras; Male; Mice; Mice, Inbred C57BL; Minichromosome Maintenance Complex Component 4; Papilloma; Polymorphism, Restriction Fragment Length; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Drug Interactions; Female; Inflammation; Lipopolysaccharides; Mice; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thioctic Acid | 2007 |
Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma, Sebaceous; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p21; Epidermis; Female; Genes, ras; Lymphoid Enhancer-Binding Factor 1; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Mutation; Sebaceous Gland Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2007 |
CD34 expression by hair follicle stem cells is required for skin tumor development in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD34; Cell Cycle; Cell Movement; Female; Hair Follicle; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Skin Neoplasms; Stem Cells; Tetradecanoylphorbol Acetate | 2007 |
DMBA/TPA-induced tumor formation is aggravated in human papillomavirus type 16 E6/E7 transgenic mouse skin.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Deoxyguanosine; Dermis; DNA Damage; Epidermis; Gene Expression; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Repressor Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Female; Gene Expression Profiling; Immunity, Cellular; Immunophenotyping; Mice; Mice, Inbred SENCAR; Oligonucleotide Array Sequence Analysis; Papilloma; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependent.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Blotting, Northern; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Dermatologic Agents; Drug Resistance, Neoplasm; Female; Humans; Interleukin-1alpha; Mice; Mice, Transgenic; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2007 |
New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chromosome Mapping; Crosses, Genetic; Drug Resistance; Female; Genes, Dominant; Genetic Linkage; Genetic Predisposition to Disease; Genotype; Male; Mice; Mice, Inbred Strains; Neoplasms, Second Primary; Papilloma; Quantitative Trait Loci; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors.
Topics: Animals; Chemokine Receptor D6; Disease Susceptibility; Disease-Free Survival; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Keratinocytes; Mice; Mice, Transgenic; Neoplasm Invasiveness; Papilloma; Receptors, CCR10; Receptors, Chemokine; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2007 |
Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo: the negative role of p50.
Topics: Animals; Cell Line; Enhancer Elements, Genetic; Epithelial Cells; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Luciferases; Mice; Mice, Transgenic; NF-kappa B p50 Subunit; Nuclear Proteins; Nucleophosmin; Promoter Regions, Genetic; Skin; Skin Neoplasms; Sp1 Transcription Factor; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription Factor RelA | 2007 |
Protective effect of Ocimum sanctum on 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and aflatoxin B1 induced skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Aflatoxin B1; Animals; Anticarcinogenic Agents; Carcinogens; Cocarcinogenesis; Female; gamma-Glutamyltransferase; Glutathione; Glutathione S-Transferase pi; HSP70 Heat-Shock Proteins; Interleukin-1beta; Lipid Peroxidation; Methylcholanthrene; Mice; Ocimum; Ornithine Decarboxylase; Plant Extracts; Plant Leaves; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2007 |
Glycyrrhizin exhibits potential chemopreventive activity on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in Swiss albino mice.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catalase; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Glycyrrhizic Acid; Lipid Peroxidation; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Decreased c-kit function inhibits enhanced skin carcinogenesis in c-Ha-ras protooncogene transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Female; Genes, ras; Humans; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papilloma; Polymerase Chain Reaction; Promoter Regions, Genetic; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins p21(ras); Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2007 |
Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Fruit; Glycosides; Humans; Inhibitory Concentration 50; Mice; Molecular Structure; Momordica charantia; Nitric Oxide Donors; Peroxynitrous Acid; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2007 |
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Topics: Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Mice; Mice, Inbred BALB C; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection | 2007 |
Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Disease Progression; Epidermis; Keratinocytes; Mice; Mice, Transgenic; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate | 2008 |
In vivo long-term effects of retinoic acid exposure in utero on induced hyperplastic epidermal foci in murine skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Carcinogens; Cell Differentiation; Disease Models, Animal; Female; Keratolytic Agents; Mice; Papilloma; Pregnancy; Prenatal Exposure Delayed Effects; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 2007 |
SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB.
Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; Enzyme Activation; Epidermis; Humans; I-kappa B Proteins; Mice; Mice, Transgenic; NF-kappa B; NF-KappaB Inhibitor alpha; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Ubiquitin-Protein Ligases | 2007 |
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; DNA-Binding Proteins; Fibroblasts; Gene Expression Regulation, Neoplastic; Genotype; Glucose; Heat Shock Transcription Factors; Humans; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Knockout; Mutation; Phenotype; Protein Biosynthesis; Proto-Oncogene Proteins c-sis; ras Proteins; RNA Interference; RNA, Small Interfering; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factors; Transduction, Genetic; Tumor Suppressor Protein p53 | 2007 |
Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Bromelains; Cyclooxygenase 2; Female; MAP Kinase Signaling System; Mice; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2008 |
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Base Sequence; Carcinogens; Carcinoma; Cocarcinogenesis; Female; Genes, ras; Genetic Predisposition to Disease; I-kappa B Kinase; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Neovascularization, Pathologic; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2007 |
Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Disease Progression; Enzyme Activation; Female; Male; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-myc; ras Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Claudin-1; Disease Progression; Epidermis; Gene Expression; Membrane Proteins; Mice; Models, Animal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tight Junctions; Time Factors | 2007 |
Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Citrus; Cyclooxygenase 2; Dermatitis; Extracellular Signal-Regulated MAP Kinases; Female; Flavones; I-kappa B Kinase; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate | 2007 |
Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption.
Topics: Adenosine Triphosphate; Animals; Aquaporin 3; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Epidermis; Glycerol; Humans; Keratinocytes; Mice; Mice, Knockout; Neoplasms, Squamous Cell; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
RasGRP1 overexpression in the epidermis of transgenic mice contributes to tumor progression during multistage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Progression; Epidermis; Female; Guanine Nucleotide Exchange Factors; Keratinocytes; Male; Mice; Mice, Transgenic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Chemotherapeutic/chemopreventive role of retinoids in chemically induced skin carcinogenesis in albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Diterpenes; Isotretinoin; Mice; Precancerous Conditions; Retinyl Esters; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A | 2007 |
Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis.
Topics: Animals; Cattle; Epithelium; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; B-Lymphocytes; Carcinoma, Squamous Cell; Cell Proliferation; Chemotaxis, Leukocyte; Cyclin-Dependent Kinase Inhibitor p16; Lymph Nodes; Lymphangiogenesis; Lymphatic Metastasis; Macrophages; Mice; Mice, Transgenic; Neovascularization, Pathologic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2008 |
Imiquimod treatment of papilloma virus and DMBA /TPA-induced cutaneous skin cancer in Mastomys coucha: an unique animal model system useful for preclinical studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoquinolines; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Imiquimod; Murinae; Papilloma; Papillomavirus Infections; Skin Neoplasms; Tetradecanoylphorbol Acetate; Treatment Outcome | 2007 |
Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinoma, Squamous Cell; Female; Genes, ras; Mice; Mice, Transgenic; Mutation; Papilloma; Protein Kinase C-epsilon; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Genetic Predisposition to Disease; HMGA Proteins; Keratinocytes; Mice; Mice, Knockout; Papilloma; Proto-Oncogene Proteins c-fos; rab GTP-Binding Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Activation of epidermal akt by diverse mouse skin tumor promoters.
Topics: Animals; Anthracenes; Anticoagulants; Carcinogens; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermis; ErbB Receptors; Female; Heparin; Indoles; Keratinocytes; Maleimides; Mice; Mice, Inbred ICR; Okadaic Acid; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2007 |
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester.
Topics: Animals; Carcinogens; Dermatitis, Contact; Fibroblasts; Interleukin-1; Keratinocytes; Mice; Mice, Mutant Strains; Phosphoinositide Phospholipase C; rap1 GTP-Binding Proteins; ras Guanine Nucleotide Exchange Factors; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
RETRACTED: Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Carcinogens; Chemoprevention; Cytochromes c; Disease Models, Animal; In Situ Nick-End Labeling; Male; Mice; Mitochondria; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Resveratrol; Skin; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate | 2008 |
RAGE signaling sustains inflammation and promotes tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Gene Expression Regulation, Neoplastic; Inflammation; Macrophage Inflammatory Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor for Advanced Glycation End Products; Receptors, Immunologic; S100 Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Suppressor role of activating transcription factor 2 (ATF2) in skin cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Activating Transcription Factor 2; Animals; Apoptosis; beta Catenin; Carcinogens; Cell Proliferation; Cyclin D1; DNA; Epidermis; Keratinocytes; Mice; Mice, Knockout; Papilloma; Presenilin-1; Proto-Oncogene Proteins c-myb; Receptor, Notch1; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tissue Array Analysis; Tumor Suppressor Proteins | 2008 |
Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Cell Transformation, Neoplastic; Cells, Cultured; MAP Kinase Kinase 1; Mice; NF-kappa B; Proto-Oncogene Proteins c-raf; Quercetin; Resveratrol; Skin; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Wine | 2008 |
Topically applied vitamin E prevents massive cutaneous inflammatory and oxidative stress responses induced by double application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in mice.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Dermatitis; Female; Hydrogen Peroxide; Lipid Peroxidation; Mice; Mice, Inbred SENCAR; Oxidative Stress; Peroxidase; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin E; Xanthine Oxidase | 2008 |
Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion.
Topics: Animals; Apoptosis Regulatory Proteins; Cell Transformation, Neoplastic; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Transgenic; Proteasome Endopeptidase Complex; Ribosomal Protein S6 Kinases, 70-kDa; RNA-Binding Proteins; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Cancer chemoprotective effects of Curcuma xanthorrhiza.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Curcuma; Dose-Response Relationship, Drug; Ear; Edema; Female; Humans; Methanol; Mice; Mice, Inbred ICR; Mutagenesis; Phytotherapy; Plant Extracts; Salmonella typhimurium; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; DNA Adducts; DNA Damage; Mice; Mice, Inbred SENCAR; Particulate Matter; Polycyclic Aromatic Hydrocarbons; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vehicle Emissions | 2008 |
Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion.
Topics: Animals; Bongkrekic Acid; Cell Line; Cyclosporine; Membrane Potentials; Mice; Mice, Inbred DBA; Mitochondria; Protein Transport; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 2008 |
Polymeric black tea polyphenols inhibit mouse skin chemical carcinogenesis by decreasing cell proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Epidermis; Female; Flavonoids; Inflammation Mediators; MAP Kinase Signaling System; Mice; Ornithine Decarboxylase; Phenols; Polymers; Polyphenols; Precancerous Conditions; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Suppressor Protein p53 | 2008 |
Anti-tumor-Promoting activity of tibolone and its metabolites.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Line, Tumor; Epstein-Barr Virus Nuclear Antigens; Female; Mice; Norpregnenes; Papilloma; Selective Estrogen Receptor Modulators; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Inhibitory effect of the rhizomes of Alpinia officinarum on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alpinia; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Carcinogens; Diarylheptanoids; Female; Inflammation; Inhibitory Concentration 50; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Plant Extracts; Rhizome; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Cancer chemopreventive activity of "rosin" constituents of Pinus spez. and their derivatives in two-stage mouse skin carcinogenesis test.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carboxylic Acids; Carcinogenicity Tests; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred ICR; Papilloma; Phenanthrenes; Pinus; Resins, Plant; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Immunohistochemistry; Mice; Mice, Transgenic; Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms; STAT3 Transcription Factor; Tamoxifen; Tetradecanoylphorbol Acetate | 2008 |
Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels.
Topics: Animals; Benz(a)Anthracenes; Cell Proliferation; Cell Transformation, Neoplastic; Epidermis; Female; Genetic Predisposition to Disease; Insulin-Like Growth Factor I; Mice; Models, Biological; Neoplasms; Protein Kinases; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2008 |
Effects of oral administration of ciclosporin A on skin carcinogenesis: a study using the two-stage carcinogenesis protocol in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Carcinogens; Cyclosporine; Dose-Response Relationship, Drug; Female; Immunosuppressive Agents; Mice; Mice, Hairless; Neoplasm Staging; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2008 |
On the role of superoxide anion radicals in skin tumour promotion.
Topics: Animals; Cells, Cultured; Chromosome Aberrations; DNA; Female; Free Radicals; Leukocytes; Mice; Mice, Inbred Strains; Salicylates; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
The tumorigenic and carcinogenic effect of TPA (12-0-tetradecanoylphorbol-13-acetate) when applied to the skin of BALB/cA mice.
Topics: Animals; Carcinogens; Female; Male; Mice; Mice, Inbred BALB C; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
Decreased beta-adrenergic responsiveness in mouse epidermal papillomas during tumor promotion with phorbol myristate acetate.
Topics: Adrenergic beta-Agonists; Animals; Cyclic AMP; Female; Isoproterenol; Mice; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Chemical carcinogenesis by the two-stage protocol in the skin Mastomys natalensis (Muridae) using topical initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-0-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Keratoacanthoma; Male; Muridae; Neoplasms, Experimental; Phorbols; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Hairless mouse skin in two-stage chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Drug Resistance; Female; Hyperplasia; Male; Mice; Mice, Hairless; Neoplasm Regression, Spontaneous; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
The study of tumor promotion in a cell culture model for mouse skin--a tissue that exhibits multistage carcinogenesis in vivo.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Cocarcinogenesis; Enzyme Induction; Epidermis; gamma-Glutamyltransferase; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Increase in histidine decarboxylase activity in mouse skin after application of tumor promoters.
Topics: Acrylamides; Animals; Carboxy-Lyases; Carcinogens; Cnidarian Venoms; Histamine; Histidine Decarboxylase; Leukocytes; Lyngbya Toxins; Mast Cells; Mice; Mice, Mutant Strains; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Mechanisms of initiation and promotion in mouse epidermis.
Topics: Acyltransferases; Animals; Animals, Newborn; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cells, Cultured; Female; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transglutaminases | 1984 |
Effect of tumor promote phorbol esters on the in vitro keratinization of rat epidermal cells in normal, premalignant and malignant stages.
Topics: Aneuploidy; Animals; Cell Differentiation; Cell Division; Cell Line; Diploidy; Embryo, Mammalian; Epidermal Cells; Epidermis; Keratins; Phorbol Esters; Phorbols; Precancerous Conditions; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on the biochemical processes linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Cocarcinogenesis; Cyclic AMP; Cyclic GMP; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Theophylline | 1981 |
Comparison of the effects of 3-isobutyl-1-methylxanthine and adenosine cyclic 3':5'-monophosphate on the induction of skin tumors by the initiation-promotion protocol and by the complete carcinogenesis process.
Topics: 1-Methyl-3-isobutylxanthine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Cyclic AMP; DNA; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Polyamines; Protein Biosynthesis; RNA; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Theophylline | 1982 |
Keratin modifications in epidermis, papillomas, and carcinomas during two-stage carcinogenesis in the SENCAR mouse.
Topics: Animals; Carcinogens; Carcinoma; Female; Keratins; Mice; Mice, Inbred Strains; Molecular Weight; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Simultaneous appearance of keratin modifications and gamma-glutamyltransferase activity as indicators of tumor progression in mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acyltransferases; Animals; Carcinoma, Squamous Cell; Female; Histocytochemistry; Keratins; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transglutaminases | 1983 |
Effect of hexachlorocyclohexane on diethylnitrosamine-induced hepatocarcinogenesis in rat and its failure to promote skin tumors on dimethylbenz[a]anthracene initiation in mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Diethylnitrosamine; Drug Interactions; Female; gamma-Glutamyltransferase; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Nitrosamines; Phorbols; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Modulation of skin tumor promotion by inhibitors of arachidonic acid metabolism.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cell Line; Cricetinae; Cricetulus; Cyclooxygenase Inhibitors; Lipoxygenase Inhibitors; Lung; Mice; Neoplasms, Experimental; Phospholipases A; Prostaglandins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Dehydroepiandrosterone (DHEA) and 3 beta-methylandrost-5-en-17-one: inhibitors of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin papilloma formation in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenes; Animals; Benz(a)Anthracenes; Dehydroepiandrosterone; Drug Administration Schedule; Drug Antagonism; Estradiol; Female; Mice; Papilloma; Phorbols; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Uterus | 1984 |
Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Carboxy-Lyases; Cyclooxygenase Inhibitors; Female; Indomethacin; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Prostaglandins; Prostaglandins E, Synthetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Can prenatal X-irradiation in mice act as an initiator stimulus in a modified 2-stage Berenblum/Mottram experiment with postnatal promotion with phorbol ester TPA?
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Female; Fetus; Leukemia; Liver Neoplasms; Lung Neoplasms; Maternal-Fetal Exchange; Mice; Ovarian Diseases; Phorbols; Pregnancy; Prostaglandins; Radiation, Ionizing; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; X-Rays | 1980 |
Phorbol myristate acetate uncouples the relationship between beta-adrenergic receptors and adenyl cyclase in mouse epidermis: a phenotypic trait in papillomas.
Topics: Adenylyl Cyclases; Animals; Cocarcinogenesis; Cyclic GMP; Enzyme Activation; Epidermis; Isoproterenol; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Receptors, Adrenergic; Receptors, Adrenergic, beta; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Dose-Response Relationship, Drug; Enzyme Induction; Female; Flavonoids; Injections, Intraperitoneal; Methylcholanthrene; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Relationship of benign papillomas to cancer induction in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Dose-Response Relationship, Drug; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Binding of phorbol dibutyrate and epidermal growth factor to cultured human epidermal cells.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Melanoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Skin tumor promotion: a comparative study of several stocks and strains of mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms; Species Specificity; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Acceleration of skin tumorigenesis in mice by submandibular and sublingual gland excision.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Kinetics; Male; Mice; Neoplasms, Experimental; Skin Neoplasms; Sublingual Gland; Submandibular Gland; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Carcinogens; Chlorogenic Acid; Cinnamates; Coumaric Acids; Ellagic Acid; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Murine susceptibility to two-stage skin carcinogenesis is influenced by the agent used for promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Cell Line; Cricetinae; Cricetulus; Female; Lung; Mice; Mice, Inbred Strains; Mutagenicity Tests; Mutagens; Mutation; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
Tumor-initiating activity of quinoline and methylated quinolines on the skin of SENCAR mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cocarcinogenesis; Female; Mice; Mutagens; Quinaldines; Quinolines; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Interaction of epidermal growth factor with basal and differentiating epidermal cells of mice resistant and sensitive to carcinogenesis.
Topics: Animals; Animals, Newborn; Calcium; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Mice, Inbred Strains; Phorbols; Receptors, Cell Surface; Skin; Skin Neoplasms; Skin Physiological Phenomena; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
Nature of the epidermal hyperplasia produced by mezerein, a weak tumor promoter, in initiated skin of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diterpenes; Female; Hyperplasia; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
Skin painting studies in Syrian hamsters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Dose-Response Relationship, Drug; Female; Male; Melanoma; Mesocricetus; Neoplasms, Experimental; Nicotiana; Papilloma; Plants, Toxic; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of 7-bromomethylbenz[a]anthracene-promoted mouse skin tumor formation by retinoic acid and dexamethasone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Dexamethasone; Drug Interactions; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1983 |
Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Administration, Oral; Administration, Topical; Animals; Cell Division; Eflornithine; Epidermis; Female; Injections, Intraperitoneal; Mice; Ornithine; Ornithine Decarboxylase; Polyamines; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
On the persistence of tumor initiation in two-stage carcinogenesis on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Cell Transformation, Neoplastic; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Transplacental skin tumor initiation of Ha/ICR mice at different fetal ages.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Fetus; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition.
Topics: Animals; DNA; Epidermis; Female; Flavonoids; Lipoxygenase Inhibitors; Mice; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Quercetin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of tumor promotion by a lecanoric acid analogue.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Female; Histidine Decarboxylase; Mice; Salicylamides; Salicylanilides; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Skin tumor formation in the European hamster (Cricetus cricetus L.) after topical initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cricetinae; Drug Synergism; Female; Male; Neoplasms; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Alteration in the distribution of the epidermal protein filaggrin during two-stage chemical carcinogenesis in the SENCAR mouse skin.
Topics: Amino Acids; Animals; Epidermis; Female; Filaggrin Proteins; Fluorescent Antibody Technique; Immunodiffusion; Intermediate Filament Proteins; Male; Mice; Mice, Inbred Strains; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds.
Topics: Animals; Antioxidants; Enzyme Induction; Epidermis; Female; Flavonoids; Lipoxygenase Inhibitors; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
A two-stage mouse skin carcinogenesis study of lyngbyatoxin A.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Dermotoxins; Lyngbya Toxins; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate-effected tumor promotion in mouse skin by nontoxic inhibition of DNA synthesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; DNA Replication; Female; Hydroxyurea; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA; Female; Methylnitronitrosoguanidine; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Phorbols; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
Studies on the promoting and complete carcinogenic activities of some oxidizing chemicals in skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Bromates; Chlorides; Female; Hydrogen Peroxide; Mice; Oxidation-Reduction; Skin Neoplasms; Sodium Hypochlorite; Tetradecanoylphorbol Acetate | 1984 |
Stages of tumour promotion in skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Aging; Animals; Animals, Newborn; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Hyperplasia; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Wounds and Injuries | 1984 |
On the role of tumour promotion in chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dexamethasone; DNA Replication; Hyperplasia; Indomethacin; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
A murine model of squamous intraepithelial neoplasia.
Topics: Administration, Topical; Animals; Antineoplastic Agents; DNA, Neoplasm; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1984 |
The relevance of gap junctions to stage I tumor promotion in mouse epidermis.
Topics: Animals; Cell Communication; Diterpenes; Dose-Response Relationship, Drug; Female; Fluocinolone Acetonide; Intercellular Junctions; Mice; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin | 1984 |
Can tumour promotion be effectively inhibited?
Topics: Animals; Antioxidants; Benzoyl Peroxide; Carcinogens; Humans; Hyperplasia; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Triethylenemelamine: an initiator of two-stage carcinogenesis in mouse skin which lacks the potential of a complete carcinogen.
Topics: Animals; Carcinogens; Cocarcinogenesis; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Triethylenemelamine | 1983 |
Alterations in epidermal functions resulting from exposure to initiators and promoters of carcinogenesis.
Topics: Animals; Aspartate Aminotransferases; Carcinogens; Cells, Cultured; Epidermis; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Skin-tumor initiation activity of coal liquids with different boiling-point ranges.
Topics: Animals; Coal; Female; Fuel Oils; Mice; Petroleum; Skin Neoplasms; Temperature; Tetradecanoylphorbol Acetate | 1983 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on epithelial tumor induction in methylcholanthrene injected Swiss albino mice.
Topics: Animals; Drug Synergism; Female; Methylcholanthrene; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Interactions of ultraviolet radiation, 12-O-tetradecanoyl-phorbol-13-acetate and retinoic acid in the skin of hairless mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Epidermis; Male; Mice; Mice, Hairless; Mitosis; Neoplasms, Radiation-Induced; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Ultraviolet Rays | 1983 |
1 alpha, 25-Dihydroxyvitamin D3 inhibits phorbol ester-dependent chemical carcinogenesis in mouse skin.
Topics: Administration, Topical; Animals; Calcitriol; Female; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
A rapid, simple screening method for skin-tumor promoters using mouse peritoneal macrophages in vitro.
Topics: Animals; Carcinogens; Female; Macrophages; Mice; Mice, Inbred ICR; Nitroblue Tetrazolium; Phagocytosis; Phorbol Esters; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on the incorporation of labelled precursors into RNA, DNA and protein in epidermis, dermis and subcutis from precancerous mouse skin with reference to enhanced tumorigenesis.
Topics: Animals; Carbon Radioisotopes; DNA Replication; Female; Kinetics; Leucine; Mice; Phorbols; Precancerous Conditions; Protein Biosynthesis; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine; Transcription, Genetic; Tritium; Uridine | 1984 |
Two-stage tumorigenesis of dermal melanocytes in the back skin of the Syrian golden hamster using systemic initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Positive two-stage carcinogenesis in female Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (dmba) as initiator and 12-o-tetradecanoylphorbol-13-acetate (tps) as promotor. Results of a pilot study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Castration; Cocarcinogenesis; Colonic Neoplasms; Female; Intestinal Neoplasms; Liver Neoplasms; Phorbols; Rats; Skin Neoplasms; Stomach; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Characteristics of neoplastic progression and tumor behavior in skin carcinogenesis by different methods: an experimental study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Keratoacanthoma; Mice; Neoplasms, Experimental; Papilloma; Precancerous Conditions; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diterpenes; Epidermal Cells; Female; Fluocinolone Acetonide; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbol Esters; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin | 1980 |
Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chemical Phenomena; Chemistry; Cocarcinogenesis; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1980 |
Protection of mice against 7,12-dimethylbenz(a)anthracene-induced skin tumors by immunization with a fluorinated analog of the carcinogen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibody Formation; Benz(a)Anthracenes; Cocarcinogenesis; Immunization; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Fetus; Gestational Age; Mice; Phorbols; Pregnancy; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Initiation and promotion at different ages and doses in 2200 mice. I. Methods, and the apparent persistence of initiated cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Initiation and promotion at different ages and doses in 2200 mice. II. Decrease in promotion by TPA with ageing.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Initiation and promotion at different ages and doses in 2200 mice. III. Linear extrapolation from high doses may underestimate low-dose tumour risks.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Risk; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Epidermis; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Cocarcinogenesis; Free Radicals; Mice; Neoplasms, Experimental; Peroxides; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Sensitivity to two-stage carcinogenesis of SENCAR mouse skin grafted to nude mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Skin Transplantation; Species Specificity; Tetradecanoylphorbol Acetate | 1982 |
On the relationship between epidermal hyperproliferation and skin tumor promotion.
Topics: Calcimycin; Cell Division; Cocarcinogenesis; Dinoprost; Dinoprostone; Epidermal Cells; Hyperplasia; Indomethacin; Prostaglandins E; Prostaglandins F; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Epidermal tumor promotion by regeneration.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Division; Epidermis; Female; Hyperplasia; Mice; Neoplasms, Experimental; Regeneration; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
The differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the initiation-promotion protocol and by the complete carcinogenesis process.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; Carcinogens; Cocarcinogenesis; Enzyme Induction; Flavonoids; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1982 |
Diterpene ester-mediated two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Cricetinae; Female; Guinea Pigs; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Milk; Neoplasms, Experimental; Phorbols; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vaginal Neoplasms | 1982 |
Epidermal-dermal junction during experimental skin carcinogenesis and cocarcinogenesis as revealed by scanning electron microscopy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1982 |
Correlation between sensitivity to tumor promotion and sustained epidermal hyperplasia of mice and rats treated with 12-O-tetra-decanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Dose-Response Relationship, Drug; Hyperplasia; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Phorbols; Rats; Rats, Inbred F344; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1982 |
Mouse skin tumor-initiating activity of 5-, 7-, and 12-methyl- and fluorine-substituted benz[a]anthracenes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cocarcinogenesis; Female; Hydrocarbons, Fluorinated; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoyl-phorbol-13-acetate-mediated skin tumor initiation and promotion in male Sprague-Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cocarcinogenesis; Diazonium Compounds; Male; Neoplasms, Experimental; Phorbols; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Stimulation of fibronectin production by retinoic acid in mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chromatography, Affinity; Female; Fibronectins; Fucose; Leucine; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Carcinogens; Female; Lyngbya Toxins; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms; Streptomyces; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion by nordihydroguaiaretic acid, a lipoxygenase inhibitor, and p-bromophenacyl bromide, a phospholipase A2 inhibitor.
Topics: Acetophenones; Animals; Catechols; Enzyme Inhibitors; Female; Lipoxygenase Inhibitors; Masoprocol; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Pyrazoles; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin.
Topics: Alkynes; Animals; Antineoplastic Agents, Phytogenic; Carboxy-Lyases; Carcinogens; Diterpenes; Eflornithine; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbol Esters; Polyamines; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1982 |
Tumor promotion by phorbol esters in skin: evidence for a memory effect.
Topics: Animals; Carcinogens; Cell Line; Epidermis; Female; Hyperplasia; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phorbol Esters; Phorbols; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Effect of retinoic acid on the synthesis of glycoproteins of mouse skin tumors during progression from promoted skin through papillomas to carcinomas.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Male; Mice; Molecular Weight; Neoplasm Proteins; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1983 |
Tumor promoting activity of 1,8-dihydroxy-3-methyl-9-anthrone (chrysarobin) in female SENCAR mice.
Topics: Animals; Anthracenes; Carcinogens; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
12-0-Tetradecanoylphorbol-13-acetate-induced amplification of mesenchymal tumorigenesis in the mouse skin.
Topics: Animals; Cocarcinogenesis; Female; Methylcholanthrene; Mice; Mice, Inbred Strains; Phorbols; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Mouse skin application in chemical carcinogenesis.
Topics: Animals; Biological Assay; Carcinogens; Cocarcinogenesis; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Respiratory Tract Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
The tumourigenic and carcinogenic effect of 12-0-tetradecanoylphorbol-13-acetate when applied to the skin of BALB/cA and hairless (hr/hr) mice.
Topics: Amyloidosis; Animals; Female; Kupffer Cells; Male; Mice; Mice, Hairless; Mice, Inbred BALB C; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Tumour-initiating activities of dihydrodiols of dibenz[a,c]anthracene.
Topics: Animals; Benz(a)Anthracenes; Female; Mice; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of tumor promotion by a biomimetic superoxide dismutase.
Topics: Animals; Antineoplastic Agents; Carcinogens; Female; Mice; Ornithine Decarboxylase; Papilloma; Salicylates; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1983 |
Onion and garlic oils inhibit tumor promotion.
Topics: Animals; Cell Transformation, Neoplastic; Drug Antagonism; Female; Garlic; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Oils; Phorbols; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Diazepam inhibition of phorbol ester tumor promotion.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Female; Male; Mice; Papilloma; Phorbols; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Tumor-initiating activity of benz[c]acridine and twelve of its derivatives on mouse skin.
Topics: Acridines; Animals; Carcinogens; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Comparative tumor-initiating activity of complex mixtures from environmental particulate emissions on SENCAR mouse skin.
Topics: Administration, Topical; Air Pollutants; Animals; Cocarcinogenesis; Female; Fuel Oils; Male; Mice; Mice, Inbred Strains; Papilloma; Petroleum; Probability; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Epidermal proliferation of nude mouse skin, pig skin, and pig skin grafts. Failure of nude mouse skin to respond to the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate.
Topics: Animals; Mice; Mice, Nude; Neoplasms, Experimental; Phorbols; Skin; Skin Neoplasms; Skin Transplantation; Swine; Tetradecanoylphorbol Acetate; Transplantation Immunology; Transplantation, Heterologous | 1980 |
Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.
Topics: Animals; Cocarcinogenesis; Epidermis; Female; Hair; Humans; Hyperplasia; Methylcholanthrene; Mice; Phorbols; Precancerous Conditions; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Simple phorbol esters as inhibitors of tumor promotion by TPA in mouse skin.
Topics: Animals; Cocarcinogenesis; DNA; Dose-Response Relationship, Drug; Epidermis; Female; Hyperplasia; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Retinoids and inhibition of ornithine decarboxylase activity.
Topics: Animals; Carboxy-Lyases; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Tumor promotion by regenerative epidermal hyperplasia in mouse skin.
Topics: Animals; Cell Transformation, Neoplastic; Hyperplasia; Mice; Regeneration; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1982 |
Must initiators come first? Tumorigenic and carcinogenic effects on skin of 3-methylcholanthrene and TPA in various sequences.
Topics: Animals; Carcinoma; Cell Division; DNA; Drug Synergism; Hyperplasia; Methylcholanthrene; Mice; Mice, Hairless; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Hyperplasia and tumor promotion.
Topics: Animals; Croton Oil; Guinea Pigs; Humans; Hyperplasia; Mice; Ornithine Decarboxylase; Polyamines; Precancerous Conditions; Prostaglandins E; Psoriasis; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Tumour promotion by TCDD in skin of HRS/J hairless mice.
Topics: Animals; Dioxins; Female; Mice; Mice, Hairless; Papilloma; Polychlorinated Dibenzodioxins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Animals; Arachidonic Acids; Biotransformation; Female; Male; Mice; Neoplasms, Experimental; Oxygenases; Papilloma; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandin Antagonists; Pyrazoles; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Effect of tumor promoters on lipid peroxidation in mouse skin.
Topics: Age Factors; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Diterpenes; Glutathione Peroxidase; Kinetics; Lipid Peroxides; Male; Mice; Neoplasms, Experimental; Phorbol Esters; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1982 |
Biological effects of phorbol ester tumor promoters in mouse skin.
Topics: Animals; Cell Division; Hyperplasia; Kinetics; Mice; Neoplasms, Experimental; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Dose response in the tetrazolium test for skin carcinogenicity.
Topics: Animals; Cantharidin; Carcinogens; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Methylcholanthrene; Mice; Mice, Nude; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tetrazolium Salts; X-Rays | 1980 |
Chemical carcinogenesis studies in mouse epidermal cell cultures.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Environmental Exposure; Enzyme Induction; Epidermal Cells; Epidermis; Methylnitronitrosoguanidine; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Effect of butyric acid on tumor promotion: a correction.
Topics: Animals; Butyrates; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
The role of anthralin in mouse skin tumour promotion.
Topics: Animals; Anthracenes; Anthralin; DNA; Enzyme Induction; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Presidential address. Recent concepts of initiation and promotion in carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; DNA; Humans; Intestinal Polyps; Liver Neoplasms, Experimental; Mice; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Characterization of arginase activity from mouse epidermis and its relation to ornithine decarboxylase induction by the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Arginase; Carboxy-Lyases; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Polyamines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
The time needed for normalization of hairless mouse epidermis after treatment with twice weekly topical skin applications of 10 nmol 12-O-tetradecanoylphorbol-13-acetate in acetone, or acetone alone, for 18 weeks. A morphologic and cell kinetic study.
Topics: Acetone; Animals; Cell Cycle; Female; Hyperplasia; Kinetics; Male; Mice; Mice, Inbred Strains; Phorbols; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Retinoic acid analogues with ring modifications. Synthesis and pharmacological activity.
Topics: Animals; Antineoplastic Agents; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin | 1981 |
Tumorigenic activity of benzo(e)pyrene derivatives on mouse skin and in newborn mice.
Topics: Animals; Animals, Newborn; Benzopyrenes; Biotransformation; Dihydroxydihydrobenzopyrenes; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Structure-activity relationships in chick embryo fibroblasts for phorbol-related diterpene esters showing anomalous activities in vivo.
Topics: Animals; Cells, Cultured; Chick Embryo; Deoxy Sugars; Deoxyglucose; Fibroblasts; Fibronectins; Inflammation; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Carcinogenicity of chloroethylene oxide, an ultimate reactive metabolite of vinyl chloride, and bis(chloromethyl)ether after subcutaneous administration and in initiation-promotion experiments in mice.
Topics: Animals; Bis(Chloromethyl) Ether; Ethylene Oxide; Female; Male; Methyl Ethers; Mice; Mutagens; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Soft Tissue Neoplasms; Tetradecanoylphorbol Acetate; Vinyl Chloride | 1980 |
Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin.
Topics: Animals; Benzopyrenes; Cocarcinogenesis; Female; Methylation; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Prostaglandin enhancement of skin tumor initiation and promotion.
Topics: Animals; Indomethacin; Mice; Neoplasms, Experimental; Phorbols; Prostaglandins; Prostaglandins E; Prostaglandins F; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Retinoic acid analogues. Synthesis and potential as cancer chemopreventive agents.
Topics: Animals; Epidermis; Female; Mice; Neoplasms; Neoplasms, Experimental; Ornithine Decarboxylase Inhibitors; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
An organ culture of adult mouse skin: an in vitro model for studying the molecular mechanism of skin tumor promotion.
Topics: Animals; Carboxy-Lyases; DNA; Enzyme Induction; Female; Indomethacin; Mice; Models, Biological; Neoplasms, Experimental; Organ Culture Techniques; Ornithine Decarboxylase; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Indomethacin enhancement of TPA tumor promotion in mice.
Topics: Animals; Drug Synergism; Female; Flurbiprofen; Indomethacin; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Long-term effect of a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, on induced differentiation of Friend leukemia cells.
Topics: Acetamides; Animals; Cell Differentiation; Cells, Cultured; Cocarcinogenesis; Diamines; Friend murine leukemia virus; Leukemia, Experimental; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Virus Diseases | 1980 |
Paradoxical effect of anthralin on 12-O-tetradecanoylphorbol-13-acetate-induced mouse epidermal ornithine decarboxylase activity, proliferation, and tumor promotion.
Topics: Animals; Anthracenes; Anthralin; Carboxy-Lyases; Cell Division; Enzyme Induction; Epidermal Cells; Epidermis; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Exceptionally high tumor-initiating activity of benzo(c)phenanthrene bay-region diol-epoxides on mouse skin.
Topics: Animals; Carcinogens; Cocarcinogenesis; Mice; Neoplasms, Experimental; Phenanthrenes; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Inhibition by putrescine of the induction of epidermal ornithine decarboxylase activity and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cocarcinogenesis; Enzyme Induction; Epidermis; Mice; Ornithine Decarboxylase; Phorbols; Putrescine; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Alkane-6,8-diol: inhibitor of tumor promotion in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Fatty Alcohols; Female; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Human lymphocyte activation is associated with the early and high-level expression of the endogenous lectin CSL at the cell surface.
Topics: Agglutination Tests; Antigens, CD; B-Lymphocytes; CD24 Antigen; CD3 Complex; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Humans; Immunoenzyme Techniques; Lectins; Ligands; Lymphocyte Activation; Membrane Glycoproteins; Phosphorylation; Sezary Syndrome; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1995 |
Inhibitory effect of rikkunshi-to, a traditional Chinese herbal prescription, on tumor promotion in two-stage carcinogenesis in mouse skin.
Topics: Animals; Dermatitis; Drugs, Chinese Herbal; Female; Methanol; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Water | 1995 |
Comparative two-stage cancer tests of ethylene oxide, N-(2-hydroxyethyl)-N-nitrosourea and X-rays.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Ethylene Oxide; Ethylnitrosourea; Lung Neoplasms; Male; Mice; Neoplasms, Radiation-Induced; Skin Neoplasms; Tetradecanoylphorbol Acetate; X-Rays | 1994 |
SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenine; Animals; Base Sequence; Cocarcinogenesis; Codon; Cytosine; DNA, Neoplasm; Exons; Female; Genes, ras; Mice; Mice, Inbred SENCAR; Mice, Nude; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Papilloma; Polymerase Chain Reaction; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Diglycerides; Enzyme Induction; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Melanins; Melanocytes; Melanoma; Melanoma, Experimental; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Signal Transduction; Skin Neoplasms; Taurodeoxycholic Acid; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1994 |
Mouse skin tumor progression results in differential expression of retinoic acid and retinoid X receptors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cell Compartmentation; Epidermis; In Situ Hybridization; Keratins; Mice; Papilloma; Receptors, Retinoic Acid; Retinoid X Receptors; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors | 1995 |
Anti-tumor-promoting activities of euglobals from Eucalyptus plants.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Burkitt Lymphoma; Cell Cycle; Cocarcinogenesis; Drug Screening Assays, Antitumor; Eucalyptus; Female; Mice; Mice, Inbred ICR; Papilloma; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Structure-Activity Relationship; Terpenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Lack of effect of retinoic acid and fluocinolone acetonide on mirex tumor promotion indicates a novel mirex mechanism.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Base Sequence; Carcinogens; Cell Division; Drug Interactions; Ear, External; Edema; Female; Fluocinolone Acetonide; Genes, ras; Genotype; Mice; Mice, Inbred Strains; Mirex; Molecular Sequence Data; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1995 |
7,12-dimethylbenz[a]anthracene induces oxidative DNA modification in vivo.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Carcinogens; DNA; DNA Damage; Female; Guanine; Hydrogen Peroxide; Mice; Mice, Inbred SENCAR; Neutrophils; Oxidation-Reduction; Peroxidase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine | 1995 |
Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acanthosis Nigricans; Animals; Carcinogenicity Tests; Collagenases; Disease Susceptibility; Epidermis; Haptoglobins; Humans; Hyperplasia; Keratosis; Mice; Mice, Transgenic; Papilloma; Promoter Regions, Genetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
12-Lipoxygenase isoenzymes in mouse skin tumor development.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Arachidonate 12-Lipoxygenase; Base Sequence; Blood Platelets; Cloning, Molecular; Cytosol; DNA, Complementary; Epidermis; Female; Gene Expression Regulation, Neoplastic; Hydroxyeicosatetraenoic Acids; Isoenzymes; Leukocytes; Mice; Molecular Sequence Data; RNA, Neoplasm; Skin Neoplasms; Stereoisomerism; Tetradecanoylphorbol Acetate | 1995 |
Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Cell Differentiation; Cells, Cultured; Female; Gene Expression Regulation, Enzymologic; HL-60 Cells; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Organ Culture Techniques; Ornithine Decarboxylase; Precancerous Conditions; Protein Kinase C; RNA, Messenger; Rotenone; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C, inhibits promotional phase in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cholesterol Esters; Enzyme Activation; Enzyme Induction; Female; Hyperplasia; Isoenzymes; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Protein Kinase C; Second Messenger Systems; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cell Line; Cell Transformation, Neoplastic; Coumaric Acids; Curcumin; Diarylheptanoids; Dose-Response Relationship, Drug; Enzyme Induction; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
The presence of a trifluoromethyl rather than a methyl substituent in the bay-region greatly decreases the DNA-binding and tumour-initiating activity of the cyclopenta[alpha]phenanthren-17-ones.
Topics: Animals; Breast Neoplasms; Carcinogens; Cell Line; DNA; DNA Adducts; Epidermis; Female; Gonanes; Humans; Methylation; Mice; Mice, Inbred SENCAR; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
Studies on the tumor initiation/promotion potential of six middle distillates (MDs) in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Carcinogenicity Tests; Carcinogens; Male; Mice; Mice, Inbred ICR; Mutagenesis; Mutagens; Petroleum; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Sapintoxin D is a weak tumour promoter in Sencar mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Mice; Mice, Inbred SENCAR; Microscopy, Fluorescence; Papilloma; Phorbol Esters; Random Allocation; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene.
Topics: Animals; Bone Morphogenetic Proteins; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Division; Epidermis; Methylnitronitrosoguanidine; Mice; Mice, Transgenic; Papilloma; Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1995 |
Genetic alterations cooperate with v-Ha-ras to accelerate multistage carcinogenesis in TG.AC transgenic mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Composition; Base Sequence; Carcinoma, Squamous Cell; Cell Division; Cell Transformation, Neoplastic; Cocarcinogenesis; Diglycerides; Female; Fibrosarcoma; Genes, p53; Genes, ras; Mice; Mice, Transgenic; Molecular Sequence Data; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Genetic susceptibility to papilloma progression in SENCAR mice.
Topics: Animals; Female; Hybridization, Genetic; Mice; Mice, Inbred BALB C; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols.
Topics: Animals; Anticarcinogenic Agents; Edema; Epidermis; Female; Hyperplasia; Interleukin-1; Mice; Mice, Inbred Strains; Phenols; Plant Extracts; RNA, Messenger; Skin Diseases; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1995 |
Anti-tumor-promoting action of FK506, a potent immunosuppressive agent.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Dermatitis, Contact; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phosphorylation; Skin Neoplasms; Tacrolimus; Tetradecanoylphorbol Acetate | 1993 |
Promotion of skin tumors by 12-O-tetradecanoylphorbol-13-acetate in two generations of descendants of male mice exposed to X-ray irradiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Fetus; Genes, ras; Male; Mice; Mutation; Neoplasms, Radiation-Induced; Papilloma; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate; Whole-Body Irradiation; X-Rays | 1993 |
Role of ornithine decarboxylase in epidermal tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Bromodeoxyuridine; Cell Line; Cells, Cultured; Fibroblasts; Genetic Vectors; Keratinocytes; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Papilloma; Polyamines; Recombinant Proteins; Retroviridae; Skin Neoplasms; Skin Transplantation; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Early overexpression of cyclin D1 protein in mouse skin carcinogenesis.
Topics: Animals; Carcinoma, Squamous Cell; Cyclin D1; Cyclins; Female; Formaldehyde; Gene Expression; Hyperplasia; Immunohistochemistry; Mice; Oncogene Proteins; Papilloma; Paraffin Embedding; Precancerous Conditions; Precipitin Tests; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tissue Fixation | 1995 |
Inhibitors of skin-tumor promotion. XIII. Inhibitory effects of euglobals and their related compounds on Epstein-Barr virus activation and on two-stage carcinogenesis of mouse skin tumors. (2).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Transformed; Female; Herpesvirus 4, Human; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Papilloma; Phloroglucinol; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1995 |
c-jun and multistage carcinogenesis: association of overexpression of introduced c-jun with progression toward a neoplastic endpoint in mouse JB6 cells sensitive to tumor promoter-induced transformation.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression; Genes, jun; Humans; Mice; Phenotype; Proto-Oncogene Proteins c-jun; RNA, Messenger; Sensitivity and Specificity; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection | 1995 |
Expression of epidermal ornithine decarboxylase and nuclear proto-oncogenes in phorbol ester tumor promotion-sensitive and -resistant mice.
Topics: Animals; Cocarcinogenesis; Drug Resistance; Epidermis; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Mice; Mice, Inbred C57BL; Mice, Inbred SENCAR; Nuclear Proteins; Ornithine Decarboxylase; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1995 |
Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis.
Topics: Amino Acid Sequence; Animals; Carcinoma; Cell Transformation, Neoplastic; Cocarcinogenesis; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Isoenzymes; Keratinocytes; Mice; Molecular Sequence Data; Papilloma; Prostaglandin-Endoperoxide Synthases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Tumor-promoting activity of 2,4-dinitrofluorobenzene.
Topics: Animals; Carcinogens; Dermatitis, Contact; Dinitrofluorobenzene; Dose-Response Relationship, Drug; Enzyme Induction; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Hyperplasia; Mice; Mice, Inbred SENCAR; Ornithine Decarboxylase; Papilloma; Protein Kinase C; RNA, Small Nuclear; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo.
Topics: 3T3 Cells; Alkaloids; Animals; Anticarcinogenic Agents; Female; Isoenzymes; Mice; Mice, Inbred Strains; Protein Kinase C; Skin; Skin Neoplasms; Staurosporine; Substrate Specificity; Tetradecanoylphorbol Acetate | 1995 |
Carcinoma formation in NMRI mouse skin painting studies is a process suggesting greater than two stages.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinogenicity Tests; Disease Models, Animal; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Malignant progression of papillomas induced by the initiation--promotion protocol in NMRI mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Disease Models, Animal; Disease Progression; Female; Mice; Mice, Inbred Strains; Models, Statistical; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Inhibition of tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by crocetin.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carotenoids; Edema; Enzyme Induction; Female; Hydrogen Peroxide; Hyperplasia; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Peroxidase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A | 1995 |
Effects of methoxychlor on skin tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Enzyme Induction; Epidermis; Female; Methoxychlor; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Antioxidant and antipromotional effects of the soybean isoflavone genistein.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Cell Differentiation; Female; Flavonoids; Gene Expression; Genistein; Glycine max; Humans; Hydrogen Peroxide; Intestine, Small; Isoflavones; Mice; Proto-Oncogene Mas; Proto-Oncogenes; RNA, Messenger; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Xanthine Oxidase | 1995 |
Lack of initiation and promotion potential of deoxynivalenol for skin tumorigenesis in Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Body Weight; Carcinoma, Squamous Cell; Data Interpretation, Statistical; Female; Hyperplasia; Mice; Organ Size; Papilloma; Random Allocation; Skin; Skin Neoplasms; Spleen; Tetradecanoylphorbol Acetate; Trichothecenes | 1995 |
Focal transgene expression associated with papilloma development in v-Ha-ras-transgenic TG.AC mice.
Topics: Animals; Cell Division; Epidermis; Gene Expression Regulation, Neoplastic; Genes, ras; Hyperplasia; Mice; Mice, Transgenic; Nuclear Proteins; Papilloma; Proliferating Cell Nuclear Antigen; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chromosome Aberrations; Chromosome Deletion; Genes, ras; Methylnitronitrosoguanidine; Mice; Mutation; Polymorphism, Restriction Fragment Length; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trisomy | 1994 |
Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carbohydrate Sequence; Drug Screening Assays, Antitumor; Female; Herpesvirus 4, Human; Mice; Mice, Inbred ICR; Molecular Sequence Data; Papilloma; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes; Virus Activation | 1994 |
Expression and function of connexin in normal and transformed human keratinocytes in culture.
Topics: Carcinoma, Squamous Cell; Cell Communication; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Connexins; Gap Junctions; Humans; Keratinocytes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Coumaric Acids; Female; Mice; Mice, Inbred ICR; Plants, Medicinal; Polymers; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Cancer chemopreventive 3-substituted-4-oxoretinoic acids.
Topics: Alkylation; Animals; Anticarcinogenic Agents; Cricetinae; Drug Stability; Enzyme Induction; Female; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin | 1994 |
A course of very small doses of DMBA, each of them allegedly with no promoting potency, acts with clear synergistic effect as a strong promoter of DMBA-initiated mouse skin carcinogenesis. A comparison of the tumorigenic and carcinogenic effects of DMBA (
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma; Drug Synergism; Mice; Mice, Hairless; Papilloma; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate | 1994 |
Curcumin inhibits TPA induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin.
Topics: Animals; Blotting, Northern; Curcumin; Densitometry; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Genes, myc; Mice; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Consumption of reduced-energy/low-fat diet or constant-energy/high-fat diet during mezerein treatment inhibited mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diet, Fat-Restricted; Dietary Carbohydrates; Dietary Fats; Diterpenes; Energy Intake; Female; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1994 |
Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Curcumin; Drug Interactions; Female; Gene Expression Regulation; Hyperplasia; Mice; Mice, Hairless; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1994 |
High dietary retinoic acid prevents malignant conversion of skin papillomas induced by a two-stage carcinogenesis protocol in female SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred SENCAR; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1994 |
Genetics of chemical carcinogenesis--II. Papilloma induction and malignant conversion in susceptible (Car-s) and resistant (Car-R) lines of mice produced by bidirectional selective breeding and in their (Car-S X Car-R) F1 hybrids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hybridization, Genetic; Male; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Cytogenetic analysis of malignant skin tumors induced in chemically treated TG-AC transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzene; Carcinoma, Squamous Cell; Female; Gene Expression; Genes, ras; Karyotyping; Male; Mice; Mice, Transgenic; Neoplasm Transplantation; Papilloma; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Phorbol ester-induced leukotriene biosynthesis and tumor promotion in mouse epidermis.
Topics: Animals; Ear, External; Edema; Epidermis; Female; Hyperplasia; Indoles; Inflammation; Leukotriene B4; Mice; Skin Neoplasms; SRS-A; Tetradecanoylphorbol Acetate | 1994 |
The use of cell proliferation data in modeling of skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Cocarcinogenesis; Kinetics; Likelihood Functions; Mice; Models, Biological; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Minimal role of enhanced cell proliferation in skin tumor promotion by mirex: a nonphorbol ester-type promoter.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Drug Synergism; Female; Hyperplasia; Mice; Mirex; Rats; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Inhibitory effect of karounidiol on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Female; Inflammation; Mice; Mice, Inbred ICR; Oleanolic Acid; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 1994 |
Tumour-promoting activity of ninhydrin on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Diterpenes; Female; Mice; Ninhydrin; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1994 |
Comparison of 7,12-dimethylbenz(a)anthracene-DNA adduction in the epidermis of two lines of mice selected for resistance (CAR-R) or susceptibility (CAR-S) to skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line; DNA; DNA Adducts; Drug Resistance; Epidermis; Female; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
The absence of a synergistic protective effect of beta-carotene and vitamin E on skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Diet; Drug Synergism; Mice; Mice, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Vitamin E | 1993 |
beta-Carotene inhibition of chemically induced toxicity in vivo and in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animal Feed; Animals; beta Carotene; Carotenoids; Cell Line; Diet; Fibroblasts; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Constitutive AP-1 DNA binding and transactivating ability of malignant but not benign mouse epidermal cells.
Topics: Animals; Base Sequence; Carcinoma, Squamous Cell; Chloramphenicol O-Acetyltransferase; DNA; Female; Keratinocytes; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Transplantation; Papilloma; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transcriptional Activation | 1994 |
2-year carcinogenicity study in the male NMRI mouse with 2-ethylhexyl acrylate by epicutaneous administration.
Topics: Acrylates; Administration, Cutaneous; Air Pollutants, Occupational; Animals; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Carcinoma, Squamous Cell; Male; Mice; Papilloma; Skin Neoplasms; Spectrophotometry, Ultraviolet; Tetradecanoylphorbol Acetate | 1994 |
Effects of krestin (PSK) on tumorigenesis induced by two-stage and complete chemical carcinogenesis.
Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Benzo(a)pyrene; Carcinoma, Squamous Cell; Female; Macrophages; Mice; Mice, Inbred Strains; Neutrophils; Papilloma; Proteoglycans; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Epidermal expression of transforming growth factor-alpha in transgenic mice: induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression.
Topics: Animals; Base Sequence; DNA Primers; Gene Expression; Genes, ras; Mice; Mice, Transgenic; Molecular Sequence Data; Papilloma; Proto-Oncogene Proteins p21(ras); RNA, Messenger; RNA, Neoplasm; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1994 |
Differential transformation efficiency but not AP-1 induction under anchorage-dependent and -independent conditions.
Topics: Animals; Cell Adhesion; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media; DNA-Binding Proteins; Homeodomain Proteins; Mice; Minor Histocompatibility Antigens; Models, Biological; Proto-Oncogene Proteins c-bcl-2; Replication Protein C; Repressor Proteins; Saccharomyces cerevisiae Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Granulocyte-macrophage colony stimulating factor gene expression and function during tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibodies; Base Sequence; Chemotactic Factors; Female; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Hydrogen Peroxide; Immunochemistry; Mice; Molecular Sequence Data; Neutrophils; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Inhibition of two-stage skin carcinogenesis as well as complete skin carcinogenesis by oral administration of TMK688, a potent lipoxygenase inhibitor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Anticarcinogenic Agents; Arachidonate Lipoxygenases; Benzo(a)pyrene; Female; Indomethacin; Lipoxygenase Inhibitors; Mice; Mice, Inbred Strains; Piperidines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
[Anti-tumor promoting activities of kampo prescriptions. II. Inhibitory effects of souseiryu-to on two-stage carcinogenesis of mouse skin tumors and mouse pulmonary tumors].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Cell Cycle; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Skin-tumour-promoting activity of processed bidi tobacco in hairless S/RV Cri-ba mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Cocarcinogenesis; Female; Mice; Mice, Mutant Strains; Nicotiana; Occupational Exposure; Papilloma; Plant Extracts; Plants, Toxic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Protection against malignant conversion of chemically induced benign skin papillomas to squamous cell carcinomas in SENCAR mice by a polyphenolic fraction isolated from green tea.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinoma, Squamous Cell; Female; Mice; Nitroquinolines; Papilloma; Plant Extracts; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1993 |
Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Base Sequence; Benzo(a)pyrene; Codon; DNA, Neoplasm; Epidermis; Female; Genes, ras; Isoenzymes; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligodeoxyribonucleotides; Papilloma; Point Mutation; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Induction of micronuclei and karyotype aberrations during in vivo mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chromosome Aberrations; Drug Administration Schedule; Drug Interactions; Karyotyping; Male; Methyl Methanesulfonate; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinoma, Squamous Cell; Drug Resistance; Female; Genetic Predisposition to Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1993 |
The reverse experiment in two-stage skin carcinogenesis. It cannot be genuinely performed, but when approximated, it is not innocuous.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cell Cycle; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Female; Glutathione; Male; Mice; Mice, Hairless; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Anti-tumor promoting activities of natural products. II. Inhibitory effects of digitoxin on two-stage carcinogenesis of mouse skin tumors and mouse pulmonary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Digitoxin; Female; Glycerol; Lung Neoplasms; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Moderate enhancement of the promotion phase of skin tumorigenesis in hairless mice by topical pretreatment with a mitosis-inhibiting epidermal pentapeptide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Amino Acid Sequence; Animals; Carcinogens; Mice; Mice, Hairless; Mitosis; Molecular Sequence Data; Oligopeptides; Papilloma; Pyrrolidonecarboxylic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Inhibition of both stage I and stage II skin tumor promotion in SENCAR mice by a polyphenolic fraction isolated from green tea: inhibition depends on the duration of polyphenol treatment.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diterpenes; Flavonoids; Mice; Phenols; Plant Extracts; Polymers; Polyphenols; Skin Neoplasms; Tea; Terpenes; Tetradecanoylphorbol Acetate | 1993 |
Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenine; Animals; Base Sequence; Clone Cells; Decanoic Acids; Diglycerides; Genes, ras; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Papilloma; Second Messenger Systems; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymine | 1993 |
Inversion of carcinogen-promoter sequence: effects on mouse skin tumorigenesis and cellular growth kinetics.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Hyperplasia; Methylcholanthrene; Mice; Mice, Inbred Strains; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Synergistic interaction between the non-phorbol ester-type promoter mirex and 12-O-tetradecanoylphorbol-13-acetate in mouse skin tumor promotion.
Topics: Adenine; Animals; Base Sequence; Carcinogens; Dose-Response Relationship, Drug; Drug Synergism; Female; Genes, ras; Mice; Mice, Inbred Strains; Mirex; Molecular Sequence Data; Mutation; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine | 1994 |
Increased expression of stromelysin-3 in basal cell carcinomas.
Topics: Blotting, Northern; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Extracellular Matrix; Gene Expression; Humans; In Situ Hybridization; Matrix Metalloproteinase 11; Metalloendopeptidases; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
Differential modulation of contact hypersensitivity and delayed hypersensitivity reactions by topical application of 12-O-tetradecanoylphorbol-13-acetate.
Topics: Administration, Topical; Animals; Cocarcinogenesis; Dermatitis, Contact; Female; Hypersensitivity, Delayed; Immunosuppressive Agents; Immunotherapy, Adoptive; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Skin Neoplasms; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 1993 |
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abietanes; Animals; Anticarcinogenic Agents; Antioxidants; Arachidonic Acid; Benzo(a)pyrene; Dermatitis, Contact; DNA; Drug Interactions; Enzyme Induction; Epidermis; Female; Hyperplasia; Magnoliopsida; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phenanthrenes; Plant Extracts; Skin; Skin Neoplasms; Spices; Tetradecanoylphorbol Acetate; Triterpenes; Tritium; Ursolic Acid | 1994 |
Intermittent 50 Hz magnetic field and skin tumor promotion in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Hyperplasia; Magnetics; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1994 |
DNA adducts, cell proliferation and papilloma latency time in mouse skin after repeated dermal application of DMBA and TPA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Cell Division; DNA Damage; Female; Mice; Papilloma; Risk Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene.
Topics: Acetates; Acetic Acid; Animals; Benzoyl Peroxide; Butanols; Carcinogens; Dose-Response Relationship, Drug; Genes, ras; Heterozygote; Homozygote; Mice; Mice, Transgenic; Papilloma; Phenol; Phenols; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Dietary fatty acid modulation of events associated with mouse skin tumor promotion.
Topics: Animals; Capillary Permeability; Dietary Fats, Unsaturated; Fatty Acid Desaturases; Fatty Acids; Female; Linoleoyl-CoA Desaturase; Mice; Ornithine Decarboxylase; Phosphatidylcholines; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Studies on inhibitors of skin tumor promotion, XII. Rotenoids from Amorpha fruticosa.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Drug Screening Assays, Antitumor; Flow Cytometry; Hexanes; Methanol; Mice; Plant Extracts; Rotenone; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Interleukin-1 alpha gene expression and localization of interleukin-1 alpha protein during tumor promotion.
Topics: Acetone; Animals; Antibodies; Autoradiography; Blotting, Northern; Cell Division; Gene Expression; Immunohistochemistry; Inflammation; Interleukin-1; Keratinocytes; Mice; Mice, Inbred Strains; Polymerase Chain Reaction; Recombinant Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine; Tritium | 1993 |
No point mutation of Ha-ras or p53 genes expressed in preneoplastic-to-neoplastic progression as modeled in mouse JB6 cell variants.
Topics: Animals; Apoptosis; Base Sequence; Cell Line, Transformed; Cells, Cultured; Codon; Disease Models, Animal; DNA Probes; Down-Regulation; Gene Expression; Genes, p53; Genes, ras; Mice; Molecular Sequence Data; Point Mutation; Precancerous Conditions; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Suppressor Protein p53 | 1993 |
Lack of initiating capacity of the genotoxic air pollutant 2-nitrofluorene in the mouse skin two-stage carcinogenesis system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Air Pollutants; Animals; Cocarcinogenesis; Female; Fluorenes; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Transplacental carcinogenicity of cisplatin: initiation of skin tumors and induction of other preneoplastic and neoplastic lesions in SENCAR mice.
Topics: Animals; Cisplatin; Cocarcinogenesis; Female; Kidney Neoplasms; Lung Neoplasms; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Papilloma; Precancerous Conditions; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Southern; Carcinoma; DNA; Genes, p53; Genes, ras; Genotype; Heterozygote; Humans; Male; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Inhibitory effects of 3'-methyl-3-hydroxy-chalcone on proliferation of human malignant tumor cells and on skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Chalcone; Chalcones; Dose-Response Relationship, Drug; HeLa Cells; Humans; Mice; Neoplasm Proteins; Neoplasms; Papilloma; Phosphorylation; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Inhibitory effects of triptogelin A-1 on 12-O-tetradecanoylphorbol-13- acetate-induced skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Bridged Bicyclo Compounds; Female; Herpesvirus 4, Human; Mice; Mice, Inbred ICR; Sesquiterpenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Sensitivity to tumor promotion of SENCAR and C57BL/6J mice correlates with oxidative events and DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Deoxyguanosine; DNA Damage; Hydrogen Peroxide; Hyperplasia; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neutrophils; Peroxidase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine | 1993 |
Inhibitory effects of semisynthetic flavonoid derivatives on the biochemical markers of tumor promotion in mouse epidermis in vivo.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Enzyme Induction; Epidermis; Female; Flavonoids; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Peroxides; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1993 |
The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Surface; Biomarkers, Tumor; Diterpenes; Female; Immunohistochemistry; Integrin alpha6beta4; Kinetics; Mice; Mice, Inbred Strains; Papilloma; Risk Factors; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Further studies on the influence of initiation dose on papilloma growth and progression during two-stage carcinogenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benzoyl Peroxide; Carcinoma, Squamous Cell; Diterpenes; Dose-Response Relationship, Drug; Female; Mice; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Inhibition of skin tumor promotion by restriction of fat and carbohydrate calories in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinoma; Cocarcinogenesis; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Intake; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Modulation of interleukin-1 alpha mRNA expression in mouse epidermis by tumor promoters and antagonists.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Down-Regulation; Epidermis; Female; Gene Expression Regulation; Humans; Interleukin-1; Mice; Mice, Inbred Strains; Protein Kinase C; RNA, Messenger; Skin; Skin Neoplasms; Skin Physiological Phenomena; Stereoisomerism; Tetradecanoylphorbol Acetate | 1993 |
Inhibition of tumor formation from grafted murine papilloma cells by treatment of grafts with staurosporine, an inducer of squamous differentiation.
Topics: Alkaloids; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Differentiation; Disease Models, Animal; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Papilloma; Protein Kinase C; Skin Neoplasms; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Absence of synergistic effects on tumor promotion in CD-1 mouse skin by simultaneous applications of two different types of tumor promoters, okadaic acid and teleocidin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Drug Synergism; Enzyme Induction; Ethers, Cyclic; Female; Lyngbya Toxins; Mice; Okadaic Acid; Ornithine Decarboxylase; Phosphorylation; Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Differential co-promoting activities of alpha, beta and gamma interferons in the murine skin two-stage carcinogenesis model.
Topics: Animals; Capillary Permeability; Carcinogens; Enzyme Induction; Female; Interferon-alpha; Interferon-beta; Interferon-gamma; Mice; Ornithine Decarboxylase; Oxygen; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
12-O-tetradecanoylphorbol-13-acetate-mediated systemic co-promotion in the murine skin multistage carcinogenesis protocol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
A study on skin tumour formation in mice with 50 Hz magnetic field exposure.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Electromagnetic Fields; Female; Hyperplasia; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Vitamin E is a complete tumor promoter in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma; Cocarcinogenesis; Diterpenes; Female; Mice; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Vitamin E | 1993 |
Differential effects of dietary beta-carotene on papilloma and carcinoma formation induced by an initiation-promotion protocol in SENCAR mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Carcinoma; Carotenoids; Cocarcinogenesis; Dose-Response Relationship, Drug; Female; Incidence; Male; Mice; Neoplasms, Multiple Primary; Papilloma; Pregnancy; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Overexpression of cyclin D1 in mouse skin carcinogenesis.
Topics: Animals; Base Sequence; Blotting, Northern; Carcinoma, Squamous Cell; Chromosome Mapping; Cyclin D1; Cyclins; Gene Amplification; Gene Expression; Mice; Molecular Sequence Data; Oncogene Proteins; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
1 alpha,25-Dihydroxyvitamin D3 enhances 12-O-tetradecanoylphorbol-13-acetate- induced tumorigenic transformation and osteopontin expression in mouse JB6 epidermal cells.
Topics: Animals; Calcitriol; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Drug Synergism; Gene Expression; Mice; Osteopontin; Phosphorylation; RNA, Messenger; Sialoglycoproteins; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1993 |
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Mice; Papilloma; Phorbol Esters; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1993 |
Gene modulation accompanying differentiation of normal versus malignant keratinocytes.
Topics: Carcinoma, Squamous Cell; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Cornified Envelope Proline-Rich Proteins; DNA Damage; ErbB Receptors; Fibronectins; Gene Expression Regulation; Genes, fos; Genes, myc; Heat-Shock Proteins; Humans; Infant, Newborn; Interleukin-1; Keratinocytes; Kinetics; Male; Membrane Proteins; Protein Precursors; Proteins; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor CHOP; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured | 1993 |
Induction of short-term biomarkers of tumor promotion in skin of CD-1 mice by petroleum middle distillates: preliminary observations.
Topics: Alkanes; Animals; Biomarkers, Tumor; Carcinogens; Female; Humans; Mice; Petroleum; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
pim-1 proto-oncogene expression in anti-CD3-mediated T cell activation is associated with protein kinase C activation and is independent of Raf-1.
Topics: Calcium; Cell Nucleus; Cytoplasm; Enzyme Activation; Enzyme Induction; Humans; Ionomycin; Isoenzymes; Leukemia-Lymphoma, Adult T-Cell; Lymphocyte Activation; Muromonab-CD3; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Proto-Oncogene Proteins c-raf; Proto-Oncogenes; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; RNA, Messenger; Sezary Syndrome; Signal Transduction; Skin Neoplasms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice.
Topics: Administration, Topical; Animals; Blotting, Western; Carcinogens; Catechols; Enzyme Inhibitors; Epidermal Cells; ErbB Receptors; Female; Hyperplasia; Isoenzymes; Keratinocytes; Mice; Mice, Inbred SENCAR; Nitriles; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Pyridines; Skin Neoplasms; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrphostins | 1995 |
Activation of stress-activator protein kinase/c-Jun N-terminal kinase by the non-TPA-type tumor promoter palytoxin.
Topics: 3T3 Cells; Acrylamides; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cnidarian Venoms; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Skin Neoplasms; Sodium; Tetradecanoylphorbol Acetate | 1996 |
Evaluation of chemopreventive effect of dietary selenium-rich egg on mouse skin tumor induced by 2'-(4-nitrophenoxy)oxirane and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diet; Eggs; Epoxy Compounds; Glutathione Peroxidase; Male; Mice; Mice, Inbred ICR; Papilloma; Selenium; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Inhibition of the tumor promoting action of 12-O-tetradecanoylphorbol-13-acetate by tubeimoside III isolated from Bolbostemma paniculatum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carbohydrate Sequence; Cell Line; Drugs, Chinese Herbal; Male; Mice; Mice, Inbred C3H; Molecular Sequence Data; Phospholipids; Plants, Medicinal; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes; Tritium | 1995 |
Antitumour activity of protein A in a mouse skin model of two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Anticarcinogenic Agents; Carcinogens; Female; Mice; Skin Neoplasms; Staphylococcal Protein A; Staphylococcus aureus; Survival Analysis; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Localization and expression of cornifin-alpha/SPRR1 in mouse epidermis, anagen hair follicles, and skin neoplasms.
Topics: Animals; Carcinoma, Squamous Cell; Cornified Envelope Proline-Rich Proteins; Epidermis; Female; Hair Follicle; Immunohistochemistry; Membrane Proteins; Mice; Mirex; Papilloma; Proteins; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Effect of free fatty acids on two-stage skin carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Cell Division; Cocarcinogenesis; Croton Oil; Fatty Acids, Nonesterified; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Lipid Peroxidation; Male; Mice; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract.
Topics: Animals; Anticarcinogenic Agents; Betacyanins; Female; Indoles; Lung Neoplasms; Mice; Mice, Inbred ICR; Pigments, Biological; Plant Extracts; Plant Roots; Plants, Edible; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
The preventive and therapeutic potential of the squalene-containing compound, Roidex, on tumor promotion and regression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aloe; Animals; Carcinogens; Drug Combinations; Drug Screening Assays, Antitumor; Female; Mice; Mineral Oil; Neoplasms, Experimental; Plants, Medicinal; Remission Induction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A; Vitamin E | 1996 |
Thapsigargin, a weak skin tumor promoter, alters the growth and differentiation of mouse keratinocytes in culture.
Topics: Animals; Calcium; Carcinogens; Cell Differentiation; Cell Division; Cells, Cultured; Drug Synergism; Female; Hyperplasia; Keratinocytes; Mice; Phenotype; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1996 |
Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Caffeic Acids; Carcinogens; DNA; DNA Damage; Female; HeLa Cells; Humans; Mice; Oxidative Stress; Papilloma; Phenylethyl Alcohol; Protein Biosynthesis; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Dose-time response in mouse skin tumor induction by 7, 12-dimethylbenz[a]anthracene and 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; DNA Adducts; Dose-Response Relationship, Drug; Female; Mice; Papilloma; Random Allocation; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Carcinogenesis in human skin grafted to SCID mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Neoplasm; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Humans; Keratins; Ki-67 Antigen; Mice; Mice, SCID; Neoplasm Proteins; Nuclear Proteins; Papilloma; Skin Neoplasms; Skin Transplantation; Tetradecanoylphorbol Acetate; Transplantation, Heterologous; Ultraviolet Rays | 1996 |
Camptothecin post-treatments inhibit the biochemical events linked to the tumor-promoting component of carcinogenesis in mouse epidermis in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Camptothecin; DNA; DNA Adducts; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Induction; Enzyme Inhibitors; Epidermis; Female; Mice; Ornithine Decarboxylase; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors | 1996 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate promoted mouse skin papilloma by digalactosyl diacylglycerols from the fresh water cyanobacterium Phormidium tenue.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anticarcinogenic Agents; Carbohydrate Sequence; Carcinogenicity Tests; Carcinogens; Cyanobacteria; Female; Galactolipids; Glycolipids; Mice; Mice, Inbred ICR; Molecular Sequence Data; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Characterization of the antitumor-promoting activity of camptothecin in SENCAR mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Diterpenes; DNA Replication; Female; Mice; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors | 1996 |
Regression and progression characteristics of papillomas induced by chrysarobin in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benzoyl Peroxide; Carcinogens; Carcinoma, Squamous Cell; Female; Free Radicals; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
High-fat diet blocks the inhibition of skin carcinogenesis and reductions in protein kinase C by moderate energy restriction.
Topics: Animals; Body Weight; Carcinogens; Carcinoma; Cocarcinogenesis; Dietary Fats; Energy Intake; Female; Isoenzymes; Mice; Mice, Inbred SENCAR; Papilloma; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
[Skin carcinogenesis induced be neonatal administration of 5-bromo-2'-deoxyuridine and subsequent treatment with 12-O-tetradecanoylphorbol-13-acetate in mice].
Topics: Animals; Bromodeoxyuridine; Carcinogens; Female; Male; Mice; Mice, Hairless; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
A hemidesmosomal transmembrane collagenous molecule, the 180-kDa bullous pemphigoid antigen (BPA II), is phosphorylated with 12-O-tetradecanoylphorbol-13-acetate in a human squamous cell carcinoma cell line (DJM-1).
Topics: Amino Acids; Animals; Antibodies, Monoclonal; Autoantigens; Autoradiography; Blotting, Western; Carcinoma, Squamous Cell; Carrier Proteins; Cattle; Cell Adhesion; Collagen; Collagen Type XVII; Cornea; Cytoskeletal Proteins; Desmosomes; Dystonin; Epithelial Cells; Epithelium; Humans; Nerve Tissue Proteins; Non-Fibrillar Collagens; Pemphigoid, Bullous; Phosphorus Radioisotopes; Phosphorylation; Precipitin Tests; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
[Inhibition of ornithine decarboxylase activity and epidermal papilloma in mice by beta-carotene].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Female; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1995 |
Inhibition of pro-inflammatory cytokine gene expression and papilloma growth during murine multistage carcinogenesis by pentoxifylline.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Female; Gene Expression Regulation, Neoplastic; Inflammation Mediators; Interleukin-1; Mice; Papilloma; Pentoxifylline; Polymerase Chain Reaction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1996 |
Dietary retinoic acid inhibits mouse skin carcinogenesis irrespective of age at initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Antineoplastic Agents; Carcinogens; Diet; Diterpenes; Female; Mice; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Tretinoin | 1996 |
Behavior of the basement membrane during carcinoma cell invasion in chemically induced carcinomas of the skin.
Topics: Animals; Basement Membrane; Benzo(a)pyrene; Collagen; Collagenases; Female; Immunohistochemistry; Integrin alpha6beta1; Integrins; Laminin; Matrix Metalloproteinase 9; Mice; Neoplasm Invasiveness; Receptors, Laminin; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Porphyrin-mediated photosensitization has a weak tumor promoting activity in mouse skin: possible role of in situ-generated reactive oxygen species.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dihematoporphyrin Ether; Drug Synergism; Mice; Papilloma; Photosensitizing Agents; Reactive Oxygen Species; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Gene expression and cellular sources of inducible nitric oxide synthase during tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinogens; DNA Primers; Enzyme Induction; Female; Keratinocytes; Mice; Mice, Inbred Strains; Models, Biological; Nitric Oxide Synthase; Polymerase Chain Reaction; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1996 |
Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion.
Topics: Animals; Body Weight; Dietary Fats, Unsaturated; Female; Linoleic Acid; Linoleic Acids; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Protection against malignant conversion in SENCAR mouse skin by all trans retinoic acid: inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization.
Topics: Alkyl and Aryl Transferases; Animals; Carcinoma; Cell Compartmentation; Cell Membrane; Cell Transformation, Neoplastic; Cytosol; Diterpenes; Enzyme Inhibitors; Mice; Papilloma; Proto-Oncogene Proteins p21(ras); Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Transferases; Tretinoin | 1996 |
Antitumour-promoting and antitumour activities of the crude extract from the leaves of Juniperus chinensis.
Topics: Administration, Topical; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Carcinoma; Cell Division; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Female; HeLa Cells; Humans; Juniperus; Malaysia; Mice; Plant Extracts; Plant Leaves; Skin Neoplasms; Specific Pathogen-Free Organisms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression.
Topics: Animals; Cell Cycle; Cell Division; Female; Gene Expression Regulation; Genes, ras; Keratinocytes; Mice; Mice, Inbred BALB C; Precancerous Conditions; Protein Kinase C; Receptors, Retinoic Acid; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcriptional Activation | 1996 |
Influence of vehicle, distant topical delivery, and biotransformation on the chemopreventive activity of apigenin, a plant flavonoid, in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Administration, Topical; Animals; Anticarcinogenic Agents; Biotransformation; Carcinogens; Chamomile; Dimethyl Sulfoxide; Drug Interactions; Enzyme Induction; Female; Flavonoids; Mice; Mice, Inbred SENCAR; Oils, Volatile; Ornithine Decarboxylase; Pharmaceutical Vehicles; Plants, Medicinal; Propylene Glycol; Propylene Glycols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Mechanism of skin tumorigenesis by contact sensitizers: the effect of the corticosteroid fluocinolone acetonide on inflammation and tumor induction by 2,4 dinitro-1-fluorobenzene in the skin of the TG.AC (v-Ha-ras) mouse.
Topics: Animals; Dermatitis, Contact; Dinitrofluorobenzene; Dose-Response Relationship, Drug; Female; Fluocinolone Acetonide; Genes, ras; Glucocorticoids; Mice; Mice, Transgenic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Genetics of chemical carcinogenesis--III. Tissue-specificity of the genes controlling susceptibility and resistance to skin carcinogenesis in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Disease Susceptibility; Female; Immunity, Innate; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Organ Specificity; Sensitivity and Specificity; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1996 |
Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Transformation, Neoplastic; Disease Progression; Endothelial Growth Factors; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, ras; Interleukin 1 Receptor Antagonist Protein; Keratinocytes; Lymphokines; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred SENCAR; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; Oncogene Protein p21(ras); Papilloma; Precancerous Conditions; Proto-Oncogene Proteins p21(ras); RNA, Messenger; RNA, Neoplasm; Sialoglycoproteins; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1996 |
Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chlorophyll; Drug Screening Assays, Antitumor; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Quantitation of early clonal expansion of two mutant 61st codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Codon; Female; Genes, ras; Mice; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1996 |
Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Carcinogens; Curcumin; DNA; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Mice; Neoplasms, Experimental; Oxidation-Reduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis.
Topics: Animals; Antigens, Viral; Carcinogens; Cells, Cultured; Female; Mice; Mice, Inbred ICR; Naphthoquinones; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Susceptibility of 129/SvEv mice in two-stage carcinogenesis protocols to 12-O-tetradecanoylphorbol-13-acetate promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Dermatitis, Contact; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Synergism; Epidermis; Hyperplasia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Neutrophils; Papilloma; Peroxidase; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1997 |
The effect of 60-Hz magnetic fields on co-promotion of chemically induced skin tumors on SENCAR mice: a discussion of three studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Electromagnetic Fields; Mice; Mice, Inbred SENCAR; Neoplasms, Radiation-Induced; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Effect of spray-dried yogurt and lactic acid bacteria on the initiation and promotion stages of chemically induced skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bifidobacterium; Body Weight; Carcinogens; Carcinoma; Eating; Energy Intake; Female; Lactobacillus acidophilus; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Yogurt | 1997 |
Effects of capsaicin on chemically-induced two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Capsaicin; Carcinogens; Cocarcinogenesis; Female; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromodeoxyuridine; Carcinogens; DNA; Female; Glutathione Peroxidase; Humans; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Papilloma; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1997 |
Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cell Cycle; Cyclin D1; Cyclin D2; Cyclin D3; Cyclin-Dependent Kinases; Cyclins; G1 Phase; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Mice; Oncogene Proteins; Papilloma; S Phase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Altered glucocorticoid receptor expression and function during mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Fluocinolone Acetonide; Hyperplasia; Keratinocytes; Mice; Mice, Inbred Strains; Papilloma; Receptors, Glucocorticoid; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors | 1997 |
Nitric oxide synthase and skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Deoxyadenosines; Epidermis; Female; Mice; Nitric Oxide Synthase; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1997 |
Analysis of the ability of 12-O-tetradecanoylphorbol-13-acetate to induce epidermal hyperplasia, transforming growth factor-alpha, and skin tumor promotion in wa-1 mice.
Topics: Amphiregulin; Animals; Antineoplastic Agents; Carcinogens; EGF Family of Proteins; Epidermal Growth Factor; Female; Glycoproteins; Growth Substances; Heparin; Heparin-binding EGF-like Growth Factor; Hyperplasia; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred SENCAR; Mice, Mutant Strains; Neutrophils; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1997 |
Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice.
Topics: Animals; Carcinogens; Epidermis; Fluorescent Antibody Technique, Indirect; Humans; Hyperplasia; Insulin-Like Growth Factor I; Keratins; Mice; Mice, Transgenic; Neoplasms, Experimental; Skin Abnormalities; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Female; Fluocinolone Acetonide; Luciferases; Male; Mice; Mice, Transgenic; Papilloma; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Retinoids; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Tretinoin | 1997 |
Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Animals, Newborn; Benzo(a)pyrene; Hair Follicle; Immunohistochemistry; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ornithine Decarboxylase; Putrescine; Skin; Skin Neoplasms; Spermidine; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Grafting assay distinguishes promotion sensitive from promotion resistant JB6 cells.
Topics: Animals; Carcinogens; Cell Line, Transformed; Cell Transformation, Neoplastic; Disease Models, Animal; Fibroblasts; Male; Mice; Mice, Inbred BALB C; Mice, Inbred SENCAR; Mice, Nude; Mutation; Neoplasm Transplantation; Phenotype; Sensitivity and Specificity; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 1997 |
Chemical carcinogens and antigens contribute to cutaneous tumor promotion by depleting epidermal Langerhans cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens; Carcinogens; Carcinoma, Squamous Cell; Female; Langerhans Cells; Mice; Mice, Inbred BALB C; Papilloma; Picryl Chloride; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Inhibitory effect of dietary curcumin on skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Curcumin; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Female; Hyperplasia; Liver Neoplasms; Mice; Mice, Inbred ICR; Oleanolic Acid; Papilloma; Phenobarbital; Plants, Medicinal; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cell Line; Citrus; Coumarins; Female; Flow Cytometry; Fluorescent Dyes; Humans; Leukemia, Promyelocytic, Acute; Leukocytes; Mice; Mice, Inbred ICR; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Umbelliferones | 1997 |
Inhibitory effects of shouseiryu-to on two-stage carcinogenesis. II. Anti-tumor-promoting activities of lignans from Asiasarum heterotropoides var. mandshuricum.
Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Cell Line; Cell Transformation, Neoplastic; Dioxoles; Female; Furans; Lignans; Lung Neoplasms; Mice; Mice, Inbred ICR; Phenols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea.
Topics: Animals; Antineoplastic Agents, Alkylating; DNA Mutational Analysis; Genes, ras; Humans; Methyltransferases; Mice; Mice, Transgenic; Neoplasms, Experimental; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Papilloma; Point Mutation; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antimetabolites, Antineoplastic; Carcinogens; Cell Division; Epidermis; Female; Fluorouracil; Hair Follicle; Mice; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Coumarins; DNA Adducts; Dose-Response Relationship, Drug; Epidermis; Furocoumarins; Mice; Mice, Inbred SENCAR; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Umbelliferones | 1997 |
Atypical association of H1 and H2 histamine receptors with signal transduction pathways during multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Count; Cimetidine; Cyclic AMP; Female; Histamine H1 Antagonists; Histamine H2 Antagonists; Hydrolysis; Mast Cells; Mice; Phosphatidylinositols; Pyrilamine; Receptors, Histamine H1; Receptors, Histamine H2; Second Messenger Systems; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Differential activation of keratinocyte phospholipase A2S by tumor promoters and other irritants.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cytosol; Eicosanoids; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Fatty Acids; Isoenzymes; Keratinocytes; Membrane Lipids; Mice; Naphthalenes; Oligonucleotides, Antisense; Papilloma; Phosphatidylcholines; Phospholipases A; Phospholipids; Pyrones; Recombinant Fusion Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1997 |
Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Blotting, Southern; Carcinogens; Cocarcinogenesis; DNA, Viral; Hybridization, Genetic; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mutation; Papillomaviridae; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Transplantation analyses of the immunogenicity of epidermal tumors generated in murine skin two-stage carcinogenesis protocols.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cocarcinogenesis; Female; Graft Rejection; Mice; Mice, Inbred SENCAR; Mice, Nude; Neoplasm Transplantation; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Decreases in phorbol ester-induced papilloma development in v-Ha-ras transgenic TG.AC mice during reduced gene dosage of bcl-2.
Topics: Animals; Carcinogens; Cocarcinogenesis; Female; Gene Expression; Gene Transfer Techniques; Genes, bcl-2; Genes, ras; Genotype; Male; Mice; Mice, Transgenic; Papilloma; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromodeoxyuridine; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cells, Cultured; Cocarcinogenesis; Female; Genes, ras; Genotype; Immunohistochemistry; Keratinocytes; Mice; Mice, Inbred BALB C; Mirex; Mutation; Nitrosourea Compounds; Papilloma; S Phase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Changes in protein expression during multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Surface; Carcinogens; Connexin 26; Connexins; Cyclin D1; Cyclins; Epidermal Growth Factor; Female; gamma-Glutamyltransferase; Heparin-binding EGF-like Growth Factor; Integrin alpha6beta4; Integrins; Intercellular Signaling Peptides and Proteins; Keratins; Mice; Mice, Inbred SENCAR; Neoplasm Proteins; Oncogene Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1997 |
Evidence that initiated keratinocytes clonally expand into multiple existing hair follicles during papilloma histogenesis in SENCAR mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Clone Cells; Female; Hair Diseases; Hair Follicle; Keratinocytes; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Association of a murine chromosome 9 locus (Psl1) with susceptibility to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Carcinogens; Chromosomes; Cocarcinogenesis; Disease Susceptibility; Female; Genetic Linkage; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Telomerase and cell proliferation in mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Mice; Mice, Inbred Strains; Mitotic Index; Papilloma; Polymerase Chain Reaction; Skin Neoplasms; Telomerase; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Mathematical modeling of skin papilloma data in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Cycle; Mice; Mice, Inbred SENCAR; Models, Biological; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Differential effects of butyric acid on mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Butyrates; Butyric Acid; Carcinogens; Female; Histamine Antagonists; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Inhibitory effect of soybean hypocotyls on Epstein-Barr virus early antigen induction and skin tumor promotion.
Topics: Animals; Antigens, Viral; Burkitt Lymphoma; Enzyme Inhibitors; Female; Glycine max; Hypocotyl; Isoflavones; Mice; Mice, Inbred ICR; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Evaluation of carcinogenic/co-carcinogenic activity of a common chewing product, pan masala, in mouse skin, stomach and esophagus.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Areca; Cocarcinogenesis; Esophageal Neoplasms; Female; Male; Mice; Mice, Hairless; Mice, Inbred ICR; Plants, Medicinal; Powders; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Analysis of two inbred strains of mice derived from the SENCAR stock with different susceptibility to skin tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Surface; Biomarkers, Tumor; Carcinogens; Cyclin D1; Disease Susceptibility; Female; Immunohistochemistry; Integrin alpha6beta4; Integrins; Mice; Mice, Inbred Strains; Papilloma; Proliferating Cell Nuclear Antigen; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transforming Growth Factor beta | 1998 |
Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Division; DNA Fragmentation; Gene Expression Regulation, Developmental; Genes, bcl-2; Humans; Keratinocytes; Keratins; Mice; Mice, Transgenic; Promoter Regions, Genetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1998 |
Phorbol 12-myristate 13-acetate can transform monocyte-derived dendritic cells to different cell types similar to those found in dermatofibroma. A possible in vitro model of the histogenesis of dermatofibroma.
Topics: Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cytokines; Dendritic Cells; Flow Cytometry; Histiocytoma, Benign Fibrous; Humans; Immunohistochemistry; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Beta2 integrin/ICAM-1 adhesion molecule interactions in cutaneous inflammation and tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; CD18 Antigens; Cell Division; Dermatitis; Disease Models, Animal; Female; Immunohistochemistry; Intercellular Adhesion Molecule-1; Leukocytes; Mice; Peroxidase; Protein Binding; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cells, Cultured; Cytokines; Ephrin-B2; Gene Expression Regulation, Neoplastic; Humans; Infant, Newborn; Melanocytes; Melanoma; Membrane Proteins; Mice; Mice, Nude; Neoplasm Metastasis; Nevus, Pigmented; Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transplantation, Heterologous; Tumor Cells, Cultured; Ultraviolet Rays | 1998 |
Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion.
Topics: Administration, Topical; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Biomarkers, Tumor; Carcinogens; Carcinoma, Basal Cell; Cell Transformation, Neoplastic; Disease Progression; Diterpenes; Female; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Inbred SENCAR; Papilloma; Phenotype; Precancerous Conditions; Receptors, Retinoic Acid; Retinoid X Receptors; Risk Factors; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factors; Transforming Growth Factor beta; Tretinoin | 1998 |
Different expression of prostaglandin-H synthase isozymes and lipoxygenases during multistage carcinogenesis in mouse skin.
Topics: Animals; Arachidonate Lipoxygenases; Carcinoma; Cyclooxygenase 1; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hydroxyeicosatetraenoic Acids; Isoenzymes; Linoleic Acids; Linoleic Acids, Conjugated; Membrane Proteins; Mice; Papilloma; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
Dietary fat and energy modulation of biochemical events in tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cytosol; Dietary Carbohydrates; Dietary Fats; Diglycerides; Energy Metabolism; Isoenzymes; Mice; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Edema; Female; Hydrogen Peroxide; Hydroxybenzoates; Hyperplasia; Malvaceae; Mice; Ornithine Decarboxylase; Peroxidase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Dietary lipid varying in corn and coconut oil influences protein kinase C in phorbol ester-treated mouse skin.
Topics: Animals; Biological Transport; Cell Membrane; Coconut Oil; Corn Oil; Dietary Fats; Female; Isoenzymes; Mice; Phorbol 12,13-Dibutyrate; Plant Oils; Protein Kinase C; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromodeoxyuridine; Carcinogens; Centrosome; Disease Susceptibility; Epidermis; Female; Gene Amplification; Humans; Keratins; Male; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Papilloma; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras); ras Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes; Tumor Suppressor Protein p53 | 1998 |
Detection of dibenzo[a,l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR-RFLP method.
Topics: Animals; Base Sequence; Benzopyrenes; Carcinogens; Codon; DNA Primers; Female; Genes, ras; Mice; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development.
Topics: Animals; Capillary Permeability; Endothelial Growth Factors; Genes, ras; Hyperplasia; Keratins; Lymphokines; Mice; Mice, Transgenic; Neovascularization, Pathologic; Neovascularization, Physiologic; Papilloma; Precancerous Conditions; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Regulatory Sequences, Nucleic Acid; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not -resistant cells.
Topics: Alternative Splicing; Animals; Carcinogens; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genetic Variation; High Mobility Group Proteins; HMGA1a Protein; Mice; Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1998 |
Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice.
Topics: Animals; Diet, Reducing; Energy Intake; Gene Dosage; Genes, p53; Infections; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Sepsis; Skin Neoplasms; Skin Ulcer; Tetradecanoylphorbol Acetate | 1998 |
Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capillary Permeability; Catechols; Curcumin; Epidermis; Fatty Alcohols; Female; Inflammation; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Potent suppressive activity of pheophytin a and b from the non-polyphenolic fraction of green tea (Camellia sinensis) against tumor promotion in mouse skin.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Dose-Response Relationship, Drug; Edema; Female; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Ornithine Decarboxylase; Pheophytins; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1998 |
Chronic and initiation/promotion skin bioassays of petroleum refinery streams.
Topics: Alkanes; Animals; Biological Assay; Carcinogenicity Tests; Carcinogens; Extraction and Processing Industry; Male; Mice; Mice, Inbred C3H; Mineral Oil; Petroleum; Random Allocation; Skin Neoplasms; Skin Tests; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Anti-tumor-promoting activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. (I).
Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Carboxylic Acids; Fumonisins; Ginsenosides; Male; Mice; Mice, Inbred ICR; Papilloma; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Suppression of mouse skin tumor promotion and induction of apoptosis in HL-60 cells by Alpinia oxyphylla Miquel (Zingiberaceae).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogens; DNA Fragmentation; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; HL-60 Cells; Humans; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Phytotherapy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Zingiberales | 1998 |
Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Eflornithine; Genes, ras; Keratoacanthoma; Mice; Mice, Transgenic; Ornithine Decarboxylase; Papilloma; Proliferating Cell Nuclear Antigen; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; DNA Adducts; Down-Regulation; Drug Screening Assays, Antitumor; Female; Genistein; Hydrogen Peroxide; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Peroxidase; Protein-Tyrosine Kinases; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Potent suppressive activity of chlorophyll a and b from green tea (Camellia sinensis) against tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chlorophyll; Chlorophyll A; Edema; Mice; Mice, Inbred BALB C; Pigments, Biological; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1998 |
Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Epidermis; Female; Immunohistochemistry; Isoenzymes; Mice; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Squamous cell hyperplastic foci: precursors of cutaneous papillomas induced in SENCAR mice by a two-stage carcinogenesis regimen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Epidermis; Female; Hyperplasia; Mice; Mice, Inbred SENCAR; Neoplasm Regression, Spontaneous; Neoplasm Staging; Papilloma; Precancerous Conditions; Sebaceous Glands; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Lack of a co-promoting effect of a 60 Hz magnetic field on skin tumorigenesis in SENCAR mice.
Topics: Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Electromagnetic Fields; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Influence of diet restriction and tumor promoter dose on cell proliferation, oxidative DNA damage and rate of papilloma appearance in the mouse skin after initiation with DMBA and promotion with TPA.
Topics: 8-Hydroxy-2'-Deoxyguanosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinogens; Cell Division; Deoxyguanosine; Diet; DNA; DNA Damage; Immunohistochemistry; Male; Mice; Oxidative Stress; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Anti-tumor-promoting activity of diterpenes from Excoecaria agallocha.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogens; Diterpenes; Euphorbiaceae; Female; Humans; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Virus Activation | 1998 |
Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antineoplastic Agents; Carcinogens; Drug Antagonism; Female; Hesperidin; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Effect of the viable-yellow (A(vy)) agouti allele on skin tumorigenesis and humoral hypercalcemia in v-Ha-ras transgenic TGxAC mice.
Topics: Agouti Signaling Protein; Alleles; Animals; Base Sequence; Body Weight; DNA Primers; Genes, ras; Hypercalcemia; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papilloma; Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Cocarcinogenesis; Dermatitis, Contact; Female; Hypolipidemic Agents; Mice; Mice, Inbred ICR; Oryza; Phenylpropionates; Phytosterols; Plant Extracts; Skin; Skin Neoplasms; Sterols; Tetradecanoylphorbol Acetate; Triterpenes | 1998 |
Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Centrosome; Disease Progression; Endothelial Growth Factors; Genes, p53; Humans; Lymphokines; Mice; Mice, Knockout; Neovascularization, Pathologic; Papilloma; Phenotype; Point Mutation; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thrombospondin 1; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors.
Topics: Animals; Antibodies; Arsenic; Cell Division; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Papilloma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tissue Distribution; Transforming Growth Factor alpha | 1998 |
Alterations in cholesterol sulfate and its biosynthetic enzyme during multistage carcinogenesis in mouse skin.
Topics: Administration, Topical; Animals; Anthracenes; Anticarcinogenic Agents; Carcinogens; Cell Differentiation; Cell Division; Cholesterol Esters; Dehydroepiandrosterone Sulfate; Epidermis; Female; Keratinocytes; Mice; Mice, Inbred SENCAR; Mice, Transgenic; Okadaic Acid; Skin Neoplasms; Sulfotransferases; Tetradecanoylphorbol Acetate; Transglutaminases; Wound Healing | 1998 |
Carcinogenicity and co-carcinogenicity studies on propoxur in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Carcinogens; Drug Interactions; Female; Insecticides; Male; Mice; Propoxur; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Dysregulated synthesis of intracellular type 1 and type 2 cytokines by T cells of patients with cutaneous T-cell lymphoma.
Topics: Case-Control Studies; Cytokines; Humans; In Vitro Techniques; Interferon-gamma; Interleukin-2; Interleukin-4; Lymphocyte Activation; Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides; Prognosis; Sezary Syndrome; Skin Neoplasms; T-Lymphocyte Subsets; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1999 |
Polyphenols inhibit promotional phase of tumorigenesis: relevance of superoxide radicals.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Caffeic Acids; Carcinogens; Coumaric Acids; Diglycerides; Diterpenes; Ellagic Acid; Flavonoids; Glycerol; Hydrolyzable Tannins; Macrophages; Male; Mice; Phenols; Polymers; Polyphenols; Skin Neoplasms; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1998 |
UVB-specific regulation of gene expression in human melanocytic cells: cell cycle effects and implication in the generation of melanoma.
Topics: Antineoplastic Agents; beta-Galactosidase; Cell Cycle; Cisplatin; Demecolcine; Genes, fos; Genes, p53; HeLa Cells; HIV Long Terminal Repeat; Humans; Hydroxyurea; Inosine; Melanocytes; Melanoma; Methylnitronitrosoguanidine; Neoplasms, Radiation-Induced; Nitrosourea Compounds; Organophosphorus Compounds; Proto-Oncogene Proteins c-fos; Recombinant Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Ultraviolet Rays | 1998 |
12-O-tetradecanoylphorbol-13-acetate induces clonal expansion of potentially malignant keratinocytes in a tissue model of early neoplastic progression.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Division; Cells, Cultured; Filaggrin Proteins; Humans; Keratinocytes; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Protein-kinase-Cmu expression correlates with enhanced keratinocyte proliferation in normal and neoplastic mouse epidermis and in cell culture.
Topics: Animals; Animals, Newborn; Carcinoma; Cells, Cultured; Enzyme Activation; Epidermal Cells; Epidermis; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Keratinocytes; Mice; Mice, Inbred Strains; Proliferating Cell Nuclear Antigen; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Cell Division; DNA; Edema; Female; Hyperplasia; Lipid Peroxidation; Mice; Mice, Inbred SENCAR; Silymarin; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
The transgenic Tg.AC mouse model for identification of chemical carcinogens.
Topics: Animals; Carcinogens; Female; Genes, ras; Male; Mice; Mice, Transgenic; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Biomarkers; Carcinogens; DNA; Epidermis; Gene Expression; Mice; Mice, Knockout; Mice, Transgenic; Nuclear Proteins; Phenotype; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rabbits; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1999 |
Increased resistance of GPx-1 transgenic mice to tumor promoter-induced loss of glutathione peroxidase activity in skin.
Topics: Animals; Carcinogens; Enzyme Induction; Female; Glutathione Peroxidase; Humans; Immunity, Innate; Metallothionein; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Promoter Regions, Genetic; Reactive Oxygen Species; Recombinant Fusion Proteins; RNA, Messenger; Selenium; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Augmentation of 12-O-tetradecanoyl 13-phorbol acetate-mediated tumor promoting response by the porphyrin photosensitization of 7,12-dimethyl benz[a]anthracene-initiated murine skin: role of in situ generated reactive oxygen species.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Mice; Papilloma; Photosensitivity Disorders; Photosensitizing Agents; Porphyrins; Reactive Oxygen Species; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthocyanins; Carcinogens; Drug Screening Assays, Antitumor; Eflornithine; Enzyme Inhibitors; Female; Flavonoids; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Peroxidase; Phenols; Polymers; Proanthocyanidins; Rosales; Seeds; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Lack of effect of a 60 Hz magnetic field on biomarkers of tumor promotion in the skin of SENCAR mice.
Topics: Animals; Biomarkers; Biomarkers, Tumor; Carcinogens; Cocarcinogenesis; Electromagnetic Fields; Enzyme Activation; Enzyme Induction; Epidermis; Mice; Mice, Inbred SENCAR; Neoplasms, Radiation-Induced; Ornithine Decarboxylase; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Differentiation; Biomarkers; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Disease Progression; Epidermis; Gene Deletion; Genes, p53; Genotype; Hyperplasia; Mice; Mice, Knockout; Mitotic Index; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53 | 1999 |
Altered expression of interleukin-1 receptor antagonist in different stages of mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Blotting, Northern; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Polarity; Cytoplasm; Disease Progression; Epidermis; Gene Expression Regulation, Neoplastic; Hyperplasia; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Keratinocytes; Mice; Mice, Inbred SENCAR; Neoplasm Proteins; Papilloma; Precancerous Conditions; RNA, Messenger; RNA, Neoplasm; Sialoglycoproteins; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1999 |
Low antibody responsiveness is found to be associated with resistance to chemical skin tumorigenesis in several lines of Biozzi mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibody Formation; Carcinogenicity Tests; Carcinogens; Disease Susceptibility; Mice; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1999 |
Chemopreventive effect of 4'-demethyl epipodophyllotoxin on DMBA/TPA-induced mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Catalase; Glutathione; Liver; Male; Malondialdehyde; Mice; Podophyllotoxin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1999 |
Enhancement of susceptibility to diverse skin tumor promoters by activation of the insulin-like growth factor-1 receptor in the epidermis of transgenic mice.
Topics: Animals; Anthracenes; Benzoyl Peroxide; Carcinogens; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Mice; Mice, Transgenic; Okadaic Acid; Receptor, IGF Type 1; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 1999 |
Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Capillary Permeability; Dietary Fats; Dinoprostone; DNA Primers; Dose-Response Relationship, Drug; Epidermis; Female; Genes, myc; Hyperplasia; Linoleic Acid; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Antitumour promoting activity of indole-3-carbinol in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Female; Indoles; Male; Mice; Skin; Skin Neoplasms; Survival Analysis; Tetradecanoylphorbol Acetate | 1998 |
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crosses, Genetic; Female; Immunity, Innate; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Neoplasm Invasiveness; Neoplasm Staging; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Potent suppressive effect of a Japanese edible seaweed, Enteromorpha prolifera (Sujiao-nori) on initiation and promotion phases of chemically induced mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carcinogenicity Tests; Carcinogens; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred ICR; Pheophytins; Plant Extracts; Seaweed; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carcinogenicity Tests; Dose-Response Relationship, Drug; Epidermis; Female; Herpesvirus 4, Human; HL-60 Cells; Humans; Hydrogen Peroxide; Intracellular Fluid; Mice; Mice, Inbred ICR; Oxidative Stress; Pyrans; Skin Neoplasms; Spiro Compounds; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 1999 |
Anti-carcinogenic activity of Taraxacum plant. I.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carboxylic Acids; Female; Fumonisins; Humans; Mice; Mice, Inbred ICR; Papilloma; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Anti-tumor-promoting effects of phenylpropanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Topics: Animals; Antineoplastic Agents; Carcinogens; Epstein-Barr Virus Nuclear Antigens; Herpesvirus 4, Human; Mice; Phenylpropionates; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Carcinogens; Female; Glycerol; Herpesvirus 4, Human; Lung Neoplasms; Mice; Mice, Inbred ICR; Papilloma; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Cyclin D1 overexpression in mouse epidermis increases cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development.
Topics: Animals; Blotting, Western; Carcinogens; Cell Division; Cyclin D1; Cyclin-Dependent Kinases; Genes, ras; Immunohistochemistry; Mice; Mice, Transgenic; Precipitin Tests; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.
Topics: Animals; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Transgenic; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 1999 |
E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model.
Topics: Animals; Apoptosis; Carrier Proteins; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Female; Genes, Tumor Suppressor; Humans; Male; Mice; Mice, Inbred SENCAR; Mice, Transgenic; Neoplasms, Experimental; Oncogenes; Retinoblastoma-Binding Protein 1; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor DP1; Transcription Factors | 1999 |
Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents; Drug Screening Assays, Antitumor; Flavonoids; Herpesvirus 4, Human; Humans; Mice; Mice, Inbred ICR; Papilloma; Phenols; Plant Extracts; Plants, Medicinal; Polymers; Polyphenols; Rosales; Skin Neoplasms; Specific Pathogen-Free Organisms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 1999 |
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Carcinogens; Carcinoma; Cell Cycle Proteins; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Genes, ras; Genes, Tumor Suppressor; Intestinal Neoplasms; Keratinocytes; Mice; Mice, Knockout; Microtubule-Associated Proteins; Mutation; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 1999 |
Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene.
Topics: Administration, Cutaneous; Amino Acid Substitution; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma in Situ; Cocarcinogenesis; Codon; DNA; DNA Mutational Analysis; DNA, Neoplasm; Dose-Response Relationship, Drug; Epidermis; Exons; Female; Genes, ras; Hyperplasia; Keratoacanthoma; Mice; Papilloma; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins p21(ras); Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Administration, Cutaneous; Animals; Anticarcinogenic Agents; Antioxidants; Ascorbic Acid; Biflavonoids; Catechin; Cocarcinogenesis; Epidermis; Female; Flavonoids; Lipid Peroxidation; Mice; Mice, Inbred SENCAR; Microsomes; Molecular Structure; Phenols; Plant Extracts; Polymers; Proanthocyanidins; Rosales; Seeds; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin E | 1999 |
Induction of melanoma in TPras transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Albinism; Animals; Carcinoma; Gene Expression Regulation; Genes, ras; Genetic Predisposition to Disease; Hair Color; Hyperplasia; Melanocytes; Melanoma; Mice; Mice, SCID; Mice, Transgenic; Monophenol Monooxygenase; Neoplasm Metastasis; Neoplasms, Radiation-Induced; Papilloma; Promoter Regions, Genetic; Skin Neoplasms; Skin Pigmentation; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1999 |
Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcimycin; Calcium; Carcinogens; Cocarcinogenesis; Diglycerides; Diterpenes; Enzyme Activation; Enzyme Induction; Epidermis; Female; Fluocinolone Acetonide; Gene Expression Regulation; Glutaredoxins; Glutathione; Ionophores; Mice; Oxidation-Reduction; Oxidoreductases; Phorbol Esters; Protein Kinase C; Proteins; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Thioredoxin-Disulfide Reductase; Thioredoxins; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin | 1999 |
A multihit, multistage model of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA Mutational Analysis; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Keratinocytes; Keratins; Mice; Models, Biological; Neoplasm Proteins; Papilloma; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; S Phase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cell Line, Transformed; Female; Genes, ras; Interleukin-1; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Okadaic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Necrosis Factor-alpha | 1999 |
Skin tumorigenesis by initiators and promoters of different chemical structures in lines of mice selectively bred for resistance (Car-r) or susceptibility (Car-s) to two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benzoyl Peroxide; Carcinoma; Methylnitrosourea; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Protection against 12-O-tetradecanoylphorbol-13-acetate induced skin-hyperplasia and tumor promotion, in a two-stage carcinogenesis mouse model, by the 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-[2,3-b]quinoxaline analogue of ellipticine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzoyl Peroxide; Carcinogens; Dermatitis, Contact; Female; Hyperplasia; Indoles; Mice; Mice, Inbred SENCAR; Precancerous Conditions; Quinoxalines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Inhibitory effects of chlorophyllin on 7,12-dimethylbenz[a]anthracene-induced bacterial mutagenesis and mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Chemoprevention; Chlorophyllides; Female; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis.
Topics: Animals; Apoptosis; DNA-Activated Protein Kinase; DNA-Binding Proteins; Epidermis; Homeodomain Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, SCID; Protein Serine-Threonine Kinases; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Sandalwood oil prevent skin tumour development in CD1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Carcinogens; Chemoprevention; Chi-Square Distribution; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Plant Oils; Reference Values; Sesquiterpenes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, ras; Humans; Mice; Mice, Transgenic; Oncogene Proteins v-fos; Papilloma; Proto-Oncogene Proteins p21(ras); Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1999 |
Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implica
Topics: Animals; Antioxidants; Cyclooxygenase 1; Cyclooxygenase 2; Female; Gene Expression Regulation; Humans; Interleukin-1; Isoenzymes; Lipid Peroxidation; Membrane Proteins; Mice; Mice, Inbred SENCAR; Microsomes; Neutrophils; Peroxidase; Prostaglandin-Endoperoxide Synthases; Silymarin; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1999 |
Detection of human soluble Thy-1 in serum by ELISA. Fibroblasts and activated endothelial cells are a possible source of soluble Thy-1 in serum.
Topics: Arthritis, Rheumatoid; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Male; Melanoma; Platelet Endothelial Cell Adhesion Molecule-1; Recombinant Proteins; Skin; Skin Neoplasms; Synovial Membrane; Tetradecanoylphorbol Acetate; Thy-1 Antigens; Tumor Necrosis Factor-alpha; Varicose Ulcer | 1999 |
Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by baicalein.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Drug Screening Assays, Antitumor; Female; Flavanones; Flavonoids; Mice; Peroxidase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Humans; Isoenzymes; Keratin-14; Keratins; Keratosis; Male; Mice; Mice, Transgenic; Neoplasm Proteins; Papilloma; Protein Kinase C; Protein Kinase C-delta; Sex Factors; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1999 |
Increased expression of p50-NF-kappaB and constitutive activation of NF-kappaB transcription factors during mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; B-Cell Lymphoma 3 Protein; Carcinogens; Epidermis; Female; Gene Expression Regulation, Neoplastic; I-kappa B Proteins; Mice; Mice, Inbred SENCAR; NF-kappa B; NF-kappa B p50 Subunit; Proto-Oncogene Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transcription Factors | 1999 |
A farnesyl transferase inhibitor suppresses TPA-mediated skin tumor development without altering hyperplasia in the ras transgenic Tg.AC mouse.
Topics: Alkyl and Aryl Transferases; Animals; Benzazepines; Crosses, Genetic; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Globins; Homozygote; Hyperplasia; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Papilloma; Promoter Regions, Genetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2000 |
Induction of skin papillomas, carcinomas, and sarcomas in mice in which the connexin 43 gene is heterologously deleted.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Connexin 43; Fibrosarcoma; Gene Deletion; Genes, ras; Mice; Mice, Inbred C57BL; Papilloma; Point Mutation; Sarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Female; Focal Nodular Hyperplasia; Ginsenosides; Liver Neoplasms, Experimental; Mice; Mice, Inbred ICR; Mice, Inbred SENCAR; Nitrates; Nitro Compounds; Panax; Papilloma; Phenobarbital; Plants, Medicinal; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vietnam | 1999 |
Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mice; Mice, Transgenic; Mutation; Oncogene Proteins, Viral; Papilloma; Papillomavirus E7 Proteins; Repressor Proteins; Severity of Illness Index; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Evidence that the epidermal targets of carcinogen action are found in the interfollicular epidermis of infundibulum as well as in the hair follicles.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Epidermis; Female; Hair Follicle; Mice; Mice, Inbred SENCAR; Papilloma; Regeneration; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2000 |
Effects of nicotinamide on mouse skin tumor development and its mode of action.
Topics: Animals; Apoptosis; Female; Mice; Niacinamide; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transglutaminases | 1999 |
Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Epidermis; Female; Humans; Isoenzymes; Male; Mice; Mice, Transgenic; Papilloma; Phenotype; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Evaluation of carcinogenic and co-carcinogenic potential Quinalphos in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Alopecia; Animals; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Insecticides; Male; Mice; Organothiophosphorus Compounds; Skin Neoplasms; Skin Ulcer; Tetradecanoylphorbol Acetate | 2000 |
[The antioxidative mechanisms of tea polyphenols in inhibiting tumor promotion by TPA].
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Female; Flavonoids; Mice; Phenols; Polymers; Polyphenols; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1998 |
Evidence against a role of general protein kinase C downregulation in skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Isoenzymes; Mice; Mice, Inbred Strains; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Inhibitory effect of euphol, a triterpene alcohol from the roots of Euphorbia kansui, on tumour promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Alcohols; Animals; Antihypertensive Agents; Carcinogens; Ear; Female; Inflammation; Lanosterol; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2000 |
Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion.
Topics: Animals; Cattle; Epidermal Cells; Epidermis; Female; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Keratins; Male; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Recombinant Fusion Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2000 |
Development and initial characterization of several new inbred strains of SENCAR mice for studies of multistage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Bacteriophage phi X 174; Brain; Carcinogens; DNA, Viral; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; HL-60 Cells; Hot Temperature; Humans; Hydrogen Peroxide; Lipid Peroxidation; Male; Methanol; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Panax; Papilloma; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2000 |
Anti-tumor-promoting effects of isoflavonoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Topics: Animals; Body Weight; Carcinogens; Female; Herpesvirus 4, Human; Isoflavones; Mice; Mice, Inbred ICR; Papilloma; Plant Extracts; Rosales; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Virus Activation | 2000 |
Expression of PGF(2alpha) receptor mRNA in normal, hyperplastic and neoplastic skin.
Topics: Adolescent; Animals; Base Sequence; Carcinogens; Dinoprost; DNA Primers; Female; Humans; Hyperplasia; Mice; Polymerase Chain Reaction; Receptors, Prostaglandin; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Inhibitory effect of flavonoids from citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
Topics: Animals; Antigens, Viral; Female; Flavonoids; Mice; Mice, Inbred ICR; Papilloma; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Virus Activation | 2000 |
Chemopreventive effects of sage oil on skin papillomas in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Anticarcinogenic Agents; Cell Division; Cell Survival; Injections, Intraperitoneal; Lamiaceae; Lethal Dose 50; Mice; Papilloma; Plant Oils; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA Mutational Analysis; Female; Genes, Neurofibromatosis 1; Genes, ras; Humans; Mice; Mice, Inbred C57BL; Papilloma; Skin; Skin Neoplasms; Skin Pigmentation; Tetradecanoylphorbol Acetate | 2000 |
Allelotype analysis of chemically induced squamous cell carcinomas in F(1) hybrids of two inbred mouse strains with different susceptibility to tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Carcinogens; Carcinoma, Squamous Cell; Chimera; Crosses, Genetic; Disease Progression; Genetic Predisposition to Disease; Genotype; Humans; Loss of Heterozygosity; Mice; Mice, Inbred SENCAR; Microsatellite Repeats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Calcitriol; Calcium; Carcinogens; Enzyme Induction; Female; Growth; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Vitamin D | 2000 |
Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cacodylic Acid; Carcinogens; Cocarcinogenesis; Female; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Inducible nitric oxide synthase mRNA is upregulated in skin tumors of v-ha-ras transgenic TG-AC mice treated with 12-o-tetradecanoylphorbol-13-acetate.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, ras; Mice; Mice, Transgenic; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2000 |
Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Antineoplastic Agents, Phytogenic; Asteraceae; Cells, Cultured; Disease Models, Animal; Female; Glycerol; Lignans; Lung Neoplasms; Mice; Mice, Inbred ICR; Mice, Inbred SENCAR; Neoplasm Transplantation; Phytotherapy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Targeted disruption of the epidermal growth factor receptor inhibits development of papillomas and carcinomas from human papillomavirus-immortalized keratinocytes.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Transformation, Viral; Cocarcinogenesis; Disease Progression; ErbB Receptors; Gene Expression; Genes, ras; Genotype; Humans; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Oncogene Proteins, Viral; Papilloma; Papillomaviridae; Papillomavirus E7 Proteins; Repressor Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Microsatellite DNA variants between the inbred SENCAR mouse strains.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Genetic Markers; Genetic Predisposition to Disease; Genetic Variation; Genotype; Mice; Mice, Inbred SENCAR; Microsatellite Repeats; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 2000 |
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Flow Cytometry; Immunity, Innate; Immunohistochemistry; In Situ Hybridization, Fluorescence; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Papilloma; Proto-Oncogene Proteins p21(ras); Skin; Skin Neoplasms; Telomerase; Telomere; Tetradecanoylphorbol Acetate; Time Factors; Tumor Suppressor Protein p53 | 2000 |
Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cattle; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cocarcinogenesis; Dimerization; Disease Progression; Epidermis; ErbB Receptors; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Genes, ras; Genes, Synthetic; Hyperplasia; Keratins; Male; Mice; Mice, Inbred ICR; Mice, Transgenic; Neoplasm Proteins; Papilloma; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Rats; Receptor, ErbB-2; Receptor, ErbB-3; Recombinant Fusion Proteins; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2000 |
Thioredoxin, thioredoxin reductase and tumour necrosis factor-alpha expression in melanoma cells: correlation to resistance against cytotoxic attack.
Topics: Cell Survival; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Interferon-gamma; Interleukins; Lymph Nodes; Lymphatic Metastasis; Melanocytes; Melanoma; Microscopy, Confocal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thioredoxin-Disulfide Reductase; Thioredoxins; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells | 2000 |
Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Diarylheptanoids; Dose-Response Relationship, Drug; Female; Herpesvirus 4, Human; Humans; Hydrocarbons, Cyclic; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Specific Pathogen-Free Organisms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Virus Activation | 2000 |
Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Carcinogens; Cell Line; Citrus; Cyclooxygenase 2; Dinoprostone; Drug Eruptions; Female; Flavones; Flavonoids; HL-60 Cells; Humans; Interferon-gamma; Isoenzymes; Lipopolysaccharides; Macrophage Activation; Macrophages; Membrane Proteins; Mice; Mice, Inbred ICR; Nitric Oxide; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 2000 |
Collagenase induction promotes mouse tumorigenesis by two independent pathways.
Topics: Animals; Anthracenes; Collagenases; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1 | 2000 |
Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter.
Topics: Azacitidine; Base Sequence; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinase 3; Lymphoma; Lymphoma, T-Cell, Cutaneous; Phosphorylation; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Suppression by citrus auraptene of phorbol ester-and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Coumarins; Cyclooxygenase 2; Dermatitis, Contact; Edema; Female; Hydrogen Peroxide; Isoenzymes; Leukocytes; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred ICR; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Umbelliferones | 2000 |
A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Biotransformation; Carcinogens; Dermatitis, Contact; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Female; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hydrogen Peroxide; Hydroxybenzoates; Mice; Mice, Inbred ICR; Monophenol Monooxygenase; Oxidative Stress; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Development of spontaneous hyperplastic skin lesions and chemically induced skin papillomas in transgenic mice expressing human papillomavirus type 16 E6/E7 genes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Female; Gene Expression; Humans; Hyperplasia; Mice; Mice, Inbred ICR; Mice, Transgenic; Monophenol Monooxygenase; Oncogene Proteins, Viral; Papilloma; Papillomaviridae; Papillomavirus E7 Proteins; Pregnancy; Repressor Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Genetics of chemical carcinogenesis: analysis of bidirectional selective breeding inducing maximal resistance or maximal susceptibility to 2-stage skin tumorigenesis in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Genetic Predisposition to Disease; Hair Color; Male; Mice; Mice, Inbred Strains; Quantitative Trait, Heritable; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 2000 |
Kurosu, a traditional vinegar produced from unpolished rice, suppresses lipid peroxidation in vitro and in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetic Acid; Animals; Antioxidants; Bepridil; Biphenyl Compounds; Edema; Female; Free Radical Scavengers; Free Radicals; Hydrogen Peroxide; Inflammation; Lipid Peroxidation; Mice; Mice, Inbred ICR; Oryza; Picrates; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiobarbituric Acid Reactive Substances; Time Factors; Vitamin E | 2000 |
Tumorigenicity of four optically active bay-region 3,4-diol 1, 2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine on mouse skin and in newborn mice.
Topics: Acridines; Animals; Animals, Newborn; Bay-Region, Polycyclic Aromatic Hydrocarbon; Carcinogens; Epoxy Compounds; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Pregnancy; Skin; Skin Neoplasms; Stereoisomerism; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2000 |
Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis.
Topics: Animals; Carcinogens; Epidermis; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, p53; Genes, ras; Keratins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 2000 |
NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cocarcinogenesis; Disease Susceptibility; Female; Male; Mice; Mice, Inbred A; Models, Animal; NAD(P)H Dehydrogenase (Quinone); Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Cancer chemopreventive agents, labdane diterpenoids from the stem bark of Thuja standishii (Gord.) Carr.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; beta Carotene; Carboxylic Acids; Carcinogens; Diterpenes; Female; Humans; Mice; Mice, Inbred ICR; Naphthalenes; Nasopharyngeal Neoplasms; Neoplasms; Papilloma; Plant Extracts; Plant Stems; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trees | 2000 |
Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents; Biological Assay; Carcinogens; Female; Glycolipids; Lipids; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2000 |
Potential carcinogenic and inhibitory activity of compounds isolated from Lilium candidum L.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Ethanol; Liliaceae; Mice; Mutagens; Plant Extracts; Polarography; Pyrroles; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2000 |
Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Citrus; Female; Flavones; Flavonoids; Mice; Nitro Compounds; Papilloma; Plant Extracts; Skin Neoplasms; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Bax gene disruption alters the epidermal response to ultraviolet irradiation and in vivo induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogens; Cell Differentiation; Epidermal Cells; Epidermis; Genes, bcl-2; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Keratinocytes; Keratins; Membrane Proteins; Mice; Mice, Knockout; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2001 |
Induction of mouse epidermal ornithine decarboxylase activity and skin tumors by 7,12-dimethylben.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoflavones; Carcinogens; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Epidermis; Female; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Disease Models, Animal; Disease Progression; Female; Hair Follicle; Isoenzymes; Lymphatic Metastasis; Male; Mice; Mice, Transgenic; Protein Kinase C; Protein Kinase C-epsilon; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Carcinogens; Curcumin; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, fos; Genes, ras; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents; Azoxymethane; Edema; Female; India; Mice; Molecular Structure; Plant Extracts; Plants, Medicinal; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Triterpenes | 2000 |
Cancer prevention by natural carotenoids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Colonic Neoplasms; Cryptoxanthins; Disease Models, Animal; Fruit; Humans; Lutein; Lycopene; Methylnitrosourea; Mice; Rats; Rats, Inbred F344; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vegetables; Xanthophylls; Zeaxanthins | 2000 |
Analysis of c-Ha-ras gene mutations in skin tumors induced in carcinogenesis-susceptible and carcinogenesis-resistant mice by different two-stage protocols or tumor promoter alone.
Topics: Animals; Benz(a)Anthracenes; Benzoyl Peroxide; Carcinogens; Carcinoma, Squamous Cell; DNA Primers; Drug Resistance, Neoplasm; Genes, ras; Genetic Predisposition to Disease; Mice; Mice, Inbred Strains; Mutation; Papilloma; Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
[p53 gene mutations in mouse skin tumors induced by DMBA-TPA-MNNG].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Exons; Genes, p53; Methylnitronitrosoguanidine; Mice; Mice, Inbred SENCAR; Papilloma; Point Mutation; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1998 |
Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Down-Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Keratin-10; Keratins; Melanoma, Experimental; Mice; Mice, Transgenic; Neoplasm Transplantation; Phenotype; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Transgenes; Up-Regulation | 2001 |
Dietary energy restriction inhibits ERK but not JNK or p38 activity in the epidermis of SENCAR mice.
Topics: Animals; Blotting, Western; Diet; DNA; Epidermis; Female; Mice; Mice, Inbred SENCAR; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1 | 2001 |
Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse.
Topics: Age Factors; Aging; Animals; Carcinogens; Centrifugation, Density Gradient; Female; Flow Cytometry; Genes, ras; Globins; Integrin beta1; Keratinocytes; Mice; Mice, Transgenic; Neoplasms, Radiation-Induced; Papilloma; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transgenes; Ultraviolet Rays | 2001 |
Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Genes, ras; Humans; Keratinocytes; Mice; Mice, Transgenic; Mutagenesis; Papilloma; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2001 |
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Aging; Alopecia; Animals; Animals, Newborn; Carcinogens; Mice; Mice, Transgenic; Neoplasm Staging; Ornithine Decarboxylase; Papilloma; Phenotype; Polyamines; Putrescine; Reference Values; Skin; Skin Neoplasms; Spermidine; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; DNA; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Papilloma; Phosphorylation; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2001 |
Tumourigenic studies on deltamethrin in Swiss albino mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Female; Insecticides; Male; Mice; Nitriles; Pyrethrins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Catalytic Domain; Cattle; DNA-Binding Proteins; Female; Gastric Mucosa; Genes, p53; Genetic Therapy; Hyperplasia; Keratinocytes; Keratins; Mice; Mice, Knockout; Mice, Transgenic; Mouth Mucosa; Neoplasms, Experimental; Papilloma; Protein Subunits; RNA; Skin; Skin Neoplasms; Stomach; Telomerase; Telomere; Tetradecanoylphorbol Acetate; Vagina; Wound Healing | 2001 |
Transplacental carcinogenic potential of the carbamate fungicide mancozeb.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Female; Fungicides, Industrial; Male; Maneb; Maternal Exposure; Maternal-Fetal Exchange; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Skin Neoplasms; Tetradecanoylphorbol Acetate; Zineb | 2001 |
Expression of microtubule-associated protein 2 in benign and malignant melanocytes: implications for differentiation and progression of cutaneous melanoma.
Topics: Acetamides; Biomarkers; Cell Differentiation; Cell Line; Cyclic AMP; Disease Progression; Gene Expression Profiling; Humans; Melanocytes; Melanoma; Microtubule-Associated Proteins; RNA, Messenger; RNA, Neoplasm; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2001 |
Topical and oral administration of the natural water-soluble antioxidant from spinach reduces the multiplicity of papillomas in the Tg.AC mouse model.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Antioxidants; Body Weight; Carcinogens; Disease Models, Animal; Female; Genes, ras; Genotype; Mice; Mice, Transgenic; Papilloma; Plant Extracts; Skin Neoplasms; Spinacia oleracea; Survival Analysis; Tetradecanoylphorbol Acetate | 2001 |
Effect of a complex environmental mixture from coal tar containing polycyclic aromatic hydrocarbons (PAH) on the tumor initiation, PAH-DNA binding and metabolic activation of carcinogenic PAH in mouse epidermis.
Topics: Animals; Biotransformation; Blotting, Western; Carcinogens; Chromatography, High Pressure Liquid; Coal Tar; DNA; Environmental Pollutants; Female; Mice; Polycyclic Compounds; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum.
Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogens; Coumarins; Female; Herpesvirus 4, Human; Humans; Mice; Mice, Inbred ICR; Papilloma; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trees; Virus Activation | 2001 |
Anti-tumor promoting diterpenes from the stem bark of Thuja standishii (Cupressaceae).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Diterpenes; Female; Mice; Mice, Inbred ICR; Plant Stems; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trees | 2001 |
Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, CD; Antigens, Neoplasm; Basigin; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cell Transformation, Neoplastic; Female; Integrin alpha3beta1; Integrins; Keratinocytes; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Papilloma; Receptors, Collagen; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tetraspanin 28 | 2001 |
Nitroglycerin: a NO donor inhibits TPA-mediated tumor promotion in murine skin.
Topics: Animals; Carcinogens; Mice; Nitric Oxide Donors; Nitroglycerin; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice.
Topics: Animals; Carcinogens; Disease Models, Animal; Enzyme Induction; Humans; Hyperplasia; Immunohistochemistry; Isoenzymes; Keratinocytes; Mice; Mice, Transgenic; Microscopy, Electron; Ornithine Decarboxylase; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.
Topics: Animals; Anticarcinogenic Agents; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; DNA; Epidermal Growth Factor; Fruit; Glucosides; Glycosides; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Plants, Medicinal; Proto-Oncogene Proteins c-jun; Rubiaceae; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 2001 |
Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biogenic Polyamines; Carcinogens; Cattle; Enzyme Induction; Enzyme Inhibitors; Keratin-15; Keratin-5; Keratins; Mice; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Promoter Regions, Genetic; Protein Biosynthesis; Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Models, Animal; Enzyme Activation; Female; Humans; Isoenzymes; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Oxidative Stress; Protein Kinase C; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Signal Transduction; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2001 |
Antioxidative and antitumor promoting effects of [6]-paradol and its homologs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Carcinogens; DNA Damage; Ear, External; Edema; Epidermis; Female; Guaiacol; Hydrogen Peroxide; Ketones; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Peroxidase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Female; Kallikreins; Keratinocytes; Mice; Neoplasms, Experimental; Serine Endopeptidases; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Cancer chemopreventive agents, serratane-type triterpenoids from Picea jezoensis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Female; Humans; Mice; Mice, Inbred ICR; Papilloma; Plants; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2001 |
Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acacia; Aneuploidy; Animals; Dioxoles; Disease Models, Animal; Female; Genes, ras; Humans; Jurkat Cells; Mice; Mice, Inbred SENCAR; Papilloma; Phenanthridines; Phytotherapy; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2001 |
Lack of effect of 94 GHz radio frequency radiation exposure in an animal model of skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Bromodeoxyuridine; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Administration Schedule; Electromagnetic Fields; Female; Incidence; Mice; Mice, Inbred SENCAR; Neoplasms, Radiation-Induced; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Female; Flavonoids; Herpesvirus 4, Human; Lymphocytes; Mice; Mice, Inbred ICR; Models, Chemical; Papilloma; Quercetin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogens; Female; Humans; In Vitro Techniques; Mice; Mice, Inbred ICR; Naphthoquinones; Papilloma; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 2001 |
Lack of promotion of 7,12-dimethylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenocorticotropic Hormone; Animals; Carcinogens; Carcinoma, Squamous Cell; Corticosterone; Electromagnetic Fields; Epidermis; Female; Incidence; Melatonin; Mice; Mice, Inbred ICR; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Discrete roles of cytokines, TNF-alpha, IL-1, IL-6 in tumor promotion and cell transformation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; DNA Primers; Female; Humans; Interleukin-1; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Okadaic Acid; Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Necrosis Factor-alpha | 2002 |
Regulation of the differentiation-related gene Drg-1 during mouse skin carcinogenesis.
Topics: Animals; Carcinogens; Cell Cycle Proteins; Cell Differentiation; Cell Transformation, Neoplastic; Genes, ras; Intracellular Signaling Peptides and Proteins; Keratinocytes; Mice; Mice, Inbred C57BL; Papilloma; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Confirmation of the mapping of a 12-O-tetradecanoylphorbol-13-acetate promotion susceptibility locus, Psl1, to distal mouse chromosome 9.
Topics: Animals; Carcinogens; Chromosome Mapping; Genetic Predisposition to Disease; Mice; Neoplasm Proteins; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Loss of critical palindromic transgene promoter sequence in chemically induced Tg.AC mouse skin papillomas expressing transgene-derived mRNA.
Topics: Animals; Carcinogens; Gene Expression Regulation, Neoplastic; Genes, ras; Genetic Predisposition to Disease; Mice; Mice, Transgenic; Papilloma; Promoter Regions, Genetic; RNA, Messenger; Sequence Deletion; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2001 |
Overexpression of bone morphogenetic protein-6 (BMP-6) in murine epidermis suppresses skin tumor formation by induction of apoptosis and downregulation of fos/jun family members.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Bone Morphogenetic Protein 6; Bone Morphogenetic Proteins; Cell Division; Down-Regulation; Epidermis; Genes, fos; Genes, jun; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Keratinocytes; Mice; Mice, Transgenic; Mutation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Bromodeoxyuridine; Carcinogens; CCAAT-Enhancer-Binding Protein-beta; Cell Division; Cell Survival; Genes, Reporter; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagens; Mutation; Oncogene Protein p21(ras); Phosphorylation; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transcriptional Activation | 2002 |
Cancer chemopreventive activity of flavanones on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Dose-Response Relationship, Drug; Female; Flavanones; Flavonoids; Herpesvirus 4, Human; Mice; Mice, Inbred ICR; Models, Chemical; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
Inhibition of both skin and lung tumorigenesis by Car-R mouse-derived cancer modifier loci.
Topics: Alleles; Animals; Animals, Outbred Strains; Carcinogenicity Tests; Carcinogens; Female; Genetic Predisposition to Disease; Inbreeding; Incidence; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 2002 |
Cancer chemopreventive activity of Achyranthes aspera leaves on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Topics: Achyranthes; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Herpesvirus 4, Human; Mice; Mice, Inbred ICR; Papilloma; Plant Extracts; Plant Leaves; Plant Preparations; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 2002 |
Interleukin-1alpha up-regulation in vivo by a potent carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and control of DMBA-induced inflammatory responses.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibodies; Carcinogens; DNA Damage; Edema; Female; Immunoglobulin G; Interleukin-1; Mice; Mice, Inbred SENCAR; Neutrophils; Oxidative Stress; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Up-Regulation | 2002 |
Overexpression of a constitutively active form of c-src in skin epidermis increases sensitivity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Carcinogens; Epidermis; Hyperplasia; Keratins; Kinetics; Mice; Mice, Transgenic; Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins pp60(c-src); Skin Neoplasms; Tetradecanoylphorbol Acetate | 2002 |
Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Animals; Animals, Genetically Modified; Carcinogens; Cattle; Genetic Predisposition to Disease; Immunohistochemistry; Keratinocytes; Keratins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Plasmids; Promoter Regions, Genetic; Putrescine; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; DNA; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Papilloma; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2002 |
Antitumor activity of compounds isolated from leaves of Eriobotrya japonica.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; Antineoplastic Agents; Biflavonoids; Carcinogens; Catechin; Female; Glucosides; Herpesvirus 4, Human; Humans; Mice; Mice, Inbred ICR; Nasopharyngeal Neoplasms; Norisoprenoids; Peroxynitrous Acid; Plant Leaves; Proanthocyanidins; Rosaceae; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate; Virus Activation | 2002 |
Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alopecia; Animals; Carcinogens; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Hair Follicle; Humans; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Mice, Transgenic; Phenotype; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Skin; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate | 2002 |
A comparison of the anticarcinogenic properties of four red wine polyphenols.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Catechin; Flavonoids; Gallic Acid; Mice; Phenols; Polymers; Quercetin; Resveratrol; Skin Neoplasms; Stilbenes; Tetradecanoylphorbol Acetate; Wine | 2002 |
Cancer chemopreventive effects of a Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Brazil; Caesalpinia; Female; Fruit; Gallic Acid; Medicine, Traditional; Mice; Mice, Inbred ICR; Papilloma; Phytotherapy; Plant Extracts; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2002 |
Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Cycle Proteins; Cell Division; Eflornithine; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epidermis; Female; Isoenzymes; Kinetics; Male; Mice; Mice, Knockout; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Kinase C; Protein Kinase C-delta; RNA, Messenger; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 2002 |
Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthraquinones; Anticarcinogenic Agents; Cassia; Emodin; Enzyme Inhibitors; Female; Mice; Mice, Inbred ICR; Phytotherapy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Cell Death; Cell Differentiation; Cell Division; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; DNA Adducts; Female; Immunohistochemistry; Isoenzymes; Keratinocytes; Membrane Proteins; Mice; Mice, Inbred C57BL; Papilloma; Prostaglandin-Endoperoxide Synthases; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2002 |
The genetic control of chemically and radiation-induced skin tumorigenesis: a study with carcinogenesis-susceptible and carcinogenesis-resistant mice.
Topics: Animals; Genes, ras; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred Strains; Mutation; Neoplasms, Radiation-Induced; Skin Neoplasms; Tetradecanoylphorbol Acetate; X-Rays | 2002 |
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Cell Division; Disease Progression; Gene Dosage; Genotype; Guanine Nucleotide Exchange Factors; Immunohistochemistry; Keratins; Mice; Mice, Knockout; Proteins; ras Proteins; Skin Neoplasms; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Tetradecanoylphorbol Acetate | 2002 |
Calgranulins S100A8 and S100A9 are negatively regulated by glucocorticoids in a c-Fos-dependent manner and overexpressed throughout skin carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents; Antigens, Differentiation; Antineoplastic Agents, Hormonal; Calcium; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Carcinogens; Carcinoma, Squamous Cell; Dexamethasone; Disease Progression; Drug Eruptions; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, fos; Keratinocytes; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Papilloma; Protein Kinase C; Proto-Oncogene Proteins c-fos; S100 Proteins; Skin Neoplasms; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2002 |
Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Epidermal Cells; Epidermis; Isoenzymes; Keratinocytes; Kinetics; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Mice, Knockout; Protein Kinase C; Protein Kinase C-alpha; RNA, Messenger; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2002 |
The carcinogenic effect of TPA (12-0-tetradecanoylphorbol-13-acetate) when applied to the skin of hairless mice.
Topics: Animals; Carcinoma, Squamous Cell; Fibrosarcoma; Mice; Mice, Nude; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1979 |
Two-stage (initiation-promotion) carcinogenesis in vivo and in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Croton Oil; Female; In Vitro Techniques; Mice; Models, Biological; Neoplasms, Experimental; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1978 |
Transmaternal modification of the Berenblum/Mottram experiment in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Fetus; Maternal-Fetal Exchange; Mice; Neoplasms, Experimental; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1978 |
Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aldehydes; Animals; Carcinoma, Squamous Cell; Decanoates; Drug Synergism; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Inhibition of phorbol ester-induced tumor promotion in mice by vitamin A analog and anti-inflammatory steroid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Drug Synergism; Female; Fluocinolone Acetonide; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A | 1979 |
Life history and histopathology of ultraviolet light-induced skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Cricetinae; Female; Mice; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Papilloma; Rats; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1978 |
The initiation of tumours on mouse skin by dihydrodiols derived from 7,12-dimethylbenz(a)anthracene and 3-methylcholanthrene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Chemical Phenomena; Chemistry; Female; Methylcholanthrene; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Phorbol as a possible systemic promoting agent for skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Synergism; Female; Injections, Intraperitoneal; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
On the biochemical mechanism of tumorigenesis in mouse skin. VII. The effects of tumor promoters on 3H-choline and 3H-glycerol incorporation into mouse epidermal phosphatidylcholine in relation to their effects on 3H-thymidine incorporation into DNA.
Topics: Animals; Choline; DNA, Neoplasm; Female; Glycerol; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Phosphatidylcholines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Tumor persistence and regression in skin carcinogenesis. An experimental study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Female; Mice; Neoplasm Regression, Spontaneous; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1978 |
An apparent inactivation of initiated cells by the potent inhibitor of two-stage mouse skin tumorigenesis, bis(2-chloroethyl)sulfide.
Topics: Animals; Cyclic AMP; DNA; Enzyme Induction; Esterases; Female; Isoproterenol; Mice; Mustard Compounds; Neoplasms, Experimental; Ornithine Decarboxylase; Skin; Skin Neoplasms; Sulfides; Tetradecanoylphorbol Acetate; Tosylarginine Methyl Ester | 1977 |
Increased cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in the epidermis of phorbol ester-treated mouse skin and in papillomas.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Colchicine; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vinblastine | 1979 |
Lymphocyte activation by the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Animals; Callitrichinae; Dimethyl Sulfoxide; Dogs; Guinea Pigs; Haplorhini; Herpesvirus 4, Human; Humans; Lymphocyte Activation; Macaca mulatta; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Mitogens; Pan troglodytes; Papio; Phorbols; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Studies with chlorinated dibenzo-p-dioxins, polybrominated biphenyls, and polychlorinated biphenyls in a two-stage system of mouse skin tumorigenesis: potent anticarcinogenic effects.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Dioxins; Drug Interactions; Enzyme Induction; Female; Hydrocarbons, Chlorinated; Mice; Neoplasms, Experimental; Polybrominated Biphenyls; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3':5'-monophosphate, and induction of mouse skin tumors in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Cyclic AMP; Dermatitis, Contact; Diterpenes; Female; Isoproterenol; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Local tumor regression after intralesional injection of croton oil.
Topics: Animals; BCG Vaccine; Croton Oil; Guinea Pigs; Lymphatic Metastasis; Male; Mice; Mice, Inbred C3H; Remission, Spontaneous; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Comparative mutagenicity, tumor-initiating activity, carcinogenicity, and in vitro metabolism of fluorinated 5-methylchrysenes.
Topics: Animals; Carcinogens; Chrysenes; Cocarcinogenesis; Drug Evaluation, Preclinical; Female; In Vitro Techniques; Male; Mice; Microsomes, Liver; Mutagens; Neoplasms, Experimental; Phenanthrenes; Rats; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice.
Topics: Animals; Carcinogens, Environmental; Cocarcinogenesis; Drug Evaluation, Preclinical; Female; Hydrocarbons, Halogenated; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Papilloma; Sarcoma, Experimental; Skin Neoplasms; Stomach Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Binding of epidermal growth factor to primary and permanent cultures of mouse epidermal cells: inhibition by tumor-promoting phorbol esters.
Topics: Animals; Binding Sites; Cells, Cultured; Epidermal Growth Factor; Mice; Neoplasms, Experimental; Peptides; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Maintenance of human skin on nude mice for studies of chemical carcinogenesis.
Topics: Animals; Carcinogens; Female; Humans; Hyperplasia; Male; Mice; Mice, Nude; Models, Biological; Neoplasms, Experimental; Skin; Skin Neoplasms; Skin Transplantation; Species Specificity; Tetradecanoylphorbol Acetate; Transplantation, Heterologous; Urethane | 1979 |
Epidermal ribosome accumulation during two-stage skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Membranes; Mice; Neoplasms, Experimental; Precancerous Conditions; Ribosomes; RNA, Neoplasm; RNA, Ribosomal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1977 |
Induction of the formation of new hair follicles in mouse tail epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hair; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tail; Tetradecanoylphorbol Acetate | 1977 |
Tumorigenicity of the dihydrodiols of dibenzo(a,h)anthracene on mouse skin and in newborn mice.
Topics: Animals; Animals, Newborn; Benz(a)Anthracenes; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Pregnancy; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Epidermal prostaglandins after topical application of a tumor promotor.
Topics: Administration, Topical; Animals; Male; Mice; Neoplasms, Experimental; Phorbols; Prostaglandins E; Prostaglandins F; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1979 |
Comparison of the skin tumor initiating activity of 3-methylcholanthrene and 3,11-dimethylcholanthrene in mice.
Topics: Animals; Female; Methylcholanthrene; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Tumorigenic activity of 3-methylcholanthrene metabolites on mouse skin and in newborn mice.
Topics: Administration, Topical; Animals; Animals, Newborn; Carcinogens; Cocarcinogenesis; Drug Administration Schedule; Female; Injections, Intraperitoneal; Liver Neoplasms; Lung Neoplasms; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells.
Topics: Agar; Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transplantation, Isogeneic | 1978 |
Skin tumor-initiating activities of the twelve isomeric phenols of benzo(a)pyrene.
Topics: Animals; Benzopyrenes; Female; Isomerism; Mice; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors | 1978 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by vitamin A analogs (retinoids).
Topics: Animals; Carboxy-Lyases; Drug Evaluation, Preclinical; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Polyamines; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Vitamin A | 1978 |
Effect of aging in two-stage carcinogenesis on mouse skin with phorbol myristate acetate as promoting agent.
Topics: Aging; Animals; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate | 1978 |
Tumor-promoting activity of 2,3-dihydrophorbol myristate acetate and phorbolol myristate acetate in mouse skin.
Topics: Animals; Dermatitis, Contact; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1978 |
Tumor-initiating activity of fluorinated 5-methylchrysenes.
Topics: Animals; Biotransformation; Chrysenes; Female; Mice; Neoplasms, Experimental; Phenanthrenes; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1978 |
Evidence that benzo(a)anthracene 3,4-diol-1,2-epoxide is an ultimate carcinogen on mouse skin.
Topics: Animals; Benz(a)Anthracenes; Biotransformation; Carcinogens; Female; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Stereoisomerism; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1978 |
Non-phorbol mouse skin tumor promoters do not mimic phorbol myristate acetate in its effects on chick embryo fibroblasts.
Topics: Acetates; Animals; Anthralin; Cantharidin; Carcinogens; Cell Membrane; Chick Embryo; Cytochalasin B; Deoxyglucose; Fibroblasts; Glycoproteins; Lauric Acids; Neoplasms, Experimental; Oleic Acids; Palmitic Acids; Phenols; Phorbols; Skin Neoplasms; Stearic Acids; Tetradecanoylphorbol Acetate | 1978 |
Comparative tumor initiating activity of 10-methylbenzo-[a]pyrene, 7,10-dimethylbenzo[a]pyrene and benzo[a]pyrene.
Topics: Animals; Benzopyrenes; Biotransformation; Female; Keratoacanthoma; Mice; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1978 |
Photosensitized reactions and carcinogenesis.
Topics: Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; DNA; Female; Methoxsalen; Mice; Mice, Nude; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Photochemotherapy; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1978 |
The induction of ornithine decarboxylase activity and its control in mouse skin epidermis.
Topics: Adenosylmethionine Decarboxylase; Alkaloids; Amines; Animals; Carboxy-Lyases; Enzyme Induction; Epidermis; Female; Indomethacin; Mice; Neoplasms, Experimental; Nucleotides, Cyclic; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Ultraviolet Rays | 1978 |
Marked differences in the skin tumor-initiating activities of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8-diol-9,10-epoxides.
Topics: Animals; Benzopyrenes; Carcinogens; Epoxy Compounds; Female; Mice; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Stereoisomerism; Tetradecanoylphorbol Acetate | 1979 |
Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion.
Topics: Animals; Carboxy-Lyases; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Vitamin A | 1979 |
Inhibition of two-stage carcinogenesis in mouse skin with bis(2-chloroethyl)sulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma, Squamous Cell; Female; Mice; Mice, Inbred ICR; Mustard Compounds; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Sulfides; Tetradecanoylphorbol Acetate | 1976 |
Regression kinetics of mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antilymphocyte Serum; Dose-Response Relationship, Drug; Female; Half-Life; Mice; Neoplasm Regression, Spontaneous; Neoplasms, Experimental; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
Epidermal cell proliferation and promoting ability of phorbol esters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Edema; Female; Hyperplasia; Inflammation; Mice; Neoplasms, Experimental; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Drug Synergism; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Mice; Neoplasms, Experimental; Phorbols; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1976 |
Improved tumour yields by means of a TPA-DMBA-TPA variation of the Berenrlum-Mottram experiment on the back skin of NMRI mice. The effect of stationary hyperplasia without inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma; Female; Hyperplasia; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Histone phosphorylation and synthesis of DNA and RNA during phases of proliferation and differentiation induced in mouse epidermis by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Cell Differentiation; Cell Division; DNA; DNA, Neoplasm; Female; Histones; Mice; Neoplasms, Experimental; Phorbols; Phosphorus; RNA; RNA, Neoplasm; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1977 |
Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.
Topics: Animals; Anti-Inflammatory Agents; Cell Division; Cells, Cultured; Depression, Chemical; DNA; Female; Fluocinolone Acetonide; Fluocinonide; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Plasminogen Activators; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1977 |
Effect of colchicine injection prior to the initiating phase of two-stage skin carcinogenesis in mice.
Topics: Animals; Cell Division; Colchicine; Female; Mice; Mice, Inbred ICR; Mitosis; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Urethane | 1977 |
Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Administration Schedule; Enzyme Induction; Female; In Vitro Techniques; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1977 |
Marked differences in the tumor-initiating activity of optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene on mouse skin.
Topics: Animals; Benzopyrenes; Female; Mice; Microsomes, Liver; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Stereoisomerism; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1977 |
Skin-tumor-initiating ability of benzo(a)pyrene-7,8-diol-9,10-epoxide (anti) when applied topically in tetrahydrofuran.
Topics: Acetone; Animals; Benzene; Benzopyrenes; Carcinogens; Drug Interactions; Female; Furans; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Solvents; Stereoisomerism; Tetradecanoylphorbol Acetate | 1977 |
Comparison of the tumor-initiating activities of benzo(a)pyrene arene oxides and diol-epoxides.
Topics: Animals; Benzopyrenes; Epoxy Compounds; Female; Glycols; Mice; Neoplasms, Experimental; Oxides; Papilloma; Skin Neoplasms; Stereoisomerism; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1977 |
Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene.
Topics: Animals; Benzopyrenes; Carcinoma, Squamous Cell; Female; Fibrosarcoma; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
Selective promoting activity of phorbol myristate acetate in experimental skin carcinogenesis.
Topics: Animals; Carcinoma, Squamous Cell; Female; Fibrosarcoma; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Phorbols; Precancerous Conditions; Rhabdomyosarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Decrease of epidermal histidase activity by tumor-promoting phorbol esters.
Topics: Ammonia-Lyases; Animals; Benz(a)Anthracenes; Carcinogens; Depression, Chemical; Histidine Ammonia-Lyase; Male; Mice; Mice, Nude; Neoplasms, Experimental; Phorbols; Polysorbates; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1975 |
Acetic acid, a potent stimulator of mouse epidermal macromolecular synthesis and hyperplasia but with weak tumor-promoting ability.
Topics: Acetates; Animals; Croton Oil; Cytidine; DNA; Dose-Response Relationship, Drug; Female; Hyperplasia; Leucine; Mice; Neoplasms, Experimental; Papilloma; Proteins; RNA; Skin; Skin Neoplasms; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thymidine | 1975 |
Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Female; Isoflavones; Lung Neoplasms; Mice; Mice, Inbred ICR; Oleanolic Acid; Plants, Medicinal; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Overexpression of three ubiquitin genes in mouse epidermal tumors is associated with enhanced cellular proliferation and stress.
Topics: Alkynes; Amino Acid Sequence; Animals; Base Sequence; Cell Division; DNA Probes; Female; Gene Expression Regulation, Neoplastic; Hot Temperature; Mice; Molecular Sequence Data; Neoplasm Proteins; RNA, Neoplasm; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitins | 1992 |
Inhibition by squalene of the tumor-promoting activity of 12-O-tetradecanoylphorbol-13-acetate in mouse-skin carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Cell Line; Enzyme Induction; HeLa Cells; Herpesvirus 4, Human; Humans; Membrane Lipids; Mice; Ornithine Decarboxylase; Phospholipids; Skin Neoplasms; Squalene; Tetradecanoylphorbol Acetate; Virus Activation | 1992 |
The effects of interferon-beta on phorbol ester or calcium ionophore-induced intercellular adhesion molecule-I expression in epidermal carcinoma cells.
Topics: Calcimycin; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Line; Enzyme Activation; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interferon-beta; Keratinocytes; Protein Kinase C; Second Messenger Systems; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Regulation of the skin immune system by retinoids during carcinogenesis.
Topics: Animals; Antigens, Surface; Dendritic Cells; Humans; Immune System; Langerhans Cells; Membrane Glycoproteins; Mice; Retinoids; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thy-1 Antigens; Ultraviolet Rays | 1992 |
Development of an in vitro model to study carcinogen-induced neoplastic progression of initiated mouse epidermal cells.
Topics: Animals; Animals, Newborn; Base Sequence; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Cells; Epidermis; Genes, ras; Keratinocytes; Keratins; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Oligodeoxyribonucleotides; Papilloma; Polymerase Chain Reaction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 1992 |
Dissociation of sensitivities to tumor promotion and progression in outbred and inbred SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Carcinoma, Squamous Cell; Female; Genes, ras; Keratins; Methylnitronitrosoguanidine; Mice; Mutation; Papilloma; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1992 |
Spontaneous malignant transformation of melanocytes explanted from Wf/Wf mice with a Kit kinase-domain mutation.
Topics: Animals; Base Sequence; Cell Death; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Genes, Dominant; Genotype; Melanocytes; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Mutant Strains; Molecular Sequence Data; Mutation; Oligodeoxyribonucleotides; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Proto-Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Aberrant expression of the simple epithelial type II keratin 8 by mouse skin carcinomas but not papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Northern; Carcinoma, Squamous Cell; Electrophoresis, Polyacrylamide Gel; Epithelium; Female; Fluorescent Antibody Technique; Gene Expression; Genes, ras; Immunoenzyme Techniques; Keratins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation; Papilloma; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Immunogenetic influences on the initiation stage of the cutaneous chemical carcinogenesis pathway.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Disease Susceptibility; DNA; DNA Adducts; Enzyme Induction; Female; Mice; Mice, Inbred C3H; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.
Topics: Animals; Base Sequence; Disease Models, Animal; DNA, Neoplasm; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, ras; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Wounds and Injuries | 1992 |
(-)-Epigallocatechin-3-gallate in Camellia sinensis leaves from Himalayan region of Sikkim: inhibitory effects against biochemical events and tumor initiation in Sencar mouse skin.
Topics: Administration, Cutaneous; Animals; Antimutagenic Agents; Catechin; DNA; Enzyme Induction; Female; Masoprocol; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Sikkim; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate; Tritium | 1992 |
Antitumor-promoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in mouse skin.
Topics: Animals; Antineoplastic Agents, Phytogenic; DNA; Drug Screening Assays, Antitumor; Ellagic Acid; Gallic Acid; Hydrogen Peroxide; Hydrolyzable Tannins; Mice; Ornithine Decarboxylase Inhibitors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Potent preventive action of alpha-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than by beta-carotene.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; beta Carotene; Carotenoids; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Specific Pathogen-Free Organisms; Tetradecanoylphorbol Acetate | 1992 |
Inhibitory effect of green tea on the growth of established skin papillomas in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Catechin; Drug Screening Assays, Antitumor; Female; Flavonoids; Injections, Intraperitoneal; Mice; Papilloma; Phenols; Plant Extracts; Polymers; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1992 |
Reversal of food restriction-induced inhibition of mouse skin tumor promotion by adrenalectomy.
Topics: Adrenal Glands; Adrenalectomy; Animals; Body Weight; Corticosterone; Dehydroepiandrosterone; DNA, Neoplasm; Female; Food; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1992 |
Inhibition of mouse skin tumorigenesis by dexamethasone occurs through a Ha-ras-independent mechanism.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenalectomy; Animals; Blotting, Northern; Dexamethasone; Female; Genes, ras; Mice; Papilloma; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester- and calcium-induced reorganization of 180-kDa bullous pemphigoid antigen on the ventral surface of cultured human keratinocytes as studied by immunofluorescence and immunoelectron microscopy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Autoantigens; Calcium; Carcinoma, Squamous Cell; Carrier Proteins; Cell Membrane; Cells, Cultured; Collagen; Collagen Type XVII; Cytoskeletal Proteins; Desmosomes; Dystonin; Fluorescent Antibody Technique; Humans; Isoquinolines; Keratinocytes; Microscopy, Immunoelectron; Molecular Weight; Nerve Tissue Proteins; Non-Fibrillar Collagens; Pemphigoid, Bullous; Piperazines; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Dietary retinoids are essential for skin papilloma formation induced by either the two-stage or the complete tumorigenesis model in female SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Diet; Diterpenes; Female; Mice; Mice, Inbred Strains; Papilloma; Retinyl Esters; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Vitamin A; Vitamin A Deficiency | 1992 |
A subpopulation of 12-O-tetradecanoylphorbol-13-acetate-induced papillomas is not inhibited by retinoic acid.
Topics: Animals; Female; Metallothionein; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1992 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonic Acid; Female; Lipoxygenase; Mice; Phenols; Prostaglandin-Endoperoxide Synthases; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1992 |
Chemoprevention of chemically induced skin tumor development by diallyl sulfide and diallyl disulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allyl Compounds; Animals; Antineoplastic Agents; Body Weight; Disulfides; Garlic; Mice; Papilloma; Plants, Medicinal; Skin Neoplasms; Sulfides; Tetradecanoylphorbol Acetate | 1992 |
Phenotypic expression of carcinogen-initiated epidermal cells to tumor cells by 12-O-tetradecanoylphorbol-13-acetate in a manner dependent on 3T3 fibroblast-derived humoral factor(s).
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Calcium; Cell Transformation, Neoplastic; Cells, Cultured; Epidermis; Macrophages; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in murine skin by systemic effects of ultraviolet irradiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Ultraviolet Rays | 1992 |
Modification of tumor promotion in the mouse skin by exposure to an alternating magnetic field.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Electromagnetic Fields; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Enhanced papilloma formation in response to skin tumor promotion in transgenic mice overexpressing the human ornithine decarboxylase gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Epidermis; Gene Expression; Mice; Mice, Transgenic; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
An enzyme-linked immunosorbent assay for p65 oncofetal protein and its potential as a new marker for cancer risk assessment in rodents and humans.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Choline; Choline Deficiency; Diethylnitrosamine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred Strains; Neoplasms; Oncogene Proteins; Rats; Rats, Inbred Strains; Risk Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Body Weight; Female; Mice; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 1992 |
Influences of sphingosine on two-stage skin tumorigenesis in Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Body Weight; Carcinoma; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Carcinogenic and cocarcinogenic studies with carbaryl following topical exposure in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Carbaryl; Carcinogenicity Tests; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
A model for initiated mouse skin: suppression of papilloma but not carcinoma formation by normal epidermal cells in grafts on athymic nude mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Fibroblasts; Genes, fos; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Papilloma; Skin Neoplasms; Skin Transplantation; Tetradecanoylphorbol Acetate | 1992 |
Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Topics: Animals; Anticarcinogenic Agents; Cyclooctanes; Dioxoles; Drugs, Chinese Herbal; Female; Inflammation; Lignans; Mice; Mice, Inbred ICR; Polycyclic Compounds; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Dietary energy and fat effects on tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dietary Fats; Energy Intake; Enzyme Activation; Epidermis; Female; Mice; Phosphatidylinositols; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Differential effects of dietary linoleic acid on mouse skin-tumor promotion and mammary carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dietary Fats; Dinoprostone; Fatty Acids; Female; Linoleic Acid; Linoleic Acids; Mammary Neoplasms, Experimental; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Further genetic analyses of skin tumor promoter susceptibility using inbred and recombinant inbred mice.
Topics: Animals; Chromosome Mapping; Crosses, Genetic; Dermatitis; Dose-Response Relationship, Drug; Epidermis; Hyperplasia; Mice; Mice, Inbred Strains; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1992 |
Antitumor-promoting activities of hydrolyzable tannins in mouse skin.
Topics: Animals; Antineoplastic Agents; Carcinoma; Enzyme Induction; Female; Hydrogen Peroxide; Hydrolyzable Tannins; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Hydrolyzable tannins: potent inhibitors of hydroperoxide production and tumor promotion in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Female; Hydrogen Peroxide; Mice; Skin; Skin Neoplasms; Tannins; Tetradecanoylphorbol Acetate | 1992 |
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benzo(a)pyrene; Edema; Enzyme Induction; Female; Flow Cytometry; Hydrogen Peroxide; Hyperplasia; Mice; Ornithine Decarboxylase; Phenols; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1992 |
Birth and death/differentiation rates of papillomas in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Cell Death; Cell Differentiation; Drug Administration Schedule; Likelihood Functions; Mice; Models, Biological; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Skin carcinomas and micronucleus induction in epidermal keratinocytes following 12-O-tetradecanoylphorbol-13-acetate and mezerein treatment.
Topics: Animals; Carcinogens; Diterpenes; Female; Keratinocytes; Kinetics; Mice; Micronucleus Tests; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1992 |
Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives.
Topics: Animals; Catechin; Chromatography, High Pressure Liquid; Enzyme Induction; Female; Mice; Ornithine Decarboxylase Inhibitors; Plant Extracts; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1992 |
Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Codon; Diglycerides; Female; Genes, ras; Immune Sera; Isoenzymes; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Papilloma; Peptides; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Toxicodynamics of tumour promoters of mouse skin. II. Binding to protein kinase C of some new diterpene esters and induction of luminol-enhanced chemoluminescence in mouse peritoneal neutrophils.
Topics: Animals; Binding Sites; Binding, Competitive; Carcinogens; Diterpenes; Dose-Response Relationship, Drug; Esters; Female; Kinetics; Luminescent Measurements; Luminol; Mice; Neutrophils; Oxygen; Peritoneal Cavity; Protein Kinase C; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Effects of dietary calcium and vitamin D3 on tumor promotion in mouse skin.
Topics: Animals; Calcium, Dietary; Cholecalciferol; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Effect of tumor-promoting agents on density and morphometric parameters of mouse epidermal Langerhans and Thy-1+ cells.
Topics: Alkanes; Animals; Anthralin; Antigens, Surface; Carcinogens; Cell Count; Dendritic Cells; Epidermis; Female; Langerhans Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thy-1 Antigens | 1991 |
Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro.
Topics: Alkaloids; Animals; Carcinogenicity Tests; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Induction; Epidermal Growth Factor; Keratinocytes; Mice; Mice, Inbred BALB C; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; RNA, Messenger; Skin Neoplasms; Staurosporine; Tetradecanoylphorbol Acetate; Transglutaminases; Tumor Cells, Cultured | 1991 |
Metastatic potential of mouse skin carcinomas produced by different protocols of chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; DNA, Neoplasm; Female; gamma-Glutamyltransferase; Lung Neoplasms; Methylnitronitrosoguanidine; Mice; Neoplasm Metastasis; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Tissue-specific expression of murine keratin K13 in internal stratified squamous epithelia and its aberrant expression during two-stage mouse skin carcinogenesis is associated with the methylation state of a distinct CpG site in the remote 5'-flanking reg
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinoma, Squamous Cell; Deoxyribonuclease I; DNA, Neoplasm; Epithelial Cells; Epithelium; Female; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Keratins; Methylation; Mice; Molecular Sequence Data; Nucleotides; Organ Specificity; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
TGF-beta 1 and skin carcinogenesis: antiproliferative effect in vitro and TGF-beta 1 mRNA expression during epidermal hyperproliferation and multistage tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Blotting, Northern; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA Replication; DNA, Neoplasm; Female; Gene Expression; Keratinocytes; Mice; Mice, Inbred Strains; Phorbol Esters; RNA; RNA, Messenger; RNA, Neoplasm; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1991 |
Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinoma, Squamous Cell; Gene Expression Regulation, Neoplastic; Keratins; Mice; Molecular Sequence Data; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Parathyroid hormone-related protein, chromogranin A, and calcitonin gene products in the neuroendocrine skin carcinoma cell lines MKL1 and MKL2.
Topics: Bombesin; Calcitonin; Calcitonin Gene-Related Peptide; Chromogranin A; Chromogranins; Humans; Microscopy, Electron; Neurosecretory Systems; Parathyroid Hormone-Related Protein; Proteins; Skin Neoplasms; Substance P; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1991 |
Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Division; Female; Gene Expression Regulation, Neoplastic; Keratinocytes; Keratins; Male; Mice; Mice, Hairless; Microscopy, Fluorescence; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
v-Ha-ras-induced mouse skin papillomas exhibit aberrant expression of keratin K13 as do their 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate -induced analogues.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Blotting, Western; Fluorescent Antibody Technique; Gene Expression; Genes, ras; Keratinocytes; Keratins; Methylation; Mice; Molecular Sequence Data; Oligonucleotides; Oncogene Protein p21(ras); Oncogene Proteins v-fos; Papilloma; RNA, Messenger; Skin Neoplasms; Skin Transplantation; Tetradecanoylphorbol Acetate | 1991 |
The chlorinated pesticide mirex is a novel nonphorbol ester-type tumor promoter in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Hyperplasia; Mice; Mice, Inbred Strains; Mirex; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Status of ornithine decarboxylase activity and DNA synthesis in mancozeb-exposed mouse skin.
Topics: Animals; Cycloheximide; DNA; Female; Fungicides, Industrial; Maneb; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Zineb | 1992 |
Transplacental and transgeneration carcinogenic effect of 7,12-dimethylbenz[a]anthracene: relationship with ras oncogene activation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Fetus; Gene Expression Regulation; Genes, ras; Lung Neoplasms; Male; Mice; Mutation; Neoplasms, Experimental; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate.
Topics: Alkynes; Animals; Carcinogens; Diterpenes; Enzyme Induction; Epidermis; Female; Flow Cytometry; Immunohistochemistry; Mice; Ornithine Decarboxylase; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1992 |
Prevalence of tumor prevention rather than tumor enhancement when repetitive UV radiation treatments precede initiation and promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinoma; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1992 |
Comparative tumor-initiating ability of 7H-dibenzo(c,g)carbazole and dibenz(a,j)acridine in mouse skin.
Topics: Acetone; Acridines; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Female; Mice; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drinking; Female; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1992 |
Enhanced induction of epidermal ornithine decarboxylase activity in C57BL/6 compared to DBA/2 mice by protein kinase C-activating skin tumor promoters: relevance to genetically mediated differences in promotion susceptibility.
Topics: Animals; Anthracenes; Carcinogens; Cluster Analysis; Disease Susceptibility; Enzyme Activation; Female; Genetic Predisposition to Disease; Lyngbya Toxins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Ornithine Decarboxylase; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |
Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part I: Quantitation of superoxide dismutase, catalase, glutathione peroxidase
Topics: Administration, Topical; Animals; Carcinoma, Squamous Cell; Catalase; Female; Glutathione Peroxidase; Mice; Mice, Inbred Strains; Oxygen; Papilloma; Phenotype; Skin; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Xanthine Dehydrogenase; Xanthine Oxidase | 1991 |
All-trans retinoic acid protects against conversion of chemically induced and ultraviolet B radiation-induced skin papillomas to carcinomas.
Topics: Animals; Carcinoma; Female; Mice; Neoplasms, Radiation-Induced; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Ultraviolet Rays | 1991 |
Assessment of the antioxidant/prooxidant status of murine skin following topical treatment with 12-O-tetradecanoylphorbol-13-acetate and throughout the ontogeny of skin cancer. Part II: Quantitation of glutathione and glutathione disulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Administration, Topical; Aging; Animals; Carcinoma, Squamous Cell; Epidermis; Female; Glutathione; Glutathione Disulfide; Mice; Oxidation-Reduction; Oxygen; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Cancer promotion in a mouse-skin model by a 60-Hz magnetic field: I. Experimental design and exposure system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Electromagnetic Fields; Environmental Exposure; Mice; Research Design; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Cancer promotion in a mouse-skin model by a 60-Hz magnetic field: II. Tumor development and immune response.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Electromagnetic Fields; Female; Killer Cells, Natural; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Coculture of neoplastic and normal keratinocytes as a model to study tumor promotion.
Topics: Animals; Calcium; Cell Communication; Cells, Cultured; Keratinocytes; Mice; Mice, Inbred BALB C; Models, Biological; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of mouse skin tumor promotion by tenuazonic acid.
Topics: Administration, Topical; Animals; Body Weight; Enzyme Induction; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Skin; Skin Neoplasms; Tenuazonic Acid; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papilloma by saponins.
Topics: Animals; Female; Herpesvirus 4, Human; Mice; Mice, Inbred ICR; Papilloma; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Virus Activation | 1991 |
Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: expanded role for electrophiles in multistage carcinogenesis.
Topics: Animals; Biotransformation; Butylated Hydroxytoluene; Cytosol; Electron Spin Resonance Spectroscopy; Female; Free Radicals; Keratinocytes; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Peroxides; Quinones; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Toxicokinetics of tumour promoters of mouse skin. II. Metabolism of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin and biological activities of metabolites.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; Female; Irritants; Male; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Sterol and triterpene derivatives from plants inhibit the effects of a tumor promoter, and sitosterol and betulinic acid inhibit tumor formation in mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Betulinic Acid; Female; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Pentacyclic Triterpenes; Phytosterols; Sitosterols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 1991 |
Promoter independence as a feature of most skin papillomas in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Genes, ras; Mice; Mutation; Neoplasm Regression, Spontaneous; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinoma; Corn Oil; Dinoprostone; Female; Linoleic Acid; Linoleic Acids; Mice; Mice, Inbred DBA; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
The potent anti-tumor-promoting agent isoliquiritigenin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Aldehyde Reductase; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 5-Lipoxygenase; Benz(a)Anthracenes; Blood Platelets; Chalcone; Chalcones; Dermatitis, Contact; Enzyme Induction; Female; Mice; Mice, Inbred Strains; Neutrophils; Ornithine Decarboxylase; Phospholipases A; Phospholipases A2; Prostaglandins; Skin; Skin Neoplasms; Sonication; Tetradecanoylphorbol Acetate | 1991 |
Evidence for a common genetic pathway controlling susceptibility to mouse skin tumor promotion by diverse classes of promoting agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Benzoyl Peroxide; DNA; Dose-Response Relationship, Drug; Edema; Female; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1991 |
Influence of diet and calorie restriction on the initiation and promotion of skin carcinogenesis in the SENCAR mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Carcinoma; Cocarcinogenesis; Diet; Energy Intake; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Urethan (ethyl carbamate) is an effective promoter of 7,12-dimethylbenz[a]anthracene-induced carcinogenesis in mouse skin two-stage experiments.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Cocarcinogenesis; Female; Lung Neoplasms; Male; Mice; Mice, Hairless; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1991 |
Effect of dietary arginine restriction upon ornithine and polyamine metabolism during two-stage epidermal carcinogenesis in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arginine; DNA; Female; Mice; Ornithine; Ornithine Decarboxylase; Papilloma; Polyamines; Putrescine; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Inhibitory effects of new types of biflavonoid-related polyphenols; lophirone A and lophiraic acid, on some tumor promoter-induced biological responses in vitro and in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrans; Cocarcinogenesis; Enzyme Activation; Female; Flavonoids; Inflammation; Male; Mice; Mice, Inbred ICR; Papilloma; Phenols; Polymers; Protein Kinase C; Rats; Rats, Inbred WKY; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of chemically-induced skin carcinogenesis in mice by peanut oil preparations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Arachis; Benzo(a)pyrene; Female; Male; Mice; Mice, Inbred C3H; Ornithine Decarboxylase; Plant Oils; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
The role of chronic acanthosis and subacute inflammation in tumor promotion in CD-1 mice by petroleum middle distillates.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acanthosis Nigricans; Administration, Topical; Animals; Body Weight; Carcinogens; Chronic Disease; Cocarcinogenesis; Dexamethasone; Dose-Response Relationship, Drug; Inflammation; Kerosene; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Tumor progression of murine epidermal cells after treatment in vitro with 12-O-tetradecanoylphorbol-13-acetate or retinoic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Synergism; Mice; Mice, Inbred BALB C; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1991 |
Pendolmycin, a new tumor promoter of the teleocidin A class on skin of CD-1 mice.
Topics: Alkaloids; Animals; Carcinogens; Enzyme Activation; Female; Indoles; Lactams; Lyngbya Toxins; Mice; Mice, Inbred Strains; Protein Kinase C; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Base Sequence; Chromosome Mapping; DNA Probes; Genotype; Globins; Heterozygote; Mice; Mice, Inbred Strains; Mitosis; Molecular Sequence Data; Oligonucleotide Probes; Papilloma; Polymerase Chain Reaction; Recombination, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Cepharanthine inhibits two-stage tumor promotion by 12-O-tetradecanoylphorbol 13-acetate and mezerein on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Alkaloids; Animals; Benzylisoquinolines; Carcinogens; Diterpenes; Drug Interactions; Enzyme Induction; Female; Immunity, Cellular; Mice; Mice, Inbred ICR; Ornithine Decarboxylase; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1991 |
[Presence of specific mutation of Ha-ras oncogene in skin tumors of mice induced under different experimental conditions].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Codon; Female; Genes, ras; Male; Mice; Mutation; Papilloma; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Guanosine Triphosphate; Mice; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Papilloma; Polyamines; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Effects of N-acyl dehydroalanines on phorbol ester-elicited tumor development and other events in mouse skin.
Topics: Alanine; Animals; Cells, Cultured; Dinoprostone; Female; Free Radical Scavengers; Hyperplasia; Luminescent Measurements; Mice; Ornithine Decarboxylase; Oxygen; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Tumor-promoting activity of ethyl phenylpropiolate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkynes; Animals; Carcinogens; Down-Regulation; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
The effect of the level of dietary corn oil on mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Capillary Permeability; Cocarcinogenesis; Corn Oil; Dietary Fats; Dinoprostone; Fatty Acids; Female; Hyperplasia; Mice; Ornithine Decarboxylase; Phospholipids; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted skin tumor formation in mice by 16 alpha-fluoro-5-androsten-17-one and its reversal by deoxyribonucleosides.
Topics: Androstenes; Animals; Body Weight; Deoxyribonucleosides; Drug Interactions; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Transformation of mouse skin endothelial cells in vivo by direct application of plasmid DNA encoding the human T24 H-ras oncogene.
Topics: Animals; Base Sequence; Blotting, Southern; Cell Transformation, Neoplastic; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Genes, ras; Humans; Mice; Mice, Inbred Strains; Molecular Sequence Data; Neoplasms, Experimental; Plasmids; Polymerase Chain Reaction; Precipitin Tests; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Effect of ascorbic acid and its synthetic lipophilic derivative ascorbyl palmitate on phorbol ester-induced skin-tumor promotion in mice.
Topics: Animals; Ascorbic Acid; Diet; DNA; Epidermis; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Osmolar Concentration; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of 12-O-tetradecanoyl phorbol-13-acetate promoted tumorigenesis by cepharanthine, a biscoclaurine alkaloid, in relation to the inhibitory effect on protein kinase C.
Topics: Alkaloids; Animals; Benzylisoquinolines; Cytosol; Drug Interactions; Enzyme Activation; Female; Histones; Mice; Phospholipids; Phosphorylation; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Modulation of tumor promotion in mouse skin by the food additive citral (3,7-dimethyl-2,6-octadienal).
Topics: Acyclic Monoterpenes; Administration, Topical; Animals; Dose-Response Relationship, Drug; Female; Mice; Monoterpenes; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Vitamin A | 1991 |
Carcinogenicity study of fecapentaene-12 diacetate on skin painting in SENCAR mice.
Topics: Adult; Animals; Drug Combinations; Female; Humans; Mice; Mutagens; Papilloma; Polyenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin E | 1991 |
Evidence for autocrine/paracrine growth stimulation by transforming growth factor-alpha during the process of skin tumor promotion.
Topics: Animals; Anthracenes; Binding, Competitive; Carcinogens; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; Mice; Protein Kinase C; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1991 |
[The effect of the irradiation of male mice on the sensitivity of 2 generations of progeny to the action of the skin tumor promoter 12-0-tetradecanoylphorbol-13-acetate].
Topics: Acetone; Animals; Disease Susceptibility; Fathers; Female; Male; Mice; Skin Neoplasms; Testis; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Initiating activity of eight pyrolysates of carbohydrates in a two-stage mouse skin tumorigenesis model.
Topics: Animals; Carbohydrates; Disease Models, Animal; Female; Hot Temperature; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Benzo[a]pyrene-induced skin damage and tumor promotion in the mouse.
Topics: Animals; Benzo(a)pyrene; Cell Division; DNA; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred ICR; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Modulation of the co-promoting activity of gamma interferon in SENCAR and C57BL/6 mouse skin by difluoromethylornithine and the scheduling and duration of interferon treatment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Eflornithine; Female; Interferon-gamma; Kinetics; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Recombinant Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chamomile; Cocarcinogenesis; Dose-Response Relationship, Drug; Enzyme Induction; Epidermis; Flavonoids; Mice; Oils, Volatile; Ornithine Decarboxylase; Papilloma; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Sensitivity of subpopulations of mouse skin papillomas to malignant conversion by urethane or 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Survival Analysis; Tetradecanoylphorbol Acetate; Time Factors; Urethane | 1990 |
Induction of cutaneous mast cell tumors by N-methyl-N'-nitro-N-nitrosoguanidine followed by TPA in female mice of 4 out of 5 strains tested.
Topics: Animals; Cell Aggregation; Cocarcinogenesis; Female; Mast Cells; Mast-Cell Sarcoma; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1990 |
Anti-tumor promoting action of phthalic acid mono-n-butyl ester cupric salt, a biomimetic superoxide dismutase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Antineoplastic Agents; Benz(a)Anthracenes; Cells, Cultured; Dermatitis, Contact; Dibutyl Phthalate; Ear Diseases; Edema; Enzyme Induction; Epidermal Cells; Epidermis; Female; Mice; Ornithine Decarboxylase; Papilloma; Phthalic Acids; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1990 |
Comparison of the effects of bilobol and 12-O-tetradecanoylphorbol-13-acetate on skin, and test of tumor promoting potential of bilobol in CD-1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Irritants; Mice; Resorcinols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Effects of beta-carotene on chemically-induced skin tumors in HRA/Skh hairless mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Body Weight; Carotenoids; Diet; Female; Mice; Mice, Hairless; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Antitumor activity in skin of Skh and Sencar mice by two dietary beta-carotene formulations.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Body Weight; Carotenoids; Diet; Female; Food, Fortified; Mice; Mice, Inbred Strains; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capillary Permeability; Cimetidine; Diphenhydramine; Female; Indomethacin; Inflammation; Masoprocol; Mice; Mice, Inbred Strains; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Mouse skin ornithine decarboxylase induction and tumor promotion by cyclohexane.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Cyclohexanes; Cycloheximide; Environmental Exposure; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Protein Biosynthesis; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
S/RV Cri-ba, a hairless mouse strain sensitive to skin tumorigenesis by suboptimal doses of 7,12-dimethylbenz[a]anthracene, initiation-promotion and two stage promotion protocols.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Cocarcinogenesis; Diterpenes; Dose-Response Relationship, Drug; Female; Mice; Mice, Hairless; Papilloma; Phorbol Esters; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1990 |
Differential effects of various skin tumor-promoting agents on prostaglandin E2 release from primary cultures of mouse epidermal cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carcinogens; Cells, Cultured; Dinoprostone; Enzyme Activation; Macrophages; Mice; Protein Kinase C; Radioimmunoassay; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Morphometric evaluation of dark and clear epidermal basal cells during early 2-stage chemical skin carcinogenesis in the hairless mouse using two different fixation methods.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Membrane; Cell Nucleus; Cocarcinogenesis; Cytoplasm; Desmosomes; Epidermis; Extracellular Space; Fixatives; Keratinocytes; Mice; Mice, Mutant Strains; Microscopy, Electron; Mitochondria; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Genetics of chemical carcinogenesis. 1. Bidirectional selective breeding of susceptible and resistant lines of mice to two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crosses, Genetic; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Immunity, Innate; Male; Mice; Mice, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
Papilloma and carcinoma production in DMBA-initiated, onion oil-promoted mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Allium; Animals; Carcinoma; Cell Transformation, Neoplastic; Female; Garlic; Mice; Papilloma; Plant Oils; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Increased sensitivity to two-stage skin carcinogenesis of mice heterozygous for the repeated epilation mutation (Er).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hair Removal; Heterozygote; Male; Mice; Mice, Inbred BALB C; Mutation; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Elevated expression of secondary, but not early, responding genes to phorbol ester tumor promoters in papillomas and carcinomas of mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Northern; Carcinogens; Carcinoma; Female; Gene Expression; Metallothionein; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Osteopontin; Papilloma; Proto-Oncogene Proteins; RNA, Messenger; Sialoglycoproteins; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tubulin; Urokinase-Type Plasminogen Activator | 1990 |
Effects of 2-phenyl-1,4-benzoquinone and 2,5-dihydroxybiphenyl on two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoquinones; Biphenyl Compounds; Epidermis; Female; Hydroquinones; Incidence; Mice; Mice, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Evidence that weak promotion of carcinogen-initiated cells prevents their progression to malignancy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoflavones; Benzyl Alcohols; Cell Transformation, Neoplastic; Cortisone; Dose-Response Relationship, Drug; Indoles; Mice; Mice, Inbred BALB C; Papilloma; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin E | 1990 |
Suppression of footpad reaction in mice by anthralin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthralin; Erythrocytes; Hindlimb; Hypersensitivity, Delayed; Isoantibodies; Male; Mice; Mice, Inbred BALB C; Skin Neoplasms; Spleen; Tetradecanoylphorbol Acetate | 1990 |
Oxidation of polycyclic hydrocarbons by oxygen radicals.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; DNA; DNA Damage; Female; Free Radicals; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Oxidation-Reduction; Polycyclic Compounds; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Nicotinamide and nicotinamide analogues as antitumor promoters in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminobenzoates; Animals; Antineoplastic Agents; Benzamides; Benzoates; Benzoic Acid; Cell Division; Clone Cells; DNA Replication; Female; Keratinocytes; Kinetics; meta-Aminobenzoates; Mice; Mice, Inbred Strains; Niacinamide; Papilloma; Poly(ADP-ribose) Polymerase Inhibitors; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Absence of papillomavirus in skin tumors induced in SENCAR mice by a two-stage carcinogenesis protocol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Viral; DNA, Viral; Female; Mice; Papilloma; Papillomaviridae; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Antitumor-promoting activity of sesquiterpene isolated from an herbal spice.
Topics: Aldehydes; Animals; Condiments; Herpesvirus 4, Human; Humans; Japan; Mice; Papilloma; Sesquiterpenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Activation | 1990 |
Studies on the anti-tumor-promoting activity of naturally occurring substances. IV. Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, inhibits the promotion of skin tumor formation by 12-O-tetradecanoylphorbol-13-acetate in 7,12-dimethylben
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Cell Line; Coumarins; Drugs, Chinese Herbal; Female; HeLa Cells; Herpesvirus 4, Human; Humans; Mice; Mice, Inbred ICR; Phosphates; Phospholipids; Skin Neoplasms; Tetradecanoylphorbol Acetate; Virus Activation | 1990 |
Anti-tumor-promoting activity of derivatives of abieslactone, a natural triterpenoid isolated from several Abies genus.
Topics: Animals; Carcinogens; Female; HeLa Cells; Lactones; Mice; Mice, Inbred ICR; Phospholipids; Skin Neoplasms; Tetradecanoylphorbol Acetate; Trees; Triterpenes | 1990 |
Fluorine probes for investigating the mechanism of activation of indeno[1,2,3-cd]pyrene to a tumorigenic agent.
Topics: Animals; Carcinogenicity Tests; DNA, Neoplasm; Female; Fluorine; Mice; Neoplasms, Experimental; Pyrenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Genes, ras; Keratinocytes; Mice; Mice, Inbred Strains; Mice, Transgenic; Plasmids; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1990 |
Inhibition of mouse skin tumor promotion by adriamycin and daunomycin in combination with verapamil or palmitoylcarnitine.
Topics: Animals; Daunorubicin; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Palmitoylcarnitine; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Verapamil | 1990 |
Embryonic mutation as a possible cause of in utero carcinogenesis in mice revealed by postnatal treatment with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Dose-Response Relationship, Radiation; Embryo, Mammalian; Female; Liver Neoplasms, Experimental; Mice; Mutation; Neoplasms, Radiation-Induced; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate; X-Rays | 1990 |
Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis.
Topics: Animals; Animals, Newborn; Cell Cycle; Cell Division; Cells, Cultured; Hair; Mice; Mice, Inbred Strains; Microscopy, Electron; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine | 1990 |
Identification of epidermal cell subpopulations with increased ornithine decarboxylase activity following treatment of murine epidermis with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cells, Cultured; Epidermal Cells; Epidermis; Female; Flow Cytometry; Mice; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Differential down-regulation of epidermal protein kinase C by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol: association with epidermal hyperplasia and tumor promotion.
Topics: Acetone; Animals; Diglycerides; Down-Regulation; Female; Glycerides; Hyperplasia; Mice; Papilloma; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Organization and disorganization of actin filaments in human epidermal keratinocytes: heat-shock treatment and recovery process.
Topics: Actin Cytoskeleton; Actins; Arsenic; Arsenites; Cytoskeleton; Epidermal Cells; Gene Expression Regulation; Heat-Shock Proteins; Hot Temperature; Humans; Keratinocytes; Skin Neoplasms; Sodium Compounds; Tetradecanoylphorbol Acetate | 1990 |
Lack of a protective effect of menhaden oil on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Antineoplastic Agents; Carcinoma; Dietary Fats; Energy Intake; Fatty Acids; Female; Fish Oils; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Carcinoma; Female; Fluocinolone Acetonide; Gene Expression Regulation; Keratins; Mice; Molecular Weight; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on phospholipid metabolism of human epidermal keratinocytes in culture.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cells, Cultured; Choline; Enzyme Activation; Epidermal Cells; Epidermis; Fetal Blood; Humans; Hydrocortisone; Keratins; Phospholipases; Phospholipids; Prostaglandins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tritium | 1986 |
Heterogeneity of ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors.
Topics: Animals; Enzyme Induction; Epidermal Cells; Epidermis; Female; Keratins; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Human melanocytes cultured from nevi and melanomas.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Cell Division; Cell Separation; Cells, Cultured; Child; Cholera Toxin; Female; Humans; Infant, Newborn; Male; Melanocytes; Melanoma; Middle Aged; Nevus; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dose-Response Relationship, Drug; Enzyme Induction; Female; Histamine Release; Histidine Decarboxylase; Irritants; Lactones; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Plant Extracts; Sesquiterpenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thapsigargin; Tritium | 1986 |
Elevated expression of Ha-ras is an early event in two-stage skin carcinogenesis in SENCAR mice.
Topics: Animals; Female; Gene Amplification; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; Papilloma; Poly A; Proto-Oncogenes; RNA; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Distribution, covalent binding, and DNA adduct formation of 7,12-dimethylbenz(a)anthracene in SENCAR and BALB/c mice following topical and oral administration.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; DNA; Mice; Mice, Inbred BALB C; Protein Binding; RNA; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1987 |
Specific alterations in keratin biosynthesis in mouse epidermis in vivo and in explant culture following a single exposure to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Differentiation; Cell Division; Electrophoresis, Polyacrylamide Gel; Epidermis; Female; Keratins; Mice; Molecular Weight; Organ Culture Techniques; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Carcinoma; Cell Transformation, Neoplastic; Female; Gene Expression Regulation; Genes; Keratins; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; gamma-Glutamyltransferase; Immunoenzyme Techniques; Keratins; Metaphase; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Early signals for keratinocyte differentiation: role of Ca2+-mediated inositol lipid metabolism in normal and neoplastic epidermal cells.
Topics: Animals; Calcimycin; Calcium; Cell Differentiation; Cells, Cultured; Choline; Epidermal Cells; Epidermis; Ethers; Inositol; Ionomycin; Keratins; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Quantitation of primary in vitro clonogenic keratinocytes from normal adult murine epidermis, following initiation, and during promotion of epidermal tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Colony-Forming Units Assay; Epidermis; Female; Keratins; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Stem Cell Assay | 1988 |
Histologic alterations produced by chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone) in SENCAR mouse skin: relationship to skin tumor promoting activity.
Topics: Administration, Cutaneous; Animals; Anthracenes; Carcinogens; Female; Hyperplasia; Keratins; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Gap-junctional intercellular communication in epidermal cell lines from selected stages of SENCAR mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Calcium; Cell Communication; Cell Line; Epidermis; Intercellular Junctions; Keratins; Mice; Microinjections; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Correlation between cell-cell contact formation and activation of protein kinase C in a human squamous cell carcinoma cell line.
Topics: Calcium; Carcinoma, Squamous Cell; Cell Communication; Enzyme Activation; Humans; Intermediate Filaments; Keratins; Osmolar Concentration; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
The influence of fixation on the relative amount of cytoplasmic ribosomes in mouse epidermal basal keratinocytes. A morphometric study of so-called "dark cells" and their putative role in epidermal carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cytoplasm; Epidermal Cells; Epidermis; Female; Fixatives; Keratins; Male; Mice; Mice, Hairless; Microscopy, Electron; Ribosomes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Dietary fat effects on the initiation and promotion of two-stage skin tumorigenesis in the SENCAR mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Dietary Fats; Energy Intake; Female; Genes, ras; Mice; Papilloma; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Daunorubicin; DNA; Doxorubicin; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; RNA; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Trifluoperazine; Verapamil | 1989 |
Multistage chemical carcinogenesis protocols produce spindle cell carcinomas of the mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Western; Carcinoma; Drug Administration Schedule; Immunoenzyme Techniques; Keratins; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Induction of terminal differentiation-resistant epidermal cells in mouse skin and in papillomas by different initiators during two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Epidermal Cells; Female; Methylnitronitrosoguanidine; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Tumor copromoting activity of gamma-interferon in the murine skin multistage carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Interferon-gamma; Mice; Papilloma; Recombinant Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Roussin red methyl ester, a tumor promoter isolated from pickled vegetables.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Esophageal Neoplasms; Nitroso Compounds; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Vegetables | 1989 |
Tumor prevention by a xanthate compound in experimental mouse-skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Cutaneous; Animals; Antineoplastic Agents; Antiviral Agents; Bridged-Ring Compounds; Carcinoma; Dose-Response Relationship, Drug; Female; Mice; Norbornanes; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones | 1989 |
Dose and frequency effect in mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dose-Response Relationship, Drug; Female; Mice; Papilloma; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate | 1989 |
Tumor induction in initiated mouse skin by phorbol esters and methyl methanesulfonate: correlation between chromosomal damage and conversion ('stage I of tumor promotion') in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chromosome Aberrations; Female; Methyl Methanesulfonate; Mice; Phorbol Esters; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Further characterization of skin tumor promotion and progression by mezerein in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Diterpenes; DNA; Female; Mice; Papilloma; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Acceleration of papilloma growth in mice fed high-fat diets during promotion of two-stage skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Sodium o-phenylphenate (OPP-Na) promotes skin carcinogenesis in CD-1 female mice initiated with 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biphenyl Compounds; Carcinoma; Drug Synergism; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Antitumor-promoting activity of garlic extracts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Garlic; HeLa Cells; Mice; Mice, Inbred ICR; Phospholipids; Phosphorus Radioisotopes; Plant Extracts; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Effects of oral versus topical administration of cyclosporine on phorbol ester promotion of murine epidermal carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Administration, Topical; Animals; Carcinoma, Squamous Cell; Cyclosporins; Hyperplasia; Male; Mice; Neutrophils; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Regulation of ornithine decarboxylase in normal and neoplastic mouse and human epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Chromatography, Gel; Epidermis; Female; Humans; Kinetics; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Model systems for defining initiation, promotion, and progression of skin neoplasms.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Cell Division; Cocarcinogenesis; Cricetinae; Disease Models, Animal; Hyperplasia; Inflammation; Mesocricetus; Mice; Mutagenicity Tests; Neoplasms, Radiation-Induced; Salmonella typhimurium; Skin; Skin Neoplasms; Solvents; Species Specificity; Tetradecanoylphorbol Acetate; Turpentine; Ultraviolet Rays | 1989 |
Tumor initiation in mouse skin by cutting oils.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Hyperplasia; Industrial Oils; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Inhibition of initiator-promoter-induced skin tumorigenesis in female SENCAR mice fed a vitamin A-deficient diet and reappearance of tumors in mice fed a diet adequate in retinoid or beta-carotene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Carotenoids; Cocarcinogenesis; Diet; Female; Liver; Male; Mice; Neoplasms, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A Deficiency; Weight Loss | 1989 |
Malignant conversion of UV radiation and chemically induced mouse skin benign tumors by free-radical-generating compounds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Amidines; Animals; Benzoyl Peroxide; Carcinogens; Cell Transformation, Neoplastic; Female; Free Radicals; Mice; Mice, Hairless; Mice, Inbred Strains; Neoplasms, Radiation-Induced; Papilloma; Peroxides; Skin; Skin Diseases; Skin Neoplasms; tert-Butylhydroperoxide; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1989 |
Comparison of octahydromezerein and mezerein as protein kinase C activators and as mouse skin tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diterpenes; Enzyme Activation; Female; Hyperplasia; Mice; Mice, Inbred Strains; Papilloma; Protein Kinase C; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Increased tumour incidence and skin tumour promotion in two generations of descendants of 7,12-dimethylbenz[a]anthracene-treated pregnant mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Male; Mice; Neoplasms, Experimental; Pedigree; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Tumor associated proteins of rat skin tumor induced by 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Surface; Carcinoma, Squamous Cell; Cell Membrane; Glycoproteins; Membrane Proteins; Papilloma; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Biological assays for irritant, tumor-initiating and tumor-promoting activities. II. Standardized initiation/promotion protocol and semiquantitative estimation of promoting (or initiating) potencies in skin of NMRI mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenicity Tests; Cocarcinogenesis; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Inhibition of 7,12-dimethylbenz[a]anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin papilloma formation in mice by dehydroepiandrosterone and two synthetic analogs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Body Weight; Dehydroepiandrosterone; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1989 |
Biological activities and cellular uptake studies of fluorescent derivatives of indole alkaloid tumor promoter teleocidin.
Topics: Animals; Antigens, Viral; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Chemical Phenomena; Chemistry, Physical; Enzyme Activation; Female; Fluorescent Dyes; HeLa Cells; Herpesvirus 4, Human; Humans; Lyngbya Toxins; Mice; Protein Kinase C; Receptors, Drug; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Differential inhibition by staurosporine, a potent protein kinase C inhibitor, of 12-O-tetradecanoylphorbol-13-acetate-caused skin tumor promotion, epidermal ornithine decarboxylase induction, hyperplasia and inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Edema; Enzyme Induction; Female; Hyperplasia; Inflammation; Kinetics; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Protein Kinase C; Reference Values; Skin; Skin Neoplasms; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Effects of acyclovir on herpes simplex virus type 1 infection in mice treated with 12-O-tetradecanoylphorbol 13-acetate.
Topics: Acyclovir; Animals; Antibodies, Viral; Female; Lip Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Simplexvirus; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Virus Infections | 1989 |
Induction of metallothionein mRNA by tumor promoters in mouse skin and its constitutive expression in papillomas.
Topics: Administration, Topical; Animals; Carcinogens; Cholecalciferol; Female; Gene Expression Regulation; Metallothionein; Mice; Mice, Inbred C57BL; Papilloma; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin | 1989 |
Inhibition by lipoxygenase inhibitors of 7-bromomethylbenz[a]anthracene-caused epidermal ornithine decarboxylase induction and skin tumor promotion in mice.
Topics: Animals; Benz(a)Anthracenes; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Enzyme Induction; Epidermis; Lipoxygenase Inhibitors; Mice; Ornithine Decarboxylase; Quercetin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
[Anti-tumor promoting activities and inhibitory effects on Epstein-Barr virus activation of Shi-un-kou and its constituents].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Depression, Chemical; Drugs, Chinese Herbal; Female; Herpesvirus 4, Human; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Virus Activation | 1989 |
Activation of the cellular Harvey ras gene in mouse skin tumors initiated with urethane.
Topics: Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; Codon; DNA Probes; Gene Amplification; Genes, ras; Mice; Mutation; Papilloma; Polymorphism, Restriction Fragment Length; Proto-Oncogene Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Stem Cell Assay; Urethane | 1989 |
Development of phorbol ester responsiveness in neonatal mouse epidermis: correlation between hyperplastic response and sensitivity to first-stage tumor promotion.
Topics: Animals; DNA; Female; Hyperplasia; Keratins; Mice; Mice, Inbred Strains; Mitosis; Ornithine Decarboxylase; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
The first stage and complete promoting activity of retinoic acid but not the analog RO-10-9359.
Topics: Animals; Etretinate; Female; Keratins; Luminescent Measurements; Mice; Neutrophils; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
Detection of distinct transforming genes in X-ray induced tumors.
Topics: Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Mice; Mice, Inbred Strains; Neoplasms, Radiation-Induced; Oncogenes; Papilloma; Restriction Mapping; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; X-Rays | 1989 |
N-nitrosocimetidine as an initiator of murine skin tumors with associated H-ras oncogene activation.
Topics: Animals; Carcinogens; Cimetidine; Cocarcinogenesis; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, ras; Mice; Mutation; Skin Neoplasms; Survival Analysis; Tetradecanoylphorbol Acetate | 1989 |
Experimental analysis of the effects of cyclosporine on the induction and growth of epithelial tumors.
Topics: Adenoma; Administration, Oral; Administration, Topical; Animals; Carcinoma, Squamous Cell; Cell Division; Cyclosporins; Lung Neoplasms; Male; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1989 |
Stimulatory role of transforming growth factors in multistage skin carcinogenesis: possible explanation for the tumor-inducing effect of wounding in initiated NMRI mouse skin.
Topics: Animals; Cell Division; Cells, Cultured; Female; Kinetics; Mice; Mice, Inbred Strains; Phorbol Esters; Skin; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Wounds and Injuries | 1989 |
Synthetic lipid second messenger sn-1,2-didecanoylglycerol: a complete tumor promoter in mouse skin.
Topics: Animals; Carcinogens; Diglycerides; Diterpenes; Female; Glycerides; Mice; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Mouse skin papillomas as a stage in cancer progression.
Topics: Animals; Benzo(a)pyrene; Cell Division; Cocarcinogenesis; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Tumorigenic conversion of xeroderma pigmentosum lymphoblastoid cells without karyotypic alteration.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Humans; Karyotyping; Lymphocyte Transfusion; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Nude; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Stem Cell Assay; Ultraviolet Rays; Xeroderma Pigmentosum | 1989 |
Tumour initiatory activity of a herbicide diuron on mouse skin.
Topics: Animals; Cell Transformation, Neoplastic; Diuron; Dose-Response Relationship, Drug; Drug Synergism; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Correlation of phorbol ester promotion in the resistant C57BL/6J mouse with sustained hyperplasia but not ornithine decarboxylase or protein kinase C.
Topics: Animals; Carcinoma; Enzyme Induction; Hyperplasia; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase; Papilloma; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate.
Topics: Animals; Ditiocarb; Dose-Response Relationship, Drug; Female; Glutathione Peroxidase; Mice; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Analysis of the rasH oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Line; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; DNA, Neoplasm; Female; Mice; Oncogenes; Papilloma; Polymorphism, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 1987 |
Reactive oxygen in the tumor promotion stage of skin carcinogenesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cocarcinogenesis; Epidermis; Female; Luminescent Measurements; Male; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Oxygen; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Inhibitory effects of glutathione level-raising agents and D-alpha-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Amino Acids; Animals; Cysteine; Enzyme Induction; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutamates; Glutamic Acid; Glutathione; Glycine; In Vitro Techniques; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin E | 1985 |
Inhibition of epidermal terminal differentiation and tumour promotion by retinoids.
Topics: Acyltransferases; Animals; Antineoplastic Agents; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Induction; Epidermis; Growth Inhibitors; Mice; Mice, Inbred BALB C; Retinoids; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transglutaminases | 1985 |
Sequential study of gamma-glutamyltransferase during complete and two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell Differentiation; Female; gamma-Glutamyltransferase; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
TPA (12-O-tetradecanoyl-phorbol-13-acetate) as a carcinogen for mouse skin. A positive dose-response relationship.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Mice; Mice, Inbred Strains; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
The influence of different fixatives and a tumor promoter, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), on the induction of so-called dark cells in mouse epidermis. A light microscopical study.
Topics: Acetone; Animals; Carcinogens; Cocarcinogenesis; Fixatives; Mice; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
[The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion].
Topics: Acrylamides; Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cnidarian Venoms; Enzyme Activation; Humans; Lyngbya Toxins; Mice; Neoplasms, Experimental; Phorbols; Plant Extracts; Protein Kinase C; Receptors, Cell Surface; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thapsigargin | 1986 |
Malignant progression of mouse skin papillomas treated with ethylnitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine, or 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Ethylnitrosourea; Female; gamma-Glutamyltransferase; Methylnitronitrosoguanidine; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acrylamides; Animals; Carcinogens; Cnidarian Venoms; Enzyme Induction; Female; Lyngbya Toxins; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Cultivation and characterization of cells derived from mouse skin papillomas induced by an initiation-promotion protocol.
Topics: Animals; Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Cocarcinogenesis; Culture Media; Epidermal Cells; Female; Mice; Mice, Inbred Strains; Mice, Nude; Neoplasm Transplantation; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine; Transglutaminases | 1986 |
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.
Topics: Animals; Bryostatins; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Activation; Epidermal Growth Factor; Epidermis; Lactones; Macrolides; Mice; Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transglutaminases | 1987 |
Transplacental induction of a specific mutation in fetal Ha-ras and its critical role in post-natal carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinoma; Cocarcinogenesis; DNA, Neoplasm; Female; Mice; Mutation; Papilloma; Polymorphism, Restriction Fragment Length; Pregnancy; Prenatal Exposure Delayed Effects; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion).
Topics: Animals; Cocarcinogenesis; Dinoprost; Dinoprostone; Epidermis; Indomethacin; Mice; Papilloma; Phorbol Esters; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Tumour-promoting and hyperplastic effects of phorbol and daphnane esters in CD-1 mouse skin and a synergistic effect of calcium ionophore with the non-promoting activator of protein kinase C, sapintoxin A.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Diterpenes; Female; Hyperplasia; Phorbol Esters; Rats; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Antipromotional activity of dietary N-(4-hydroxyphenyl)retinamide in two-stage skin tumorigenesis in CD-1 and SENCAR mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diet; Drug Antagonism; Female; Fenretinide; Mice; Mice, Inbred Strains; Neoplasms, Multiple Primary; Phorbols; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Modulation of natural killer activity by 12-O-tetradecanoylphorbol-13-acetate and benzoyl peroxide in phorbol ester-sensitive (SENCAR) and resistant (B6C3F1) mice.
Topics: Administration, Topical; Animals; Benzoyl Peroxide; Drug Resistance; Immunity, Innate; Killer Cells, Natural; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred Strains; Peroxides; Phytohemagglutinins; Skin Neoplasms; Spleen; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 1988 |
Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Hydroxides; Hydroxyl Radical; Lipoxygenase Inhibitors; Mannitol; Mice; Phorbols; Skin Neoplasms; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Free Radicals; Lipoxygenase Inhibitors; Luminescent Measurements; Mice; Neutrophils; Phorbols; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Identification of cembratriene-4,6-diol as antitumor-promoting agent from cigarette smoke condensate.
Topics: Animals; Antigens, Viral; Antineoplastic Agents; Diterpenes; Female; Herpesvirus 4, Human; Mice; Nicotiana; Ornithine Decarboxylase; Plants, Toxic; Skin; Skin Neoplasms; Smoke; Tetradecanoylphorbol Acetate | 1985 |
Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; ErbB Receptors; Female; Glycyrrhetinic Acid; HeLa Cells; Lyngbya Toxins; Mice; Mice, Inbred ICR; Phorbols; Phospholipids; Phosphorus Radioisotopes; Quercetin; Receptors, Cell Surface; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Effects of anti-promoters and strain of mouse on tumor promoter-induced oxidants in murine epidermal cells.
Topics: Animals; Antioxidants; Diglycerides; Female; Free Radicals; Luminescent Measurements; Male; Mice; Mice, Inbred Strains; Neutrophils; Skin; Skin Neoplasms; Species Specificity; Superoxides; Tetradecanoylphorbol Acetate; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trifluoperazine | 1986 |
Cholera toxin, a potent inducer of epidermal hyperplasia but with no tumor promoting activity in mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cholera Toxin; Cocarcinogenesis; Cyclic AMP; Diterpenes; Enzyme Induction; Epidermis; Hyperplasia; Mice; Ornithine Decarboxylase; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1986 |
v-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis.
Topics: Animals; Carcinoma; Clone Cells; Cocarcinogenesis; Genes, Viral; Harvey murine sarcoma virus; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Oncogene Protein p21(ras); Oncogenes; Papilloma; RNA, Messenger; RNA, Neoplasm; RNA, Viral; Sarcoma Viruses, Murine; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Phorbol diacetate inhibits superoxide anion radical production and tumor promotion by mezerein.
Topics: Animals; Carcinogens; Diterpenes; Female; Free Radicals; Hyperplasia; Macrophages; Mice; Phorbol Esters; Skin; Skin Neoplasms; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1986 |
The probable role of superoxide produced by blast cells in leukaemic cutaneous spreading.
Topics: Acute Disease; Adult; Aged; Female; Humans; In Vitro Techniques; Leukemia; Leukemia, Myeloid, Acute; Male; Middle Aged; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1986 |
Epidermal changes following application of 7,12-dimethylbenz(a)anthracene and 12-O-tetradecanoylphorbol-13-acetate to human skin transplanted to nude mice studied with histological species markers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aged; Animals; Epidermis; Female; Humans; Hyperplasia; Male; Mice; Mice, Nude; Middle Aged; Skin Neoplasms; Skin Transplantation; Species Specificity; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1986 |
Inhibitory effect of toluene on tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Drug Antagonism; Male; Mice; Mice, Inbred C3H; Phorbols; Skin Neoplasms; Solvents; Tetradecanoylphorbol Acetate; Toluene | 1986 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and epidermal ornithine decarboxylase activity in mouse skin by palmitoylcarnitine.
Topics: Animals; Calcium; Carnitine; Dose-Response Relationship, Drug; Egtazic Acid; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Palmitoylcarnitine; Phorbols; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin.
Topics: 3-O-Methylglucose; 9,10-Dimethyl-1,2-benzanthracene; Animals; Berberine; Berberine Alkaloids; Biological Transport; Carcinogens; Cells, Cultured; Female; Fibroblasts; HeLa Cells; In Vitro Techniques; Lyngbya Toxins; Methylglucosides; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Phosphates; Phospholipids; Radioisotopes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and tumor promotion by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) in mouse skin.
Topics: Animals; Calcium; Calmodulin; Enzyme Induction; Female; Lyngbya Toxins; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Papilloma; Phorbols; Protein Kinase C; Skin; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate | 1986 |
Histogenesis of the intradermal melanocytic tumor in BDF1 mice induced by topical application of 9,10-dimethyl-1,2-benzanthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Melanocytes; Melanoma; Mice; Mice, Inbred Strains; Microscopy, Electron; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
[Factors controlling tumor promotion induced by TPA].
Topics: Animals; Benzoquinones; Enzyme Activation; Lipoxygenase Inhibitors; Mice; Ornithine Decarboxylase; Palmitoylcarnitine; Papilloma; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinones; Skin Neoplasms; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
Influence of the duration of topical 13-cis-retinoic acid treatment on inhibition of mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; DNA; Female; Isotretinoin; Mice; Mice, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1986 |
Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Cocarcinogenesis; Female; Free Radicals; Keratoacanthoma; Mice; Mice, Inbred Strains; Papilloma; Peroxides; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Three-stage tumorigenesis in mouse skin: DNA synthesis as a prerequisite for the conversion stage induced by TPA prior to initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; DNA; Female; Hydroxyurea; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Modulation of mouse skin tumor promotion by dietary 13-cis-retinoic acid and alpha-difluoromethylornithine.
Topics: Animals; Diet; Eflornithine; Female; Isotretinoin; Mice; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Inhibition of the prenatal dimethylbenz[a]anthracene-induced tumour initiation in mice by prior administration of 7,8-benzoflavone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Administration, Oral; Animals; Benzoflavones; Cocarcinogenesis; Female; Flavonoids; Lung Neoplasms; Mice; Neoplasms, Experimental; Papilloma; Pregnancy; Prenatal Exposure Delayed Effects; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
3-Amino-1-methyl-5H-pyrido[4,3-b]-indole initiates two-stage carcinogenesis in mouse skin but is not a complete carcinogen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carbolines; Carcinogens; Cocarcinogenesis; Dimethyl Sulfoxide; Female; Mice; Mice, Inbred Strains; Mutagens; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Modulation of phorbol ester receptors in mouse skin by application of quercetin.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Flavonoids; Lyngbya Toxins; Mice; Mice, Inbred Strains; Protein Kinase C; Quercetin; Receptors, Drug; Receptors, Immunologic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tritium | 1986 |
Experimental evidence that skin carcinogenesis is a multistep phenomenon.
Topics: Animals; Anthralin; Benzoyl Peroxide; Iodoacetates; Iodoacetic Acid; Lyngbya Toxins; Mice; Neoplasm Staging; Rabbits; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Retinoic acid enhancement of an early step in the transformation of mouse epidermal cells in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Dose-Response Relationship, Drug; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Hyperthermia and phorbol ester tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Female; Hyperthermia, Induced; Mice; Papilloma; Phorbols; Skin; Skin Neoplasms; Skin Temperature; Tetradecanoylphorbol Acetate | 1986 |
Role of cytoskeleton changes and expression of the H-ras oncogene during promotion of neoplastic transformation in mouse epidermal JB6 cells.
Topics: Actin Cytoskeleton; Animals; Cell Adhesion; Cell Line; Cytoskeleton; Drug Administration Schedule; Fibronectins; GTP-Binding Proteins; Intermediate Filaments; Mice; Muscle Proteins; Oncogene Proteins, Viral; Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tubulin; Vinculin | 1986 |
Cell-mediated immune response in mice during the two-step carcinogenesis experiment by 7,12-dimethylbenz(a)anthracene and 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens; Dinitrofluorobenzene; Erythrocytes; Female; Hypersensitivity, Delayed; Immunity, Cellular; Mice; Mice, Inbred ICR; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Inhibition and enhancement of skin tumors in mice by dimethyl sulfoxide depending on method of application.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Dimethyl Sulfoxide; Drug Interactions; Male; Mice; Skin Neoplasms; Solvents; Tetradecanoylphorbol Acetate | 1986 |
Altered expression of oncogenes in mouse epidermis following exposure to benzo(a)pyrene diol epoxides.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Transformation, Neoplastic; Dihydroxydihydrobenzopyrenes; DNA, Neoplasm; Female; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; Oncogenes; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects.
Topics: Animals; Benzoquinones; Chalcone; Chalcones; Enzyme Induction; Female; Lipoxygenase Inhibitors; Masoprocol; Mice; Ornithine Decarboxylase; Propiophenones; Protein Kinase C; Quercetin; Quinones; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Differential carcinogenic effects of intraperitoneal initiation with 7,12-dimethylbenz(a)anthracene or urethane and topical promotion with 12-O-tetradecanoylphorbol-13-acetate in skin and internal tissues of female SENCAR and BALB/c mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Cocarcinogenesis; Female; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate; Urethane | 1986 |
Tumorigenesis in athymic nude mouse skin by chemical carcinogens and ultraviolet light.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Disease Susceptibility; Ear Neoplasms; Ethylnitrosourea; Female; Heterozygote; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Radiation-Induced; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1987 |
Sebaceous adenomas with associated epidermal hyperplasia and papilloma formation as a major type of tumor induced in mouse skin by high doses of carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Carcinoma; Epidermis; Hyperplasia; Mice; Mice, Nude; Papilloma; Sebaceous Gland Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Skin tumor promotion is associated with increased type V collagen content in the dermis.
Topics: Animals; Calcimycin; Cell Transformation, Neoplastic; Collagen; Epidermis; Female; Mice; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Sequential studies of skin tumorigenesis in phosphoglycerate kinase mosaic mice: effect of resumption of promotion on regressed papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Mice; Mice, Inbred BALB C; Mosaicism; Papilloma; Phosphoglycerate Kinase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Promotion of skin tumours by TPA in the progeny of mice exposed pre-natally to DMBA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crosses, Genetic; Female; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Chronic 12-O-tetradecanoylphorbol-13-acetate treatment prevents restoration of collagen loss associated with its inflammatory effect on mouse skin.
Topics: Animals; Calcimycin; Collagen; Female; Mice; Phorbol Esters; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Carcinoma, Squamous Cell; Cell Nucleus; Mice; Mice, Inbred Strains; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Irritants; Mice; Ornithine Decarboxylase; Plant Oils; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thailand | 1987 |
Evaluation of epidermal cell kinetics following freezing or wounding of mouse skin and their potential as initiators of carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Cycle; Epidermal Cells; Female; Freezing; Hyperplasia; Mice; Mice, Inbred Strains; Skin; Skin Neoplasms; Skin Ulcer; Tetradecanoylphorbol Acetate; Time Factors; Wounds, Penetrating | 1987 |
Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: a comparison between SENCAR and NMRI mice.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; DNA Replication; Female; Flurbiprofen; Indomethacin; Mice; Ornithine Decarboxylase; Prostaglandins E; Pyrazoles; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Characterization of skin tumor promotion and progression by chrysarobin in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Initiating, promoting and carcinogenic activities of three naphthofurans in a mouse skin long-term study.
Topics: Animals; Benzo(a)pyrene; Cocarcinogenesis; Furans; Mice; Nitrofurans; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors | 1987 |
A novel system for studying in vivo effects of tumor promoters on DNA tumor viruses.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cocarcinogenesis; Cricetinae; DNA Tumor Viruses; DNA, Viral; Drug Interactions; Male; Mesocricetus; Papilloma; Papillomaviridae; Polyomaviridae; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Sequential studies of skin tumorigenesis in PGK mosaic mice: the effect of repeated exposure to a carcinogen on regressed mouse skin papillomas.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Interactions; Mice; Mice, Inbred BALB C; Mosaicism; Papilloma; Phenotype; Phosphoglycerate Kinase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Elevated expression and point mutation of the Ha-ras proto-oncogene in mouse skin tumors promoted by benzoyl peroxide and other promoting agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoyl Peroxide; Female; Gene Expression Regulation; Mice; Mutation; Papilloma; Peroxides; Proto-Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Differentiating among proposed mechanisms for tumor promotion in mouse skin with the use of the multievent model for cancer.
Topics: 4-Nitroquinoline-1-oxide; Acetone; Animals; Cell Transformation, Neoplastic; Mathematics; Mice; Models, Biological; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1987 |
Tumor-promoting phorbol esters cause a stable reduction of dermal collagen in mouse skin.
Topics: Animals; Calcimycin; Cell Division; Collagen; Female; Fluocinolone Acetonide; Mice; Phorbol Esters; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1987 |
Comparison of sensitivity of Swiss albino and hairless Swiss bare mice to two stage skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Susceptibility; Female; Male; Mice; Mice, Hairless; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1987 |
Induction of melanogenesis in Schwann cell and perineural epithelium by 9,10-dimethyl-1,2-benzanthracene (DMBA) and 12-o-tetradecanoylphorbol-13-acetate (TPA) in BDF1 mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Epithelium; Female; Melanocytes; Mice; Mice, Inbred Strains; Schwann Cells; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Tumorigenesis and carcinogenesis in mouse skin treated with hyperthermia during stage I or stage II of tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hyperthermia, Induced; Mice; Peptide Hydrolases; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Comparison of the histological changes in the skin of DBA/2 and C57BL/6 mice following exposure to various promoting agents.
Topics: Animals; Anthracenes; Benzo(a)pyrene; Carcinogens; Diterpenes; Lyngbya Toxins; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Skin; Skin Neoplasms; Species Specificity; Terpenes; Tetradecanoylphorbol Acetate | 1987 |
Persistence of carcinogenic effect in intact progeny of mice treated transplacentally with 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Fetus; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Neoplasms, Experimental; Pregnancy; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alleles; Animals; Calcium; Cell Line; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Oncogenes; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 1988 |
The tumor-initiating and -promoting effects of ionizing radiations in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Mice; Mice, Inbred ICR; Neoplasms, Radiation-Induced; Radiation, Ionizing; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Inhibition of mouse skin tumor promotion and of promoter-induced epidermal polyamine biosynthesis by methylglyoxal bis(butylamidinohydrazone).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Male; Mice; Mice, Inbred Strains; Mitoguazone; Ornithine Decarboxylase Inhibitors; Papilloma; Polyamines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
The influence of a hyperthermia treatment on chemically induced tumor initiation and progression in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; DNA Repair; Female; Glutathione; Hyperthermia, Induced; Methylnitronitrosoguanidine; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Enhancement of mezerein-promoted papilloma formation by treatment with 12-O-tetradecanoylphorbol-13-acetate or mezerein prior to initiation.
Topics: Animals; Calcimycin; Diterpenes; Drug Synergism; Female; Hyperplasia; Mice; Papilloma; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1988 |
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Enzyme Induction; Ethers, Cyclic; Humans; Leukemia, Myeloid, Acute; Lyngbya Toxins; Mice; Okadaic Acid; Ornithine Decarboxylase; Porifera; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Susceptibility to phorbol ester skin tumor promotion in (C57BL/6 x DBA/2) F1 mice is inherited as an incomplete dominant trait: evidence for multi-locus involvement.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Crosses, Genetic; Genes, Dominant; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1988 |
Influence of dose of initiator on two-stage skin carcinogenesis in BALB/c mice with cellular mosaicism.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Mosaicism; Papilloma; Phenotype; Phosphoglycerate Kinase; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1988 |
Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-promoted tumor formation in CD-1 and Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Female; Mice; Mice, Inbred Strains; Papilloma; Retinoids; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1988 |
Sensitivity of HRA/Skh hairless mice to initiation/promotion of skin tumors by chemical treatment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Mice; Mice, Hairless; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Modulation of chrysarobin skin tumor promotion.
Topics: Animals; Anthracenes; Carcinogens; Cocarcinogenesis; Eflornithine; Female; Fluocinolone Acetonide; Mice; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1988 |
Sensitivity of the skin of different mouse strains to the promoting effect of 12-0-tetradecanoyl-phorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Papilloma; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1988 |
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonic Acid; Arachidonic Acids; Caffeic Acids; Catechols; Chlorogenic Acid; Cinnamates; Coumaric Acids; Curcumin; DNA; Edema; Female; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Role of cutaneous GSH in 12-O-tetradecanoyl-phorbol 13-acetate-induced mouse skin tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Glutathione; Maleates; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Tumor progression in Sencar mouse skin as a function of initiator dose and promoter dose, duration, and type.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Female; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1988 |
Effects of retinoids and inhibitors of arachidonic acid metabolism on tumor-promoter-induced soft agar colony formation of mouse epidermal cells and rat urinary bladder cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Colony-Forming Units Assay; Diterpenes; Epidermis; Female; Male; Masoprocol; Mice; Quinacrine; Rats; Rats, Inbred F344; Retinoids; Retinyl Esters; Saccharin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Stem Cell Assay; Urinary Bladder Neoplasms; Vitamin A | 1988 |
[Inhibitory effect of glycyrrhizin and caffeine on two-stage carcinogenesis in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Infective Agents; Caffeine; Cocarcinogenesis; Female; Glycyrrhetinic Acid; Glycyrrhizic Acid; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Amino Acid Sequence; Animals; Carcinoma, Squamous Cell; Cloning, Molecular; DNA, Neoplasm; Female; Gene Amplification; Gene Rearrangement; Immunoblotting; Matrix Metalloproteinase 3; Metalloendopeptidases; Mice; Molecular Sequence Data; Multigene Family; Neoplasm Proteins; Papilloma; Peptide Hydrolases; Plasmids; RNA, Neoplasm; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Tumorigenic and molecular characterization of novel phorbol ester-resistant and -sensitive lines of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Autoradiography; Brain; Breeding; Carcinogenicity Tests; Drug Resistance; Epidermis; Female; Male; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phorbol Esters; Phosphorylation; Protein Kinase C; Skin Neoplasms; Substrate Specificity; Tetradecanoylphorbol Acetate | 1988 |
Genes and signal transduction in tumor promotion: conclusions from studies with promoter resistant variants of JB-6 mouse epidermal cells.
Topics: Animals; Arginine Vasopressin; Carcinogens; Carcinoma, Bronchogenic; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Heat-Shock Proteins; Mice; Oncogenes; Oxidation-Reduction; Phosphatidylinositols; Protein Kinase C; Protein Kinases; Skin Neoplasms; Stress, Physiological; Tetradecanoylphorbol Acetate; Transduction, Genetic | 1985 |
Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes.
Topics: Calcimycin; Cell Division; Cell Line; Epidermal Growth Factor; Humans; Oncogenes; Protein Biosynthesis; Protein Kinase C; Protein Kinases; Proto-Oncogene Mas; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Alterations in epidermal polyamine levels and DNA synthesis following topical treatment with chrysarobin in SENCAR mice.
Topics: Administration, Topical; Animals; Anthracenes; Biogenic Polyamines; DNA; Female; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Comparison of the effect of sn-1,2-didecanoylglycerol and 12-O-tetradecanoylphorbol-13-acetate on cutaneous morphology, inflammation and tumor promotion in CD-1 mice.
Topics: Animals; Carcinogens; Diglycerides; Edema; Enzyme Induction; Female; Glycerides; Hyperplasia; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C.
Topics: Alkaloids; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Mice; Ornithine Decarboxylase; Protein Kinase C; Skin Neoplasms; Staurosporine; Tetradecanoylphorbol Acetate | 1988 |
Effects of TPA dose variation and mezerein on skin tumorigenesis by initiation promotion protocol in S/RV Cri mice.
Topics: Animals; Carcinogens; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Mice; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1988 |
Ciclosporin inhibits phorbol-ester-induced hyperplastic transformation and tumor promotion in mouse skin probably by suppression of Ca2+/calmodulin-dependent processes such as phosphorylation of elongation factor 2.
Topics: Animals; Calcium; Calmodulin; Cell Transformation, Neoplastic; Chromatography, DEAE-Cellulose; Cocarcinogenesis; Cycloheximide; Cyclosporins; Cytosol; Electrophoresis, Polyacrylamide Gel; Mice; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphorus Radioisotopes; Phosphorylation; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Inhibition of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced synthesis of epidermal ornithine decarboxylase messenger RNA and diacylglycerol-promoted mouse skin tumor formation by retinoic acid.
Topics: Animals; Diglycerides; Dimethyl Sulfoxide; Enzyme Activation; Female; Glycerides; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Protein Kinase C; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1988 |
Alteration of cholesterol biosynthetic pathways in the skin of mice administered polycyclic aromatic hydrocarbons.
Topics: Animals; Azacosterol; Carcinogens; Cholesterol; Male; Mass Spectrometry; Methylcholanthrene; Mice; Polycyclic Compounds; Skin; Skin Neoplasms; Sterols; Tetradecanoylphorbol Acetate | 1988 |
Differential effects of phorbol ester tumor promoters on 3-methylcholanthrene-induced epithelial and mesenchymal skin tumorigenesis.
Topics: Animals; Carcinoma; Diterpenes; Female; Mesenchymoma; Methylcholanthrene; Mice; Mice, Inbred Strains; Phorbol Esters; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1988 |
Inhibition of the tumor-promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleanane-type triterpenoid compounds.
Topics: Animals; Cells, Cultured; Glycyrrhetinic Acid; Mice; Mice, Inbred C3H; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Triterpenes | 1988 |
Effects of fluocinolone acetonide on mouse skin sterol metabolism and two-stage carcinogenesis.
Topics: Animals; Chromatography, Gas; Dose-Response Relationship, Drug; Fluocinolone Acetonide; Methylcholanthrene; Mice; Skin; Skin Neoplasms; Sterols; Tetradecanoylphorbol Acetate | 1988 |
Comparison of some biochemical properties of epidermis in tumor promotion-susceptible and -resistant strains of mice.
Topics: Animals; Enzyme Induction; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Ornithine decarboxylase from mouse epidermis and epidermal papillomas: differences in enzymatic properties and structure.
Topics: Animals; Epidermis; Hot Temperature; Isoelectric Point; Kinetics; Mice; Molecular Weight; Nucleotides; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Effects of dietary retinyl palmitate or 13-cis-retinoic acid on the promotion of tumors in mouse skin.
Topics: Administration, Cutaneous; Animals; Cell Transformation, Neoplastic; Diet; Diterpenes; Dose-Response Relationship, Drug; Female; Isotretinoin; Mice; Papilloma; Retinyl Esters; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Vitamin A | 1987 |
The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.
Topics: Animals; Carcinoma, Squamous Cell; Cell Transformation, Viral; Endopeptidases; Gene Expression Regulation; Matrix Metalloproteinase 3; Mice; Neoplasm Proteins; Neoplasms, Experimental; Papilloma; RNA, Messenger; RNA, Neoplasm; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Characterization of an inbred strain of the SENCAR mouse that is highly sensitive to phorbol esters.
Topics: Animals; Diterpenes; Female; Histocompatibility Testing; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Skin; Skin Neoplasms; Skin Transplantation; Terpenes; Tetradecanoylphorbol Acetate | 1987 |
Early inflammatory changes in the skin of SENCAR and C57BL/6 mice following exposure to 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Capillary Permeability; Dose-Response Relationship, Drug; Edema; Female; Inflammation; Leukocytes; Mice; Mice, Inbred C57BL; Protein Kinase C; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1987 |
Enhanced pancreatic and skin tumorigenesis in cabbage-fed hamsters and mice.
Topics: Animals; Body Weight; Brassica; Cricetinae; Dietary Fats; Female; Gallbladder Neoplasms; Male; Mesocricetus; Mice; Nitrosamines; Pancreatic Neoplasms; Selenium; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triiodothyronine; Vitamin A | 1987 |
Inhibition of both stage I and stage II mouse skin tumour promotion by retinoic acid and the dependence of inhibition of tumor promotion on the duration of retinoic acid treatment.
Topics: Animals; Female; Mice; Ornithine Decarboxylase; Proto-Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1987 |
Initiating activity in a two-stage mouse skin model of nine mutagenic pyrolysates of amino acids, soybean globulin and proteinaceous food.
Topics: Animals; Carbolines; Female; Imidazoles; Mice; Mutagens; Quinolines; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin.
Topics: Animals; Antineoplastic Agents; Bryostatins; Enzyme Activation; Female; Hyperplasia; Lactones; Macrolides; Mice; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Tumour initiating activity of mancozeb--a carbamate fungicide in mouse skin.
Topics: Animals; Carcinogens; Female; Maneb; Mice; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiocarbamates; Zineb | 1987 |
Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC).
Topics: Animals; Butyrates; Butyric Acid; Dose-Response Relationship, Drug; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1987 |
Ionizing radiation enhances malignant progression of mouse skin tumors.
Topics: Acetone; Animals; Carcinoma; Cocarcinogenesis; Female; Methylnitronitrosoguanidine; Mice; Neoplasms, Radiation-Induced; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Murine epidermal xanthine oxidase activity: correlation with degree of hyperplasia induced by tumor promoters.
Topics: Animals; Carcinogens; Epidermis; Female; Fluocinolone Acetonide; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin; Xanthine Oxidase | 1987 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of ornithine decarboxylase activity, DNA synthesis, and tumor promotion in mouse skin by ascorbic acid and ascorbyl palmitate.
Topics: Administration, Topical; Animals; Ascorbic Acid; Diglycerides; DNA Replication; Drug Interactions; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Palmitic Acid; Palmitic Acids; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Ionizing radiation as an initiator: effects of proliferation and promotion time on tumor incidence in mice.
Topics: Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cocarcinogenesis; Dose-Response Relationship, Radiation; Female; Mice; Neoplasms, Radiation-Induced; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1987 |
Mechanism of mouse skin tumor promotion by n-dodecane.
Topics: Acetone; Alkanes; Animals; Cocarcinogenesis; Diterpenes; Female; Mice; Papilloma; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1987 |
Initiating potential of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and 3,3',4',5,7-pentahydroxyflavone (quercetin) in two-stage mouse skin carcinogenesis.
Topics: Animals; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Female; Flavonoids; Furylfuramide; Mice; Nitrofurans; Quercetin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen.
Topics: Animals; Autoradiography; Benzo(a)pyrene; Carbon Radioisotopes; Carcinogens; Cell Division; Epidermal Cells; Epidermis; Female; Mice; Mice, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine; Tritium | 1986 |
Ionizing radiation as an initiator in the mouse two-stage model of skin tumor formation.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; X-Rays | 1986 |
Effect of mouse skin tumor promoters upon [3H]uridine exchange and focus formation in cultures of C3H/10T1/2 mouse fibroblasts.
Topics: Animals; Carcinogens; Cells, Cultured; Dimethyl Sulfoxide; Diterpenes; Female; Fibroblasts; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H; Polychlorinated Dibenzodioxins; Pregnancy; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors; Uridine | 1986 |
[Regulation of tumor promotion by 1 alpha, 25-dihydroxyvitamin D3, an active form of vitamin D3].
Topics: Animals; Calcitriol; Calcium; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Antioxidants as antitumor promoters.
Topics: Animals; Antioxidants; Cell Transformation, Neoplastic; DNA Damage; Humans; Kinetics; Mice; Nucleoproteins; Poly Adenosine Diphosphate Ribose; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Effect of application frequency on epidermal ornithine decarboxylase induction by chrysarobin in SENCAR mice.
Topics: Animals; Anthracenes; Carcinogens; Drug Administration Schedule; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
sn-1,2-Diacylglycerols mimic the effects of 12-O-tetradecanoylphorbol-13-acetate in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis.
Topics: Animals; Diglycerides; DNA; Female; Glycerides; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Involvement of protein kinase C activation in ornithine decarboxylase gene expression in primary culture of newborn mouse epidermal cells and in skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cells, Cultured; Diglycerides; Enzyme Activation; Epidermis; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Palmitoylcarnitine; Protein Kinase C; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Type C Phospholipases | 1986 |
Association of carcinoma yield with early papilloma development in SENCAR mice.
Topics: Animals; Carcinogens; Carcinoma; Cocarcinogenesis; Disease Models, Animal; Drug Evaluation, Preclinical; False Negative Reactions; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Comparison of the tumorigenic response of SENCAR and C57BL/6 mice to benzo(a)pyrene and the inter-experimental variability over a three-year period.
Topics: Animals; Benzo(a)pyrene; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1986 |
Phorbol myristate acetate and catechol as skin cocarcinogens in SENCAR mice.
Topics: Animals; Carcinogens; Catechols; Cocarcinogenesis; Drug Evaluation, Preclinical; Female; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1986 |
Pathology of aging female SENCAR mice used as controls in skin two-stage carcinogenesis studies.
Topics: Acetone; Aging; Animals; Cardiovascular System; Female; Genitalia, Female; Hematopoietic System; Kidney; Liver; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Respiratory System; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
[Chemoprevention of cancer].
Topics: Animals; Berberine; Flavonoids; Mice; Quercetin; Retinoids; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Antineoplastic Agents, Phytogenic; Female; Mice; Mice, Inbred ICR; Oleanolic Acid; Sapogenins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Triterpenes; Ursolic Acid | 1986 |
Studies of skin tumorigenesis in PGK mosaic mice: many promoter-independent papillomas and carcinomas do not develop from pre-existing promoter-dependent papillomas.
Topics: Animals; Biopsy; Carcinoma; Mice; Mice, Inbred BALB C; Mosaicism; Papilloma; Phenotype; Phosphoglycerate Kinase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Didemnin B inhibits biological effects of tumor promoting phorbol esters on mouse skin, as well as phosphorylation of a 100 kD protein in mouse epidermis cytosol.
Topics: Animals; Binding Sites; Cyclosporins; Cytosol; Depsipeptides; Female; Immunosuppressive Agents; Mice; Peptides, Cyclic; Phosphorylation; Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Regulation of ornithine decarboxylase gene expression in mouse epidermis and epidermal tumors during two-stage tumorigenesis.
Topics: Animals; Epidermis; Female; Gene Amplification; Gene Expression Regulation; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Terminal differentiation-resistant epidermal cells in mice undergoing two-stage carcinogenesis.
Topics: Animals; Cell Differentiation; Cells, Cultured; Female; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Precancerous Conditions; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Induction of anchorage-independent growth of mouse JB6 cells by cholera toxin.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Cholera Toxin; DNA Replication; Kinetics; Mice; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine; Tretinoin | 1987 |
A new medium for primary cultures of adult murine epidermal cells: application to experimental carcinogenesis.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Culture Media; Epidermal Cells; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Papilloma development on young and senescent mouse skin treated with 12-O-tetradecanoylphorbol 13-acetate.
Topics: Aging; Animals; Hyperplasia; Mice; Mice, Inbred BALB C; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Ultrastructure of chemically induced mouse skin tumours.
Topics: Animals; Carcinoma; Female; Fibrosarcoma; Keratoacanthoma; Liposarcoma; Methylcholanthrene; Mice; Rhabdomyosarcoma; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Inhibition of tumor promotion in mouse skin by 1 alpha,25-dihydroxyvitamin D3.
Topics: Animals; Calcitriol; Calcium; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Enhancement of two-stage skin carcinogenesis by exposure of distant skin to UV radiation.
Topics: Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Fibrosarcoma; Immune Tolerance; Mice; Mice, Inbred C3H; Neoplasms, Radiation-Induced; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Ultraviolet Rays | 1985 |
Inhibition of phorbol ester--induced human epidermal ornithine decarboxylase activity by oral compounds: a possible role in human chemoprevention studies.
Topics: Adult; Cells, Cultured; Enzyme Induction; Female; Humans; Indomethacin; Isotretinoin; Male; Ornithine Decarboxylase Inhibitors; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
A study of experimental carcinogenesis on mouse dorsal skin using: ultraviolet, PUVA and retinoid.
Topics: Animals; Kinetics; Male; Methylcholanthrene; Mice; Photochemotherapy; PUVA Therapy; Retinoids; Skin Neoplasms; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate; Time Factors; Ultraviolet Rays | 1985 |
Effects of short-term exposure to the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Female; Mice; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Tumor-promoting effects of di(2-ethylhexyl)phthalate in JB6 mouse epidermal cells and mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Epidermis; Female; Mice; Phthalic Acids; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Proto-oncogene expression during two-stage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Female; Gene Expression Regulation; Mice; Oncogenes; Papilloma; RNA, Neoplasm; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Two-stage tumor promotion in mouse skin: an alternative interpretation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; Croton Oil; Fluocinolone Acetonide; Mice; Mice, Inbred Strains; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone; Tretinoin | 1985 |
12-O-tetradecanoylphorbol-13-acetate-induced rapid loss of persistent 7,12-dimethylbenz[a]anthracene-DNA adducts in mouse epidermis and dermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; DNA; Epidermis; Female; Mice; Mice, Inbred BALB C; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Soft agar colony formation of mouse epidermal cells during the early phase of two-stage chemically induced carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Agar; Animals; Cocarcinogenesis; Colony-Forming Units Assay; Epidermis; Male; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tumor Stem Cell Assay | 1985 |
Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biotransformation; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Skin Neoplasms; Superoxide Dismutase; Tetradecanoylphorbol Acetate | 1985 |
Stimulatory effect of 1 alpha, 25-dihydroxyvitamin D3 on the formation of skin tumors in mice treated chronically with 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Body Weight; Calcitriol; Cocarcinogenesis; Female; Mice; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1985 |
Partial inversion of the initiation-promotion sequence of multistage tumorigenesis in the skin of NMRI mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Diterpenes; Female; Mice; Phorbol Esters; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
12-O-tetradecanoylphorbol-13-acetate promotes tumors prior to initiation in two-stage promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diterpenes; Enzyme Induction; Female; Mice; Models, Biological; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Initiation and promotion in young and old animals. Implications for human tumour formation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Autopsy; Female; Humans; Mathematics; Mice; Models, Biological; Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
The skin tumor-promoter 12-O-tetradecanoylphorbol-13-acetate induces transcription of the c-fos proto-oncogene in human bladder epithelial cells.
Topics: Cells, Cultured; Epithelium; Humans; Phorbols; Proto-Oncogene Mas; Proto-Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Urinary Bladder | 1986 |
[Role of cell-cell interaction in tumor promotion].
Topics: Animals; Carcinogens; Cell Communication; Cell Transformation, Neoplastic; Cricetinae; Extracellular Space; Homeostasis; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Phorbol Esters; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Benzoyl peroxide promotion of transformation of JB6 mouse epidermal cells: inhibition by ganglioside GT but not retinoic acid.
Topics: Animals; Benzoyl Peroxide; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Gangliosides; Mice; Peroxides; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
Mechanism of mouse skin tumor promotion by chrysarobin.
Topics: Animals; Anthracenes; Anthralin; Carcinogens; Dose-Response Relationship, Drug; Edema; Female; Hyperplasia; Mice; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Cutaneous changes during prolonged application of 12-O-tetradecanoylphorbol-13-acetate on mouse skin and residual effects after cessation of treatment.
Topics: Animals; Epidermis; Female; Hyperplasia; Mast Cells; Mice; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Initiation and promotion in cultures of C3H10T1/2 mouse embryo fibroblasts.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Embryo, Mammalian; Fibroblasts; Mice; Mice, Inbred C3H; Respiratory Tract Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Tumor promotion and tumor progression.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Humans; Mutation; Neoplasms; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Dermal collagen metabolism during tumor promotion with 12-O-tetradecanoylphorbol-13-acetate in mouse skin.
Topics: Animals; Collagen; Female; Hydroxyproline; Methylcholanthrene; Mice; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Association of DNA strand breaks with accelerated terminal differentiation in mouse epidermal cells exposed to tumor promoters.
Topics: Animals; Benzoyl Peroxide; Cell Transformation, Neoplastic; Cells, Cultured; Dimethyl Sulfoxide; DNA, Single-Stranded; Mice; Mice, Inbred BALB C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Quantification of tumour initiating effect of jute batching oil and its distillates over mouse skin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Enzyme Induction; Female; Mice; Mineral Oil; Skin Neoplasms; Spectrophotometry, Ultraviolet; Tetradecanoylphorbol Acetate | 1985 |
Mechanisms of transformation and promotion of mouse epidermal cells.
Topics: Animals; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Mice; Oncogenes; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Dose and schedule of oral retinoic acid and indomethacin needed to effectively inhibit phorbol ester-induced epidermal ornithine decarboxylase activity.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Indomethacin; Male; Mice; Mice, Inbred Strains; Ornithine Decarboxylase Inhibitors; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
Cisplatin as an initiating agent in two-stage mouse skin carcinogenesis.
Topics: Animals; Carcinogens; Cisplatin; Cocarcinogenesis; Female; Injections, Intraperitoneal; Mice; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Urethane | 1985 |
Promotion of epidermal carcinogenesis by repeated damage to mouse skin.
Topics: Age Factors; Animals; Carcinogens; Female; Hyperplasia; Mice; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Enhancement by adriamycin of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase activity, ornithine decarboxylase induction and skin tumor promotion.
Topics: Administration, Topical; Animals; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Enzyme Induction; Epidermis; Female; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Mice; Ornithine Decarboxylase; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1985 |