tetradecanoylphorbol acetate has been researched along with Pituitary Neoplasms in 99 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (44.44) | 18.7374 |
| 1990's | 45 (45.45) | 18.2507 |
| 2000's | 9 (9.09) | 29.6817 |
| 2010's | 1 (1.01) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Paul, AL; Gutiérrez, S; Mukdsi, JH; Petiti, JP; Torres, AI | 1 |
| Andreoli, V; Bocco, JL; De Paul, AL; Gutiérrez, S; Palmeri, CM; Petiti, JP; Sosa, Ldel V; Torres, AI | 1 |
| Chen, TC; Couldwell, WT; Gopalakrishna, R; Hinton, DR; Law, RE; Simard, M; Su, YZ; Weiss, MH; Zhang, W | 1 |
| Bai, X; Hu, W; Jiang, X; Lei, T; Xue, D | 1 |
| Bai, X; Lei, T; Liu, K; Liu, Q; Xue, D | 1 |
| Burrin, JM; Fowkes, RC; Grossman, AB; Khalaf, S; Korbonits, M; Mozid, AM; Nanzer, AM; Patel, MV | 1 |
| Dong, Q; Duan, W; Lim, WG; Tan, BJ; Zhou, S; Zhu, Y | 1 |
| Kihara, S; Ohba, T; Okamura, H; Shimasaki, S; Yamamoto, H | 1 |
| Lin, MW; Wang, YJ; Wu, SN | 1 |
| Abdel-Fattah, R; Agi, CU; Amos, S; Fang, Z; Hussaini, IM; Laws, ER; Leung, GK; Lopes, MB; Redpath, GT; Trotter, C; Xiao, A; Zhao, Y | 1 |
| Becu-Villalobos, D; Díaz-Torga, G; Pérez-Millán, MI; Vela, J | 1 |
| Canonico, PL; Judd, AM; MacLeod, RM | 1 |
| Kowalchyk, JA; Martin, TF | 1 |
| Dannies, PS; Delbeke, D; Kojima, I; Rasmussen, H | 1 |
| Jaken, S; Phillips, MA | 1 |
| Brostrom, CO; Brostrom, MA; Brotman, LA; Green, SS | 1 |
| Heisler, S | 4 |
| Bocckino, SB; Brostrom, CO; Brostrom, MA; Green, SS | 1 |
| Brostrom, CO; Brostrom, MA; Brotman, LA | 1 |
| Hirota, K; Kanda, Y; Koike, K; Miyake, A; Ohmichi, M; Saltiel, AR; Sawada, T | 1 |
| Sheppard, KE | 1 |
| Ahn, SK; Hong, SH; Kim, DS; Kim, KE; Maurer, RA; Park, SD; Yoon, JH | 1 |
| Cramb, G; Gilkes, AF; Guild, SB | 1 |
| Aylwin, SJ; Burrin, JM; Desai, BJ; Geddes, JF; Holdstock, JG; Monson, JP; Wood, DF | 1 |
| Guild, SB; McFerran, BW | 1 |
| De Vries, GW; Garst, M; Harcourt, D; Lee, G; McLaughlin, A; Perez, J; Wenzel, MB; Wheeler, LA | 1 |
| Drouhault, R; Roudbaraki, MM; Vacher, P | 1 |
| Guild, SB; MacEwan, DJ; McFerran, BW | 1 |
| Haymes, AA; Hinkle, PM | 1 |
| Boulla, G; Gourdji, D; Passegue, E; Richard, JL | 1 |
| Arzt, E; Gumprecht, H; Hopfner, U; Sauer, J; Stalla, GK | 1 |
| Chandler, WF; Horvath, E; Jin, L; Kovacs, K; Lloyd, RV; Stefaneanu, L | 1 |
| Demura, H; Dobashi, I; Horiba, N; Ohmori, N; Suda, T; Tozawa, F; Yamada, M; Yamakado, M | 1 |
| Chang, EY; Mains, RE; Milgram, SL | 1 |
| Alvaro, V; Joubert, D; Prévostel, C; Slosberg, E; Weinstein, BI | 1 |
| Clark, RB; Eppler, CM; Friedman, J; Hipkin, RW; Schonbrunn, A | 1 |
| Lin, J; Wilk, S | 1 |
| Hanew, K; Ikeda, H; Tanaka, A; Utsumi, A; Yokogoshi, Y | 1 |
| Adams, EF; Buchfedlder, M; Fahlbusch, R; Lei, T; Liu, Q | 1 |
| Molinoff, PB; Wohlpart, KL | 1 |
| Greer, MA; Sato, N; Wang, X | 1 |
| Bosma, MM; Hille, B | 1 |
| Biagi, BA; Duchemin, AM; Enyeart, JA; Enyeart, JJ; Foster, DN; Mlinar, B | 1 |
| McKnight, GS; Schecterson, LC | 1 |
| Brostrom, CO; Brostrom, MA; Cade, C | 1 |
| Akerblom, IE; Mellon, PL; Ridgway, EC | 1 |
| Fujimoto, J; Gershengorn, MC; Straub, RE | 1 |
| Tashjian, AH; Törnquist, K | 1 |
| Greer, MA; Greer, SE; McAdams, S; Sato, N; Wang, XB | 1 |
| Mackanos, EA; Pettit, GR; Ramsdell, JS | 1 |
| Kitaoka, M; Kojima, I; Ogata, E; Takano, K; Tanaka, Y; Teramoto, A | 1 |
| Eipper, BA; Thiele, EA | 1 |
| Ramsdell, JS | 2 |
| Demura, H; Emoto, N; Isozaki, O; Ohmura, E; Shizume, K; Tsushima, T | 1 |
| Hsieh, KP; Martin, TF; Porter, BW | 1 |
| Axelrod, J; Bishop, JF; Făgărăşan, MO; Rinaudo, MS | 1 |
| Glembotski, CC; Shields, PP; Sprenkle, AB; Taylor, EW | 1 |
| Akita, Y; Ohno, S; Suzuki, K; Yajima, Y | 1 |
| Stewen, P; Törnquist, K | 1 |
| d'Emden, M; Day, KH; Day, RN; Iverson, RA; Maurer, RA | 1 |
| Bishop, JF; Gehlert, DR; Patel, J; Vyas, S | 1 |
| Danoff, A; Fleischer, N; Pasmantier, R; Schubart, UK | 1 |
| Buisson, N; Gourdji, D; Laverriere, JN; Martial, JA; Morin, A; Tixier-Vidal, A | 1 |
| Baird, A; Mormède, P | 1 |
| Casnellie, JE; Hinkle, PM; Kaji, H | 1 |
| Buisson, N; Gourdji, D; Laverrière, JN; Martial, JA; Richard, JL; Tixier-Vidal, A | 1 |
| Axelrod, J; Eskay, R; Făgăraşan, MO | 1 |
| Reisine, T | 1 |
| Björo, T; Gautvik, KM; Gordeladze, JO; Haug, E; Ostberg, BC; Torjesen, PA | 1 |
| Davis, JR; Johnson, AP; Lynch, SS; Sheppard, MC; Vidal, ME; Wilson, EM | 1 |
| Cronin, MJ; Sando, JJ; Summers, ST; Walker, JM | 1 |
| Cronin, MJ; Summers, ST | 1 |
| Clegg, S; Kolesnick, RN | 1 |
| Jenkins, JS; Prysor-Jones, RA; Silverlight, JJ; Whitley, GS | 1 |
| Ibayashi, H; Ikuyama, S; Kato, K; Natori, S; Nawata, H | 1 |
| Bjøro, T; Gautvik, KM; Gordeladze, JO; Haug, E; Ostberg, BC; Sand, O; Torjesen, P | 1 |
| Bishop, JF; Farah, JM; O'Donohue, TL; Patel, J | 1 |
| Dannies, PS; Delbeke, D; Martinez-Campos, A; Scammell, JG | 1 |
| Koenig, RJ | 1 |
| Martin, TF; Ronning, SA | 2 |
| Desjardins, D; Heisler, S | 1 |
| Barker, JL; Dufy, B; Jaken, S | 1 |
| Reisine, T; Zatz, M | 1 |
| Gurtler, V; Wark, JD | 1 |
| Albert, PR; Tashjian, AH; Wolfson, G | 1 |
| Beretta, L; Boutterin, MC; Sobel, A | 1 |
| Drust, DS; Martin, TF | 1 |
| Fearon, CW; Tashjian, AH | 1 |
| Cattini, PA; Klassen, M; Nachtigal, M | 1 |
| Pettit, GR; Ramsdell, JS; Tashjian, AH | 1 |
| Kolesnick, RN | 1 |
| Kolesnick, RN; Paley, AE | 1 |
| Ballester, R; Rosen, OM | 1 |
| Dannies, PS; Delbeke, D; Kojima, I | 1 |
99 other study(ies) available for tetradecanoylphorbol acetate and Pituitary Neoplasms
| Article | Year |
|---|---|
Specific subcellular targeting of PKCalpha and PKCepsilon in normal and tumoral lactotroph cells by PMA-mitogenic stimulus.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Female; Fluorescent Antibody Technique; Lactotrophs; Mitogens; Nuclear Envelope; Pituitary Neoplasms; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Transport; Rats; Subcellular Fractions; Tetradecanoylphorbol Acetate | 2009 |
GH3B6 pituitary tumor cell proliferation is mediated by PKCalpha and PKCepsilon via ERK 1/2-dependent pathway.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Flavonoids; Flow Cytometry; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pituitary Neoplasms; Protein Kinase C-alpha; Protein Kinase C-epsilon; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2010 |
Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway.
Topics: Adenoma; Adult; Animals; Apoptosis; Carcinoma; Cell Division; DNA Fragmentation; Enzyme Inhibitors; Humans; Isoenzymes; Male; Mice; Middle Aged; Neoplasm Proteins; Pituitary Neoplasms; Protein Kinase C; Signal Transduction; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas.
Topics: Adenoma; Growth Hormone; Growth Hormone-Releasing Hormone; GTP-Binding Protein alpha Subunits, Gs; Humans; Pituitary Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
The role of protein kinase C and its effect on GHRH in the regulation of hormone secretion by somatotrophinomas.
Topics: Growth Hormone; Growth Hormone-Releasing Hormone; GTP-Binding Protein alpha Subunits, Gs; Humans; Oligopeptides; Pituitary Neoplasms; Prolactin; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway.
Topics: Androstadienes; Animals; Butadienes; Carcinogens; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ghrelin; Indoles; Maleimides; MAP Kinase Signaling System; Nitriles; Peptide Hormones; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pituitary Gland; Pituitary Neoplasms; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrphostins; Wortmannin | 2004 |
The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals.
Topics: Animals; Cattle; Cell Membrane; CHO Cells; Cricetinae; Cytoplasm; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Melatonin; Membrane Proteins; Mitogen-Activated Protein Kinases; Myristoylated Alanine-Rich C Kinase Substrate; Neurites; Phosphorylation; Pituitary Neoplasms; Point Mutation; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Transfection | 2005 |
Activation of follistatin promoter by GnRH in LbetaT2 gonadotroph cells.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Follicle Stimulating Hormone; Follistatin; Gene Expression Regulation; Genes, Reporter; Gonadotropin-Releasing Hormone; MAP Kinase Kinase 1; MAP Kinase Kinase Kinase 2; Mice; Models, Biological; Pituitary Neoplasms; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Receptors, LHRH; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 2006 |
Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells.
Topics: Acetophenones; Action Potentials; Adenoma; Animals; Benzopyrans; Carcinogens; Cell Line; Cell Line, Tumor; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Neurons; Pituitary Neoplasms; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Kinase C-delta; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 2007 |
Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line.
Topics: Adenoma; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pituitary Neoplasms; Protein Kinase C; Pyrones; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2007 |
Different kinases regulate activation of voltage-dependent calcium channels by depolarization in GH3 cells.
Topics: Animals; Calcium; Calcium Channels, L-Type; Carcinogens; Cell Line; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; ErbB Receptors; Female; Fluorescent Dyes; Fura-2; Isoquinolines; Membrane Potentials; Pituitary Gland; Pituitary Neoplasms; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Rats; Rats, Inbred WF; Sulfonamides; Tetradecanoylphorbol Acetate | 2007 |
Prolactin release from MtTW15 and 7315a pituitary tumors is refractory to TRH and VIP stimulation.
Topics: Animals; Bucladesine; Cell Line; Female; Phosphates; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Pituitary Neoplasms; Prolactin; Rats; Rats, Inbred BUF; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Theophylline; Thyrotropin-Releasing Hormone; Type C Phospholipases; Vasoactive Intestinal Peptide | 1984 |
Evidence for the role of calcium and diacylglycerol as dual second messengers in thyrotropin-releasing hormone action: involvement of diacylglycerol.
Topics: Animals; Bacillus cereus; Calcium; Cell Line; Clostridium perfringens; Diglycerides; Glycerides; Melitten; Pituitary Neoplasms; Prolactin; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Time Factors; Type C Phospholipases | 1984 |
Synergistic stimulation of prolactin release by phorbol ester, A23187 and forskolin.
Topics: Animals; Calcimycin; Calcium; Cell Line; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Phorbols; Pituitary Neoplasms; Prolactin; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Time Factors | 1984 |
Specific desensitization to tumor-promoting phorbol esters in mouse pituitary cells. Evidence that desensitization is a two-step process.
Topics: Adrenocorticotropic Hormone; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Kinetics; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pituitary Neoplasms; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Regulation of Ca2+-dependent cyclic AMP accumulation and Ca2+ metabolism in intact pituitary tumor cells by modulators of prolactin production.
Topics: Animals; Calcium; Cell Line; Cyclic AMP; Epidermal Growth Factor; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Prostaglandins; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1983 |
12-O-tetradecanoyl-phorbol-13-acetate-induced ACTH secretion in pituitary tumor cells.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Cell Line; Cells, Cultured; Cyclic AMP; Dexamethasone; Indomethacin; Mice; Phorbols; Phospholipases A; Phospholipases A2; Pituitary Neoplasms; Prostaglandins; Tetradecanoylphorbol Acetate | 1984 |
Ca2+ and hormones interact synergistically to stimulate rapidly both prolactin production and overall protein synthesis in pituitary tumor cells.
Topics: Amino Acids; Animals; Calcium; Cell Line; Drug Synergism; Egtazic Acid; Kinetics; Neoplasm Proteins; Pituitary Neoplasms; Prolactin; Protein Biosynthesis; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription, Genetic; Trifluoperazine | 1984 |
Calcium-dependent adenylate cyclase of pituitary tumor cells.
Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Cell Line; Egtazic Acid; Kinetics; Magnesium; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1982 |
Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; Genes, ras; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pituitary Neoplasms; Protein Kinase C; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1994 |
Calcium and protein kinase C regulation of the glucocorticoid receptor in mouse corticotrope tumor cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcimycin; Calcium; Cycloheximide; Dexamethasone; Enzyme Activation; Kinetics; Mice; Pituitary Neoplasms; Protein Kinase C; Receptors, Glucocorticoid; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Involvement of a cAMP-responsive DNA element in mediating TRH responsiveness of the human thyrotropin alpha-subunit gene.
Topics: Animals; Base Sequence; Binding Sites; Calcium; Colforsin; Consensus Sequence; Cyclic AMP; DNA; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes; Glycoprotein Hormones, alpha Subunit; Humans; Molecular Sequence Data; Pituitary Neoplasms; Rats; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Sequence Deletion; Tetradecanoylphorbol Acetate; Thyrotropin; Thyrotropin-Releasing Hormone; Transcription Factor Pit-1; Transcription Factors; Tumor Cells, Cultured | 1994 |
Phorbol ester activation of protein kinase C inhibits CNP-stimulated cyclic GMP production in the mouse AtT-20 pituitary tumour cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cell Line; Colforsin; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Mice; Natriuretic Peptide, C-Type; Pituitary Neoplasms; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Effects of pituitary adenylate cyclase-activating polypeptide on hormone secretion by human pituitary adenomas in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenoma; Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Glycoprotein Hormones, alpha Subunit; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Neuropeptides; Neurotransmitter Agents; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Neoplasms; Prolactin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
The effects of calyculin A upon calcium-, guanine nucleotides- and phorbol 12-myristate 13-acetate-stimulated ACTH secretion from AtT-20 cells.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Guanine Nucleotides; Guanosine Triphosphate; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Pituitary Neoplasms; Radioimmunoassay; Tetradecanoylphorbol Acetate | 1995 |
The antiinflammatory activity of topically applied novel calcium-channel antagonists.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcium; Calcium Channel Blockers; Chemotaxis, Leukocyte; Clobetasol; Ear, External; Epidermis; Female; Humans; Hyperplasia; Inflammation; Mice; Neutrophils; Nifedipine; Peroxidase; Phosphatidylinositol Diacylglycerol-Lyase; Phosphodiesterase Inhibitors; Phospholipases A; Phosphoric Diester Hydrolases; Pituitary Neoplasms; Potassium Chloride; Pyrazoles; Terpenes; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1995 |
Arachidonic acid increases cytosolic calcium and stimulates hormone release in rat lactotrophs.
Topics: Animals; Arachidonic Acid; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Line; Cells, Cultured; Cobalt; Cytosol; Dose-Response Relationship, Drug; Female; Kinetics; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Rats; Rats, Wistar; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thyrotropin-Releasing Hormone; Time Factors; Tumor Cells, Cultured | 1995 |
Involvement of multiple protein kinase C isozymes in the ACTH secretory pathway of AtT-20 cells.
Topics: Adrenocorticotropic Hormone; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Calcium; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Irritants; Isoenzymes; Male; Mice; Phenanthridines; Phorbol Esters; Pituitary Gland, Anterior; Pituitary Neoplasms; Protein Kinase C; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Activation of protein kinase C increases Ca2+ sensitivity of secretory response of GH3 pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Kinetics; Pituitary Neoplasms; Potassium Chloride; Prolactin; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1993 |
Multiple intracellular signallings are involved in thyrotropin-releasing hormone (TRH)-induced c-fos and jun B mRNA levels in clonal prolactin cells.
Topics: Adenylyl Cyclases; Animals; Calcium; Clone Cells; Colforsin; Cyclic AMP; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Ionomycin; Neoplasm Proteins; Nuclear Proteins; Phorbol 12,13-Dibutyrate; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1995 |
Expression of interleukin-1 receptor antagonist in human pituitary adenomas in vitro.
Topics: Adenoma; Base Sequence; Endotoxins; Fluorescent Antibody Technique; Gene Expression; Humans; Interleukin 1 Receptor Antagonist Protein; Molecular Sequence Data; Pituitary Neoplasms; Polymerase Chain Reaction; Receptors, Interleukin-1; RNA, Messenger; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Pituitary specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues.
Topics: Adenoma; Adrenocorticotropic Hormone; Blotting, Northern; Cells, Cultured; Dimethyl Sulfoxide; DNA-Binding Proteins; Growth Hormone; Humans; In Situ Hybridization; Pituitary Gland; Pituitary Neoplasms; Prolactin; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyrotropin; Transcription Factor Pit-1; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Corticotropin-releasing hormone, proopiomelanocortin, and glucocorticoid receptor gene expression in adrenocorticotropin-producing tumors in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenoma; Adrenocorticotropic Hormone; Adult; Aged; Arginine Vasopressin; Breast Neoplasms; Corticotropin-Releasing Hormone; Cushing Syndrome; Dexamethasone; Esophageal Neoplasms; Female; Gene Expression; Humans; Hydrocortisone; Lung Neoplasms; Male; Metyrapone; Middle Aged; Pituitary Neoplasms; Pro-Opiomelanocortin; Receptors, Glucocorticoid; RNA, Messenger; Tetradecanoylphorbol Acetate | 1993 |
Processing and routing of a membrane-anchored form of proneuropeptide Y.
Topics: Animals; Binding Sites; Cell Membrane; Immunohistochemistry; Mice; Mixed Function Oxygenases; Multienzyme Complexes; Neuropeptide Y; Peptide Fragments; Pituitary Neoplasms; Precipitin Tests; Protein Precursors; Rabbits; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Ectopic expression of a mutant form of PKCalpha originally found in human tumors: aberrant subcellular translocation and effects on growth control.
Topics: Animals; Cell Division; DNA, Neoplasm; ErbB Receptors; Fibroblasts; Histones; Humans; Isoenzymes; Mice; Mice, Nude; Pituitary Neoplasms; Point Mutation; Protein Kinase C; Protein Kinase C-alpha; Rats; Stimulation, Chemical; Subcellular Fractions; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Transduction, Genetic; Translocation, Genetic | 1997 |
Agonist-induced desensitization, internalization, and phosphorylation of the sst2A somatostatin receptor.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Antineoplastic Agents, Hormonal; Binding Sites; Carcinogens; Enzyme Activation; Hormone Antagonists; Octreotide; Pertussis Toxin; Phosphorylation; Pituitary Neoplasms; Protein Binding; Protein Kinase C; Rats; Receptors, Somatostatin; Somatostatin; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Quantitation and regulation of pyroglutamyl peptidase II messenger RNA levels in rat tissues and GH3 cells.
Topics: Aminopeptidases; Animals; Brain; Gene Expression Regulation, Enzymologic; Male; Organ Specificity; Pituitary Neoplasms; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tissue Distribution; Triiodothyronine; Tumor Cells, Cultured | 1998 |
Secretory mechanisms of growth hormone (GH)-releasing peptide-, GH-releasing hormone-, and thyrotropin-releasing hormone-induced GH release in patients with acromegaly.
Topics: Acromegaly; Adenoma; Adult; Colforsin; Drug Combinations; Female; Growth Hormone-Releasing Hormone; Human Growth Hormone; Humans; Male; Masoprocol; Middle Aged; Oligopeptides; Pituitary Neoplasms; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1998 |
Relationship between GHRP-6 and TPA in the regulation of growth hormone secretion by human pituitary somatotrophinomas.
Topics: Adenoma; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Oligopeptides; Phosphatidylinositol Phosphates; Pituitary Neoplasms; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Characterization of 5-HT- and ionomycin-stimulated changes in levels of intracellular calcium and PI hydrolysis in P11 cells.
Topics: Animals; Calcium; Ionomycin; Phosphatidylinositols; Pituitary Neoplasms; Protein Kinase C; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Lidocaine inhibits prolactin secretion in GH4C1 cells by blocking calcium influx.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenoma; Animals; Calcium; Colforsin; Lidocaine; Pituitary Neoplasms; Potassium; Procaine; Prolactin; Rats; Tetradecanoylphorbol Acetate; Tetrodotoxin; Tumor Cells, Cultured | 1992 |
Electrophysiological properties of a cell line of the gonadotrope lineage.
Topics: Animals; Calcium Channels; Cell Line; Electrophysiology; Gonadotropin-Releasing Hormone; Membrane Potentials; Pituitary Neoplasms; Potassium Channels; Rats; Sodium Channels; Tetradecanoylphorbol Acetate; Tetrodotoxin; Thyrotropin-Releasing Hormone | 1992 |
Ca2+ channel modulation and kinase-C activation in a pituitary cell line: induction of immediate early genes and inhibition of proliferation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cell Division; Cell Line; DNA Replication; Enzyme Activation; Genes, fos; Genes, Regulator; Isomerism; Kinetics; Membrane Potentials; Pituitary Neoplasms; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Thymidine | 1992 |
Role of cyclic adenosine 3',5'-monophosphate-dependent protein kinase in hormone-stimulated beta-endorphin secretion in AtT20 cells.
Topics: Animals; beta-Endorphin; Calcium Channels; Cell Line, Transformed; Cholera Toxin; Cyclic AMP; Gene Expression; Isoproterenol; Mice; Mutagenesis; Pituitary Neoplasms; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Thionucleotides; Transfection; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1991 |
Rapid induction of polyadenylate binding protein and stimulation of translational initiation in pituitary tumor cells exposed to phorbol ester.
Topics: Carrier Proteins; Dactinomycin; Deoxyadenosines; Gene Expression Regulation; Humans; Methionine; Peptide Chain Initiation, Translational; Pituitary Gland, Anterior; Pituitary Neoplasms; Poly A; Poly(A)-Binding Proteins; Polyribosomes; RNA, Messenger; Tetradecanoylphorbol Acetate | 1991 |
An alpha-subunit-secreting cell line derived from a mouse thyrotrope tumor.
Topics: Animals; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dexamethasone; DNA-Binding Proteins; Gene Expression Regulation; Glycoprotein Hormones, alpha Subunit; Mice; Pituitary Gland, Anterior; Pituitary Neoplasms; Regulatory Sequences, Nucleic Acid; Second Messenger Systems; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription Factors; Tumor Cells, Cultured | 1990 |
Chloride channel blockers inhibit ACTH secretion from mouse pituitary tumor cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Adrenocorticotropic Hormone; Animals; Cell Line; Chloride Channels; Colforsin; Corticotropin-Releasing Hormone; Ion Channels; Kinetics; Membrane Proteins; Mice; ortho-Aminobenzoates; Osmolar Concentration; Pertussis Toxin; Pituitary Neoplasms; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Thyrotropin-releasing hormone (TRH) and phorbol myristate acetate decrease TRH receptor messenger RNA in rat pituitary GH3 cells: evidence that protein kinase-C mediates the TRH effect.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Line; DNA Probes; Gene Expression Regulation, Neoplastic; Isoquinolines; Kinetics; Piperazines; Pituitary Neoplasms; Poly A; Protein Kinase C; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; RNA; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1991 |
pH homeostasis in pituitary GH4C1 cells: basal intracellular pH is regulated by cytosolic free Ca2+ concentration.
Topics: Adenosine Triphosphate; Amiloride; Animals; Calcium; Clone Cells; Cytosol; Deoxyglucose; Drug Interactions; Energy Metabolism; Enzyme Activation; Homeostasis; Hydrogen-Ion Concentration; Hypertonic Solutions; Ionomycin; Kinetics; Pituitary Neoplasms; Potassium; Protein Kinase C; Rats; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1992 |
Quinidine inhibits prolactin secretion induced by thyrotropin-releasing hormone, high medium potassium or hyposmolarity in GH4C1 cells.
Topics: Anti-Arrhythmia Agents; Humans; Osmolar Concentration; Pituitary Neoplasms; Potassium; Prolactin; Quinidine; Tetradecanoylphorbol Acetate; Thyrotropin; Thyrotropin-Releasing Hormone; Time Factors; Tumor Cells, Cultured | 1991 |
Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
Topics: Animals; Antineoplastic Agents; Bryostatins; Cell Adhesion; Cell Cycle; Cell Division; Cell Line; DNA Replication; Epidermal Growth Factor; Kinetics; Lactones; Macrolides; Pituitary Neoplasms; Protein Kinase C; Rats; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymidine; Thyrotropin-Releasing Hormone | 1991 |
Inhibition of growth hormone secretion by activin A in human growth hormone-secreting tumour cells.
Topics: Activins; Adult; Calcimycin; Calcium; Cytoplasm; Dose-Response Relationship, Drug; Female; Growth Hormone; Humans; Inhibins; Male; Middle Aged; Pituitary Neoplasms; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1991 |
Effect of secretagogues on components of the secretory system in AtT-20 cells.
Topics: Animals; Carboxypeptidase H; Carboxypeptidases; Corticotropin-Releasing Hormone; Dexamethasone; Endorphins; GTP-Binding Proteins; Mice; Mixed Function Oxygenases; Multienzyme Complexes; Oxidoreductases Acting on CH-NH Group Donors; Pituitary Neoplasms; Protein Processing, Post-Translational; RNA, Messenger; Signal Transduction; Somatostatin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Transforming growth factor-alpha and -beta are potent and effective inhibitors of GH4 pituitary tumor cell proliferation.
Topics: Activins; Animals; Cell Adhesion; Cell Count; Cell Division; DNA; Inhibins; Interphase; Mitosis; Phorbol 12,13-Dibutyrate; Pituitary Neoplasms; Prolactin; Protein Kinase C; Rats; Recombinant Proteins; S Phase; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Transforming Growth Factor beta; Tumor Cells, Cultured | 1991 |
Phorbol ester, not growth hormone releasing factor, consistently stimulates growth hormone release from somatotroph adenomas in culture.
Topics: Adenoma; Adult; Aged; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Male; Middle Aged; Pituitary Neoplasms; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1991 |
The sustained second phase of hormone-stimulated diacylglycerol accumulation does not activate protein kinase C in GH3 cells.
Topics: Animals; Antibodies; Biological Transport; Brain; Calcium; Cell Line; Cell Membrane; Chickens; Diglycerides; Enzyme Activation; Female; Glycerides; Immunoblotting; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1990 |
Interleukin 1 induces early protein phosphorylation and requires only a short exposure for late induced secretion of beta-endorphin in a mouse pituitary cell line.
Topics: Animals; beta-Endorphin; Cell Line; Corticotropin-Releasing Hormone; Cyclic AMP; Electrophoresis, Gel, Two-Dimensional; Interleukin-1; Kinetics; Mice; Molecular Weight; Neoplasm Proteins; Phosphates; Phosphoproteins; Phosphorylation; Pituitary Gland, Anterior; Pituitary Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Rat pro-atrial natriuretic factor expression and post-translational processing in mouse corticotropic pituitary tumor cells.
Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Atrial Natriuretic Factor; Cadmium; Cadmium Chloride; Carboxypeptidase H; Carboxypeptidases; Chromatography, High Pressure Liquid; Gene Expression; Isoproterenol; Mice; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Peptide Mapping; Pituitary Neoplasms; Plasmids; Protein Precursors; Protein Processing, Post-Translational; Rats; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1990 |
Possible role of Ca2(+)-independent protein kinase C isozyme, nPKC epsilon, in thyrotropin-releasing hormone-stimulated signal transduction: differential down-regulation of nPKC epsilon in GH4C1 cells.
Topics: Animals; Brain; Calcium; Cell Line; Chromatography; Durapatite; Hydroxyapatites; Isoenzymes; Kinetics; Pituitary Neoplasms; Protein Kinase C; Rabbits; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1990 |
Priming effect of hyperosmotic stress on TRH-induced activation of Na+/H+ exchange in GH4C1 rat pituitary cells.
Topics: Animals; Carrier Proteins; Cell Line; Fluoresceins; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Osmolar Concentration; Pituitary Neoplasms; Rats; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1990 |
Clustered point mutation analysis of the rat prolactin promoter.
Topics: Animals; Base Sequence; Binding Sites; Cyclic AMP; DNA; DNA-Binding Proteins; Genetic Markers; Luciferases; Molecular Sequence Data; Mutagenesis; Pituitary Neoplasms; Prolactin; Promoter Regions, Genetic; Rats; Repetitive Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription Factor Pit-1; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1990 |
Effects of protein kinase C down-regulation on secretory events and proopiomelanocortin gene expression in anterior pituitary tumor (AtT-20) cells.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Cell Membrane; Cytosol; Gene Expression Regulation; Genes; Homeostasis; Kinetics; Phorbol 12,13-Dibutyrate; Phosphorylation; Pituitary Neoplasms; Pro-Opiomelanocortin; Protein Kinase C; Receptors, Drug; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Induction of distinct phenotypes in clonal and variant GH4 pituitary cells.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules, Neuronal; Cell Division; Cell Movement; Clone Cells; Epidermal Growth Factor; Epithelial Cells; Phenotype; Pituitary Gland; Pituitary Neoplasms; Prolactin; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Stimulation of adrenocorticotropin secretion from AtT-20 cells by the calcium channel activator, BAY-K-8644, and its inhibition by somatostatin and carbachol.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Adrenocorticotropic Hormone; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Mice; Nifedipine; Pituitary Neoplasms; Somatostatin; Tetradecanoylphorbol Acetate; Time Factors; Virulence Factors, Bordetella | 1985 |
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Animals; Colforsin; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glucagon; Insulinoma; Isoproterenol; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate | 1986 |
Preferential role of calcium in the regulation of prolactin gene transcription by thyrotropin-releasing hormone in GH3 pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Cell Line; Genes; Kinetics; Pituitary Neoplasms; Prolactin; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription, Genetic | 1988 |
Estrogens, cyclic adenosine 3',5'-monophosphate, and phorbol esters modulate the prolactin response of GH3 cells to basic fibroblast growth factor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cyclic AMP; Drug Interactions; Estradiol; Fibroblast Growth Factors; Growth Hormone; Kinetics; Pituitary Neoplasms; Prolactin; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1988 |
Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Hydrogen-Ion Concentration; Immunoassay; Molecular Weight; Phosphorylation; Phosphotyrosine; Pituitary Gland; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1988 |
Thyroliberin and dihydropyridines modulate prolactin gene expression through interacting pathways in GH3 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Gene Expression; Isradipine; Kinetics; Oxadiazoles; Pituitary Neoplasms; Prolactin; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1989 |
Interleukin 1 potentiates the secretion of beta-endorphin induced by secretagogues in a mouse pituitary cell line (AtT-20).
Topics: Animals; beta-Endorphin; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Drug Synergism; Enzyme Activation; Interleukin-1; Kinetics; Mice; Pituitary Neoplasms; Protein Kinase C; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1989 |
Phorbol esters and corticotropin releasing factor stimulate calcium influx in the anterior pituitary tumor cell line, AtT-20, through different intracellular sites of action.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Corticotropin-Releasing Hormone; Cyclic AMP; Mice; Pituitary Gland, Anterior; Pituitary Neoplasms; Potassium Channels; Tetradecanoylphorbol Acetate; Tetraethylammonium Compounds; Tetrodotoxin; Tumor Cells, Cultured | 1989 |
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkylation; Animals; Calcium; Colforsin; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Pertussis Toxin; Pituitary Neoplasms; Polymyxin B; Prolactin; Protein Kinase C; Rats; Somatostatin; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
Regulation of growth hormone secretion and messenger ribonucleic acid accumulation in human somatotropinoma cells in vitro.
Topics: Adenoma; Adult; Colforsin; Female; Growth Hormone; Humans; Male; Pituitary Neoplasms; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Phorbol esters increase adenylate cyclase activity and stability in pituitary membranes.
Topics: Adenylyl Cyclases; Calcium; Cell Membrane; Cyclic AMP; Humans; Kinetics; Models, Biological; Phorbol 12,13-Dibutyrate; Phorbol Esters; Pituitary Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Phorbol esters induce two distinct changes in GH3 pituitary cell adenylate cyclase activity.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Enzyme Activation; Guanylyl Imidodiphosphate; Manganese; Pituitary Neoplasms; Protein Kinase C; Rats; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1988 |
1,2-Diacylglycerols, but not phorbol esters, activate a potential inhibitory pathway for protein kinase C in GH3 pituitary cells. Evidence for involvement of a sphingomyelinase.
Topics: Animals; Cell Line; Cell Membrane; Cytosol; Diglycerides; Enzyme Activation; Glycerides; Kinetics; Phosphoric Diester Hydrolases; Pituitary Neoplasms; Protein Kinase C; Sphingomyelin Phosphodiesterase; Tetradecanoylphorbol Acetate | 1988 |
An analogue of creatine increases TRH-stimulated prolactin secretion and phosphoinositide hydrolysis in rat pituitary tumor cells.
Topics: Aminoquinolines; Animals; Calcimycin; Creatine; Dose-Response Relationship, Drug; Guanidines; Hydrolysis; Inositol Phosphates; Lactates; Lithium; Phosphatidylinositols; Phosphocreatine; Pituitary Neoplasms; Prolactin; Propionates; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1988 |
The inhibitory guanine nucleotide-binding regulatory subunit of adenylate cyclase has an adenylate cyclase-independent modulatory effect on ACTH secretion from mouse pituitary tumor cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Bacterial Toxins; Cell Line; Cyclic AMP; GTP-Binding Proteins; Mice; Pertussis Toxin; Pituitary Neoplasms; Somatostatin; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1985 |
Phorbol ester and phospholipase C-induced growth hormone secretion from pituitary somatotroph adenoma cells in culture: effects of somatostatin, bromocriptine, and pertussis toxin.
Topics: Adenoma; Bromocriptine; Cells, Cultured; Drug Interactions; Growth Hormone; GTP-Binding Proteins; Humans; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Pituitary Neoplasms; Protein Kinase C; Secretory Rate; Somatostatin; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1987 |
Phorbol esters and thyroliberin have distinct actions regarding stimulation of prolactin secretion and activation of adenylate cyclase in rat pituitary tumour cells (GH4C1 cells).
Topics: Adenylyl Cyclases; Animals; Cell Line; Colforsin; Diglycerides; Enzyme Activation; Guanylyl Imidodiphosphate; Phorbol Esters; Pituitary Neoplasms; Polymyxin B; Prolactin; Rats; Somatostatin; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1988 |
Activation of distinct second messenger systems in anterior pituitary corticotrophic tumor cells alters the phosphorylation states of both shared and distinct cytosolic proteins.
Topics: Adenylyl Cyclases; Animals; beta-Endorphin; Cell Line; Colforsin; Cytosol; Endorphins; Enzyme Activation; Kinetics; Mice; Neoplasm Proteins; Phosphorus Radioisotopes; Phosphorylation; Pituitary Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
Dopamine inhibits prolactin release when cyclic adenosine 3',5'-monophosphate levels are elevated.
Topics: Animals; Calcimycin; Colforsin; Cyclic AMP; Dopamine; Female; Fluorescent Antibody Technique; Microscopy, Fluorescence; Pituitary Neoplasms; Prolactin; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1986 |
Regulation of thyroxine 5'-deiodinase by thyroid hormones and activators of protein kinase C in GH4C1 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcimycin; Cell Line; Colforsin; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Hypothyroidism; Iodide Peroxidase; Phorbol Esters; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyroid Hormones; Thyrotropin-Releasing Hormone; Thyroxine; Trifluoperazine; Triiodothyronine; Triiodothyronine, Reverse | 1986 |
Characterization of phorbol ester- and diacylglycerol-stimulated secretion in permeable GH3 pituitary cells. Interaction with Ca2+.
Topics: Animals; Calcium; Cell Line; Cell Membrane Permeability; Diglycerides; Drug Synergism; Glycerides; Kinetics; Phorbols; Phosphatidylinositol Phosphates; Phosphatidylinositols; Pituitary Neoplasms; Prolactin; Proteoglycans; Rats; Tetradecanoylphorbol Acetate | 1986 |
Effects of prolonged phorbol ester exposure on ACTH secretion from mouse pituitary tumor cells.
Topics: Adrenocorticotropic Hormone; Animals; Cells, Cultured; Colforsin; Mice; Pituitary Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Intracellular Ca2+-dependent protein kinase C activation mimics delayed effects of thyrotropin-releasing hormone on clonal pituitary cell excitability.
Topics: Action Potentials; Animals; Calcium; Cell Line; Cell Membrane; Clone Cells; Diglycerides; Electrophysiology; Enzyme Activation; Phosphatidylinositols; Pituitary Gland; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1987 |
Interactions among lithium, calcium, diacylglycerides, and phorbol esters in the regulation of adrenocorticotropin hormone release from AtT-20 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Animals; Calcium; Cell Line; Colforsin; Corticotropin-Releasing Hormone; Diglycerides; Dose-Response Relationship, Drug; Drug Interactions; Glycerides; Inositol Phosphates; Lithium; Mice; Phorbol Esters; Pituitary Gland, Anterior; Pituitary Neoplasms; Potassium; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1987 |
Glucocorticoids antagonize induction of prolactin-gene expression by calcitriol in rat pituitary tumour cells.
Topics: Animals; Calcitriol; Cell Line; Epidermal Growth Factor; Gene Expression Regulation; Glucocorticoids; Hydrocortisone; Male; Pituitary Neoplasms; Prolactin; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1986 |
Diacylglycerol increases cytosolic free Ca2+ concentration in rat pituitary cells. Relationship to thyrotropin-releasing hormone action.
Topics: Animals; Calcium; Cell Line; Cytosol; Diglycerides; Glycerides; Kinetics; Pituitary Neoplasms; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1987 |
Phosphorylation of intracellular proteins related to the multihormonal regulation of prolactin: comparison of normal anterior pituitary cells in culture with the tumor-derived GH cell lines.
Topics: Animals; Cell Line; Cells, Cultured; Dopamine; Female; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Rats; Rats, Inbred Strains; Reference Values; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 1988 |
Protein kinase C translocates from cytosol to membrane upon hormone activation: effects of thyrotropin-releasing hormone in GH3 cells.
Topics: Animals; Barium; Biological Transport; Cell Line; Cell Membrane; Cytosol; Pituitary Neoplasms; Potassium; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Type C Phospholipases | 1985 |
Thyrotropin-releasing hormone induces redistribution of protein kinase C in GH4C1 rat pituitary cells.
Topics: Animals; Calcium; Cell Line; Dose-Response Relationship, Drug; Pituitary Gland; Pituitary Neoplasms; Prolactin; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tissue Distribution | 1985 |
Prolactin secretion in permeable GH3 pituitary cells is stimulated by Ca2+ and protein kinase C activators.
Topics: Aminoquinolines; Animals; Calcium; Cell Line; Cell Membrane Permeability; Cytoplasm; Diglycerides; Enzyme Activation; L-Lactate Dehydrogenase; Pituitary Gland; Pituitary Neoplasms; Prolactin; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1985 |
Regulation of human chorionic somatomammotropin gene expression in rat pituitary tumour cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Division; Chloramphenicol O-Acetyltransferase; Dexamethasone; DNA, Recombinant; Epidermal Growth Factor; Gene Expression Regulation; Glucose; Humans; Insulin-Like Growth Factor II; Pituitary Gland, Anterior; Pituitary Neoplasms; Placental Lactogen; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Triiodothyronine; Tumor Cells, Cultured | 1988 |
Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.
Topics: Animals; Binding Sites; Binding, Competitive; Bryostatins; Cell Line; Diglycerides; Enzyme Activation; Eukaryota; Glycerides; Kinetics; Lactones; Macrolides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Pituitary Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells.
Topics: Animals; Ceramides; Choline; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Glycerides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Pituitary Neoplasms; Rats; Sphingomyelin Phosphodiesterase; Sphingomyelins; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1987 |
1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action.
Topics: Animals; Cytidine Diphosphate Choline; Diglycerides; Glycerides; Phorbol Esters; Phosphatidylcholines; Pituitary Neoplasms; Rats; Stearic Acids; Tetradecanoylphorbol Acetate | 1987 |
Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.
Topics: Animals; Brain; Cell Line; Cell Membrane; Cytosol; Half-Life; Immune Sera; Immunosorbent Techniques; Methionine; Phorbols; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Comparison of patterns of prolactin release in GH4C1 cells and primary pituitary cultures.
Topics: Animals; Calcimycin; Cell Line; Cells, Cultured; Female; Kinetics; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1985 |